Jerry Canterbury, paralyzed plaintiff in lawsuit that established ‘informed consent,’ dies at 78 - The Washington Post
> In 1959, at 19, he agreed to undergo a spinal surgery known as a laminectomy — a procedure expected to resolve a ruptured disc and that he said his doctor described as “no more serious than an ordinary, everyday operation.” The day after the surgery, Mr. Canterbury fell at the hospital while attempting to empty his bladder. Another operation followed. By the time he was discharged more than three months later, he was partially paralyzed in the legs and permanently incontinent. He would spend the rest of his life on crutches, then in a wheelchair and finally confined to a bed. Mr. Canterbury, who has died at 78, sued his surgeon, William T. Spence, accusing him of having failed to adequately warn him of the risks of his surgery. The physician ultimately prevailed, but a 1972 federal appeals court decision in the case became a foundation of the doctrine of informed consent and, by extension, the modern practice of medicine.
medicine  history  law  ethics 
2 days ago
What Price Success? Ionis Drug Worked in Phase 3 but Had Serious Side Effects | ALZFORUM
> TTR amyloidosis is but one of many diseases Ionis is targeting with ASOs. Its ASO therapies are in various stages of development to suppress huntingtin, SOD1, C9orf72, and tau (see May 2013 news; Jun 2012 news; Nov 2015 news; and Jan 2017 news).—Jessica Shugart
ASO  RNA  amyloid 
3 days ago
Charles Proteus Steinmetz - Wikipedia
> Steinmetz was called the "forger of thunderbolts", being the first to create artificial lightning in his football field-sized laboratory and high towers built at General Electric, using 120,000 volt generators. He erected a lightning tower to attract natural lightning, and studied the patterns and effects of lightning resulting in several theories and ideas.[citation needed]
science  history  lightning 
6 days ago
Michael C. Ain, M.D.
Badass ortho surgeon who has achondroplasia.
surgery  medicine  hero  achondroplasia 
6 days ago
Visual release hallucinations - Wikipedia
> Mentally healthy people with significant vision loss may have vivid, complex recurrent visual hallucinations (fictive visual percepts). One characteristic of these hallucinations is that they usually are "lilliputian" (hallucinations in which the characters or objects are smaller than normal). The most common hallucination is of faces or cartoons.[4] Sufferers understand that the hallucinations are not real, and the hallucinations are only visual, that is, they do not occur in any other senses, e.g. hearing, smell or taste.[5][6] Among older adults (> 65 years) with significant vision loss, the prevalence of Charles Bonnet syndrome has been reported to be between 10% and 40%; a 2008 Australian study found the prevalence to be 17.5%.[2] Two Asian studies, however, report a much lower prevalence.[7][8] The high incidence of non-reporting of this disorder is the greatest hindrance to determining the exact prevalence; non-reporting is thought to be a result of sufferers being afraid to discuss the symptoms out of fear that they will be labelled insane.[6]
hallucination  vision  psychiatry 
7 days ago
Asthma and obesity: does weight loss improve asthma control? a systematic review
> Weight loss in obese individuals with doctor-diagnosed asthma is associated with a 48%–100% remission of asthma symptoms and use of asthma medication. Published studies, furthermore, reveal that weight loss in obese asthmatics improves asthma control, and that especially surgically induced weight loss results in significant improvements in asthma severity, use of asthma medication, dyspnoea, exercise tolerance, and acute exacerbations, including hospitalizations due to asthma. Furthermore, weight loss in obese asthmatics is associated with improvements in level of lung function and airway responsiveness to inhaled methacholine, whereas no significant improvements have been observed in exhaled nitric oxide or other markers of eosinophilic airway inflammation.
asthma  obesity  weightloss 
8 days ago
Review of Alain de Botton’s “Pleasures and Sorrows of Work” – Steamboats Are Ruining Everything
> I will hate you till the day I die and wish you nothing but ill will in every career move you make. I will be watching with interest and schadenfreude.
alain_botton  schadenfreude  hate  take_down 
9 days ago
Rejection Letter - Charlie's Diary
Satire about the worldwide hack yesterday being rejected as implausible fiction.
security  computers  2017  humor 
10 days ago
Folie à deux - Wikipedia
> Folie à deux and its more populous cousins are in many ways a psychiatric curiosity. The current Diagnostic and Statistical Manual of Mental Disorders states that a person cannot be diagnosed as being delusional if the belief in question is one "ordinarily accepted by other members of the person's culture or subculture" (see entry for delusion). It is not clear at what point a belief considered to be delusional escapes from the folie à... diagnostic category and becomes legitimate because of the number of people holding it. When a large number of people may come to believe obviously false and potentially distressing things based purely on hearsay, these beliefs are not considered to be clinical delusions by the psychiatric profession and are labelled instead as mass hysteria.
psychiatry  psychosis 
10 days ago
Charleston Gazette-Mail | Trump officials seek opioid solutions in WV
> Asked about drug treatment options, Price touted faith-based programs while showing less support for medication-assisted programs in which addicts are weaned off heroin with other opioids like Suboxone and methadone.
“If we’re just substituting one opioid for another, we’re not moving the dial much,” he said. “Folks need to be cured so they can be productive members of society and realize their dreams.”
2017  religion  psychiatry  addiction  tom_price  opioid 
13 days ago
Ultrasound treatment of neurological diseases [mdash] current and emerging applications : Nature Reviews Neurology : Nature Research
Ultrasound therapy to treat disorders of the brain, hopefully will be more approved therapies over the coming decade or so.
OCD  ultrasound  neurosurgery  neurology  psychiatry  parkinsons  tremor 
13 days ago
At 45, ex-detective shifts investigation skills to medicine | Cornell Chronicle
> He’s most interested in the biology of aging, and specifically, how science has extended lifespans but hasn’t extended health spans at a corresponding rate. “Our experiences in life tell us that things get old and then they break,” Saffran said. “While that process seems perfectly normal and reasonable, it’s actually not necessary for biological systems to respond to age in this way.” He intends to investigate why this happens, and hopes to improve the health of our aging population in the process. Poised to eventually receive the same degree as his mentor, Kaplitt, Saffran is still sometimes in awe of the opportunities ahead of him. “I thought you have to be such a genius to do this kind of thing,” he says. “It’s the single greatest accomplishment of my life that is not directly connected to my daughter.”
mdphd  christian_saffran  police  post_mdphd  aging 
14 days ago
The Impact of Physician Weight Discussion on Weight Loss in US Adults
> Overweight and obese participants were significantly more likely to report a 5% weight loss in the past year if their doctor had told them they were overweight (adjusted OR (AOR) 1.88; 95% CI 1.45-2.44; AOR 1.79; 95% CI 1.30-2.46, respectively).
weight_loss  obesity  doctor 
15 days ago
Ray Allen talks about his passion for teaching others about the Holocaust
> “I am proud to serve in this role and to continue to share the important messages and lessons we all need to remember from the Holocaust,” Allen said in a statement. “I want to inspire people to break down stereotypes, and treat one another — regardless of race, religion or anything else — like family. It’s more important now than ever.”
ray_allen  nba  history  holocaust 
15 days ago
Total knee replacement for athletes | Total joint replacement for athletes | Sports after total knee replacement | Sports after hip replacement The Stone Clinic
> The wearing out of plastic components most often occurs in mal position or mal tracking of the joint. Improved tracking is facilitated by strong muscles, better balance and more normal gait, all of which come from a strong core and strong trunk muscles. Total body fitness conditioning is the key to a long lasting joint replacement. Most modern knee replacements have plastic components that are interchangeable if worn out. So why limit an entire later lifetime of sports by the fear of them wearing out?

Finally to running: Running is the most common request we get from our athletes who need total knees. The data is that whether you run a mile or walk a mile, the total force on the joint is the same, since you take fewer steps when running. The peak forces are higher depending on the type of surface, the smoothness of the gait, the shoe wear and other factors. If you must run, run with great form on soft surfaces with new absorbent shoes. I have never seen a total knee become worn out from running nor have any of my peers who I have asked. In general cycling is a more logical sport as it limits the impact, but logic is not the reason we run.
running  knee  knee_replacement 
16 days ago
The association between socioeconomic status and adult fast-food consumption in the U.S.
> Fast-food consumption among adults varies little across SES, measured as income and wealth.
Descriptive analyses indicate a weak, inverted U-shaped association between fast-food and SES.
Checking nutrition labels frequently and drinking less soda predict less adult fast-food intake.
More work hours predict greater fast-food intake.
food  income  SES  economics 
16 days ago
Queens pursued more aggressive war policies - Marginal REVOLUTION
> We find that polities led by queens were more likely to engage in war than polities led by kings. Moreover, the tendency of queens to engage as aggressors varied by marital status. Among unmarried monarchs, queens were more likely to be attacked than kings. Among married monarchs, queens were more likely to participate as attackers than kings, and, more likely to fight alongside allies. These results are consistent with an account in which marriages strengthened queenly reigns because married queens were more likely to secure alliances and enlist their spouses to help them rule. Married kings, in contrast, were less inclined to utilize a similar division of labor. These asymmetries, which reflected prevailing gender norms, ultimately enabled queens to pursue more aggressive war policies.
war  history  monarchy 
16 days ago
Reductress » Why I’m Settling For a Man Who’s Not My High School Poster of Aragorn
> I used to have pretty unreasonable standards when it came to men. I’d turn them down no matter how great they seemed, simply because they didn’t meet the very specific set of expectations I’d developed over the course of my life. I stayed single for years, until one day, I finally gave up on the fantasy of meeting the ideal guy altogether – a motionless and slightly faded 27” x 41” poster image of Aragorn, from the Lord of the Rings trilogy. Now, I’m finally ready to settle for a man who’s not that poster.
humor  dating 
17 days ago
Overcoming Bias : What TED Needs
> The most discouraging talk I heard was by Jim Yong Kim, President of the World Bank Group. He talked about how he fought the World Bank for years, because they insisted on using cost-effectiveness criteria to pick medical investments. He showed us pictures of particular people helped by less cost-effective treatments, daring us to say they were not worth helping. And he said people in poor nations have status-based “aspirations” for the same sort of hospitals and schools found in rich nations, even if they aren’t cost-effective, and who are we to tell them no. Now that he runs the World Bank (nominated by Obama in 2012), his priorities can now win more. The audience cheered. So sad.
politics  2017  economics  markets  ted 
17 days ago
Investigating the case of human nose shape and climate adaptation
Part of why different ancestral groups may have different nose sizes > We find that width of the nares is correlated with temperature and absolute humidity, but not with relative humidity. We conclude that some aspects of nose shape may indeed have been driven by local adaptation to climate. However, we think that this is a simplified explanation of a very complex evolutionary history, which possibly also involved other non-neutral forces such as sexual selection.
nose  face  genomics 
18 days ago
Restorative justice conferencing (RJC) using face-to-face meetings of offenders and victims: effects on offender recidivism and victim satisfaction - The Campbell Collaboration
> The evidence of a relationship between conferencing and subsequent convictions or arrests over two years post-random assignment is clear and compelling, with nine out of 10 results in the predicted direction and a standardized mean difference for the ten experiments combined (Cohen’s d = -.155; p = .001). The impact of RJCs on 2-year convictions was reported to be cost-effective in the 7 UK experiments, with up to 14 times as much benefit in costs of the crimes prevented (in London), and 8 times overall, as the cost of delivering RJCs. The effect of conferencing on victims’ satisfaction with the handling of their cases is uniformly positive (d = .327; p<.05), as are several other measures of victim impact.
crime  justice  law  RCT 
18 days ago
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
> In this study, we have demonstrated that inhibition of ASIC1a using Hi1a provides exceptional levels of neuroprotection even when the peptide is administered up to 8 h after stroke onset. Along with facilitating a substantially reduced level of penumbral damage, Hi1a is unique in providing some protection of the striatal core region, which is generally considered therapeutically unrecoverable owing to rapid and irreversible necrotic cell death ( .. Hi1a was neuroprotective even when administered 8 h after onset of ET-1–mediated MCAO. Although we did not determine the degree and duration of ET-1–mediated cerebral ischemia, previous studies have reported either complete or partial recovery of blood flow at 8 h after stroke (33–35). In this context, we have shown that the neuroprotection afforded by Hi1a is unlikely to result from a vasodilatory effect, given that it did not reverse ET-1–mediated vasoconstriction of isolated cerebral arteries
stroke  neuroprotection 
19 days ago
Total recall: the people who never forget | Science | The Guardian
> When I first spoke to McGaugh, he told me that the real question at the heart of HSAM wasn’t why his subjects remember, but why we forget. “The overall summary of all of this is that they’re bad forgetters,” he said. And forgetting is what humans do; often what we need to do. The title character in Jorge Luis Borges’s story Funes the Memorious, who acquires a perfect memory as the result of an accident, can no longer sleep because he is kept awake by the thousand mundane memories that whined like mosquitoes in his ears. The “peculiar mixture of forgetting with our remembering,” wrote William James, one of the founders of modern psychology, “is the very keel on which our mental ship is built.” “If we remembered everything,” he continued, “we should on most occasions be as ill off as if we remembered nothing.”
memory  happiness 
20 days ago
Neutral vs. Conservative: The Eternal Struggle | Slate Star Codex
> Stanford historian Robert Conquest once declared it a law of politics that “any organization not explicitly right-wing sooner or later becomes left-wing”. I have no idea why this should be true, and yet I’ve seen it again and again. Taken to its extreme, it suggests we’ll end up with a bunch of neutral organizations that have become left-wing, plus a few explicitly right-wing organizations. Given that Conquest was writing in the 1960s, he seems to have predicted the current situation remarkably well.
politics  media  scott_alexander  history 
20 days ago
Short and long term memory: For half a century, neuroscientists thought they knew how memory worked. They were wrong — Quartz
> Short-term memory, Cleeremans says, allows you to find the specific street and space where you parked the car that day. But long-term memory accumulates all these individual instances into a broad set of data, so you know the streets where you’re most likely to find a parking space and enables you to develop a great car-parking strategy.
memory  hippocampus  pfc  neuroscience 
20 days ago
The shock tactics set to shake up immunology : Nature News & Comment
> Tracey acknowledges this criticism, but still sees huge potential in electrical stimulation. “In our lifetime, we will see devices replacing some drugs,” he says. Delivering shocks to the vagus or other peripheral nerves could provide treatment for a host of diseases, he argues, from diabetes to high blood pressure and bleeding. “This is the beginning of a field.” ... Last October, the US National Institutes of Health announced a programme called Stimulating Peripheral Activity to Relieve Conditions (SPARC), which will provide US$238 million in funding until 2021 to support research updating the maps of neural circuitry in the thoracic and abdominal cavities.
neurology  electrophysiology 
20 days ago
Psychedelic compound in ecstasy moves closer to approval to treat PTSD : Nature News & Comment
> During his conference presentation, Mithoefer played a video of a former US marine under the influence of MDMA recounting the time his military jeep exploded during a tour in Iraq. The soldier, positioned on a narrow bed between Mithoefer and his wife Annie, a psychiatric nurse, describes the panic that accompanies his memories. But then, he says, an inner-voice assures him that he’ll be all right. “I feel things come up and then blow away like sand,” the marine says. Michael Mithoefer says it’s been five years since the marine’s session. “We are still in touch,” he says, “and that effect has lasted.”
mdma  ptsd  psychiatry 
25 days ago
Keep Your Identity Large | Thing of Things
> Identify as things that aren’t based on empirical claims. If you identify as a libertarian, then you’re signing on to a bunch of empirical claims, like “the minimum wage is bad for poor people” and “environmental regulations cause more harm than good” and “police officers abuse people’s civil liberties.” If it turns out that actually police officers are totally nice to black people everywhere, this might be a threat to your identity as a libertarian, and then you’re going to have flamewars about the subject.
identity  ozy  psychology 
26 days ago
Manchester Liberalism - Wikipedia
> Manchester Liberalism are terms for the political, economic, and social movements of the 19th century that originated in Manchester, England. Led by Richard Cobden and John Bright, it won a wide hearing for its argument that free trade would lead to a more equitable society, making essential products available to all. Its most famous activity was the Anti-Corn Law League that called for repeal of the Corn Laws that kept food prices high. It expounded the social and economic implications of free trade and laissez-faire. The Manchester School took the theories of economic liberalism advocated by classical economists such as Adam Smith and made them the basis for government policy. The School also promoted pacifism, anti-slavery, freedom of the press, and separation of church and state.[1]
history  politics  liberalism 
28 days ago
More Evidence that Excessive Blood Pressure Lowering Can Heighten Cardiovascular Risk - NEJM Journal Watch
> Mean BP achieved on treatment was a stronger predictor of CV outcomes than was baseline BP or last recorded BP before an adverse CV event. For most outcomes, risk was lowest at mean achieved systolic and diastolic BPs of 120 to 140 mm Hg and 70 to 80 mm Hg, respectively. The composite outcome, CV-related death, heart failure hospitalization, and all-cause death all occurred significantly more commonly at lower systolic BPs, and all outcomes except stroke were more frequent at lower diastolic BPs.
blood_pressure  cardiovascular 
29 days ago
Vascular Dementia: A Historical Background | International Psychogeriatrics | Cambridge Core
Really nice short history of vascular dementia. It was thought to be the major cause of senile dementia from ~1910-1970.
alzheimers  dementia  vascular 
4 weeks ago
The Inescapable Gravity Of Biotech’s Key Clusters: The Great Consolidation Of Talent, Capital, & Returns | LifeSciVCLifeSciVC
> Biotech historians in the future might call it the “Great Consolidation of Talent and Capital.” While Silicon Valley quickly emerged in Tech a few decades ago as the nexus of all things IT and venture capital, in biotech it’s been far more geographically egalitarian in the past. San Francisco and Boston were clearly important leaders in the early decades of the field, but so were other biotech clusters: Seattle, San Diego, Raleigh, Philly/NJ, Colorado, etc… Most of these also had legacy Pharma or big Biotech footprints that were important for cultivation of talent. And great firms grew out of places well beyond Boston and San Francisco: early winners like Immunex, IDEC, Centacor, Medimmune, and Celltech, just to name a few – and firms like Celgene (San Deigo, NJ) and Amgen (Thousand Oaks) – all born in other geographies.

In recent years, this has changed – Boston and San Francisco are now the preeminent biotech clusters. And their gravity in the ecosystem is only getting stronger.
biotech  boston  san_francisco 
4 weeks ago
More surgeons must start doing basic science : Nature News & Comment
> Non-surgical medical departments are not affected in the same way. This is probably because the time pressures on surgeons are even greater than those on other physicians. Surgeons are faced with the same increases in administrative duties as other medical-faculty members, but their clinical duties have grown faster. US hospitals depend increasingly on the income that surgeons generate — and have little motivation for encouraging them to spend time on research.
surgery  science  medicine 
4 weeks ago
The genetic basis of parental care evolution in monogamous mice : Nature : Nature Research
> Together, our results indicate that variation in an ancient neuropeptide contributes to interspecific differences in parental care.
genetics  parenting  psychology  neuroscience 
4 weeks ago
Aaron Hernandez Commits Suicide : news
> Because his murder conviction is in appeal, and his recent gun charge will go into appeal...now that he is dead, those appeals cannot be heard and those convictions will be vacated. And while this doesn't help with the civil suits his family/estate will face from the victims families, it does make it so that officially Aaron Hernandez does not have any convictions under his name. Now what that means in the grand scheme of things is his family is now technically entitled to his NFL pension, his...
suicide  finance  law  nfl  prison  incentives 
4 weeks ago
The double doctorate | The Thesis Whisperer
Lol > Moreover, doing a second doctorate made it palpability clear that I did not fluke the task the first time around.
5 weeks ago
Why Are Doctors Giving Anti-Psychotic Drugs to Toddlers?
> Frankie wants to use the money to advance research toward finding a cure for tardive dyskinesia. “My mom wants to do therapy [for me]. I just disagree with that,” he tells me. “I want to start a foundation to find a cure for the disease.”
antipsychotics  child_psyc  tardive_dyskinesia 
6 weeks ago
Running as a Key Lifestyle Medicine for Longevity. - PubMed - NCBI
> In general, runners have a 25-40% reduced risk of premature mortality and live approximately 3years longer than non-runners
lifespan  running 
6 weeks ago
Effect of frequent interruptions of prolonged sitting on self-perceived levels of energy, mood, food cravings and cognitive function. - PubMed - NCBI
Getting up to walk for 5 mins every hour is critical to decrease fatigue, decrease food cravings, and increase mood by the end of the day. > In a randomized crossover trial, 30 sedentary adults completed each of three conditions: 6 h of uninterrupted sitting (SIT), SIT plus 30 min of moderate-intensity treadmill walking in the morning (ONE), and SIT plus six hourly 5-min microbouts of moderate-intensity treadmill walking (MICRO). ...Both ONE and MICRO increased self-perceived energy and vigor compared to SIT (p < 0.05 for all). MICRO, but not ONE, improved mood, decreased levels of fatigue and reduced food cravings at the end of the day compared to SIT (p < 0.05 for all). Cognitive function was not significantly affected by condition.
cognition  sitting  mood 
6 weeks ago
Ibn al-Nafis - Wikipedia
> an Arab physician mostly famous for being the first to describe the pulmonary circulation of the blood. The work of Al-Nafis regarding the right sided (pulmonary) circulation pre-date the much later work (1628) of William Harvey's De motu cordis. Both theories attempt to explain circulation. ... He was an expert on the Shafi'i school of jurisprudence and an expert physician.[2] He also performed several human dissections during the course of his work.
history  medicine 
6 weeks ago
Sauna Bathing and Mortality | Lifestyle Behaviors | JAMA Internal Medicine | The JAMA Network
Probably a socioeconomic confound, but still pretty interesting. > After adjustment for CVD risk factors, compared with men with 1 sauna bathing session per week, the hazard ratio of SCD was 0.78 (95% CI, 0.57-1.07) for 2 to 3 sauna bathing sessions per week and 0.37 (95% CI, 0.18-0.75) for 4 to 7 sauna bathing sessions per week (P for trend = .005). Similar associations were found with CHD, CVD, and all-cause mortality (P for trend ≤.005).
sauna  temperature 
6 weeks ago
Fire Simulation and Cardiovascular Health in Firefighters. - PubMed - NCBI
> After fire simulation training, core temperature increased (1.0±0.1°C) and weight reduced (0.46±0.14 kg, P<0.001 for both). In comparison with control, exposure to fire simulation increased thrombus formation under low-shear (73±14%) and high-shear (66±14%) conditions (P<0.001 for both) and increased platelet-monocyte binding (7±10%, P=0.03). There was a dose-dependent increase in forearm blood flow with all vasodilators (P<0.001), which was attenuated by fire simulation in response to acetylc...
temperature  fire  cardiology 
6 weeks ago
Hip Pinning | Houston Methodist
> Most hip fractures would actually heal without surgery, but the problem is that the patient would be in bed for eight to 12 weeks. Surgeons have learned over the years that confining an aging adult to bed for this period of time has a far greater risk of creating serious complications than the surgery required to fix a broken hip. The goal of the hip pinning procedure is to set the bones securely in place, allowing the patient to get out of bed as soon as possible.

The hip pinning procedure ...
hip_dislocation  ortho 
6 weeks ago
After suffering a knife wound to the stomach while performing fellatio, a teenager became pregnant despite being born without a vagina.
Most amazing case report of all time. > A plausible explanation for this pregnancy is that spermatozoa gained access to the reproduc- tive organs via the injured gastrointestinal tract. It is known that spermatozoa do not survive long in an environment with a low pH (Jeffcoate 1975), but it is also known that saliva has a high pH and that a starved person does not produce acid under normal circumstances (Bernards Bouman 1976). It is likely’that the patient became pregnant with her first or nearl...
sex  pregnancy  case_report  obgyn 
6 weeks ago
Religion and Psychiatry.pdf
> Most of the young hi-tech millionaires that I have seen continue doing much of the 9 same: they start new companies, they try to repeat their success. Why? They tell themselves it is to prove it was not a fluke, to prove they can do it alone, without a particular partner or mentor. They raise the bar. To feel that they and their family are secure, they no longer need one or two million in the bank – they need five, ten, even twenty-five million to feel secure. They realize the pointlessness an...
psychotherapy  irvin_yalom  philosophy 
6 weeks ago
Is It Really Dementia? - The New York Times
> The list of other causes for dementia-like symptoms runs surprisingly long. Among the leading culprits, Dr. Doraiswamy said, are depression and anxiety. Like dementia, they can interfere with the ability to concentrate and remember.
dementia  ddx 
6 weeks ago
OpenAI makes humanity less safe | Compass Rose
> I think that the meat of the AI safety problem will involve creating entirely new fields of mathematics or computer science -- it's that hard a problem -- and thus will *not* be nicely contiguous with a career as an ML researcher/engineer. But people have strong incentives to prefer to believe in a world where solving the most important problems requires no sacrifice of professional success, so they're incentivized to believe that AI safety is relatively easy and tractable with the toolkit of already-existing ML.
math  sarah_constantin  AI  career 
7 weeks ago
The Case Of The Suffocating Woman | Slate Star Codex
Theory that panic disorder is due to your body incorrectly thinking that you are suffocating or short of breath.
panic  pregnancy  psychiatry  sex  scott_alexander 
7 weeks ago
Integrating a Neuroscience Perspective Into Clinical Psychiatry | Neurology | JAMA Psychiatry | The JAMA Network
> Most teaching faculty—and psychiatrists in general—are understandably immersed in the practical demands of clinical work. At the same time, neuroscientists are immersed in cutting-edge research, which is often focused on molecular studies or animal models that may seem remote from the clinical reality of patient care. As seen in various sociopolitical contexts, each group may exist in its own echo chamber and communicate primarily (if not exclusively) with those who share similar perspectives. Opportunities for dialogue between researchers and clinicians are limited, all the more so because each group speaks a fundamentally different language. Thus, a major part of the challenge at hand is to facilitate communication across this deep cultural divide.
mdphd  psychiatry 
7 weeks ago
Zoltan to run for Governor of California in 2018 : transhumanism
> I just don't think yourself and many other transhumanists understand how the media and dissemination of ideas works. It's an ad-driven business with shareholders to answer to. So to get out one's message, it needs something provocative and original to sell those ads. The Immortality Bus and my provocative outreach, while wacky to some, is just that. If it doesn't do something provocative, the movement will remain what it has for 30 years, virtually unknown to all but academics. It's a trade of...
zoltan_istvan  media  advertising  transhumanism 
7 weeks ago
Haldane, On Being the Right Size
> To turn to zoology, suppose that a gazelle, a graceful little creature with long thin legs, is to become large, it will break its bones unless it does one of two things. It may make its legs short and thick, like the rhinoceros, so that every pound of weight has still about the same area of bone to support it. Or it can compress its body and stretch out its legs obliquely to gain stability, like the giraffe. I mention these two beasts because they happen to belong to the same order as the gazelle, and both are quite successful mechanically, being remarkably fast runners.
animals  size  js_haldane  evolution  politics 
7 weeks ago
Did Reddit’s April Fool’s gag solve the issue of online hate speech? | Ars Technica
> Of course, a community site that requires so much vigilance sounds exhausting, though it stands to reason that other sites will create their own versions of Reddit's highly visible experiment. Still, r/place may forever change our outlook—and, gosh, even our hopes—about how online communities could one day evolve to better reflect the real-world checks and balances that make slandering or abusing someone difficult. For now, we can at least remember r/place as a testament to the human spirit—in the form of outdated Windows taskbars, beloved video game characters, and a lack of a certain Cheeto-haired person.
internet  reddit  hate  art  community 
7 weeks ago
Everything Is Broken – The Message – Medium
> imagine billions of little unknowable boxes within boxes constantly trying to talk and coordinate tasks at around the same time, sharing bits of data and passing commands around from the smallest little program to something huge, like a browser — that’s the internet. All of that has to happen nearly simultaneously and smoothly, or you throw a hissy fit because the shopping cart forgot about your movie tickets.
security  internet 
7 weeks ago
Reversible cerebral vasoconstriction syndrome - The Lancet Neurology
> Reversible cerebral vasoconstriction syndrome (RCVS) is characterised by severe headaches, with or without other acute neurological symptoms, and diffuse segmental constriction of cerebral arteries that resolves spontaneously within 3 months.1, 2 Manifestations are attributed to a transient disturbance of the regulation of cerebral arterial tone. Thunderclap headache—severe pain peaking in seconds—is usually the first symptom and typically recurs for 1–2 weeks.3, 4, 5 Ischaemic and haemorrhagic stroke are the major complications of the syndrome.5, 6, 7, 8, 9 In 2007, Calabrese and colleagues2 proposed the name RCVS and a set of diagnostic criteria to regroup all similar cases that had been reported since the 1970s under several other names (panel 1).10, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 Since then, large case series of the syndrome have been published.5, 7, 8, 9, 24 In this Review, I focus on the clinical and radiological features of RCVS. I describe the clinical heterogeneity of the syndrome, appropriate investigations, and approaches to diagnosis (including possible differential diagnoses) and management. I aim to show that, although the pathological process is unknown and no specific diagnostic test or proven treatment is available, diagnosis is easy and an important step in the care of patients with RCVS.
neurology  stroke 
7 weeks ago
Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial - The Lancet Neurology
Would've been a big deal if this trial had been positive. > The multidomain intervention and polyunsaturated fatty acids, either alone or in combination, had no significant effects on cognitive decline over 3 years in elderly people with memory complaints
fish_oil  lifestyle  alzheimers  RCT 
7 weeks ago
8.4 Million New Yorkers Suddenly Realize New York City A Horrible Place To Live - The Onion - America's Finest News Source
> At 4:32 p.m. Tuesday, every single resident of New York City decided to evacuate the famed metropolis, having realized it was nothing more than a massive, trash-ridden hellhole that slowly sucks the life out of every one of its inhabitants. With audible murmurs of "This is no way to live," "What the hell am I doing here—I hate it here," and "Fuck this place. Fuck this horrible place," all 8.4 million citizens in each of the five boroughs packed up their belongings and told reporters they would...
nyc  humor 
7 weeks ago
The Rise of Evidence-Based Psychiatry - Scientific American Blog Network
> Osheroff won the lawsuit and, on appeal, settled with Chestnut Lodge outside of court. (Chestnut Lodge, a lovely historical landmark, eventually folded, was converted to upscale condos, and subsequently burned to the ground.) The case sparked a decades-long debate—one with “considerable spunk”—that captured the attention of the psychiatric community: “Has psychiatry reached the point where use of the psychodynamic model is viewed as malpractice when it is the exclusive treatment for serious me...
daniel_barron  psychiatry  law  depression 
7 weeks ago
Cognitive Predictors of Resistiveness in Dementia Patients - The American Journal of Geriatric Psychiatry
> Executive dysfunction as measured by the EXIT is a major determinant of resistiveness to care in long-term care residents with dementia, possibly as a result of such patients' tendency toward inertia.
dementia  executive_function  jonathan_stewart 
7 weeks ago
Choosing Psychiatry as a Career
> And the issues she brings up are common to almost everyone I know who decided on psych. ESPECIALLY if you switch from another specialty (like surgery or medicine) to psychiatry, you will probably go through the following mental process:
- I won’t be a “real” doctor, and I won’t ever use 95% of the information I spent four years toiling to learn in medical school.
- I’ll let down my family/friends/myself who thought I was going to go into a more prestigious specialty.
- Psychiatry doesn’t fit ...
elana_miller  psychiatry  post_mdphd 
7 weeks ago
Vantablack - Wikipedia
> Vantablack is a substance made of vertically aligned carbon nanotube arrays[1] and is the blackest artificial substance known, absorbing up to 99.965% of radiation in the visible spectrum.[2][3]
engineering  light_therapy 
7 weeks ago
I Talked To Some Trump Voters, Too – The Awl
> I spoke with Freddy O’Brien, a fifth-generation Bleaksviller who operates the bar. He told me he’d already talked about his support for Donald Trump to reporters from The New York Times, The Washington Post, USA Today, The Daily Mail, The Hindustan Times, and Stormfront so far that day, but that he’d be willing to do one more interview before hosting an opioid and pizza party for the high-school football team (which I assume is the linchpin of the community). I asked him why he disliked Hillar...
humor  trump  politics 
7 weeks ago
XYY syndrome - Wikipedia
> XYY syndrome is a genetic condition in which a human male has an extra male (Y) chromosome, giving a total of 47 chromosomes instead of the more usual 46. This produces a 47,XYY karyotype, which occurs every 1 in 1,000 male births.[1] Some medical geneticists question whether the term "syndrome" is appropriate for this condition[2] because its clinical phenotype is normal[2][3] and the vast majority of XYY males do not know their karyotype.[4]
genetics  chromosome  cognition 
7 weeks ago
Data Colada | [58] The Funnel Plot is Invalid Because of This Crazy Assumption: r(n,d)=0
> That funnel plot asymmetry above does not tell us “There is publication bias.”
That funnel plot asymmetry above tells us “These researchers are putting some thought into their sample sizes.”
statistics  publication_bias 
7 weeks ago
Evolution: Diet drives primate brain size : Nature : Nature Research
> The primates that ate fruit had significantly larger brains than those that ate just leaves; and the more fruit they ate, the larger was the ratio of their brain size to their body size. The authors think this could be due to a combination of factors — one being the high nutritional content of fruit, another being cognitive adaptations that help the primates to forage for fruit. Such adaptations could allow them, for example, to extract fruit from protective skins. The team also found no correlation between brain size and the level of social complexity. This contradicts a widely accepted theory that states that large brains evolved to help primates manage large social networks.
diet  brain  neuroscience  evolution 
7 weeks ago
Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit : Nature : Nature Research
Pretty cool neuroscience. > The relationship between this general function and the specialized spatial activity patterns is unclear. A conceptual framework reconciling these views is that spatial representation is just one example of a more general mechanism for encoding continuous, task-relevant variables. Here we tested this idea by recording from hippocampal and entorhinal neurons during a task that required rats to use a joystick to manipulate sound along a continuous frequency axis. We found neural representation of the entire behavioural task, including activity that formed discrete firing fields at particular sound frequencies. Neurons involved in this representation overlapped with the known spatial cell types in the circuit, such as place cells and grid cells. These results suggest that common circuit mechanisms in the hippocampal–entorhinal system are used to represent diverse behavioural tasks, possibly supporting cognitive processes beyond spatial navigation.
hippocampus  neuroscience 
7 weeks ago
About Us - X-Therma
> X-Therma is located in the San Francisco Bay Area. We are selected as a User at the Lawrence Berkeley National Laboratory, where we have access to state-of-the-art instruments and facilities for rapid discovery. At X-Therma, we developed a state-of-the-art ice-blocking preservation solution that is DMSO-free, protein-free, serum-free, and chemically defined. Our first-in-class, hyper effective (500x), and non-toxic antifreeze material offers safer transport and long-term Biobanking, that is going to transform the regenerative medicine market by enabling new technologies and therapies. Classified as a class I medical device, X-Therma’s product maintains significant regulatory advantages.
cryobiology  start_up 
7 weeks ago
Rare sighting reveals deep-sea octopus's unusual breakfast : Nature News & Comment
> Despite the fact that female H. atlanticus can grow up to 4 metres long, the species doesn’t require as much energy to stay alive as other octopuses do. “They’re running on a slower clock,” Haddock says. So eating low-calorie jellies works for them, especially if they focus on nutritious parts such as the stomach, an area that was missing from the egg-yolk jelly in the 2013 video.
trade_offs  octopus  diet 
8 weeks ago
Fresh versus frozen embryo transfers for assisted reproduction | Cochrane
> We found evidence showing seemingly no difference between the strategies in cumulative live birth rate per woman. Our findings suggest that if the cumulative live birth rate is 58% following a conventional IVF/ICSI strategy, the rate following a freeze-all strategy would be between 56% and 65%.
IVF  OHSS  vitrification 
8 weeks ago
Cancer Vegetarianism & Diet
Data suggesting that veganism is probably not protective against cancer, and that the main impact of diet on cancer is likely via obesity. > Among the diet-related factors, overweight/obesity convincingly increases the risks of several common cancers. After tobacco, overweight/obesity appears to be the most important avoidable cause of cancer in populations with Western patterns of cancer incidence. Among non-smoking individuals in these populations, avoidance of overweight is the most important...
cancer  obesity  diet  vegetarian 
8 weeks ago
Does usage of a parachute in contrast to free fall prevent major trauma?: a prospective randomised-controlled trial in rag dolls | SpringerLink
> It is undisputed for more than 200 years that the use of a parachute prevents major trauma when falling from a great height. Nevertheless up to date no prospective randomised controlled trial has proven the superiority in preventing trauma when falling from a great height instead of a free fall. The aim of this prospective randomised controlled trial was to prove the effectiveness of a parachute when falling from great height.
humor  academia 
8 weeks ago
Should We Prescribe Light Therapy for Our Sleepy Parkinson Disease Patients? - NEJM Journal Watch
Bright light (for hour at a time) effective for sleepiness in PD. > Thirty-one Parkinson disease patients who were free of dementia, free of primary sleep disorders, and receiving optimized dopaminergic therapy were randomized to bright-light therapy or dim red light (control) therapy. Additionally, the baseline Epworth Sleepiness Scale was 12 or greater, indicating moderate to severe problems with alertness. Light (bright or dim) was administered in the morning and the evening for 1 hour each on a total of 14 days. Disease duration was relatively short for the participants in the bright-light therapy arm (5.9 years vs. 8.4 years for controls). Improvements in the primary outcome variable, the Epworth Sleepiness Scale score, favored the bright-light group (mean scores at baseline and at 4 weeks, 15.81 and 11.19 with bright light, 15.47 and 13.67 with dim light).
neurology  sleep 
8 weeks ago
Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non-asphyxial out-of-hospital cardiac arrest - Zhan - 2017 - The Cochrane Library - Wiley Online Library
Rescue breathing seems to improve outcomes a small amount. > Increased availability of automated external defibrillators (AEDs), and AED use in CPR need to be examined, and also whether continuous chest compression CPR is appropriate for paediatric cardiac arrest.
cpr  aed  acls  meta_analysis 
8 weeks ago
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