Increased blood levels of persistent organic pollutants (POP) in obese individuals after weight loss-A review
Most research in this field, including animal studies, is carried out on a single compound or group of selected compounds, not taking the "cocktail effect" into consideration. This does not reflect the true range of POP to which humans are actually exposed. Few chronic investigations have been published and, in particular, few studies were available that compared the increase in POP concentrations with clinical consequences as individuals lost weight. These limitations call for caution in interpreting results. The benefits of losing weight still far outweigh the potential adverse health risks. However, further studies are recommended to determine the clinical significance of increased blood levels of POPs following rapid and excessive weight loss, particularly for women attending weight reduction treatment before pregnancy.
Science  Human  POPs  Obesity 
january 2017
Air pollution and cardiovascular mortality with over 25 years follow-up: A combined analysis of two British cohorts
Adverse effects of air pollution on cardiovascular disease (CVD) mortality are well established. There are comparatively fewer studies in Europe, and in the UK particularly, than in North America. We examined associations in two British cohorts with >25years of follow-up. Elevated non-significant hazard ratios for CVD mortality were seen with 1991 BS and SO2 and with ESCAPE PM10 and PM2.5 in fully adjusted linear models.
Science  Human  AirPollution  Cardiovascular 
january 2017
Scientists Loved and Loathed by an Agrochemical Giant
But Dr. Cresswell’s initial research for Syngenta did not support the varroosis claims. “We are finding it pretty unlikely that varoosis is responsible for honey bee declines,” he wrote to Syngenta in 2012. An executive wrote back, suggesting that Dr. Cresswell look more narrowly at “loss data” of beehives rather than at broader bee stock trends, “As this may give a different answer!”
News  ScienceAndPolicy  Pesticides 
january 2017
Concern Over EDCs Continues to Grow
In a follow-up interview with MedPage Today, Andrea Gore expressed her hopes for advancements in the field for the coming new year. "I hope that the scientists who are conducting the research on EDCs, and the physicians who are treating increasing numbers of sick patients with chronic diseases, are recognized as the bona fide experts who are called upon to develop and implement policies about chemical safety. The experts guiding regulatory policy need to be free of any connections to the chemical industry to ensure that there are no conflicts of interest."
News  Regulation  EndocrineDisruption 
january 2017
EU investigation could put furniture fire rules up in flames
Brussels has launched an investigation into whether Ireland’s furniture fire safety regulations — the strictest in Europe — comply with EU free-market rules, following a complaint by manufacturers.
News  FlameRetardants  Regulation 
january 2017
Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS)
The NTP concludes that both PFOA and PFOS are presumed to be an immune hazard to humans based on a high level of evidence from animal studies that PFOA and PFOS suppressed the antibody response and a moderate level of evidence from studies in humans. The evidence that these chemicals affect multiple aspects of the immune system supports the overall conclusion that both PFOA and PFOS alter immune functions in humans.
Science  Review  PFCs  Immunological 
january 2017
This Pesticide Is Prohibited in Britain. Why Is It Still Being Exported?
Paraquat, one of many pesticides that can’t be used in Europe but is sold in the United States and elsewhere, has been linked to Parkinson’s disease in a growing body of research.
News  Pesticides  Regulation 
january 2017
U.K. Seeks to Ban Plastic Microbeads in Cosmetics Next Year
One shower alone can send as many as 100,000 beads down the drain and they end up in the sea as they are too small to be filtered out in sewage treatment, according to Defra. “Adding tiny pieces of plastic to products like face washes and body scrubs is incredibly damaging to our sea life -– they can swallow them, but cannot digest them,” Environment Secretary Andrea Leadsom said in a statement.
News  Cosmetics 
january 2017
Stop playing whack-a-mole with hazardous chemicals
When new parents see the words “BPA-free” on a baby bottle or sippy cup, they are meant to assume that the product is safe. This may well not be the case — quite to the contrary. In fact, in some cases, hormone-disrupting BPA, or bisphenol-A, has simply been swapped for a similar chemical — BPS, or bisphenol-S — that may well pose even greater dangers to child health. In this way, manufacturers have done an end run around on the much-publicized dangers of BPA without addressing the underlying problem.
News  SaferChemicals 
january 2017
Cancer Prevention During Early Life
CDC’s Division of Cancer Prevention and Control sponsored a special issue in the journal Pediatrics about factors from before birth through early childhood that may affect a person’s chance of getting cancer. The authors of papers in this issue are experts from many different professions, showing the importance of working together to address potential cancer causes and risk factors.
Science  Cancer  Prevention 
january 2017
From Asbestos to Pesticides to Pork
In the 1990s, a consulting firm called Failure Analysis Associates ran tongue-in-cheek ads aimed at corporate lawyers that retold the Icarus myth as a courtroom drama. The arty-looking promos boasted that Failure’s expert testimony in “Icarus vs. Wax Aviation” would put the onus on pilot error, getting the company off the hook. The formula has turned the firm, now named Exponent, Inc., into a publicly traded giant in litigation defense and regulatory science. It’s a go-to destination for major industries with liability problems–even as it is derided by critics as a hired gun whose findings are for sale.
News  ScienceAndPolicy 
january 2017
Could African-American beauty products pose health risks?
One in 12 beauty and personal care products marketed to African-American women in the US contains highly hazardous ingredients, according to research released Tuesday by the Environmental Working Group, a nonprofit environmental organization in the US specializing in research and advocacy.
News  Cosmetics 
january 2017
Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment
Our results suggest an inverse association between male preconception concentrations of select phthalate metabolites and blastocyst quality, likely occurring after genomic activation. If corroborated with other studies, such findings will have public health and clinical significance for both the general population and those undergoing IVF.
Science  Human  Phthalates  Reproductive 
january 2017
Endocrine disruptors: A denial of the state of the science
Another article has again two consultants out of the three authors and talks about endocrine disruptors as an "urban legend" posing “imaginary health risks.” Making fun of the "hypothetical" effects of endocrine disruptors, such as the "reduced penis length and size," they pose the question of "whether the whole issue of EDC is more within the competence of Dr. Sigmund Freud than that of toxicology." ... Can these texts really be incorporated into "scientific knowledge?" Why does the Commission give so much credit to documents that resemble lobbying material?
News  EndocrineDisruption  Regulation 
january 2017
Endocrine disruptors: The manufacture of a lie
The key phrase on which the regulatory edifice proposed by the Commission is built had been drafted even before any scientific expertise had really begun.
News  Regulation  EndocrineDisruption 
january 2017
Serum Testosterone Concentrations and Urinary Bisphenol A, Benzophenone-3, Triclosan, and Paraben Levels in Male and Female Children and Adolescents
To our knowledge, this is the first study to report an association of both BP-3 and BPA with serum TT in adolescents. Associations between BPA and TT differed according to sex in adolescents, with inverse associations in boys and positive associations in girls. BP-3 was associated with significantly lower TT in adolescent boys only. However, because of the limitations inherent to the cross-sectional study design, further studies are needed to confirm and elucidate on our findings.
Science  Human  Cosmetics  BPA  EndocrineDisruption 
january 2017
Particulate Matter Exposure and Preterm Birth: Estimates of U.S. Attributable Burden and Economic Costs
An estimated 3.32% of PTBs nationally (corresponding to 15,808 PTBs) in 2010 could be attributed to PM2.5 (PM2.5 > 8.8 μg/m3). Attributable PTBs cost were estimated at $5.09 billion [sensitivity analysis (SA): $2.43-9.66 B], of which $760 million were spent for medical care (SA: $362 M-1.44 B). The estimated PM2.5 attributable fraction (AF) of PTB was highest in urban counties, with highest AFs in the Ohio Valley and the southern United States.
Science  Reproductive  AirPollution 
january 2017
Review of developmental origins of health and disease publications in environmental epidemiology
We conducted a scoping literature review to describe the human evidence for the DOHaD hypothesis and to identify, 1) where there may be reasonable data to draw conclusions, and 2) areas warranting further research. Using PubMed and Web of Science we identified 425 publications through 2014 that met our criteria for evaluating the DOHaD hypothesis in environmental epidemiology. These publications covered 60 different chemicals. The majority of publications focused on neurological/cognitive outcomes, followed by cancer, and respiratory outcomes.
Science  Review  Human  Developmental 
december 2016
Exposure to traffic-related air pollution and risk of development of childhood asthma: A systematic review and meta-analysis
The overall risk estimates from the meta-analyses showed statistically significant associations for BC, NO2, PM2.5, PM10 exposures and risk of asthma development. Our findings support the hypothesis that childhood exposure to TRAP contributes to their development of asthma. Future meta-analyses would benefit from greater standardization of study methods including exposure assessment harmonization, outcome harmonization, confounders' harmonization and the inclusion of all important confounders in individual studies.
Science  Review  Human  AirPollution  Respiratory 
december 2016
EU court backs disclosure of pesticides information
The Court of Justice has made a ruling in response to two court cases questioning whether pesticides are covered under the Aarhus Convention
News  Pesticides  Regulation 
december 2016
Let’s stop the manipulation of science
Around a hundred scientists ask Europe and the international community to act against endocrine disrupting chemicals. They condemn the use of strategies for manufacturing doubt employed by industries in the climate change battle.
EndocrineDisruption  News  Regulation 
december 2016
Predictors of urinary organophosphorus flame retardant concentration among pregnant women
PFR metabolites were detected in every urine sample, with BDCIPP, DHPH, ip-PPP and BCIPHIPP detected in >80% of samples. Geometric mean concentrations were higher than what has been reported previously for similarly-timed cohorts. Women with higher pre-pregnancy BMI tended to have higher levels of urinary metabolites. For example, those classified as obese at the start of pregnancy had ip-PPP levels that were 1.52 times as high as normal weight range women (95% confidence interval: 1.23, 1.89).
Science  Human  FlameRetardants  Exposure 
december 2016
Stand firm on hormone disruptors
Ahead of a key meeting on endocrine-disrupting chemicals, Leonardo Trasande argues that policy must follow the science.
News  EndocrineDisruption  Regulation 
december 2016
Guest column – Professor Åke Bergman, Swetox
Firstly, governments, other research and monitoring bodies have spent enormous amounts of money, hiring professionals to search for environmental contaminants and detect and report on chemicals already known by the manufacturers. Secondly, resources that could have been invested in the safety of chemicals, through toxicological and ecotoxicological testing, have been used to search for unknown chemicals. How long will the EU and national governments accept this?
News  Regulation 
december 2016
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
The available epidemiological evidence suggest that prenatal exposure to several of these ubiquitous EDCs is associated with adverse neurobehaviour (BPA and phthalates) and excess adiposity or increased risk of obesity and/or overweight (PFAS). Quantifying the effects of EDC mixtures, improving EDC exposure assessment, reducing bias from confounding, identifying periods of heightened vulnerability and elucidating the presence and nature of sexually dimorphic EDC effects would enable stronger inferences to be made from epidemiological studies than currently possible.
Science  Review  EndocrineDisruption  Obesity  Neurotoxicity 
december 2016
Maternal bisphenol A exposure alters rat offspring hepatic and skeletal muscle insulin signaling protein abundance
Maternal bisphenol A had sex- and tissue-specific effects on insulin signaling components, which may contribute to increased risk of glucose intolerance in offspring. Glucose transporters were consistently altered at both ages as well as in both sexes and may contribute to glucose intolerance.
Science  Animal  LiverFunction  Diabetes  BPA 
december 2016
Occupational phthalate exposure and health outcomes among hairdressing apprentices
Positive associations for females were observed between MnBP and fat-free mass index (FFMI) and age; negative associations were found between MEHP, MEOHP, MEHHP, sum of MEHP, MEHHP, MEOHP and vital capacity and also between MEHP and forced vital capacity (FVC of predicted value (PV)). Lengths of exposure were associated to MnBP, MEHHP, and MEP. We also documented positive associations between anthropometry (body mass index, waist-to-height ratio (WHtR), FFMI, fat mass index) and pulmonary function FVC% of PV for females and negative associations between WHtR, waist-to-hip ratio, FFMI and ratio of forced expiratory volume in 1 s (FEV1) to FVC (FEV1/FVC).
Science  Human  Phthalates  Respiratory  Obesity 
december 2016
Commission study shows low industry response to Article 33 requests
Only 23% of construction material companies gave required information about presence of SVHCs
News  Regulation 
december 2016
Revised EDC criteria still ‘too ambiguous’, warn scientists
A group of eminent scientists has warned the European Commission that the redrafted endocrine disrupting chemicals criteria “do not go far enough” to address concerns that have been raised previously
News  EndocrineDisruption  Regulation 
december 2016
Wal-Mart Is First, Amazon Is Worst in New Ranking on Chemicals
Here’s one area where Wal-Mart Stores Inc. is handily beating Amazon.com Inc.: telling shoppers what ingredients are in the products they’re buying. That’s the conclusion of a scorecard that ranks major retailers’ policies on harmful chemicals. Wal-Mart holds the top spot, followed by Target Corp. Amazon occupies last place in the study, which is scheduled to be released Wednesday.
News  SaferChemicals 
december 2016
Bromine-containing dyes dwarf flame retardants in house dust
The health hazards of brominated flame retardants lurking in household dust have made the news for years because of the ease with which humans can be exposed to the endocrine-disrupting compounds. Studies have hinted there are also large concentrations of unknown and potentially harmful brominated compounds in dust, but the number of compounds remained unclear and scientists didn’t have an efficient way to identify them, says Jianxian Sun, an environmental toxicologist at the University of Saskatchewan.
News  FlameRetardants 
december 2016
UK to be challenged over furniture fire safety rules
The European Furniture Industries Confederation (EFIC) is planning to lodge a formal complaint with the European Commission in the next few weeks, claiming the tests furniture for the UK market has to pass block trade and lead to unnecessary use of hazardous chemicals.
News  Regulation  FlameRetardants 
december 2016
Environmental Chemicals in an Urban Population of Pregnant Women and Their Newborns from San Francisco
In contrast to the conclusions of a recent review, we found evidence that several PCBs and OCPs were also often higher in cord than maternal serum (median cord:maternal ratio > 1) when concentrations are assessed on a lipid-adjusted basis. Our findings suggest that for many chemicals, fetuses may experience higher exposures than their mothers and highlight the need to characterize potential health risks and inform policies aimed at reducing sources of exposure.
Science  Human  POPs  Exposure 
december 2016
Urinary bisphenol A is associated with insulin resistance and obesity in reproductive-aged women
Urinary BPA levels were positively correlated with BMI, waist circumference, fasting serum insulin and HOMA-IR. MEHHP, MEOHP and MnBP were not associated with any of the above parameters. In the multiple regression analysis, the BPA levels were significantly associated with BMI and waist circumference after adjusting for age, smoking and alcohol consumption status, triglycerides (TG), total cholesterol (TC) and high-density lipoprotein (HDL). Fasting insulin and HOMA-IR values were also significantly related to urinary BPA concentration after adjusting for confounding variables. Metabolically unhealthy women exhibited significantly higher levels of urinary BPA (P = 0·01) compared to metabolically healthy women.
Science  Human  BPA  Diabetes  Obesity 
december 2016
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis
Eleven percent of pregnant women were classified as exposed to EDCs at work during pregnancy, based on job title. Classification of exposure to one or more EDC group was associated with an increased risk of term LBW [odds ratio (OR) = 1.25; 95% CI: 1.04, 1.49], as were most specific EDC groups; this association was consistent across cohorts. Further, the risk increased with increasing number of EDC groups (OR = 2.11; 95% CI: 1.10, 4.06 for exposure to four or more EDC groups). There were few associations (p < 0.05) with the other outcomes; women holding job titles classified as exposed to bisphenol A or brominated flame retardants were at higher risk for longer length of gestation.
Science  Human  EndocrineDisruption  Developmental 
december 2016
Prenatal Exposure to Perfluorocarboxylic Acids (PFCAs) and Fetal and Postnatal Growth in the Taiwan Maternal and Infant Cohort Study
In girls, prenatal perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) concentrations were inversely associated with birth weight [e.g., βbirth weight (kg) = -0.06, 95% CI: -0.11, -0.01 per 1 ln-unit PFUnDA increase]; prenatal PFDeA and PFUnDA were associated with elevated odds of SGA; and PFDeA, PFUnDA, and PFDoDA were associated with lower average childhood height z-score. In boys, prenatal PFNA, and PFDoDA were associated with reductions in height at certain ages in childhood, but not with size at birth.
Science  Human  Developmental  PFCs 
december 2016
Associations between Repeated Measures of Maternal Urinary Phthalate Metabolites and Thyroid Hormone Parameters during Pregnancy
Although our results were generally null, in repeated measures analyses we observed that phthalate metabolites were largely inversely associated with thyrotropin and positively associated with free and total thyroid hormones. Cross-sectional analyses by study visit revealed that the magnitude and/or direction of these relationships varied by timing of exposure during gestation.
Science  Human  Phthalates  Thyroid 
december 2016
Institutes in the Lead: Identifying Environmental Factors in Breast Cancer
In a way, it all started in Long Island, New York. The year was 1993. An apparent cluster of breast cancer cases had been discovered in Nassau and Suffolk counties, and some residents worried that pesticide applications on former farmland could be to blame. They demanded an investigation. The U.S. Congress soon agreed and asked the National Institute of Environmental Health Sciences (NIEHS) and the National Cancer Institute (NCI) to research the potential role of environmental exposures in these cases. In the decades since, these institutes have conducted and funded countless studies on potential environmental risk factors for breast cancer.
News  Cancer 
december 2016
Fire retardant chemicals: health hazard or a life saver?
Former civil servant and fire regulations expert Terry Edge says it's time people in the UK were told just what chemicals are in our furniture and given the option to buy non-FR products if we want
News  FlameRetardants  Regulation 
november 2016
Little support from national authorities for potency in EDC criteria
The UK Health and Safety Executive (HSE) was the only regulatory voice supporting the inclusion of potency in the European definition of endocrine disrupting compounds (EDCs), at an international conference on 15-16 November.
News  EndocrineDisruption  Regulation 
november 2016
New research report on flame retardant chemicals shows Canada's failure to protect health
A new report by a coalition of Canadian researchers highlights the failure of federal regulations to keep harmful flame retardant chemicals out of homes and consumer products. Toxic by Design, released today by the Endocrine Disruptors Action Group (EDAction), investigates how flaws in Canada's regulatory approach to toxic flame retardants have far-reaching health effects.
News  FlameRetardants  Regulation 
november 2016
These Common Chemicals Are Linked to Type-2 Diabetes: Study
Common household chemicals found in a wide range of products from carpets to cleaning products can alter hormones and contribute to type-2 diabetes—likely costing Europeans billions of dollars annually, according to new research.
News  EndocrineDisruption  Diabetes 
november 2016
Metabolism Disrupting Chemicals and Metabolic Disorders
This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome.
Science  Review  Obesity  EndocrineDisruption 
november 2016
Fragranced products: Risks for people and profits?
New research has found that over one-third of Americans report health problems when exposed to common fragranced consumer products, and that fragranced products may affect profits, with more than 20% of respondents entering a business, but leaving as quickly as possible if they smell air fresheners or some fragranced product.
News  AirPollution 
november 2016
Four in 10 UK councils exceed air pollution limits, figures show
Ministers reveal 169 local authorities breached annual legal limits on nitrogen oxide, linked to lung disease, last year.
News  AirPollution  Exposure 
november 2016
Revealed: How dirty production of NHS drugs helps create superbugs
The NHS is buying drugs from pharmaceutical companies in India whose dirty production methods are fuelling the rise of superbugs, and there are no checks or regulations in place to stop this happening. New tests on water samples taken outside pharmaceutical factories in India which sell to the NHS found they contained bacteria which were resistant to the antibiotics made inside the plants.
News  AntibioticResistance 
november 2016
Environmental risk factors for pancreatic cancer: an update
Among the most dangerous agents involved in the initiation phase, there are the inhalation of cigarette smoke, and the exposure to mutagenic nitrosamines, organ-chlorinated compounds, heavy metals, and ionizing radiations. Moreover, pancreatitis, high doses of alcohol drinking, the body microbial infections, obesity, diabetes, gallstones and/or cholecystectomy, and the accumulation of asbestos fibers seem to play a crucial role in the progression of the disease.
Science  Review  Cancer 
november 2016
Reducing Developmental Neurotoxin Exposure (JAMA)
Citing an alarming increase in childhood neurodevelopmental disorders such as autism and attention-deficit/hyperactivity disorder (ADHD), a group of scientists, health professionals, and children’s health advocates is calling for increased monitoring, assessment, and reduction of neurotoxic chemicals. The Targeting Environmental Neuro-Developmental Risks (TENDR) Consensus Statement, published in July in Environmental Health Perspectives, is “a call to action to reduce exposures to toxic chemicals that can contribute to the prevalence of neurodevelopmental disabilities in America’s children.”
News  Prevention  Neurotoxicity 
november 2016
Health Problems from Common Chemicals Cost $340 Billion Per Year: Study
Conditions linked to everyday chemicals—used in cosmetics, plastics and common household items like sofas—lead to $340 billion in treatment and lost productivity costs annually in the U.S., according to a new study.
News  EndocrineDisruption 
november 2016
The Scientific Advise Mechanism – Is it better regulation?
Ultimately, the system of scientific advice should be systemic, synced to political timeframes, and have a say not only in policy proposals but on political agenda setting. Philip Hines talks us through the Commission’s Scientific Advise Mechanism.
News  ScienceAndPolicy  Stack:CSA 
november 2016
Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis
EDC exposure in the USA contributes to disease and dysfunction, with annual costs taking up more than 2% of the GDP. Differences from the European Union suggest the need for improved screening for chemical disruption to endocrine systems and proactive prevention.
Science  EndocrineDisruption 
october 2016
Plastic substitutes and other breakthroughs from 25 years of green chemistry
As green chemistry prepares to enter its next quarter century, we asked some pioneers in the field to tell us about some of its most important advancements. Here’s what they told us.
News  SaferChemicals 
october 2016
Air pollution could be to blame for hundreds of traffic accidents, warn researchers 
A study looking a five years of data showed that when levels of nitrogen dioxide (NO2) rise just one microgramme per cubic metre, the number of collisions rises by two per cent.
News  AirPollution 
october 2016
EU drops law to limit cancer-linked chemical in food after industry complaint
Campaigners say leaked documents show ‘undue influence’ by the food industry after plans to limit acrylamide - found in starchy foods such as crisps, cereals and baby foods - are weakened
News  Regulation 
october 2016
TSCA 2.0: A New Era in Chemical Risk Management
Early indicators suggest the new law will more effectively protect people—including vulnerable populations such as children and pregnant women—than the old law it replaces. But stakeholders are watching closely to see if the changes really do live up to their promise.
News  Regulation 
october 2016
Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union
There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens, and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission).
Science  Regulation  EndocrineDisruption 
october 2016
Recent Fast Food Consumption and Bisphenol A and Phthalates Exposures among the U.S. Population in NHANES, 2003-2010
We observed evidence of a positive, dose-response relationship between fast food intake and exposure to phthalates (p-trend < 0.0001) but not BPA; participants with high consumption (≥ 34.9% TEI from fast food) had 23.8% (95% CI: 11.9%, 36.9%) and 39.0% (95% CI: 21.9%, 58.5%) higher levels of ΣDEHPm and DiNPm, respectively, than nonconsumers. Fast food-derived fat intake was also positively associated with ΣDEHPm and DiNPm (p-trend < 0.0001). After adjusting for other food groups, ΣDEHPm was associated with grain and other intake, and DiNPm was associated with meat and grain intake.
Science  Human  Exposure  Phthalates 
october 2016
Reducing Phthalate, Paraben, and Phenol Exposure from Personal Care Products in Adolescent Girls: Findings from the HERMOSA Intervention Study
This study demonstrates that techniques available to consumers, such as choosing personal care products that are labeled to be free of phthalates, parabens, triclosan, and BP-3, can reduce personal exposure to possible endocrine-disrupting chemicals. Involving youth in the design and implementation of the study was key to recruitment, retention, compliance, and acceptability of the intervention.
Science  Human  EndocrineDisruption  Exposure 
october 2016
Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5 during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort
Despite relatively low exposures, our results suggest a monotonic positive relationship between PM2.5 exposure during preconception and pregnancy and IUI. IUI may be a sensitive biomarker for assessing early biological effect of PM2.5 exposure on the developing fetus.
Human  Science  AirPollution  Reproductive 
october 2016
Acute Impact of Hourly Ambient Air Pollution on Preterm Birth
Acute increases in ambient air pollution concentrations above certain levels before onset of labor may stimulate preterm birth.
Science  Human  AirPollution  Reproductive 
october 2016
Neurodevelopmental Deceleration by Urban Fine Particles from Different Emission Sources: A Longitudinal Observational Study
An interquartile range increase in indoor traffic-related PM2.5 was associated with reductions in cognitive growth equivalent to 22% (95% CI: 2%, 42%) of the annual change in working memory, 30% (95% CI: 6%, 54%) of the annual change in superior working memory, and 11% (95% CI: 0%, 22%) of the annual change in the inattentiveness scale. None of the other PM2.5 sources was associated with adverse effects on cognitive development.
Science  Human  AirPollution  Neurotoxicity 
october 2016
Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China
Based on the Gesell Developmental Schedules, the proportions of children with developmental delays were < 6%. Adverse associations between head circumference at birth and prenatal OP exposure were demonstrated. Both prenatal and postnatal OP exposure was significantly associated with increased risk of being developmentally delayed. Specifically, odds ratio (OR) value for prenatal DEs was 9.75 (95% CI: 1.28, 73.98, p = 0.028) in the adaptive area, whereas in the social area, OR values for postnatal DEs and DAPs were 9.56 (95% CI: 1.59, 57.57, p = 0.014) and 12.00 (95% CI: 1.23, 117.37, p = 0.033), respectively. Adverse associations were observed only in boys, not in girls.
Science  Human  Pesticides  Neurotoxicity 
october 2016
Bisphenol A and Adiposity in an Inner-City Birth Cohort
Analyses of the CCCEH longitudinal birth cohort found associations between prenatal urinary BPA concentrations and FMI, %BF, and WC. Our results suggest that prenatal BPA exposure may contribute to developmental origins of adiposity. These findings are consistent with several prior studies, raising concern about the pervasiveness of BPA.
Science  Human  BPA  Obesity 
october 2016
Urinary Concentrations of Bisphenol A and Phthalate Metabolites Measured during Pregnancy and Risk of Preeclampsia
Urinary concentrations of BPA and several phthalate metabolites were significantly associated with increased risk of preeclampsia. If validated, these results indicate an environmental contribution of endocrine-disrupting chemicals to preeclampsia and suggest a modifiable means to reduce the mortality and morbidity associated with this condition.
Science  Human  Phthalates  Reproductive 
october 2016
Lactational Exposure to Polybrominated Diphenyl Ethers and Its Relation to Early Childhood Anthropometric Measurements
Overall, PBDE exposures via breast milk were not associated with early-life anthropometric measures in the PIN Babies cohort. When stratified by sex, PBDEs in milk were inversely associated with WHZ for boys; however, associations did not follow a consistent pattern across the concentration gradient and were imprecisely estimated. Among girls, PBDEs tended to be associated with increased WHZ except for BDE-153, which was inversely associated with WHZ, though all estimates were imprecisely estimated.
Science  Human  FlameRetardants  Developmental 
october 2016
Endocrine Aspects of Environmental "Obesogen" Pollutants
The key concept is the identification of adipose tissue not only as a preferential site of storage of EDCs, but also as an endocrine organ and, as such, susceptible to endocrine disruption.
Science  Review  Obesity  EndocrineDisruption 
october 2016
Health of more than 90% of world’s population affected by air pollution ‘emergency’, WHO says
More than nine out of every 10 people on the planet live in areas where air pollution breaches official safety limits – and millions of people are dying as a result, according to new research by the World Health Organisation (WHO).
News  AirPollution 
october 2016
A Systematic Review and Meta-Analysis of Multiple Airborne Pollutants and Autism Spectrum Disorder
After considering strengths and limitations of the body of research, we concluded that there is "limited evidence of toxicity" for the association between early life exposure to air pollution as a whole and diagnosis of ASD. The strongest evidence was between prenatal exposure to particulate matter and ASD. However, the small number of studies in the meta-analysis and unexplained statistical heterogeneity across the individual study estimates means that the effect could be larger or smaller (including not significant) than these studies estimate.
Science  Review  Human  AirPollution  Neurotoxicity 
october 2016
Denmark's environment minister: Why the Commission's EDCs criteria fall short
The Commission proposals are not in line with the globally accepted approach for identification of substances of high concern, nor with the WHO definition of an endocrine disruptor. I am particularly worried about the fact that the criteria only apply to substances that are known to cause an adverse effect relevant for human health and that evidence has to be extensively documented. This goes far beyond the requirements that we apply to other substances of high concern.
News  Regulation  EndocrineDisruption 
october 2016
Fire safety chemicals ‘threaten’ public health, alliance warns
The use of chemical flame retardants in furniture to improve fire safety can also have severe implications for public health, a number of associations have warned. An alliance of stakeholders representing equipment makers, environmental NGOs, cancer organisations, firefighters, and labour unions have expressed concern about the safety of using flame retardants in furniture.
News  FlameRetardants  Stack:CPESMedia 
october 2016
Denmark wants EU ban on harmful flame retardants
The environment and food minister, Esben Lunde Larsen, has announced that he intends to work towards an EU ban on flame retardants in products that children can come into contact with. The three flame retardants, TCEP, TDCP and TCPP, are suspected of being carcinogenic and were recently found in dust particles in children’s rooms. They have already been banned in a number of toy products by the EU, but the Danes want the ban to be more expansive.
News  FlameRetardants  Regulation 
october 2016
Toxic chemicals in household dust linked to cancer and infertility
Household dust harbours a cocktail of toxic chemicals that have been linked to an increased risk of a range of health hazards, from cancer to problems with fertility, researchers in the US have found. The chemicals are shed from a host of common products, from flooring to electrical goods as well as beauty and cleaning products.
News  Exposure 
october 2016
Modern life is killing our children: Cancer rate in young people up 40 per cent in 16 years
Modern life is killing children with the number of youngsters diagnosed with cancer rising 40 per cent in the past 16 years because of air pollution, pesticides, poor diets and radiation, scientists have warned.
News  Cancer 
october 2016
Why a Chemical Banned From Soap Is Still in Your Toothpaste
Toothpastes that contain triclosan have been “demonstrated to be effective at reducing plaque and gingivitis,” said Andrea Fischer, an F.D.A. spokeswoman. Before approving the toothpaste in 1997, the agency requested that the Colgate-Palmolive company conduct toxicology studies, and the F.D.A. ultimately decided it was safe and effective.
News  Biocides  Regulation 
october 2016
Childhood cancer cases in UK have risen by 40% since 1998
The number of cancer cases in children has leapt by 40 per cent in the UK in less than two decades because of pollution, pesticides and gadgets, new analysis has shown.
News  Cancer 
october 2016
Early Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function
We found no evidence for an adverse effect of early life PFAS exposure on metabolic function in mid-childhood. In fact, children with higher PFAS concentrations had lower insulin resistance.
Science  Human  PFCs  Diabetes 
october 2016
FDA issues final rule on safety and effectiveness of antibacterial soaps
The U.S. Food and Drug Administration has issued a final rule establishing that over-the-counter (OTC) consumer antiseptic wash products containing certain active ingredients can no longer be marketed. Companies will no longer be able to market antibacterial washes with these ingredients because manufacturers did not demonstrate that the ingredients are both safe for long-term daily use and more effective than plain soap and water in preventing illness and the spread of certain infections. Some manufacturers have already started removing these ingredients from their products.
News  Biocides  Regulation 
october 2016
First trimester phthalate exposure and male newborn genital anomalies
First trimester urinary DEHP metabolite concentrations were associated with increased odds of any newborn genital anomaly, and this association was primarily driven by isolated hydrocele which made up the majority of anomalies in newborn males. The association with hydrocele has not been previously reported and suggests that it may be an endpoint affected by prenatal phthalate exposures in the first trimester of development. Future human studies should include hydrocele assessment in order to confirm findings.
Science  Human  Reproductive  Phthalates 
october 2016
Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline.
Science  Human  Kidney  AirPollution 
october 2016
Associations of persistent organic pollutants in serum and adipose tissue with breast cancer prognostic markers
The risk of p53 expression was higher among women in the lowest quartile of serum PCB-138 concentrations, but no significant trend was observed (p-trend=0.161). These findings indicate that human exposure to certain persistent organic pollutants might be related to breast cancer aggressiveness. We also highlight the influence on exposure assessment of the biological matrix selected, given that both serum and adipose tissue might yield relevant information on breast cancer prognosis.
Science  Human  POPs  Cancer 
september 2016
Effects of early exposure to phthalates and bisphenols on cardiometabolic outcomes in pregnancy and childhood
In total, 54 studies were identified and included. The majority of studies found effects of phthalates and bisphenols on maternal, child growth, and cardiometabolic outcomes. Currently results suggest that early life exposure to phthalates and bisphenols may have a substantial influence on perinatal and postnatal cardiometabolic programming. In a large part of the investigated outcomes studies show contradictory results. However, the majority of the existing evidence is based on non-cohort studies with single samples neglecting time-variant effects and complicating conclusions regarding causal inference.
Science  Human  Review  Phthalates  Cardiovascular  Reproductive 
september 2016
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