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ROS signalling in the biology of cancer - ScienceDirect
Thorough summary of ROS sources in cancer cells and effects

Increased reactive oxygen species (ROS) production has been detected in various cancers and has been shown to have several roles, for example, they can activate pro-tumourigenic signalling, enhance cell survival and proliferation, and drive DNA damage and genetic instability. Counterintuitively ROS can also promote anti-tumourigenic signalling, initiating oxidative stress-induced tumour cell death. Tumour cells express elevated levels of antioxidant proteins to detoxify elevated ROS levels, establish a redox balance, while maintaining pro-tumourigenic signalling and resistance to apoptosis. Tumour cells have an altered redox balance to that of their normal counterparts and this identifies ROS manipulation as a potential target for cancer therapies. This review discusses the generation and sources of ROS within tumour cells, the regulation of ROS by antioxidant defence systems, as well as the effect of elevated ROS production on their signalling targets in cancer. It also provides an insight into how pro- and anti-tumourigenic ROS signalling pathways could be manipulated in the treatment of cancer.
16 days ago by Segalllab
Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance: Cancer Cell
Interesting role for Ca influx in stimulating survival against ROS and chemotherapy.

Cancer cell survival is dependent on oxidative-stress defenses against reactive oxygen species (ROS) that accumulate during tumorigenesis. Here, we show a non-canonical oxidative-stress defense mechanism through TRPA1, a neuronal redox-sensing Ca2+-influx channel. In TRPA1-enriched breast and lung cancer spheroids, TRPA1 is critical for survival of inner cells that exhibit ROS accumulation. Moreover, TRPA1 promotes resistance to ROS-producing chemotherapies, and TRPA1 inhibition suppresses xenograft tumor growth and enhances chemosensitivity. TRPA1 does not affect redox status but upregulates Ca2+-dependent anti-apoptotic pathways. NRF2, an oxidant-defense transcription factor, directly controls TRPA1 expression, thus providing an orthogonal mechanism for protection against oxidative stress together with canonical ROS-neutralizing mechanisms. These findings reveal an oxidative-stress defense program involving TRPA1 that could be exploited for targeted cancer therapies.
calcium  ROS  chemotherapy 
17 days ago by Segalllab
ROS-Industrial is an Open Source robotics software project that extends the
advanced capabilities of ROS to new manufacturing applications. Supported
by ROS-I Consortium which is led by SwRI, Fraunhofer IPA and ARTC.
4 weeks ago by kaliatech
7 Best Robotics Courses, Certification & Training [2018 - 19] [UPDATED]
30+ Experts have compiled this list of Best Robotics Course, Tutorial, Training, Class, and Certification available online for 2018. It includes both paid
ros  education 
4 weeks ago by kaliatech
AWS DeepRacer - the fastest way to get rolling with machine learning
AWS DeepRacer is the fastest way to get rolling with machine learning, literally. Get hands-on with a fully autonomous 1/18th scale race car driven by reinforcement learning, 3D racing simulator, and global racing league.
robotics  ros 
6 weeks ago by kaliatech

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