How to break a Monolith into Microservices
A guide to the common steps we've observed in breaking a monolithic application up into microservices
april 2018
How Do We Write Now? | Tin House
I am thinking of the most sacred headspace of all, which exists in absolute opposition to the thick loud smog of the present. That is the headspace of the first book. Before anything happens. The air there is so thin and sharp and keeps you in a kind of exquisite pain. It is crowded with flowers, which open into red throats like tiger lilies, ready to speak. They are an opening to possibility, they are a trembling in the air, they are the fact that anything can be a poem. The tongue tastes two things: nectar and stamps. Well, that’s a lie. It tastes blood, too, and the food of your childhood, and the backs of other people’s necks. The animals just wait in the gold parted grass, with more eye ear and whisker than they have here. It is a paradise like the sonnet, where everything is named and a snake has been purposely introduced.
april 2018
How Cambridge Analytica’s Facebook targeting model really worked
The researcher who built the model claims it wasn't very accurate on an individual level.
security  politics 
april 2018
Opinion | Jill McCabe: The president attacked my reputation. It’s time to set the record straight.
There was no connection between my campaign and my husband’s role at the FBI.
april 2018
‘I made Steve Bannon’s psychological warfare tool’: meet the data war whistleblower
Christopher Wylie goes on the record to discuss his role in hijacking the profiles of millions of Facebook users in order to target the US electorate
politics  security 
march 2018
TablePlus | Modern, Native Tool for Database Management
A modern, native tool with elegant UI that allows you to simultaneously manage multiple DB such as MySQL, Postgres, SQL Server, SQLite, Microsoft SQL Server and more.
mac  sql  work 
february 2018
Anti-vaccine activists are playing with fire in Minnesota
“They are everywhere. Like, every event, every forum.”

This is how anti-vaccine activists were described  by a community outreach worker in Minneapolis, where the Somali-American population was systematically and incessantly warned against vaccines. Activists including Andrew Wakefield — who published a fraudulent  paper in the late ’90s pushing the vaccine-autism myth – made multiple visits to the Minneapolis area to engage a community that was trying to find its place in society.

Read the rest...
may 2017
Now This Is A Drug That Does Not Work
I’ve already written about how Eli Lilly’s inhibitor of cholesteryl ester transfer protein (CETP) did not work in the clinic. Now that the data from their failed trial have been published in the NEJM, though, it’s worth taking a look at a few graphs (first pointed out to me on Twitter by Sek Kathiresan . Shown are the effects of evacetrapib on HDL and LDL, and he’s right: if you’d seen these graphs ten years ago, you’d have said that you’re looking at a cardiovascular wonder drug for sure. LDL down 30%, HDL up 125% – what else do you want?

Well, you want actual cardiovascular outcomes. And that’s where this graph comes in. 12,000 total patients for over two years, and this is what you get: nothing. You lose – good day, sir ! Absolutely no change in CV events whatsoever. There is something that we don’t understand here, about the various effects of CETP inhibition, or the various types of HDL and LDL and their downstream effects, or about the influence of these two on cardiovascular health in general. CETP inhibitors have been a total wipeout for every single company that has tried to develop a drug in this area. Merck has not yet released data on their own compound in this area, anacetrapib, but let’s put it this way: if it works, it’ll be one of the major medical mysteries of our time.

And I think I’ll add this every time we have a big drug trial wipe out: keep in mind, that under a safety-only regulatory regime, that people would have been taking this drug (and paying for it, one way or another) for the last few years now, and it would have done them no good at all. When they could have been actually taking something that might help them. We do not know enough about investigational drugs to approve them without efficacy data.
may 2017
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