Decompression Sickness — NEJM
> The skin mottling, also known as cutis marmorata, is a recognized dermatologic manifestation of decompression sickness. Air in the portal venous system can also be a complication of decompression sickness. Its incidence is unknown, since abdominal imaging is not routinely performed for this diagnosis. The air in the portal system is thought to arise when a diver ascends too quickly and air expands rapidly, which damages the surrounding tissue. The patient underwent treatment with hyperbaric oxygen. The skin mottling and abdominal pneumatosis resolved after two sessions in the hyperbaric chamber.
diving  scuba  liver 
21 hours ago
Hypothalamic stem cells control ageing speed partly through exosomal miRNAs | Nature
Injecting stem cells into the hypothalamus significantly slows down aging. > ageing retardation and lifespan extension were achieved in mid-aged mice that were locally implanted with healthy hypothalamic stem/progenitor cells that had been genetically engineered to survive in the ageing-related hypothalamic inflammatory microenvironment
hypothalamus  aging  neurosurgery 
4 days ago
North Sentinel Island - Wikipedia
> North Sentinel Island is one of the Andaman Islands, which includes South Sentinel Island, in the Bay of Bengal. It is home to the Sentinelese who, often violently, reject any contact with the outside world, and are among the last people worldwide to remain virtually untouched by modern civilization. As such, only limited information about the island is known.
civilization  anthropology 
5 days ago
Santa Rosa, Sonoma, Napa California fires: 36 dead, hundreds missing - The Washington Post
> Taken together, the disastrous blazes — more than 20 in all since Sunday, including at least six in Sonoma County — have killed more people than any other California wildfire on record. Hundreds are still missing on Friday. Statewide, an estimated 5,700 structures have been destroyed, including whole neighborhoods reduced to smoldering rubble. About 90,000 people have been displaced by the fires, officials say.
fire  california  disaster  santa_rosa 
7 days ago
Dietary Carbohydrates Impair Healthspan and Promote Mortality: Cell Metabolism
> The prospective cohort study, named PURE, found that in >135,000 participants from 18 countries, nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, requesting a fundamental change of current nutritional guidelines. Experimental evidence from animal models provides synergizing mechanistic concepts as well as pharmacological options to mimic low-carb or ketogenic diets.
sugar  carbohydrates  diet  mortality 
7 days ago
FDA advisers back gene therapy for rare form of blindness : Nature News & Comment
> The treatment consists of a virus loaded with a normal copy of the RPE65 gene. The virus is injected into the eye, where the gene is expressed and supplies a normal copy of the RPE65 protein. In a randomized controlled trial that enrolled 31 people, Spark showed that, on average, patients who received the treatment improved their ability to navigate a special obstacle course1. This improvement was sustained for the full year during which the company gathered data.
blind  gene_therapy  ophtho 
8 days ago
Why Better Mental-Health Care Won't Stop Mass Shootings - The Atlantic
> While improving access to mental-health care might help lots of suffering Americans, researchers who study mass shootings doubt it would do much to curb tragedies like these. According to their work, the sorts of individuals who commit mass murder often are either not mentally ill or do not recognize themselves as such. Because they blame the outside world for their problems, mass murderers would likely resist therapies that ask them to look inside themselves or to change their behavior.
mental_illness  guns  violence  2017  psychiatry 
12 days ago
Slate Star Scratchpad — dataandphilosophy: ...
> I once had a patient who lost a friend in a mass shooting. Aside from the inherent trauma, he was actually really traumatized by the way the media covered it and instantly turned his friend’s death into a contest of “this proves why Republicans are bad” vs. “this proves why Democrats are bad”, which he had to watch every time he turned on the TV or the computer. A lot of these served (unintentionally) to trivialize or excuse his friend’s death .... and it all kind of blends together as Subjects For Hot Takes And Thinkpieces. If you don’t like the word “sacredness” or “respectfulness”, at least use “separateness”.
tragedy  scott_alexander  sacred 
12 days ago
Subjective Memory Complaints Tied to Tau | ALZFORUM
> In a new study, Quiroz found that mutation carriers reported higher levels of subjective memory complaints (SMCs) than noncarriers in the decades before onset of symptoms, but SMCs did not increase with age. Thus, in this young cohort destined to develop AD, memory complaints do not escalate as disease progresses. ... The data emphasize the value of partner reports over solely self-report, which has been a matter of debate in the field, said Quiroz. “In this case the study partner report is very powerful,” she told Alzforum.
alzheimers  memory 
12 days ago
Medieval Fitness Tips - Medievalists.net
> If you cannot go outside your lodgings, either because the weather does not permit or it is raining, climb the stairs rapidly three or four times, and have in your room a big heavy stick like a sword and wield it now with one hand, now with the other, as if in a scrimmage, until you are almost winded…Jumping is a similar exercise.
exercise  history 
12 days ago
Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia - Goldstein - 2017 - Journal of the American Geriatrics Society - Wiley Online Library
*Lower* risk of dementia in participants taking PPIs in this study.

Also probably due to confounding variables. No effect is likely here IMO.
PPI  alzheimers  epidemiology 
13 days ago
Why is Xenon banned in sport? : askscience
> Xenon increases Erythropoietin (EPO) levels which promotes the formation of red blood cells by the bone marrow. There is some anecdotal evidence that some top tier athletes were using it to increase testosterone production as well.
doping  sports  oxygen 
15 days ago
Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy — NEJM
> A total of 17 boys received Lenti-D gene therapy. At the time of the interim analysis, the median follow-up was 29.4 months (range, 21.6 to 42.0). All the patients had gene-marked cells after engraftment, with no evidence of preferential integration near known oncogenes or clonal outgrowth. Measurable ALD protein was observed in all the patients. No treatment-related death or graft-versus-host disease had been reported; 15 of the 17 patients (88%) were alive and free of major functional disability, with minimal clinical symptoms. One patient, who had had rapid neurologic deterioration, had died from disease progression. Another patient, who had had evidence of disease progression on MRI, had withdrawn from the study to undergo allogeneic stem-cell transplantation and later died from transplantation-related complications.
adrenoleukodystrophy  MRI  neurology  gene_therapy 
16 days ago
Energy Secretary Perry’s Electric Resiliency Rule Could Be a Big Win for Nuclear and the Climate. Here’s Why — Environmental Progress
> The reason is because while the rule would keep nuclear plants producing power, it wouldn’t necessarily do the same for coal plants. If implemented properly, the rule could result in a system of “cold standby” for coal plants — ready to run in case of an emergency, but otherwise not producing power (or pollution). Nuclear plants are cheaper to operate than coal plants. As such, under this rule, nuclear plants would likely be favored ahead of both coal and natural gas plants.
nuclear  resiliency  energy 
16 days ago
Dietary Sodium and Cardiovascular Disease Risk — Measurement Matters — NEJM
> The benefit of reducing dietary sodium for lowering the risk of cardiovascular disease has been questioned because some studies have also linked low sodium intake with increased CVD risk. Application of Hill's criteria, however, indicates that the association is not causal.
salt_truthing  salt  diet 
19 days ago
CABINET // Talk and Demonstration / “Dream-Parliament,” with Matthew Spellberg, Cat Powell, and David Leo Rice
> Dreams are some of the most private experiences humans know: no one can follow you into a dream. And yet, humans have long felt a need to make them sharable. Across history, dream-songs, dream-dances, and dream rituals have arisen, complete with complex protocols, to make it possible for people to share their dreams. Our own culture is poor in such techniques, but in this it is the exception; elsewhere, there have been dream-circles and dream-recitations, dream-predictions and dream-journeys, conventions for making dream-paintings and inducing dream-initiations. In remote places, such practices continue.
matthew_spellberg  dreams 
20 days ago
Feeling Dreams in Romeo and Juliet - Spellberg - 2013 - English Literary Renaissance - Wiley Online Library
> But this structure also articulates the underlying nature of Romeo and Juliet's undoing: to aspire to a life lived through pure sensation, to entertain the great Epicurean and materialist fantasy of understanding oneself to be first and foremost a being of and subject to matter, is to tempt with the annihilation of the subjective self.
literature  shakespeare  matthew_spellberg  dreams 
20 days ago
Universal health care - Wikipedia
> Almost all European systems are financed through a mix of public and private contributions.[22] Most universal health care systems are funded primarily by tax revenue (like in Portugal[22] Spain, Denmark, and Sweden). Some nations, such as Germany and France[23] and Japan[24] employ a multipayer system in which health care is funded by private and public contributions. However, much of the non-government funding is by contributions by employers and employees to regulated non-profit sickness funds. Contributions are compulsory and defined according to law.
healthcare  france  europe 
20 days ago
Treating Apathy in Alzheimer Disease - NEJM Journal Watch
Ritalin seems effective for AD in older men. > Significant improvements for methylphenidate vs. placebo were first seen at 4 weeks for overall apathy scores; at 8 weeks for the behavior, cognition, and motivation domains of apathy; and at 12 weeks for depression and emotion scores, MMSE scores, activities of daily living, and caregiver burden. Adverse events and serious adverse events were similar in the groups, with only one serious event possibly attributable to medication.
methylphenidate  alzheimers 
21 days ago
Calico – Career
Computational biologist job @ Calico
career  job 
22 days ago
Whole What? — Doctor K Private Medicine
> As a general rule, three or more grams of fiber per serving means you can be confident about eating the carbohydrate.

Fiber slows down digestion. This helps make you feel fuller, faster. And, slower absorption of carbohydrates means blood sugar and insulin levels increase gradually, rather than the sharp glycemic spikes caused by eating processed grains.
fiber  food  diet  carbohydrates 
22 days ago
Early versus Delayed Rehabilitation after Acute Muscle Injury — NEJM
> Starting rehabilitation 2 days after injury rather than waiting for 9 days shortened the interval from injury to pain-free recovery and return to sports by 3 weeks without any significant increase in the risk of reinjury. The observed difference supports the importance of early loading of injured musculotendinous tissue.
muscles  rehab 
22 days ago
FODMAP - Wikipedia
Restricting this can be useful in IBS. > FODMAPs are short chain carbohydrates that are poorly absorbed in the small intestine. They include short chain oligo-saccharide polymers of fructose (fructans) and galactooligosaccharides (GOS, stachyose, raffinose), disaccharides (lactose), monosaccharides (fructose), and sugar alcohols (polyols), such as sorbitol, mannitol, xylitol and maltitol.[1][2][3]
The term FODMAP is an acronym, derived from "Fermentable, Oligo-, Di-, Mono-saccharides And Polyols".[1] Although FODMAPs are naturally present in food and the human diet, FODMAP restriction has been found to improve symptom control in people with irritable bowel syndrome (IBS) and other functional gastrointestinal disorders (FGID).[4][5][6][7][8][9] Prior to the formation of the FODMAP concept, diet was seldom used as first line therapy for management of IBS and other FGID.
food  diet  digestion 
23 days ago
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 : Nature : Nature Research
> GDF15 regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses; we show that Gfral knockout mice are hyperphagic under stressed conditions and are resistant to chemotherapy-induced anorexia and body weight loss. GDF15 activates GFRAL-expressing neurons localized exclusively in the area postrema and nucleus tractus solitarius of the mouse brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitute part of the ‘emergency circuit’ that shapes feeding responses to stressful conditions7. GDF15 levels increase in response to tissue stress and injury, and elevated levels are associated with body weight loss in numerous chronic human diseases
GDF15  weight_loss  hypothalamus  neuroscience 
23 days ago
Scientists Discover Some of the Oldest Signs of Life on Earth - The Atlantic
> In a rock formation called the Saglek Block, Yuji Sano and Tsuyoshi Komiya from the University of Tokyo found crystals of the mineral graphite that contain a distinctive blend of carbon isotopes. That blend suggests that microbes were already around, living, surviving, and using carbon dioxide from the air to build their cells. If the two researchers are right—and claims about such ancient events are always controversial—then this Canadian graphite represents one of the earliest traces of life on Earth.

The Earth was formed around 4.54 billion years ago. If you condense that huge swath of prehistory into a single calendar year, then the 3.95-billion-year-old graphite that the Tokyo team analyzed was created in the third week of February.
carbon_dating  carbon  life  earth  history 
23 days ago
Inside the Toronto South Detention Centre, Toronto's $1-billion hellhole
An attempt to make life better for prisons and save money at the same time seems to have backfired horribly.
toronto  prison  suffering 
23 days ago
National Trends in Suicide Attempts Among Adults in the United States | Psychiatry | JAMA Psychiatry | The JAMA Network
> A recent overall increase in suicide attempts among US adults has disproportionately affected younger adults with less formal education
24 days ago
Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma : Nature : Nature Research
> Here we show that HGG growth depends on microenvironmental NLGN3, identify signalling cascades downstream of NLGN3 binding in glioma, and determine a therapeutically targetable mechanism of secretion. Patient-derived orthotopic xenografts of paediatric GBM, DIPG and adult GBM fail to grow in Nlgn3 knockout mice. NLGN3 stimulates several oncogenic pathways, such as early focal adhesion kinase activation upstream of PI3K–mTOR, and induces transcriptional changes that include upregulation of several synapse-related genes in glioma cells. NLGN3 is cleaved from both neurons and oligodendrocyte precursor cells via the ADAM10 sheddase.
glioma  OPC  NLGN3  cancer 
29 days ago
BBC - Future - How flying seriously messes with your mind
Didn't realize this was such a thing. > Physicist and television presenter Brian Cox and musician Ed Sheeran have both admitted they can get a bit over-emotional when watching movies on aircraft. A new survey by Gatwick Airport in London found 15% of men and 6% of women said they were more likely to cry when watching a film on a flight than they would if seeing it at home... The boredom on a flight and relief given by an inflight movie, combined with the privacy of the small screen and headphones used to watch one, could lead to tears of joy, not sadness, he says.
crying  psychology  neuroscience  movies  airplanes  gender 
29 days ago
More Evidence that Dementia Case Numbers Are Falling | ALZFORUM
> While previous epidemiological studies did not specifically examine birth years, those older findings are roughly congruent with the Einstein Aging Study data, reporting the greatest drop in dementia cases after 1990, the authors noted. People born after 1929 would have entered their 60s in that decade. Most cases of late-onset dementia occur after age 60. The Rotterdam Study found a 25 percent decrease in dementia incidence in the 1990s, while the Framingham Heart Study recently reported that incidence dropped starting in the late 1980s and continued to decline into the 2010s (Schrijvers et al., 2012; Satizabal et al., 2016). 
vascular  dementia  aging  epidemiology 
4 weeks ago
Pholcus phalangioides - Wikipedia
> An urban legend states that Pholcidae are the most venomous spiders in the world but that it is nevertheless harmless to humans because its fangs cannot penetrate human skin. Both of these claims have been proven untrue. Recent research has shown that pholcid venom has a relatively weak effect on insects.[6] In the MythBusters episode "Daddy Long-Legs" it was shown that the spider's fangs (0.25 mm) could penetrate human skin (0.1 mm), but that only a very mild burning feeling was felt for a few seconds.[7]
spider  insects  myth 
4 weeks ago
QuickStats: Percentage of Women Who Missed Taking Oral Contraceptive Pills Among Women Aged 15–44 Years Who Used Oral Contraceptive Pills and Had Sexual Intercourse, Overall and by Age and Number of Pills Missed — National Survey Of Family Growth, Uni
Per month: > Among women aged 15–44 years who used oral contraceptive pills in the last 4 weeks and had sexual intercourse in the past 12 months, 69% of women reported missing no pills, 15% missed one pill, and 16% missed two or more pills
4 weeks ago
Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields: Cell
Potentially game-changing neuroscience study, showing that you might be able to have the same effects of deep brain stimulation without neurosurgery, by modulating the frequency of transcranial electrical field stimulation.
DBS  neuroscience  electricity 
4 weeks ago
Artificial intelligence pioneer says we need to start over - Axios
> But Hinton suggested that, to get to where neural networks are able to become intelligent on their own, what is known as "unsupervised learning," "I suspect that means getting rid of back-propagation." "I don't think it's how the brain works," he said. "We clearly don't need all the labeled data."
geoff_hinton  AI  science  neural_networks 
4 weeks ago
Tragedy, Perseverance, and Chance — The Story of CAR-T Therapy — NEJM
> Moreover, toxicities remain formidable. Though tocilizumab is now often used to manage the cytokine-release syndrome, other toxic effects, such as cerebral edema, remain poorly understood and difficult to manage.
neurology  CAR-T  cancer  science 
4 weeks ago
Sex and STEM Occupation Predict Autism-Spectrum Quotient (AQ) Scores in Half a Million People
> As predicted, sex and occupation differences were observed: on average, males (m = 21.55, SD = 8.82) scored higher than females (m = 18.95; SD = 8.52), and individuals working in a STEM career (m = 21.92, SD = 8.92) scored higher than individuals non-STEM careers (m = 18.92, SD = 8.48). Also as predicted, age and geographic region were not meaningfully correlated with AQ. These results support previous findings relating to sex and STEM careers in the largest set of individuals for which AQ scores have been reported and suggest the AQ is a useful self-report measure of autistic traits.
ASD  career  gender 
5 weeks ago
Preparing Young Americans for a Complex World - The New York Times
> At Mill Valley Middle School in California, two teachers, Rod Septka and Maggie Front, working with more affluent students, have seen this approach evoke a similar response. When the recent drought in California was daily news, they looked at how people in the state were conserving water. Then they examined how people cope with water-related problems in Bangladesh, Israel, Sudan, Bolivia, China, Ethiopia, Indonesia, Peru and Syria. The students did extensive research and data gathering. One student was astonished that so many people around the world couldn’t just go into their kitchen and get water from a tap. Then the water crisis in Flint, Mich., became news, and they looked at water access in terms of wealth and race. That led a student who had been previously disengaged in school to discover her activist voice, said Front. And studying water rights brought her to a related concern: women’s rights.
mill_valley  school  education 
5 weeks ago
Cypre, Inc.
Kolin's 3D tissue engineering biotech startup in SF
kolin_hribar  cancer  biotech 
5 weeks ago
Patriarchy is the Problem | Otium
> I appreciate the clarity of your perspective, but really, the thing I’m trying to learn and master is how to give people like me the tools to overcome people like you.
sarah_constantin  philosophy  power  patriarchy 
5 weeks ago
Blogborygmi: A year without blogging
> All this was before the 2016 presidential election really heated up. Eventually last year, every news story was quickly put in terms of your team vs the other team. Our team is always noble and wise, but the other team is misguided at best, hypocritical and probably evil, often dumb or short-sighted, and if they're making any gains it's because they're cheating. Interacting with old friends online became a fraught exercise. Even the #FOAMed community began to see polarization and personal attacks.
nick_genes  blogging  internet  politics  2017 
5 weeks ago
Suicide Attempt Risk Among Soldiers in Units With Suicide Attempt History | Psychiatry | JAMA Psychiatry | The JAMA Network
> In adjusted models, soldiers were more likely to attempt suicide if 1 or more suicide attempts occurred in their unit during the past year (odds ratios [ORs], 1.4-2.3; P < .001), with odds increasing as the number of unit attempts increased. ... The population-attributable risk proportion for 1 or more unit suicide attempts in the past year indicated that, if this risk could be reduced to no unit attempts, 18.2% of attempts would not occur.
suicide  contagion  army  war 
5 weeks ago
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy : Nature : Nature Research
More evidence that chemotherapy initially works for glioblastoma -- but it selects for the stem cells that are resistant to it, which eventually create form tumor growth that is resistant to the chemo. > We also identify rare ‘outlier’ clones that deviate from these dynamics, and further show that chemotherapy facilitates the expansion of pre-existing drug-resistant glioblastoma stem cells
glioblastoma  cancer  chemotherapy 
5 weeks ago
Fiber supplements: Safe to take every day? - Mayo Clinic
> There's no evidence that daily use of fiber supplements — such as psyllium (Metamucil, Konsyl, others) or methylcellulose (Citrucel) — is harmful. Fiber has a number of health benefits, including normalizing bowel function and preventing constipation.
fiber  diet 
5 weeks ago
Hypnosis: There’s an App for that. A systematic review of hypnosis apps
> Of 1455 apps identified on iTunes, 407 met inclusion criteria and were further reviewed. Most common hypnosis app targets were: weight loss (23%), boosting self-esteem (20%), and relaxation/stress reduction (19%). 83% of apps delivered hypnosis via audio track, and 37% allowed tailoring. Less than 14% of apps reported disclaimers. None of the apps reported having been tested for efficacy, and none reported being evidence-based. Although apps have the potential to enhance hypnosis delivery, it seems as though technology has raced ahead of the supporting science. Recommendations from clinical researchers and policy makers are needed to inform responsible hypnosis app development and use.
app  hypnosis 
5 weeks ago
65536 (number) - Wikipedia
Pretty cool number.
> When expressed using Knuth's up-arrow notation, 65536 is {\displaystyle 2\uparrow 16} , which is equal to {\displaystyle 2\uparrow 2\uparrow 2\uparrow 2} , which is equivalent to {\displaystyle 2\uparrow \uparrow 4} or {\displaystyle 2\uparrow \uparrow \uparrow 3} .
number  cool  math 
5 weeks ago
What is /r/iamverysmart, and why does everyone hate it? Is it a joke? : OutOfTheLoop
> Some people hate the sub because there are too many times where its subscriber base can't tell the difference between pretending to be smart, and actually being smart. There is a fine line between mocking the stupid who think they're smart, and being ant-intellectual. Too often, /r/iamverysmart crosses that line.... It's another of the Reddit "shame people for being awkward on the internet" subreddits. As reddit has gotten more mainstream popularity, its started to reflect more mainstreamish values, and as such it's now ok to bully and shame people who don't fit that mainstream mold on here.
reddit  snark  internet 
5 weeks ago
Intellectual Honesty
> “Intellectually honest” means you make arguments you think are true, as opposed to making the arguments you are “supposed” to make and/or avoiding making arguments that you think are true that you aren’t “supposed” to make.
honesty  intellectual 
5 weeks ago
Update: Increase in Human Infections with Novel Asian Lineage Avian Influenza A(H7N9) Viruses During the Fifth Epidemic — China, October 1, 2016–August 7, 2017 | MMWR
> Although human infections with Asian H7N9 viruses from poultry are rare and no efficient or sustained human-to-human transmission has been detected, when human infections do occur, they are associated with severe illness and high mortality. Continued vigilance is important to identify changes in the virus that might have epidemiologic implications, such as increased transmission from poultry to humans or transmission between humans.
flu  pandemic 
5 weeks ago
Clomid therapy for anovulatory infertility - American Journal of Obstetrics & Gynecology
One of the first articles on Clomid for infertility by Nathan Kase, an inspiring doctor at Sinai.
clomid  infertility  nathan_kase 
5 weeks ago
Stem Cells Rescue Movement in Monkey Model of Parkinson’s | ALZFORUM
> Ole Isacson of Harvard University pointed out that the 16,000 cells needed for therapeutic benefit here match the number he found a few years ago in monkeys (Hallett et al., 2015). “A major technical achievement that enhances our ability to plan the clinical trials is that the number of surviving cells needed for therapeutic benefit is in the same range,” he told Alzforum. The authors conclude that for people, about 100,000 cells would be the minimum needed for a motor effect, according to the paper. “That helps FDA determine the reasonable dose,” said Isacson.
immunology  neurology  parkinsons  stem_cells 
5 weeks ago
Charles Barkley making the promise to go to a fat farm and become healthier, to now. - Streamable
"I've eaten more vegetables in the last 3 months than I've eaten in the last 50 years"
veggies  charles_barkley  nba  diet 
6 weeks ago
Sudden unexpected death in epilepsy patients is often misdiagnosed as sudden cardiac death
> many physicians view SUDEP as a sudden cardiac death (SCD), for which the relation to seizures is often uncertain. This view is at odds with evidence gathered during the last decade, suggesting that most SUDEP occurs in the immediate aftermath of a generalized tonic-clonic seizure through centrally mediated autonomic failure, distinct from mechanisms at stake in SCD.
epilepsy  death 
6 weeks ago
The Very First Written Use of the F Word in English (1528) | Open Culture
> Here the word appears (for the first time if not the last) noted down by hand in the margins of a proper text, in this case Cicero's De Officiis. "It's a monk expressing his displeasure at an abbot," writes Katharine Trendacosta at i09. "In the margins of a guide to moral conduct. Because of course." She quotes Melissa Mohr, author of Holy Sh*t: A Brief History of Swearing, as declaring it "difficult to know" whether this marginalia-making monk meant the word literally, to accuse this abbott of "questionable monastic morals," or whether he used it "as an intensifier, to convey his extreme dismay." Either way, it holds a great deal of value for scholars of language, given, as the OED puts it, "the absence of the word from most printed text before the mid twentieth century" and the "quotation difficulties" that causes. If you find nothing to like in the F word's ever-increasing prevalence in the media, think of it this way: at least future lexicographers of swearing will have more to go on.
language  history  english 
7 weeks ago
Brain surgery: Most lobotomies were done on women : Nature : Nature Research
> Our review of the literature on lobotomies in France, Switzerland and Belgium from 1935–85 reveals that the surgical procedure was alarmingly common for female patients (84% of 1,340 subjects). It is not clear whether this reflects a higher prevalence of mental illness among women at the time or their perceived inferior position in those societies, dating from the Napoleonic Code of 1804.
lobotomy  history  surgery  psychiatry  gender 
7 weeks ago
Pioneering new cancer drug will cost $475,000. Analysts call it a bargain
> On Wednesday, Novartis revealed that it would charge $475,000 for a course of treatment, a price Bruno Strigini, the company’s head of oncology, said would allow patients to access Kymriah while providing Novartis a return on its investment. The cost is well below Wall Street analyst expectations, which reached as high as $750,000 for a dose. And it’s cheaper than the roughly $700,000 price tag that U.K. regulators said would be fair considering Kymriah’s benefits.

Novartis also said it is working with Medicare on a system in which the government would only pay for CAR-T treatment if patients respond within a month.

In a clinical trial, a single dose of Kymriah left 83 percent of participants cancer-free after three months, results oncologists have hailed as a major advance for patients with few other options. The most frequent side effect was an inflammatory storm called cytokine release syndrome, a reaction to CAR-T that can prove fatal in some patients but is commonly controlled with immunosuppressant drugs.
cancer  car-t 
7 weeks ago
Stop blocking postdocs’ paths to success : Nature News & Comment
> Importantly, grant-review committees should consider training track records during evaluations of applications from established labs. It is encouraging that the Howard Hughes Medical Institute (a non-profit medical-research organization in Chevy Chase, Maryland) has started to put more emphasis on a mentor's training record as one criterion when making decisions about renewing funding. Similarly, I believe that an individual's training track record should be factored in when considering the award of prestigious science prizes. Why should we honour those who don't support science's next generation?
science  grants  funding 
7 weeks ago
Long Live the Microglia! Studies Trace Their Lifespans in Mice and Humans | ALZFORUM
> In another study published in Cell Reports on July 25, researchers led by Jonas Frisén of the Karolinska Institute in Stockholm leveraged traces of carbon-14 left over from atomic bombs to estimate the lifespan of microglia in the human brain. They reported that human microglia live for an average 4.2 years, and that nearly a third of the cells are replenished annually.
microglia  neuroscience 
7 weeks ago
> Blindness has not been for me a total misfortune; it should not be seen in a pathetic way. It should be seen as a way of life: one of the styles of living. Being blind has its advantages. I owe to the darkness some gifts: the gift of Anglo-Saxon, my limited knowledge of Icelandic, the joy of so many lines of poetry, of so many poems, and of having written another book, entitled, with a certain falsehood, with a certain arrogance, In Praise of Darkness. ... I too, if I may mention myself, have always known that my destiny was, above all, a literary destinythat bad things and some good things would happen to me, but that, in the long run, all of it would be converted into words. Particularly the bad things, since happiness does not need to be transformed: happiness is its own end.
borges  blind  poetry  happiness 
8 weeks ago
8,000 Years Ago, 17 Women Reproduced for Every One Man - Pacific Standard
> Once upon a time, 4,000 to 8,000 years after humanity invented agriculture, something very strange happened to human reproduction. Across the globe, for every 17 women who were reproducing, passing on genes that are still around today—only one man did the same.

"It wasn't like there was a mass death of males. They were there, so what were they doing?" asks Melissa Wilson Sayres, a computational biologist at Arizona State University, and a member of a group of scientists who uncovered this moment in prehistory by analyzing modern genes.

Another member of the research team, a biological anthropologist, hypothesizes that somehow, only a few men accumulated lots of wealth and power, leaving nothing for others. These men could then pass their wealth on to their sons, perpetuating this pattern of elitist reproductive success. Then, as more thousands of years passed, the numbers of men reproducing, compared to women, rose again. "Maybe more and more people started being successful," Wilson Sayres says. In more recent history, as a global average, about four or five women reproduced for every one man.
fertility  mating  gender  sex  history  genetics  agriculture 
8 weeks ago
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