5857
Why Jefferson's vision of American Islam matters today
> Indeed, we find evidence for this in the Founding Father’s 1821 autobiography, where he happily recorded that a final attempt to add the words “Jesus Christ” to the preamble of his legislation failed. And this failure led Jefferson to affirm that he had intended the application of the Statute to be “universal.” By this he meant that religious liberty and political equality would not be exclusively Christian. For Jefferson asserted in his autobiography that his original legislative intent had been “to comprehend, within the mantle of its protection, the Jew and the Gentile, the Christian and Mahometan [Muslim], the Hindoo, and Infidel of every denomination.”
islam  thomas_jefferson  history  us 
4 hours ago
How the Democrats Lost Their Way on Immigration - The Atlantic
> If the right has grown more nationalistic, the left has grown less so. A decade ago, liberals publicly questioned immigration in ways that would shock many progressives today. ... In 2005, a left-leaning blogger wrote, “Illegal immigration wreaks havoc economically, socially, and culturally; makes a mockery of the rule of law; and is disgraceful just on basic fairness grounds alone.” In 2006, a liberal columnist wrote that “immigration reduces the wages of domestic workers who compete with immigrants” and that “the fiscal burden of low-wage immigrants is also pretty clear.” His conclusion: “We’ll need to reduce the inflow of low-skill immigrants.” That same year, a Democratic senator wrote, “When I see Mexican flags waved at proimmigration demonstrations, I sometimes feel a flush of patriotic resentment. When I’m forced to use a translator to communicate with the guy fixing my car, I feel a certain frustration.” The blogger was Glenn Greenwald. The columnist was Paul Krugman. The senator was Barack Obama.
immigration  politics 
yesterday
Bahá'í Faith - Wikipedia
> The Bahá'í Faith (Persian: بهائی‎‎ Bahā'i) is a religion teaching the essential worth of all religions, and the unity and equality of all people.[1] Established by Bahá'u'lláh in 1863, it initially grew in the Middle East and now has between 5-7 million adherents, known as Bahá'ís, spread out into most of the world's countries and territories, with the highest concentrations in India and Iran.[2][3]
religion  bahai  history 
2 days ago
I’m a Spoonie | The Invisible Hypothyroidism
> The idea of the spoon theory, by Christine Miserandino, is that many people with a disability or chronic illness must carefully plan their daily activities to use their spoons wisely, while most people with better health or who do not have a disability, do not need to worry about running out of them. Spoons are a unit of measurement used to track how much energy a person has throughout the day.
disability  hypothyroid  fatigue 
2 days ago
Impact of Energy Intake, Physical Activity, and Population-wide Weight Loss on Cardiovascular Disease and Diabetes Mortality in Cuba, 1980–2005 | American Journal of Epidemiology | Oxford Academic
> The crisis reduced per capita daily energy intake from 2,899 calories to 1,863 calories. During the crisis period, the proportion of physically active adults increased from 30% to 67%, and a 1.5-unit shift in the body mass index distribution was observed, along with a change in the distribution of body mass index categories. The prevalence of obesity declined from 14% to 7%, the prevalence of overweight increased 1%, and the prevalence of normal weight increased 4%. During 1997–2002, there were declines in deaths attributed to diabetes (51%), coronary heart disease (35%), stroke (20%), and all causes (18%).
obesity  cuba  natural_experiment  CR  diet 
4 days ago
When I "see heat waves" rising from a hot, dry street, what is it that I'm actually seeing? : askscience
"Heat waves": > The heat is changing the density of the air, because heat makes things expand. This in turn changes the refractive index of the air, and hence the direction through which light rays pass through the air. The ripple, reflection-type illusion is the light rays refracting differently through the air.
vision  illusion  physics 
4 days ago
you can’t fake it – Freddie deBoer – Medium
> Go to a feminist academic conference where everyone has read, absorbed, and agreed with intellectual rejections of judgments of physical attractiveness. I promise you that most everyone in that space will nonetheless undertake an unchosen and immediate mental accounting of the relative physical attractiveness of most everyone in the room. They won’t voice it, thank god, and they’ll work to minimize its impact on the way they interact with each other, and that’s what matters. And they’ll have different individual sense of who is more attractive than who, and thank god for all of us. But nobody won’t notice who’s hotter than who. I’m just trying to be real with you here.
There’s been an admirable expansion lately in what kind of looks are considered hot, and every kind of person has someone who finds them attractive. But still, hot people exist, and science says they reap the benefits.
Trust me: none of this is an endorsement. All of it sucks. I agree 100% with the critique of these things. I just find the critique totally toothless when it comes to the persistence and power of this social phenomenon.
academia  freddie_deboer  attractiveness  evolution  2017  trends 
4 days ago
Slavery in Britain - Wikipedia
Slavery was eliminated in UK empire in 1807-1833, much sooner than it was eliminated in the US. > According to the Domesday Book census, over 10% of England's population in 1086 were slaves.[14] In 1102, the Church Council of London convened by Anselm issued a decree: "Let no one dare hereafter to engage in the infamous business, prevalent in England, of selling men like animals."[15] However, the Council had no legislative powers, and no act of law was valid unless signed by the monarch. ... William Wilberforce, a member of the House of Commons as an independent, became intricately involved in the abolition of the slave trade in Britain. His conversion to Evangelical Christianity in 1784 played a key role in interesting him in this social reform.[37] William Wilberforce's Slave Trade Act 1807 abolished the slave trade in the British Empire. It was not until the Slavery Abolition Act 1833 that the institution finally was abolished, but on a gradual basis. Since land owners in the British West Indies were losing their unpaid labourers, they received compensation totaling £20 million.[38]
slavery  britain  history 
4 days ago
Medical Aspects of the Persistent Vegetative State — NEJM
> Three months after injury, 33 percent of the patients had recovered consciousness; 67 percent had died or remained in a vegetative state. Recovery had occurred in 46 percent of the patients at 6 months and in 52 percent at 12 months. Recovery after 12 months was reported in only 7 of the 434 patients47,49. One patient recovered consciousness 30 months after injury and remained severely disabled47, 111. The Traumatic Coma Data Bank study reported that 6 of 93 adult patients in a vegetative state recovered consciousness one to three years after injury49. Four of these six patients had severe disability, and one had moderate disability; the status of the sixth patient could not be determined
coma  vegetative  neurology 
4 days ago
Are Liberals Dying Out? | Quillette
> Societies that forgo the exoskeleton of religion should reflect carefully on what will happen to them over several generations. We don’t really know, because the first atheistic societies have only emerged in Europe in the last few decades. They are the least efficient societies ever known at turning resources into offspring.2
fertility  religion  atheism  demographics 
4 days ago
Religious 'nones' projected to decline as share of world population | Pew Research Center
> And between 2010 and 2015, adherents of religions are estimated to have given birth to an average of 2.45 children per woman, compared with an average of 1.65 children among the unaffiliated.
religion  fertility 
4 days ago
For experimental cancer therapy, a struggle to ensure supply keeps up with demand | Science | AAAS
> The demand took off when doctors began reporting impressive results in leukemia and, later, lymphoma, with response rates ranging from 40% to 50% in lymphoma to more than 90% in some leukemias. More researchers joined the fray, keen to test CAR-T therapy in patients with other cancers. Companies joined in, too, anticipating a burgeoning market. Dozens of trials are underway, and two CAR-T cell products, for childhood and young adult ALL and aggressive B-cell lymphoma, may be approved later this year by the U.S. Food and Drug Administration (FDA).
cancer  car-t  2017  science 
7 days ago
We Could Have Had Cellphones Four Decades Earlier - Reason.com
> The government would not allocate spectrum to realize the engineers' vision of "cellular radio" until 1982, and licenses authorizing the service would not be fully distributed for another seven years. That's one heck of a bureaucratic delay.
law  regulation  phone  communication 
7 days ago
MisterYouAreSoDumb comments on Nootropics Depot asking for a lot of personal information just to make a purchase...
Most banks seem to not deal with businesses if they accept cryptocurrency. > That's correct, we were shut down for getting ACH transfers in from Coinbase and Bitpay. Not only that, I was personally banned from the bank, and a bank account for another company of mine totally unrelated to nootropics was shut down as well. The regional director of business relations for the bank tried to keep us up, but the risk department at the bank shut him down. He also contacted the risk departments at 5 other major banks, since he felt bad, and they all told him they have the same policy. If your bank is seeing repeated deposits from companies associated with Bitcoin into your business bank account, then they can and will shut your account down. Their argument is that it's too risky for them, since they cannot verify the source of all incoming funds to the account. This is due to the shitty financial regulations the went in place since 2008. They are too vague and overreaching, and banks err on the side of extreme caution.
The banks I know have this policy are BBVA, Chase, Bank of America, Wells Fargo, BMO Harris, Alliance Bank, and a couple other smaller ones. I have just stopped asking, as they are all going to be that way. There was no verbiage in writing in the bank documents for the bank that shut us down. I was only able to get verbal confirmation of the rule. However, I have started to see the verbiage in recent new bank account signups that we have filled out. A bank recently even asked us a series of questions on account signup, and one of them dealt with cryptocurrency. Many bank's risk departments will not give you detailed information, though. It always requires getting a director level person to press them on it.
cryptocurrency  banking  2017  finance  law 
7 days ago
EXPLAINING THE GENDER GAP IN CRIME: THE ROLE OF HEART RATE - CHOY - 2017 - Criminology - Wiley Online Library
Kind of absurd but interesting. > A low resting heart rate partially mediated the relationship between gender and all types of adult criminal offending, including violent and nonviolent crime. The mediation effects were significant after controlling for body mass index, race, social adversity, and activity level. Resting heart rate accounted for 5.4 percent to 17.1 percent of the gender difference in crime.
gender  crime  HR 
7 days ago
Microglia-dependent synapse loss in type I interferon-mediated lupus : Nature : Nature Research
> Notably, up to 75% of patients with SLE experience neuropsychiatric symptoms that range from anxiety, depression and cognitive impairment to seizures and, in rare cases, psychosis—collectively this is referred to as central nervous system (CNS) lupus. In some cases, certain autoantibodies, such as anti-NMDAR or anti-phospholipid antibodies, promote CNS lupus.
lupus  psychiatry  microglia  synapse 
7 days ago
Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles: Cell
The liver fluctuates by over 40% in size throughout the day?? > Here, we show that, in mice, liver mass, hepatocyte size, and protein levels follow a daily rhythm, whose amplitude depends on both feeding-fasting and light-dark cycles. Correlative evidence suggests that the daily oscillation in global protein accumulation depends on a similar fluctuation in ribosome number.
liver  ribosome  diurnal 
8 days ago
Women Dressed As Handmaids Descend On Ohio Statehouse To Protest Anti-Abortion Law : pics
> If courts defined life starting at conception, you potentially could argue a persons rights over their body is irrelevant if someone needed it specifically to survive. So if I had a rare blood disease and a random stranger had the only blood match known to help me - one could argue they should be forced to routinely donate blood to keep me alive- because we've established that if I need a body to survive it's murder to not allow me use of it if I'll die without it.
law  abortion  slippery_slope  life 
8 days ago
Health Effects of Overweight and Obesity in 195 Countries over 25 Years — NEJM
> In 2015, high BMI contributed to 4.0 million deaths, which represented 7.1% of the deaths from any cause; it also contributed to 120 million disability-adjusted life-years , which represented 4.9% of disability-adjusted life-years from any cause among adults globally. A total of 39% of the deaths and 37% of the disability-adjusted life-years that were related to high BMI occurred in persons with a BMI of less than 30. Cardiovascular disease was the leading cause of death and disability-adjusted life-years related to high BMI and accounted for 2.7 million deaths and 66.3 million disability-adjusted life-years
obesity  trends  cardiovascular 
9 days ago
Whataboutism - Wikipedia
> Whataboutism is a propaganda technique first used by the Soviet Union, in its dealings with the Western world.[1] When Cold War criticisms were levelled at the Soviet Union, the response would be "What about..." followed by the naming of an event in the Western world.[2][3] It represents a case of tu quoque (appeal to hypocrisy),[4] a logical fallacy that attempts to discredit the opponent's position by asserting the opponent's failure to act consistently in accordance with that position, without directly refuting or disproving the opponent's initial argument.
propaganda  language  politics 
10 days ago
Unpopular Opinion: Strongly Negative Interpretation of Hannah : 13ReasonsWhy
> While I like 13 reasons why for entertainment purposes it really upsets me people want to turn it into a PSA about mental illness. Its depiction of depression is so hollywood-like I feel like it'd be like trying to turn Breaking Bad into a PSA about drug use.
suicide  media  tv  mental_illness  PSA 
11 days ago
Knee Arthroplasty Sports | Knee Replacement Sports
> Perhaps even more surprising is that researchers found that those who took part in the non-recommended sports actually showed higher knee and function scores than the control group. The control group had a higher rate of loosening, wear, fracture and overall mechanical implant failure than the sport group at 11 percent compared to 8.5 percent in the sport group. Adjusting for a variety of lifestyle factors, doctors say the sport group had a 10 percent increased risk of mechanical failure, but they don’t consider that to be statistically significant.
TNR  knee  surgery  sports  aging 
11 days ago
Influence of donor age on induced pluripotent stem cells. - PubMed - NCBI
> We find that iPSCs from older donors retain an epigenetic signature of age, which can be reduced through passaging. Clonal expansion via reprogramming also enables the discovery of somatic mutations present in individual donor cells, which are missed by bulk sequencing methods. We show that exomic mutations in iPSCs increase linearly with age, and all iPSC lines analyzed carry at least one gene-disrupting mutation, several of which have been associated with cancer or dysfunction. Unexpectedly, elderly donors (>90 yrs) harbor fewer mutations than predicted, likely due to a contracted blood progenitor pool. These studies establish that donor age is associated with an increased risk of abnormalities in iPSCs and will inform clinical development of reprogramming technology.
stem_cells  aging  epigenetics 
13 days ago
Association Between Deliberate Self-harm and Violent Criminality | Psychiatry | JAMA Psychiatry | The JAMA Network
> The crude hazard ratio was 4.9 (95% CI, 4.8-5.0) for violent crime conviction in exposed individuals compared with the unexposed group. Women who self-harm were at particularly high risk for expressing violent behaviors. After adjustment for relevant psychiatric comorbidities and socioeconomic status, an almost doubled hazard of violent offense remained (hazard ratio, 1.8; 95% CI, 1.8-1.9).
psychiatry  suicide  violence  mental_illness 
15 days ago
Is Pharma Research Worse Than Chance? | Slate Star Codex
> The two most exciting developments in psychopharmacology in the 21st century so far have been ketamine for depression and MDMA for PTSD.
ptsd  psychiatry  mdma  hallucination  depression  ketamine 
16 days ago
Some Case Studies in Early Field Growth | Open Philanthropy Project
> The birth of the field of bioethics, as I understand it, provides an interesting case study in the transfer of authority over a domain (medical ethics) from one group (doctors) to another (bioethicists), in large part due to the first group’s relative neglect of that domain.
bioethics  ethics  history  law  medicine 
17 days ago
Consilience - Wikipedia
> In science and history, consilience (also convergence of evidence or concordance of evidence) refers to the principle that evidence from independent, unrelated sources can "converge" to strong conclusions. That is, when multiple sources of evidence are in agreement, the conclusion can be very strong even when none of the individual sources of evidence is significantly so on its own. Most established scientific knowledge is supported by a convergence of evidence: if not, the evidence is comparatively weak, and there will not likely be a strong scientific consensus.
science  vocab 
18 days ago
The Genomic Health Of Ancient Hominins | bioRxiv
> We also observed a temporal trend whereby genomes from the recent past are more likely to be healthier than genomes from the deep past. This calls into question the idea that modern lifestyles have caused genetic load to increase over time. Focusing on individual genomes, we find that the overall genomic health of the Altai Neandertal is worse than 97% of present day humans and that Otzi the Tyrolean Iceman had a genetic predisposition to gastrointestinal and cardiovascular diseases.
genetics  history  health  anthropology 
18 days ago
Helmet Shmelmet: Why It's OK To Ride A Bike In NYC Without One: Gothamist
> Slip of the keyboard there, sorry. Pedestrians have triple the per-km-traveled death rate compared to bicyclists. 45% of 750 bikers die due to TBI in a typical year. 40% of 4300 pedestrians die of TBI. Motorist TBI deaths totally eclipse both groups. Why are helmets pushed for bicyclists, but not the other groups, who impose much more cost to society?
helmet  biking  walking  safety  tbi 
20 days ago
PANDAS - Wikipedia
> Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a hypothesis that there exists a subset of children with rapid onset of obsessive-compulsive disorder (OCD) or tic disorders and these symptoms are caused by group A beta-hemolytic streptococcal (GABHS) infections.[1] The proposed link between infection and these disorders is that an initial autoimmune reaction to a GABHS infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations. It has been proposed that this autoimmune response can result in a broad range of neuropsychiatric symptoms.[2][3]
psychiatry  infection  autoimmune  GABHS 
20 days ago
Alcohol septal ablation - Wikipedia
> Using wires and balloons to localize the septal artery feeding the diseased muscle under both fluoroscopic (X-ray) and echocardiographic (ultrasound) guidance, a small amount of pure alcohol is infused into the artery to produce a small heart attack. Patients typically experience mild chest discomfort during the procedure, which takes approximately 60–90 minutes to complete. Analgesics and mild sedatives are administered as needed. Patients typically are maintained in the hospital for three to four days to monitor for any complications, including the need for a permanent pacemaker in 5–10%.
alcohol  heart_disease  surgery 
21 days ago
Vancomycin-Resistant Staphylococcus aureus Isolate from a Patient in Pennsylvania
> A vancomycin-resistant Staphylococcus aureus (VRSA) isolate was obtained from a patient in Pennsylvania in September 2002.
vancomycin  antibiotics 
21 days ago
Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation | Science
> Patients receiving deep brain stimulation of the subthalamus, including the zona incerta (ZI), for the treatment of movement disorders can exhibit characteristics of binge eating (1–3), a common eating disorder characterized by recurrent episodes of consuming large quantities of food, particularly highly palatable food (4, 5). ...Laser stimulation (20 Hz) above the PVT of ChIEF-tdTomato mice significantly inhibited normal, sweet, and high-fat food intake during 1-hour tests (Fig. 4D and fig. S8B). The mean latency for mice to stop eating was 6.1 ± 2.0 s after the laser (20 Hz) was turned on
weight  appetite  neuroscience  optogenetics  zona_incerta 
21 days ago
Mummy DNA unravels ancient Egyptians’ ancestry : Nature News & Comment
> data from 90 mummies buried between 1380 bc, during Egypt’s New Kingdom, and ad 425, in the Roman era. The findings show that the mummies’ closest kin were ancient farmers from a region that includes present-day Israel and Jordan. Modern Egyptians, by contrast, have inherited more of their DNA from central Africans.
dna  genetics  ancestry 
21 days ago
72,000 Iowans could be first to lose coverage as insurance market collapses
> Some Iowans could sign up for faith-based “health care sharing ministries,” in which religious people agree to help cover each other’s medical expenses. Such options aren’t full insurance. The plans require participants to attest to religious beliefs, and they exclude costs for such things as birth control, out-of-wedlock pregnancies and injuries sustained in drunken-driving accidents. The ministries also can exclude payment for pre-existing health problems. But they do count as qualifying coverage for Americans trying to comply with the Affordable Care Act’s requirement that most Americans obtain insurance.
iowa  healthcare  2017  religion  insurance 
21 days ago
Violence is soaring in parts of Mexico that supply America’s heroin - Washington Post
> Mexico provides more than 90 percent of America’s heroin, up from less than 10 percent in 2003, when Colombia was the main supplier. Poppy production has expanded by about 800 percent in a decade as U.S. demand has soared. The western state of Guerrero is the center of this business, producing more than half of Mexico’s opium poppies, the base ingredient for heroin. Guerrero also has become the most violent state in Mexico, with more than 2,200 killings last year.
mexico  violence  heroin  2017 
22 days ago
Silicon Valley doctor Dr. Molly wants to usher in the era of personalized medicine — Quartz
> The general practitioner wants to see real medical rigor behind people trying to hack their health. Her concierge medicine practice in San Francisco serves a small number of patients for anywhere from $5,000 for an initial assessment to upwards of $40,000 per year for comprehensive care (every patient has a second, primary care physician as well). Her clients are often engineers and executives looking to hit peak performance, or recover from an over-stressed work-life. Maloof, who earned her medical degree from the University in Illinois in 2011, sees part of her work as ensuring they they are doing it safely, backed up by the maximum amount of evidence.
post_mdphd  sf  medicine  future  concierge 
22 days ago
Stan (fan) - Wikipedia
> A stan is an avid fan and supporter of a celebrity, tv show, group, or a film or film series. The object of the stan's affection is often called their "fave". Based on the 2000 song "Stan" by American rapper Eminem,[1] the term has frequently been used to describe artist devotees whose fanaticism matches the severity of the obsessive character in the song. The word has been described as a portmanteau of "stalker" and "fan".[citation needed]
vocab 
25 days ago
LMFAO - Wikipedia
LMFAO called it quits right after they released Party Rock Anthem, which was an insanely popular hit. Talk about going out on top. > On September 21, 2012, the duo released a statement announcing their hiatus. Redfoo said, "I feel like we've been doing this for so long, four or five years" and that he and SkyBlu would not be performing together anytime soon as they would be taking their careers in different directions.[18] Once the news surfaced that band members Redfoo and SkyBlu had split, the group went to MTV News to set the record straight. SkyBlu said, "Well, you know, first of all, we're not breaking up. I know that for sure. We're family and stuff, so it's always love ... It's interesting because somebody will say one thing [and] it's just like high school, then all of a sudden [it's] 'They're breaking up. They're fighting.'"[19] However, it has been revealed by SkyBlu that their plan is for fans to see the band as individuals and then come back stronger than ever.[20] In 2015, the band alleged that Muskegon-based Pigeon Hill Brewing Co.'s LMFAO Stout infringed on its trademarked name, according to a cease-and-desist letter sent on August 11.[21] After weeks of litigation, the Pigeon Hill Brewing Company announced that both they and the band LMFAO have reached an agreement resulting in the brewery retaining its trademark for its LMFAO Stout.[22]
music 
28 days ago
OrangeredStilton comments on With latency as low as 25ms, SpaceX to launch broadband satellites in 2019
> You know, if Decronym did listen to particular comments and reply to them, you'd get a chain of Decronym and Lawbot replying to each other forever.
Which is why Decronym doesn't do that, despite repeated suggestions for it to do so.
reddit  programming  comments 
28 days ago
Tissue-independent cancer drug gets fast-track approval from US regulator : Nature News & Comment
> The new approval, announced on 23 May, expands the use of a drug called pembrolizumab, manufactured by pharmaceutical giant Merck & Co. of Kenilworth, New Jersey. The drug fosters the immune system’s attack on tumours by blocking a protein called PD-1, which normally holds the immune system in check. The FDA had previously approved pembrolizumab for use in several cancers, including lung and skin cancer. But physicians can now use pembrolizumab in any solid tumour that has a particular defect in its ability to repair damaged DNA.
oncology  cancer  clinical_trial  fda  2017 
28 days ago
Jerry Canterbury, paralyzed plaintiff in lawsuit that established ‘informed consent,’ dies at 78 - The Washington Post
> In 1959, at 19, he agreed to undergo a spinal surgery known as a laminectomy — a procedure expected to resolve a ruptured disc and that he said his doctor described as “no more serious than an ordinary, everyday operation.” The day after the surgery, Mr. Canterbury fell at the hospital while attempting to empty his bladder. Another operation followed. By the time he was discharged more than three months later, he was partially paralyzed in the legs and permanently incontinent. He would spend the rest of his life on crutches, then in a wheelchair and finally confined to a bed. Mr. Canterbury, who has died at 78, sued his surgeon, William T. Spence, accusing him of having failed to adequately warn him of the risks of his surgery. The physician ultimately prevailed, but a 1972 federal appeals court decision in the case became a foundation of the doctrine of informed consent and, by extension, the modern practice of medicine.
medicine  history  law  ethics 
4 weeks ago
What Price Success? Ionis Drug Worked in Phase 3 but Had Serious Side Effects | ALZFORUM
> TTR amyloidosis is but one of many diseases Ionis is targeting with ASOs. Its ASO therapies are in various stages of development to suppress huntingtin, SOD1, C9orf72, and tau (see May 2013 news; Jun 2012 news; Nov 2015 news; and Jan 2017 news).—Jessica Shugart
ASO  RNA  amyloid 
4 weeks ago
Charles Proteus Steinmetz - Wikipedia
> Steinmetz was called the "forger of thunderbolts", being the first to create artificial lightning in his football field-sized laboratory and high towers built at General Electric, using 120,000 volt generators. He erected a lightning tower to attract natural lightning, and studied the patterns and effects of lightning resulting in several theories and ideas.[citation needed]
science  history  lightning 
5 weeks ago
Michael C. Ain, M.D.
Badass ortho surgeon who has achondroplasia.
surgery  medicine  hero  achondroplasia 
5 weeks ago
Visual release hallucinations - Wikipedia
> Mentally healthy people with significant vision loss may have vivid, complex recurrent visual hallucinations (fictive visual percepts). One characteristic of these hallucinations is that they usually are "lilliputian" (hallucinations in which the characters or objects are smaller than normal). The most common hallucination is of faces or cartoons.[4] Sufferers understand that the hallucinations are not real, and the hallucinations are only visual, that is, they do not occur in any other senses, e.g. hearing, smell or taste.[5][6] Among older adults (> 65 years) with significant vision loss, the prevalence of Charles Bonnet syndrome has been reported to be between 10% and 40%; a 2008 Australian study found the prevalence to be 17.5%.[2] Two Asian studies, however, report a much lower prevalence.[7][8] The high incidence of non-reporting of this disorder is the greatest hindrance to determining the exact prevalence; non-reporting is thought to be a result of sufferers being afraid to discuss the symptoms out of fear that they will be labelled insane.[6]
hallucination  vision  psychiatry 
5 weeks ago
Asthma and obesity: does weight loss improve asthma control? a systematic review
> Weight loss in obese individuals with doctor-diagnosed asthma is associated with a 48%–100% remission of asthma symptoms and use of asthma medication. Published studies, furthermore, reveal that weight loss in obese asthmatics improves asthma control, and that especially surgically induced weight loss results in significant improvements in asthma severity, use of asthma medication, dyspnoea, exercise tolerance, and acute exacerbations, including hospitalizations due to asthma. Furthermore, weight loss in obese asthmatics is associated with improvements in level of lung function and airway responsiveness to inhaled methacholine, whereas no significant improvements have been observed in exhaled nitric oxide or other markers of eosinophilic airway inflammation.
asthma  obesity  weightloss 
5 weeks ago
Review of Alain de Botton’s “Pleasures and Sorrows of Work” – Steamboats Are Ruining Everything
> I will hate you till the day I die and wish you nothing but ill will in every career move you make. I will be watching with interest and schadenfreude.
alain_botton  schadenfreude  hate  take_down 
5 weeks ago
Rejection Letter - Charlie's Diary
Satire about the worldwide hack yesterday being rejected as implausible fiction.
security  computers  2017  humor 
5 weeks ago
Folie à deux - Wikipedia
> Folie à deux and its more populous cousins are in many ways a psychiatric curiosity. The current Diagnostic and Statistical Manual of Mental Disorders states that a person cannot be diagnosed as being delusional if the belief in question is one "ordinarily accepted by other members of the person's culture or subculture" (see entry for delusion). It is not clear at what point a belief considered to be delusional escapes from the folie à... diagnostic category and becomes legitimate because of the number of people holding it. When a large number of people may come to believe obviously false and potentially distressing things based purely on hearsay, these beliefs are not considered to be clinical delusions by the psychiatric profession and are labelled instead as mass hysteria.
psychiatry  psychosis 
5 weeks ago
Charleston Gazette-Mail | Trump officials seek opioid solutions in WV
> Asked about drug treatment options, Price touted faith-based programs while showing less support for medication-assisted programs in which addicts are weaned off heroin with other opioids like Suboxone and methadone.
“If we’re just substituting one opioid for another, we’re not moving the dial much,” he said. “Folks need to be cured so they can be productive members of society and realize their dreams.”
2017  religion  psychiatry  addiction  tom_price  opioid 
6 weeks ago
Ultrasound treatment of neurological diseases [mdash] current and emerging applications : Nature Reviews Neurology : Nature Research
Ultrasound therapy to treat disorders of the brain, hopefully will be more approved therapies over the coming decade or so.
OCD  ultrasound  neurosurgery  neurology  psychiatry  parkinsons  tremor 
6 weeks ago
At 45, ex-detective shifts investigation skills to medicine | Cornell Chronicle
> He’s most interested in the biology of aging, and specifically, how science has extended lifespans but hasn’t extended health spans at a corresponding rate. “Our experiences in life tell us that things get old and then they break,” Saffran said. “While that process seems perfectly normal and reasonable, it’s actually not necessary for biological systems to respond to age in this way.” He intends to investigate why this happens, and hopes to improve the health of our aging population in the process. Poised to eventually receive the same degree as his mentor, Kaplitt, Saffran is still sometimes in awe of the opportunities ahead of him. “I thought you have to be such a genius to do this kind of thing,” he says. “It’s the single greatest accomplishment of my life that is not directly connected to my daughter.”
mdphd  christian_saffran  police  post_mdphd  aging 
6 weeks ago
The Impact of Physician Weight Discussion on Weight Loss in US Adults
> Overweight and obese participants were significantly more likely to report a 5% weight loss in the past year if their doctor had told them they were overweight (adjusted OR (AOR) 1.88; 95% CI 1.45-2.44; AOR 1.79; 95% CI 1.30-2.46, respectively).
weight_loss  obesity  doctor 
6 weeks ago
Ray Allen talks about his passion for teaching others about the Holocaust
> “I am proud to serve in this role and to continue to share the important messages and lessons we all need to remember from the Holocaust,” Allen said in a statement. “I want to inspire people to break down stereotypes, and treat one another — regardless of race, religion or anything else — like family. It’s more important now than ever.”
ray_allen  nba  history  holocaust 
6 weeks ago
Total knee replacement for athletes | Total joint replacement for athletes | Sports after total knee replacement | Sports after hip replacement The Stone Clinic
> The wearing out of plastic components most often occurs in mal position or mal tracking of the joint. Improved tracking is facilitated by strong muscles, better balance and more normal gait, all of which come from a strong core and strong trunk muscles. Total body fitness conditioning is the key to a long lasting joint replacement. Most modern knee replacements have plastic components that are interchangeable if worn out. So why limit an entire later lifetime of sports by the fear of them wearing out?

Finally to running: Running is the most common request we get from our athletes who need total knees. The data is that whether you run a mile or walk a mile, the total force on the joint is the same, since you take fewer steps when running. The peak forces are higher depending on the type of surface, the smoothness of the gait, the shoe wear and other factors. If you must run, run with great form on soft surfaces with new absorbent shoes. I have never seen a total knee become worn out from running nor have any of my peers who I have asked. In general cycling is a more logical sport as it limits the impact, but logic is not the reason we run.
running  knee  knee_replacement 
6 weeks ago
The association between socioeconomic status and adult fast-food consumption in the U.S.
> Fast-food consumption among adults varies little across SES, measured as income and wealth.
Descriptive analyses indicate a weak, inverted U-shaped association between fast-food and SES.
Checking nutrition labels frequently and drinking less soda predict less adult fast-food intake.
More work hours predict greater fast-food intake.
food  income  SES  economics 
6 weeks ago
Queens pursued more aggressive war policies - Marginal REVOLUTION
> We find that polities led by queens were more likely to engage in war than polities led by kings. Moreover, the tendency of queens to engage as aggressors varied by marital status. Among unmarried monarchs, queens were more likely to be attacked than kings. Among married monarchs, queens were more likely to participate as attackers than kings, and, more likely to fight alongside allies. These results are consistent with an account in which marriages strengthened queenly reigns because married queens were more likely to secure alliances and enlist their spouses to help them rule. Married kings, in contrast, were less inclined to utilize a similar division of labor. These asymmetries, which reflected prevailing gender norms, ultimately enabled queens to pursue more aggressive war policies.
war  history  monarchy 
6 weeks ago
Reductress » Why I’m Settling For a Man Who’s Not My High School Poster of Aragorn
> I used to have pretty unreasonable standards when it came to men. I’d turn them down no matter how great they seemed, simply because they didn’t meet the very specific set of expectations I’d developed over the course of my life. I stayed single for years, until one day, I finally gave up on the fantasy of meeting the ideal guy altogether – a motionless and slightly faded 27” x 41” poster image of Aragorn, from the Lord of the Rings trilogy. Now, I’m finally ready to settle for a man who’s not that poster.
humor  dating 
6 weeks ago
Overcoming Bias : What TED Needs
> The most discouraging talk I heard was by Jim Yong Kim, President of the World Bank Group. He talked about how he fought the World Bank for years, because they insisted on using cost-effectiveness criteria to pick medical investments. He showed us pictures of particular people helped by less cost-effective treatments, daring us to say they were not worth helping. And he said people in poor nations have status-based “aspirations” for the same sort of hospitals and schools found in rich nations, even if they aren’t cost-effective, and who are we to tell them no. Now that he runs the World Bank (nominated by Obama in 2012), his priorities can now win more. The audience cheered. So sad.
politics  2017  economics  markets  ted 
6 weeks ago
Investigating the case of human nose shape and climate adaptation
Part of why different ancestral groups may have different nose sizes > We find that width of the nares is correlated with temperature and absolute humidity, but not with relative humidity. We conclude that some aspects of nose shape may indeed have been driven by local adaptation to climate. However, we think that this is a simplified explanation of a very complex evolutionary history, which possibly also involved other non-neutral forces such as sexual selection.
nose  face  genomics 
6 weeks ago
Restorative justice conferencing (RJC) using face-to-face meetings of offenders and victims: effects on offender recidivism and victim satisfaction - The Campbell Collaboration
> The evidence of a relationship between conferencing and subsequent convictions or arrests over two years post-random assignment is clear and compelling, with nine out of 10 results in the predicted direction and a standardized mean difference for the ten experiments combined (Cohen’s d = -.155; p = .001). The impact of RJCs on 2-year convictions was reported to be cost-effective in the 7 UK experiments, with up to 14 times as much benefit in costs of the crimes prevented (in London), and 8 times overall, as the cost of delivering RJCs. The effect of conferencing on victims’ satisfaction with the handling of their cases is uniformly positive (d = .327; p<.05), as are several other measures of victim impact.
crime  justice  law  RCT 
6 weeks ago
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
> In this study, we have demonstrated that inhibition of ASIC1a using Hi1a provides exceptional levels of neuroprotection even when the peptide is administered up to 8 h after stroke onset. Along with facilitating a substantially reduced level of penumbral damage, Hi1a is unique in providing some protection of the striatal core region, which is generally considered therapeutically unrecoverable owing to rapid and irreversible necrotic cell death ( .. Hi1a was neuroprotective even when administered 8 h after onset of ET-1–mediated MCAO. Although we did not determine the degree and duration of ET-1–mediated cerebral ischemia, previous studies have reported either complete or partial recovery of blood flow at 8 h after stroke (33–35). In this context, we have shown that the neuroprotection afforded by Hi1a is unlikely to result from a vasodilatory effect, given that it did not reverse ET-1–mediated vasoconstriction of isolated cerebral arteries
stroke  neuroprotection 
7 weeks ago
Total recall: the people who never forget | Science | The Guardian
> When I first spoke to McGaugh, he told me that the real question at the heart of HSAM wasn’t why his subjects remember, but why we forget. “The overall summary of all of this is that they’re bad forgetters,” he said. And forgetting is what humans do; often what we need to do. The title character in Jorge Luis Borges’s story Funes the Memorious, who acquires a perfect memory as the result of an accident, can no longer sleep because he is kept awake by the thousand mundane memories that whined like mosquitoes in his ears. The “peculiar mixture of forgetting with our remembering,” wrote William James, one of the founders of modern psychology, “is the very keel on which our mental ship is built.” “If we remembered everything,” he continued, “we should on most occasions be as ill off as if we remembered nothing.”
memory  happiness 
7 weeks ago
Neutral vs. Conservative: The Eternal Struggle | Slate Star Codex
> Stanford historian Robert Conquest once declared it a law of politics that “any organization not explicitly right-wing sooner or later becomes left-wing”. I have no idea why this should be true, and yet I’ve seen it again and again. Taken to its extreme, it suggests we’ll end up with a bunch of neutral organizations that have become left-wing, plus a few explicitly right-wing organizations. Given that Conquest was writing in the 1960s, he seems to have predicted the current situation remarkably well.
politics  media  scott_alexander  history 
7 weeks ago
Short and long term memory: For half a century, neuroscientists thought they knew how memory worked. They were wrong — Quartz
> Short-term memory, Cleeremans says, allows you to find the specific street and space where you parked the car that day. But long-term memory accumulates all these individual instances into a broad set of data, so you know the streets where you’re most likely to find a parking space and enables you to develop a great car-parking strategy.
memory  hippocampus  pfc  neuroscience 
7 weeks ago
The shock tactics set to shake up immunology : Nature News & Comment
> Tracey acknowledges this criticism, but still sees huge potential in electrical stimulation. “In our lifetime, we will see devices replacing some drugs,” he says. Delivering shocks to the vagus or other peripheral nerves could provide treatment for a host of diseases, he argues, from diabetes to high blood pressure and bleeding. “This is the beginning of a field.” ... Last October, the US National Institutes of Health announced a programme called Stimulating Peripheral Activity to Relieve Conditions (SPARC), which will provide US$238 million in funding until 2021 to support research updating the maps of neural circuitry in the thoracic and abdominal cavities.
neurology  electrophysiology 
7 weeks ago
Psychedelic compound in ecstasy moves closer to approval to treat PTSD : Nature News & Comment
> During his conference presentation, Mithoefer played a video of a former US marine under the influence of MDMA recounting the time his military jeep exploded during a tour in Iraq. The soldier, positioned on a narrow bed between Mithoefer and his wife Annie, a psychiatric nurse, describes the panic that accompanies his memories. But then, he says, an inner-voice assures him that he’ll be all right. “I feel things come up and then blow away like sand,” the marine says. Michael Mithoefer says it’s been five years since the marine’s session. “We are still in touch,” he says, “and that effect has lasted.”
mdma  ptsd  psychiatry 
7 weeks ago
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