dandv + life + extension   83

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening - Liao - 2010 - Aging Cell - Wiley Online Library
Dietary restriction did not extend lifespan of certain mice strains, and shortened some

"Strikingly, the majority of strains showed no extension of lifespan under the level of DR used in this study (Fig. 1C,D). Only 5% of the strains for males and 21% of the strains for females showed statistically significant life extension under DR, using single strain P‐values < 0.05. DR shortened lifespan in more strains (27% and 26%; males and females, respectively; P < 0.05–0.001). Although sample sizes were small, mean lifespan of males and females were significantly correlated under both AL (r = 0.50, P = 0.002) and DR (r = 0.42. P = 0.012) conditions. In addition, doubling sample size by combining the two sexes yielded a similar result: DR shortened life in more strains than showed lengthened life (supporting Fig. S2)"
life  extension  calorie  restriction 
9 hours ago by dandv
Cancer Research Points to Key Unknowns about Popular "Antiaging" Supplements - Scientific American
these findings do not necessarily point to ready answers for consumers interested in NR or NMN supplements, so much as they highlight questions for scientists to address in the coming years

NAD+ is a ubiquitous and fundamental molecule, involved in many biological pathways and cellular operations. Its ingestion could lead to a mix of positive and negative outcomes, the balance of which might depend on context. NAD+precursors, consumed orally, may be taken up by some tissues more than others. And different cell types are known to employ distinct metabolic programs, which could lead to tissue-specific responses to NAD+.

the idea that elevating NAD+ levels could fuel cancer growth remains a hypothesis, but it is one that has attracted considerable attention.

Zhang’s study is one of the first to directly show that providing supplemental NAD+, via the precursor NMN, was associated with increased cancerous growths in mice. But Elysium’s Guarente is skeptical of the data, arguing that Zhang’s study showed a small effect in a small number of animals and that it has yet to be replicated by other groups. “I don’t think the evidence is there at all to say that raising NAD+ levels would favor cancer,” Guarente says.
cancer  life  extension  against  NMN  NAD 
june 2019 by dandv
Is strength training associated with mortality benefits? A 15year cohort study of US older adults. - PubMed - NCBI
Older adults who reported guideline-concordant ST had 46% lower odds of all-cause mortality than those who did not

The association between ST and death remained after adjustment for past medical history and health behaviors.

Layman's: https://www.menshealth.com/fitness/a19517546/lifting-weights-helps-you-live-longer/
strength  training  weight  lifting  reduce  mortality  delay  death  life  extension 
april 2019 by dandv
NAD+ Sublingual – Is it bioavailable? New product being launched. : longevity
NAD is not something you take...it is made by taking NR and/or NMN and those raise your NAD levels.
healthspan  increase  life  extension  longevity  supplements 
february 2019 by dandv
BioViva Science | Health Testing and Analysis
Telomerase and myostatin inhibitor stem cell treatments. Consultation with a radiologist $100/15 minutes
life  extension  procedure 
february 2019 by dandv
Testing the first combination therapies for longevity | Geroscience
Both pairs did better with allantoin attached, and the combination including rifampicin and rapamycin doubled mean lifespan, the largest effect ever found with an adult-onset drug intervention.

These well-medicated worms didn’t take any hits to healthspan, either. The triple therapies resulted in 7-13% more of life spent in optimal health compared to untreated controls, so that after the last unmedicated worm had died, over half of treated worms were still living it up in their best years.
life  extension  drugs  healthspan  longevity 
february 2019 by dandv
The American Public Increasingly Desires Life Extension | | LEAF
[[study by YouGov that included around 1200 participants, one in five (19%) people agreed with the statement “I want to live forever” without any promises related to perfect health. 42% of the participants chose “I want to live longer than a normal lifespan, but not forever”, while 23% said, “I don’t want to live longer than a normal lifespan.” People in different age groups reacted to this survey differently; it turns out that the idea of radical life extension was more supported by young people (24%) than by people over 55 (13%), while support for the status quo was the opposite (19% of young people didn’t want to live longer than a normal lifespan, while this position was shared by 29% of people aged 55 and older).]]

Men want radical life extension more than women, especially in Russia
life  extension  survey  attitude 
january 2019 by dandv
Aubrey de Grey – Life extension drugs Clinical Trials in Five Years | | LEAF
"Historically, clinical trials had to be completed before anybody could get these drugs, but now we are getting new policies; there is a thing called adaptive licensing, which is becoming popular in the US and elsewhere, where the therapy becomes approved at an earlier stage, and then it’s monitored after that.

The big pharmaceutical companies don’t really do much of their own research in the first place. They just wait to see what happens, and then they buy small companies."
life  extension  future  fast  clinical  trials  adaptive  licensing 
january 2019 by dandv
Antibiotics eliminate senescent cells associated with ageing
scientists have shown for the first time that an FDA-approved antibiotic – Azithromycin – can effectively target and eliminate senescent cells in culture.

At a single low-dosage, Azithromycin was shown to effectively kill and eliminate the senescent cells, with an efficiency of 97 percent.

Moreover, the normal healthy cells thrived in the presence of Azithromycin.

"It was an astonishing result, and one that got us thinking about the implications for treating or preventing a variety of ageing-associated diseases," said Professor Michael P. Lisanti, the research lead.
life  health  extension  treat  aging  medicine  pill 
january 2019 by dandv
Stem Cell Clinical Trials Show Remarkable Results Against Age-related Frailty | | LEAF
Note - allogenic! So harvesting your own bone marrow may not be worth it if you're old. And a market may develop for "donors" with good MSCs.

"In the first trial, 15 patients with age-related frailty were given a single transplant of MSCs from donors aged between 20 and 45[6]. Six months later, all patients in the trial showed an improved level of fitness, lower levels of inflammatory tumor necrosis factor (TNF), and improved quality of life in general. TNF is one of the regulators of inflammation and contributes to the chronic age-related inflammation known as “inflammaging”, which drives a number of age-related diseases[7].

The second trial was a randomized, double-blind study including a placebo group. An improved physical performance level was observed in patients, and, again, the level of systemic TNF, and thus inflammation, was reduced[8]. Once again, there were no adverse effects observed in the patients, and the researchers wrote:

Treated groups had remarkable improvements in physical performance measures and inflammatory biomarkers, both of which characterize the frailty syndrome.

David G. Le Couter and colleagues have written about the clinical trials in a guest editorial in The Journals of Gerontology:

There are always caveats associated with interpreting efficacy in small numbers of subjects, yet it is remarkable that a single treatment seems to have generated improvement in key features of frailty that are sustained for many months"

https://www.leafscience.org/stem-cell-therapy-for-aging-frailty/ is less excited.
healthspan  extension  life  longevity  stem  cell  transplant  infusion 
january 2019 by dandv
The First Therapy that Targets Aging is in Human Trials Now
"senolytics increased both healthspan and lifespan in mice

in people, until clinical trials are completed, we cannot really say; however, the data so far appears to favor healthspan rather than lifespan"

Also, fisetin from strawberries
healthspan  extension  life  longevity 
december 2018 by dandv
C60 fullerene is widely reported to reduce pain due to inflammation

See also
* doubled lifespan in rats - https://www.reddit.com/r/Nootropics/comments/2uyzls/anyone_tried_c60_fullerene/

* fixed multiple sclerosis and mushy paw in cats - https://www.reddit.com/r/longevity/comments/52np0q/c60_and_olive_oil_me_and_the_cats/
life  extension  longevity  substance  supplement  2read 
december 2018 by dandv
Metformin Is a Direct SIRT1-Activating Compound | | LEAF
Aging causes levels of NAD+ to fall. NAD+ is needed to trigger SIRT1 expression which is beneficial to health and metabolism.

Metformin is able to compensate for the age-related fall of NAD+ and trigger SIRT1 directly. So Metformin appears to resist the aging process by keeping the metabolism working and reducing inflammation by activating SIRT1.
life  extension  metformin 
november 2018 by dandv
Time Is Precious, So Let's Enjoy More of It | | LEAF
There is nothing wrong with wanting to enjoy something for a long time, and only the beneficiary should get to decide how long is long enough. If you’re playing a game of golf for two hours and really feel like you want to go on for another two, how would you like it if I came along and decided for you that you’ve played long enough? That’s pretty much what happens when people tell you that the human lifespan is long enough—they’re breaking into your private golf course and telling you that you ought to stop playing. It’s none of their business, really.
life  healthspan  extension  advocacy 
august 2018 by dandv
C60 and Olive Oil: me and the cats : longevity
Don't buy it because it's very unstable when exposed to light. Make it yourself.
life  extension  cure  multiple  sclerosis 
june 2018 by dandv
Is the Preservation of Beauty as we Age Just Vanity? | | LEAF
 the goal of preserving one’s beauty isn’t necessarily frivolous, although it may be considered only a secondary benefit of anti-aging medicine. Some people might think that rejuvenation biotechnology is nothing but the wish of people who’re excessively preoccupied with their appearance, but they’d be missing the point just as much as anyone interested only in the beauty-preserving benefits of rejuvenation would be.
beauty  vanity  advocacy  life  extension 
april 2018 by dandv
What would be the first thing to do after you get the treatment making you negligibly senescent?
Lots of people would just do the same things. Also many actually interesting ideas.
Facebook  discussion  post  life  extension 
february 2018 by dandv
Young Again: How One Cell Turns Back Time - NYTimes.com
Right before an egg is fertilized, it is swept clean of deformed proteins in a dramatic burst of housecleaning.

a worm’s eggs carry a surprisingly heavy burden of damaged proteins, even more than in the surrounding cells. But in eggs that were nearing the worm’s sperm, the researchers found far less damage.

When Dr. Bohnert let them mate with males, however, the clumps disappeared from the eggs. “In thirty minutes you typically see them cleared out,” he said.The clumps come into contact with little bubbles called lysosomes, which extend fingerlike projections that pull the clumps inside. The sperm signal causes the lysosomes to become acidic. That change switches on the enzymes inside the lysosomes, allowing them to swiftly shred the clumps.

the worms normally keep their eggs in a dormant state. The eggs accumulate a lot of damage, but make little effort to repair it.

Only in the last minutes before fertilization do they destroy protein clumps and damaged proteins, so that their offspring won’t inherit that burden. 

The germline may not be the only place where cells restore themselves in this way.

Throughout our lives, we maintain a supply of stem cells that can rejuvenate our skin, guts and brains. It may be that stem cells also use lysosomes to eradicate damaged proteins.

“That would have huge implications,” Dr. Conboy said. It might be possible, for example, to treat diseases by giving aging tissues a signal to clean house.
rejuvenation  immortality  life  extension  SENS 
november 2017 by dandv
Google is super secretive about its anti-aging research. No one knows why. - Vox
Potentially withholding information about advances in biomedical science or cures for diseases is unacceptable: Lives are ultimately at stake. “Anything that slows down progress in biomedical research can’t be condoned.”
aging  science  life  extension  against  Calico 
november 2017 by dandv
Serge Faguet – Interview with a Biohacker | | LEAF
Sleep, HIIT, plant diet, metformin plus other supplements. No mention of weightlifting.
life  extension  QS  biohacking 
november 2017 by dandv
Ambrosia: Human tests suggest young blood cuts cancer and Alzheimer's risk | New Scientist
carcinoembryonic antigens fell by around 20 per cent in the blood of people who received the treatment. However, there was no control group or placebo treatment in the study, and it isn’t clear whether a 20 per cent reduction in these proteins is likely to affect someone’s chances of developing cancer. One participant, a 55-year-old man with early onset Alzheimer’s, began to show improvements after one plasma treatment, and his doctors decided he could be allowed to drive a car again. An older woman with more advanced Alzheimer’s is reportedly showing slow improvements, but her results have not been as dramatic.

Karmazin says he thinks plasma transfusions actually reverse it. But if this is true, the effects don’t last forever. “Some people have felt great since they had the treatment 9 months ago,” he says. “Others have felt the effects wore off after a few months.”

Neither the intensity nor staying power of the treatment’s effects seemed to have any obvious relationship to the age of the people treated. “Whether you’re 40 or 80, the effect is really similar,” says Karmazin. “Ageing is just wear and tear.”

Karmazin wants to do placebo-controlled studies, but it will be more difficult to fund these as people aren’t likely to pay thousands of dollars to possibly receive a sham treatment instead of young plasma
rejuvenation  life  extension  longevity  blood  plasma  transfer 
june 2017 by dandv
Intrinsic resistance to the idea of life extension or wrong messaging? – LEAF
Make sure to mention physical and mental youth when asking people how long they'd like to live
life  extension  longevity  lifespan  survey 
april 2017 by dandv
Peptide targeting senescent cells restores stamina, fur, and kidney function in old mice -- ScienceDaily
"Regular infusions of a peptide that can selectively seek out and destroy broken-down cells that hamper proper tissue renewal, called senescent cells, showed evidence of improving healthspan in naturally aged mice and mice genetically engineered to rapidly age. The proof-of-concept study found that an anti-senescent cell therapy could reverse age-related loss of fur, poor kidney function, and frailty. It is currently being tested whether the approach also extends lifespan"
aging  reversal  life  extension 
march 2017 by dandv
How Silicon Valley Is Trying to Hack Its Way Into a Longer Life | Time.com
Layman's summary of the most popular anti-aging interventions: parabiosis (Ambrosia), full-genome sequencing (Health Nucleus from HLI), anti-aging supplements (Elysium Basis), nootropics (Nootrobox), calories restriction
longevity  life  extension 
february 2017 by dandv
Forget blood transfusions, the fountain of youth could be closer to hand – LEAF
“We hope to start in six months and have results in three years. -- Irina Conboy at UC Berkeley

Many researchers initially thought that the positive results in these tests were due to there being pro-youthful signals in the young blood, however more recent research suggests that the likely reason is the dilution of pro-aging factors present in the old blood rather than there being any “secret sauce” in young blood.

See also https://www.theguardian.com/science/2016/nov/22/scientists-to-reset-blood-proteins-in-attempt-to-slow-ageing-process-calico
life  extension  blood  filtering 
february 2017 by dandv
Study shows promising safety results for anti-aging drug: First rapamycin metabolic study results in nonhuman primates results in new grant -- ScienceDaily
minimal metabolic side effects after continuous, long-term treatment with encapsulated rapamycin in a marmoset (monkey) model - 2015 November study
rapamycin  life  extension  drug 
january 2017 by dandv
One Man’s Quest to Hack His Own Genes
Hanley designed plasmids, ordered them ($10k), and injected them + electroporesis for absorption. They should increase HGH production, and preliminary results show it did.

However, HGH doesn't seem to correlate with longevity - https://www.fightaging.org/archives/2017/01/the-adventurous-are-undergoing-enhancement-gene-therapies/
self  gene  therapy  life  extension 
january 2017 by dandv
Peter Thiel Is Very, Very Interested in Young People's Blood | Inc.com
plasma is relatively abundant and has a two-year shelf life. He speculates that a surge of popular attention for parabiosis might inspire more blood donations by young donors, whose blood tends to provide greater benefit when administered in more conventional therapeutic transfusions.
parabiosis  plasma  transfusion  life  extension 
december 2016 by dandv
Ageing research: Blood to blood : Nature News & Comment
By joining the circulatory system of an old mouse to that of a young mouse, scientists have produced some remarkable results. In the heart, brain, muscles and almost every other tissue examined, the blood of young mice seems to bring new life to ageing organs, making old mice stronger, smarter and healthier. It even makes their fur shinier.

Up to the mid-twentieth century, scientists used parabiotic pairs of mice or rats to study a variety of phenomena. For example, one team ruled out the idea that dental cavities are the result of sugar in the blood by using a pair of parabiosed rats, of which only one was fed a daily diet of glucose. The rats had similar blood glucose levels owing to their shared circulation, yet only the rat that actually ate the sugar developed cavities2.

And of the 69 pairs, 11 died from a mysterious condition termed parabiotic disease, which occurs approximately one to two weeks after partners are joined, and may be a form of tissue rejection.

Using inbred lab mice, genetically matched to one another, seems to reduce the risk of parabiotic disease. Joined mice eat, drink and behave normally — and they can be separated successfully.

after old and young rats were joined for 9–18 months, the older animals' bones became similar in weight and density to the bones of their younger counterparts5. More than 15 years later, in 1972, two researchers at the University of California studied the lifespans of old–young rat pairs. Older partners lived for four to five months longer than controls, suggesting for the first time that circulation of young blood might affect longevity.

Within five weeks, the young blood restored muscle and liver cells in the older mice, notably by causing aged stem cells to start dividing again9. The team also found that young blood resulted in enhanced growth of brain cells in old mice, although the work was left out of their 2005 paper describing the results. All in all, the results suggested that blood contains the elusive factor or factors that coordinate ageing in different tissues.

Oxytocin levels decline with age in both men and women, and when injected systemically into older mice, the hormone quickly — within a couple of weeks — regenerates muscles by activating muscle stem cells.

young blood promotes repair of damaged spinal cords in older mice [and] reverses age-related thickening of the walls of the heart

old mice exposed to young blood did indeed have increased neuron growth, and that young mice exposed to old blood had reduced growth. Plasma alone had the same effects.

young plasma activates brain plasticity and memory formation in older mice, and increases learning and memory. “We could not believe that this worked,” says Wyss-Coray.

In the past two decades, researchers have identified the anti-ageing properties of numerous treatments, including calorie-restricted diets; resveratrol, a chemical found in the skin of grapes; telomerase, an enzyme that protects the integrity of chromosomes; rapamycin, an immune-suppressing drug that extends lifespan in mice; and stem cells, which decline in function and number as people age.

Only two of these — caloric restriction and rapamycin — have been shown to reliably slow or reverse the effects of ageing across many mammalian tissue types, but neither has turned into an anti-ageing treatment. The former has produced conflicting results in primates; the latter has toxic side effects.

Young blood, by contrast, seems to turn back the effects of ageing, potentially with few known safety concerns in humans and, so far, with corroborated results from parabiotic ageing studies in multiple labs.

An experiment to test [lifespan extending] claims would take upwards of six years — first waiting for the mice to age, then for them to die naturally, then analysing the data. “If we had funding to do this, I'd do it. But we don't,” says Michael Conboy. Still, he adds, “I hope that someone, somewhere is.”
parabiosis  life  extension  longevity  oxytocin  aging 
december 2016 by dandv
Bioquark interview? - MoneyWeek
$1M funding, pretty big goals - regenerate organs, limbs
life  extension  regeneration  rejuvenation  2followup 
november 2016 by dandv
(2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. - PubMed - NCBI
In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
resveratrol  healthspan  extension  life  mice  study 
september 2016 by dandv
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
"that two-thirds of people in the USA who consume multiple dietary supplements consume resveratrol"

"SIRT1 activation shows promise for the treatment of aging and age-related diseases. Clinical trials indicate that STACs are efficacious but questions remain."
resveratrol  life  extension  SIRT1  activator 
september 2016 by dandv
Mainstream science embraces ending ageing with major Mayo Clinic-backed research strategy - Factor
"care for the elderly currently accounts for 43% of the total healthcare spending in the US, or approximately $1 trillion a year, and this number is expected to rise as baby boomers reach retirement age

a modest increase in lifespan and healthspan (2.2 years) could reduce those expenses by $7 trillion by 2050."
aging  research  economic  benefits  longevity  life  extension 
september 2016 by dandv
Tim Ferriss: "How to Cage the Monkey Mind" | Talks at Google - YouTube
Tim Ferriss answers two of my questions during his interview at Google:

Longevity recommendations @ 52:23 (my question submitted online):
1. Fasts to purge pre-cancerous cells (you don't want uncontrolled growth). Experience ketosis or fasting for semi-extended periods of time (2-3+ days). Tim does one three-day fast per month (only water). Also, hyperbaric oxygen (2.5 atm for 60-90 minutes 3x/week). You can also take exogenous ketones (e.g. mixing a powder and drinking it)
2. Metformin - the medication that has the most support for prophylactic life extension
3. Don't drive a car :)

Next (@55:28): How to combat insomnia (I was also in the audience):
0. Throw all the variables at the experiment, and if you get the desired effect, start removing variables once you have a winning combination.
1. Replace coffee with tea. There are coffee pills. Decrease your caffeine intake. Eliminate caffeine consumption past 5pm [NB: you may be a slow caffeine metabolizer - check your 23andme]
2. Some type of meditation in the morning, e.g. 10-20 minutes using an app like Headspace. This fixes the "monkey mind" cause of insomnia.
3. Reading fiction before bed, to take you from a problem-solving mode to a story-consuming mode.
4. Use f.lux or the like on your screens
5. Microdose with psychedelics, at sub-hallucinogenic levels. Psilocybin worked for some.
Tim  Ferriss  longevity  lifespan  combat  insomnia  sleep  Dascalescu  video  life  extension 
august 2016 by dandv
Long-term benefits of 'senolytic' drugs on vascular health in mice -- ScienceDaily
"the first study to show that regular and continual clearance of senescent cells improves age-related vascular conditions -- and that the method may be a viable approach to reduce cardiovascular disease and death."

"Our finding that senolytic drugs can reduce cardiovascular calcification is very exciting, since blood vessels with calcified plaques are notoriously difficult to reduce in size, and patients with heart valve calcification currently do not have any treatment options other than surgery,"
life  extension  senolytic  drugs  kill  senescent  cells 
may 2016 by dandv
Clearing out the clutter: ‘senolytic’ drugs improve vascular health in mice | KurzweilAI
Mayo Clinic researchers have demonstrated the first study in which repeated treatments to remove senescent cells (cells that stop dividing due to age or stress) in mice improve age-related vascular conditions — and may possibly reduce cardiovascular disease and death.
life  extension  anti  aging  kill  senescent  cells 
may 2016 by dandv
Mimicking the Fasting Mimicking Diet - My 5-Day Experiment
[[cutting daily calories in half for just four days every two weeks reduced biomarkers for aging, diabetes, heart disease and cancer with no adverse effects. FMD was tested on yeast, mice, and humans and the results remained consistent among all three groups.

The nutrition rules of the FMD can be summarized as follows:

Day 1: Total caloric intake of 4.5 to 7 kcal/lb of body weight (10% protein, 56% fat, 34% carbs)
Days 2-5: Total caloric intake of 3 to 5 kcal/lb of body weight (9% protein, 44% fat, 47% carbs)

The fast is then followed by a 25-day “refeeding” period (return to regular diet). The study recommends repeating the 5-day fasting/25-day refeeding cycle 3-4 times in a row to maximize effects.

Fasting Mimicking Diet Nutrient Guidelines:

Low protein and low carbohydrate, with no or minimal animal-derived products
High macronutrient content (30-50% of recommended daily intake of vitamins minerals, and essential fatty acids, with 50% of them coming from natural sources)
Proteins from plant-based sources
Carbohydrates ideally from complex carbohydrate plant sources
Fats primarily from “healthy” oils (coconut oil, olive oil) and nuts (almonds, walnuts)
Less than 30g of sugars on day 1, and less than 20g of sugars on days 2-5

Overall, I was very impressed with my FMD results.
I was most happy with the FMD’s effects on glucose and ketones, as well as cognitive effects (focus, dreaming).]]

Mirror: https://web.archive.org/web/20160505102303/http://www.quantifiedbob.com/2016/04/fasting-mimicking-diet/
Quantified  Self  fasting  mimicking  diet  keto  life  extension 
may 2016 by dandv
Mapping out cell conversion | EurekAlert! Science News
"When tested, Mogrify was able to accurately predict the set of cellular factors required for previously published cell conversions correctly. To further validate Mogrify's predictive ability, the team conducted two novel cell conversions in the laboratory using human cells, and these were successful in both attempts solely using the predictions of Mogrify."

More lay version: http://www.sciencealert.com/new-algorithm-points-the-way-towards-regrowing-limbs-and-organs/page-2
regenerative  biotech  medicine  life  extension  grow  tissue  organs  health  GameChanger 
january 2016 by dandv
Experimental drug targeting Alzheimer's disease shows anti-aging effects - Salk Institute for Biological Studies
The old mice that received J147 performed better on memory and other tests for cognition and also displayed more robust motor movements. Importantly, because of the large amount of data collected on the three groups of mice, it was possible to demonstrate that many aspects of gene expression and metabolism in the old mice fed J147 were very similar to those of young animals. These included markers for increased energy metabolism, reduced brain inflammation and reduced levels of oxidized fatty acids in the brain.

Prior research at http://www.ncbi.nlm.nih.gov/pubmed/23673233
anti  against  aging  drug  Alzheimer's  longevity  life  extension 
december 2015 by dandv
2015: Anti-ageing pill pushed as bona fide drug : Nature News & Comment
"The TAME test is for metformin, which suppresses glucose production by the liver and increases sensitivity to insulin. The drug has been used for more than 60 years and is safe and prolongs healthy life and lifespan in worms3 and in some mouse strains1. Data also suggest that it could delay heart disease, cancer, cognitive decline and death in people with diabetes4. Plans call for the trial to enrol 3,000 people aged 70–80 years at roughly 15 centres around the United States. The trial will take 5–7 years and cost US$50 million, Barzilai estimates, although it does not yet have funding."
life  extension  metformin  trial  2followup  FDA  aging 
june 2015 by dandv
Telomere extension turns back aging clock in cultured human cells, study finds | News Center | Stanford Medicine
“This new approach paves the way toward preventing or treating diseases of aging,”

“Now we have found a way to lengthen human telomeres by as much as 1,000 nucleotides, turning back the internal clock in these cells by the equivalent of many years of human life,”

"The researchers used modified messenger RNA to extend the telomeres."
life  extension  news  aging  genetics 
may 2015 by dandv
Because most people lie to themselves about death instead of worrying about it, we are neglecting a radical possibility brought by advancing technology: our imminent nonexistence might not be as inevitable as we think.

Over a hundred times more money is spent on R&D for curing baldness than for curing aging. We may someday find ourselves with extended lifespans as an unintended side effect of taking a pill that gives us fuller hair.

Either way, whether aging is cured within my lifetime or afterwards, it won't happen soon enough. Good people are suffering and dying, and that needs to change in a way that's never been done before.
life  extension  argument  manifesto  Garrett  Lisi 
april 2015 by dandv
Directory of Innovative Anti-Aging Doctors, Health And Wellness Practitioners - Life Extension
Search by zip code may work better than search by state. Vet the results against ratemds.com or the like though (bunch of weirdos show up in listings).

"The directory of Innovative Doctors, Health And Wellness Practitioners is a worldwide listing of anti-aging doctors and other medical professionals who practice or have expressed interest in all aspects of preventive medicine, hormone replacement therapy, nutrition and dietary supplements."
life  extension  doctor  medic  physician  health  directory  search 
february 2015 by dandv
The economic benefits of life extension
The current medical paradigm is to go after each individual disease as it emerges in a perpetual game of therapeutic whac-a-mole. The result is that individuals begin to accumulate infirmities. About 50% of Medicare beneficiaries are being treated for 5 different chronic conditions. This is ultimately a losing proposition, because aging bodies accrue more and more lethal and disabling conditions that compete to kill them. If an older patient doesn't die of a heart attack, prostate cancer could do him in. Ultimately, more than 25% of Medicare spending goes toward the 5% of beneficiaries who die each year.

According to the National Cancer Institute, Americans have a 5.4% chance of developing cancer and a 2.2% chance of dying from the disease before age 45. The probability of developing cancer climbs to 24% between ages 55 and 64, while the chance of dying increases to nearly 19%.

The Centers for Disease Control and Prevention estimates that treating chronic diseases accounts for about 75 percent of total health system costs.

In 2013, U.S. health care spending reached $2.9 trillion, more than 17 percent of the country's gross domestic product (GDP). Medicare spending was $586 billion, about 20 percent of all national health spending in 2013. Nearly 30 percent of Medicare spending—about $170 billion—was spent on patients' last six months of life.

A modest deceleration in the rate of biological aging would produce the equivalent of simultaneous major breakthroughs against every single fatal and non-fatal disease associated with growing older.

In 2014, the Harvard stem cell researchers Amy Wagers and Richard Lee reported the results of experiments in which they surgically stitched the circulatory systems of young mice to those of old mice. They found that factors in the blood of young mice enhanced the functionality of adult stem cells in the old mice, so that they rejuvenated muscle and heart tissue and improved blood flow to the brains of the old mice. That, in turn, sparked the growth of new brain cells. They isolated a protein from the blood of young mice called GDF11 and injected it into old mice, where it had essentially the same rejuvenating effects. The researchers are now talking to venture capitalists about financing a company that would aim to bring GDF11 into human trials.

Based on various calculations of what people appear to be willing to pay to avoid deleterious outcomes or to accept hazardous jobs, statisticians conservatively conclude that people on average value a year of life at about $100,000. Using this value, Goldman and colleagues estimate that between 2010 and 2060 their delayed aging scenario "yields a social benefit of approximately $7.1 trillion."

Over the course of the 20th century the average life expectancy of a 30-year-old man increased from 34.9 years to 46.2 years. As a thought experiment, the authors invite doubters to contemplate "a current 30-year-old who is offered the choice of (a) his current standard of living and health or (b) a lump sum of $1 million and the life expectancy of a 30-year-old in 1900, which is 11.3 years shorter."
life  extension  economy  benefits 
february 2015 by dandv
Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research
Delayed aging could increase life expectancy by an additional 2.2 years, most of which would be spent in good health. The economic value of delayed aging is estimated to be $7.1 trillion over fifty years. In contrast, addressing heart disease and cancer separately would yield diminishing improvements in health and longevity by 2060—mainly due to competing risks.
against  cancer  research  for  aging  life  extension  cost  benefit 
july 2014 by dandv
Transfer of young blood into older mice reversed cognitive effects of aging
Heterochronic parabiosis. 20% increase in connections between brain cells.

"When he put the animals into a water maze, a test where they have to remember the location of a hidden platform, he found that the older mice did almost as well as mice of 4-6 months old. Untreated older mice would make many errors and swim down blind alleys in their attempts to find the hidden platform, whereas the mice that had received plasma from young mice located the platform first time, in most cases."

"Turning the idea into a therapy for humans will take much more research, but Villeda said there was no reason not to think that, at some point in the future, people in their 40s or 50s could take therapies based on the rejuvenating chemical factors in younger people's blood, as a preventative against the degenerative effects of ageing."

I was at the talk he delivered at http://healthextension.co/dr-saul-villeda-at-health-extension-salon-6/ (slides are at http://www.slideshare.net/Health_Extension/saul-villeda-at-health-extension-salon-6 and video at http://vimeo.com/62838551; see 27:50)
young  blood  transfer  successful  aging  reverse  reversal  health  life  extension 
january 2014 by dandv
Turning off 'aging genes'
[[computer algorithm that predicts which genes can be "turned off" to create the same anti-aging effect as calorie restriction.

"Most algorithms try to find drug targets that kill cells to treat cancer or bacterial infections," says Yizhak. "Our algorithm is the first in our field to look for drug targets not to kill cells, but to transform them from a diseased state into a healthy one."]]
life  healthspan  health  extension  genetics  aging  algorithm 
january 2014 by dandv
"I Choose Life" - Facebook group to share stories advocating life extension
"Aging sucks. There’s so much to do. Life is so awesome. When you’re someone like me, who’s starting to study piano seriously, learning a concert; likes sailing, former national champion; likes writing; tennis; theater; swimming; learning languages; playing guitar; flamenco; tango; salsa; zouk; likes to travel; to read; physics; biology; research and on goes the list, life seems incredibly short to learn, assimilate, master all kinds of inspiring human activities. And just when we’re about to grasp it, to understand it, it is time to exit the stage—It does not make sense."
against  death  choose  life  extension  longevity 
december 2013 by dandv
Harvard scientists reverse the ageing process in mice – now for humans | Science | The Guardian
Study: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09603.html

The experimental treatment developed by researchers at the Dana-Farber Cancer Institute, Harvard Medical School, turned weak and feeble old mice into healthy animals by regenerating their aged bodies.

"What we saw in these animals was not a slowing down or stabilisation of the ageing process. We saw a dramatic reversal – and that was unexpected,"

At Harvard, they bred genetically manipulated mice that lacked an enzyme called telomerase that stops telomeres getting shorter. Without the enzyme, the mice aged prematurely and suffered ailments, including a poor sense of smell, smaller brain size, infertility and damaged intestines and spleens. But when DePinho gave the mice injections to reactivate the enzyme, it repaired the damaged tissues and reversed the signs of ageing.

"These were severely aged animals, but after a month of treatment they showed a substantial restoration, including the growth of new neurons in their brains,"

Repeating the trick in humans will be more difficult. Mice make telomerase throughout their lives, but the enzyme is switched off in adult humans, an evolutionary compromise that stops cells growing out of control and turning into cancer. Raising levels of telomerase in people might slow the ageing process, but it makes the risk of cancer soar.
aging  reverse  mice  telomerase  life  extension 
july 2013 by dandv
5 billionaires who want to live forever - Dmitry Itskov (1) - FORTUNE
1. Dmitry Itskov, 31 - created the 2045 Initiative, which brought 30 top Russian scientists on board to create an international research center to study immortality
2. David Murdock (money via DOLE), started the California Health and Longevity Institute. Another project, Duke University's MURDOCK Study aims to understand the genetics of diseases and cures.
3. John Sperling (via APOL). Funded the Kronos Longevity Research Institute.
4. Robert Miller (Future Electronics, Canada). Donated to Alcor research.
5. Don Laughlin - customer of Alcor
billionaire  life  extension  immortality  research  funding  investor 
july 2013 by dandv
First gene therapy successful against aging-associated decline: Mouse lifespan extended up to 24% with a single treatment
Gene therapy consisting of inducing cells to express telomerase was successful in mice, extending their lifespan by between 13% (treatment at 2 years of mouse age) and 24% (treatment atone year of age).
therapy  gene  study  telomerase  aging  anti  extension  life  life_extension 
may 2012 by dandv
Eradicating Aging Cells Could Prevent Disease - Technology Review
Prior to this study, it was unclear how senescent cells contributed to aging. The cells make up a very small proportion of all tissue, somewhere between 1 and 4 percent in even the oldest animals, and many doubted that such a small number of cells could have such a toxic effect. Rather, they thought, when the cells lost their ability to divide, the inability to replace lost tissue might be what caused symptoms of aging.

The new research appears to validate the idea of senescent-cell toxicity. "Now that we know the cells play a role in aging, it's worth investing in trying to find a way to eliminate them," says Felipe Sierra, the director of aging biology at the National Institute on Aging, who was not involved in the research.

Not only does the study propose a biomarker for aging, levels of p16Ink4a, but it validates the idea that it might be possible to create a drug that targets senescent cells without causing harm to healthy cells.
life  extension  anti  aging  biomarker  2followup  senescence  senescent  cells 
november 2011 by dandv
Silicon Valley billionaire backs futuristic philanthropy
Breakthrough Philanthropy closed-doors event organized by Patri Friedman to raise awareness of more radical ideas that could use more funding: seasteading, rejuvenation, singularity etc.

"Other presentations will be made by representatives from Humanity Plus, which promotes the idea that high-tech prosthetics and other scientific advancements can enhance human physical capabilities; the Foresight Institute, which focuses on the potential for medical and manufacturing advances through nanotechnology, or building things at the atomic level; and the SENS Foundation, which sponsors research into prolonging life by reversing the damage caused by normal aging."

"Thiel acknowledged that there are plenty of deserving charities struggling to meet more immediate needs, such as food, shelter and education. He said those causes are important, but he thinks the majority of philanthropy is already focused in that direction."
philanthropy  future  radical  cause  singularity  rejuvenation  life  extension  fundraising  Thiel  Friedman  Silicon  Valley  BayArea 
december 2010 by dandv
Interview with David Pearce: utopian biology?
Potentially, indefinite lifespan will be wonderful. But it's only one strand of becoming truly post-human. Recall how studies suggest that six months after winning the lottery or becoming paralysed in an accident, most people will have reverted to their previous average level of well-being or ill-being before their windfall/accident. [...] Likewise, following a short-lived burst of euphoria at being granted eternal youth, something analogous might befall us too. As our emotional thermostats kicked in, we might soon be almost as malaise-ridden as before. Unless we recalibrate the mind's hedonic tone, our quality of life as quasi-immortals won't be much higher than our quality of life as lived for three score years and ten. On a brighter note, I think this worry is misplaced. The combination of indefinite life-spans and radical mood-enrichment is a recipe for eternal bliss. This may serve as a good definition - in a medico-scientific as well as popular sense - of paradise.
David  Pearce  interview  paradise  engineering  transhumanism  life  extension  mood  altering  posthumanism  future  bioethics  longevity 
august 2010 by dandv
New Device Prints Human Tissue | LiveScience
“Scientists and engineers can use the 3D bio printers to enable placing cells of almost any type into a desired pattern in 3D,” Murphy said. “Researchers can place liver cells on a preformed scaffold, support kidney cells with a co-printed scaffold, or form adjacent layers of epithelial and stromal soft tissue that grow into a mature tooth. Ultimately the idea would be for surgeons to have tissue on demand for various uses, and the best way to do that is get a number of bio-printers into the hands of researchers and give them the ability to make three dimensional tissues on demand.”
3D  printer  print  printing  organ  cell  cells  cool  invention  health  biotech  regenerate  life  extension  longevity  immortality 
february 2010 by dandv
Calorie intake linked to cell lifespan, cancer development
"restricting consumption of glucose, the most common dietary sugar, can extend the life of healthy human-lung cells and speed the death of precancerous human-lung cells, reducing cancer's spread and growth rate. The research has wide-ranging potential in age-related science, including ways in which calorie-intake restriction can benefit longevity and help prevent diseases like cancer that have been linked to aging"
calorie  restriction  cancer  health  cell  cure  life  extension  longevity  nutrition  diet 
february 2010 by dandv
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