improvement   4010

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This is How to Increase The Odds of Reaching Your Goals by 95%
Goals take time, hard work, perseverance and commitment to achieve. And results often do not come as quickly as you hope. You can easily lose the motivation in the process and give up. But everything…
productivity  improvement 
8 days ago by kleninz
DiffProf
Finding code improvements through power usage in Android apps.
android  development  improvement  power 
10 days ago by traggett
Embrace being a programmable biorobot, hack your own cravings.
There are certain things, at certain times, that I start to acutely crave. These cravings are programmed behaviors that always execute in the same mechanical, linear way. I’d like this to not happen…
improvement 
26 days ago by kleninz
Epicentre | Recherche épidémiologique
Epicentre conducts research and training activities in the range of MSF interventions.
A partner with great teams in the world of medical research, its work is anchored in modern scientific knowledge, in particular in the field of epidemiology.
epidemiology  msf  research  quality  improvement  medicine  globalhealth  ebm 
6 weeks ago by pgorrindo
Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial - ScienceDirect
Patients with CHF and depression had low blood omega-3 concentrations that were associated with an elevated risk of mortality.

Methods

This study was a randomized, double-blind, placebo-controlled pilot clinical trial using a 400/200 eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) fish oil at 2 g and an almost pure EPA at 2 g, compared with a matched placebo, daily for 12 weeks for patients with CHF and major depressive disorder. Statistical analyses included the intention-to-treat population and “completers” (defined as participants consuming ≥70% of the capsules and completing the final endpoint evaluation between 10 and 14 weeks).

Results

A total of 108 patients with CHF and major depressive disorder and a score ≥18 on the Hamilton Depression Scale who were randomized at 1:1:1 to the 3 interventions at 3 enrolling centers from June 12, 2014, to May 19, 2016; 80 (74.1%) qualified as completers. Intention-to-treat analyses revealed that the levels of all omega-3 variables were significantly elevated in the omega-3 groups, whereas the placebo group showed little change; there were no between-group differences with overall depression measurements. Per-protocol exploratory analyses showed that scores on the social functioning measurement of the 36-item Short Form Health Survey improved notably in the 400/200 EPA/DHA (p = 0.040) and EPA (p = 0.10) groups compared with the placebo group. Spearman correlation analysis indicated that increased omega-3 indices were associated with improved cognitive depressive symptoms.

Conclusions

Omega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3. Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation. Further studies with larger sample sizes are necessary to confirm the benefits of omega-3 supplementation on modifying psychosocial factors for patients with CHF. (Omega-3 Supplementation for Co-Morbid Depression and Heart Failure Treatment [OCEAN]; NCT02057406)
depression  CHF  major  depressive  disorder  peer-reviewed  research  human  clinical  trial  in  vivo  situ  cognition  functional  improvement  treatment  cognitive  comorbidity  mortality  risk  benefit  supplements  omega-3  DHA  EPA  RCT 
7 weeks ago by Michael.Massing

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