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Reproducibility Project: Cancer Biology | Collections | eLife
The Reproducibility Project: Cancer Biology is an initiative to independently replicate selected results from a number of high-profile papers in the field of cancer biology. For each paper a Registered Report detailing the proposed experimental designs and protocols for the replications is peer reviewed and published prior to data collection; the results of these experiments are then published as a Replication Study. The project is a collaboration between the Center for Open Science and Science Exchange.

The aim of the project is two-fold: to provide evidence about reproducibility in preclinical cancer research, and to identify the factors that influence reproducibility more generally. Interpreting the results reported in the Replication Studies requires a nuanced approach, as explained in this Editorial. To date four of the studies have reproduced important parts of the original papers; three of the studies have reproduced parts of the original papers but also contain results that could not be interpreted or are not consistent with some parts of the original paper; two of the studies could not be interpreted; and two studies did not reproduce the parts of the original papers that they attempted to reproduce.
cancer  reproducibility  Science  statistics 
yesterday by cnk
Berkson's paradox - Wikipedia
For example, if the risk factor is diabetes and the disease is cholecystitis, a hospital patient without diabetes is more likely to have cholecystitis than a member of the general population, since the patient must have had some non-diabetes (possibly cholecystitis-causing) reason to enter the hospital in the first place. That result will be obtained regardless of whether there is any association between diabetes and cholecystitis in the general population.

An example presented by Jordan Ellenb...
statistics  math  mathematics  paradox  probability 
yesterday by hellsten
Berkson's paradox
An example presented by Jordan Ellenberg: Suppose Alex will only date a man if his niceness plus his handsomeness exceeds some threshold. Then nicer men do not have to be as handsome to qualify for Alex's dating pool. So, among the men that Alex dates, Alex may observe that the nicer ones are less handsome on average (and vice versa), even if these traits are uncorrelated in the general population. Note that this does not mean that men in the dating pool compare unfavorably with men in the population. On the contrary, Alex's selection criterion means that Alex has high standards. The average nice man that Alex dates is actually more handsome than the average man in the population (since even among nice men, the ugliest portion of the population is skipped). Berkson's negative correlation is an effect that arises within the dating pool: the rude men that Alex dates must have been even more handsome to qualify.
Wikipedia  paradoxes  statistics  mathematics  Psychology 
yesterday by ianchanning

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