force   1831

« earlier    

8 - How can we get Block Bundle Type for block in code? - Drupal Answers
use \Drupal\block_content\BlockContentInterface;

* Implements HOOK_preprocess_block().
* @param $variables
function mymodule_preprocess_block(&$variables) {
$content = $variables['elements']['content'];
if (isset($content['#block_content']) && $content['#block_content'] instanceof BlockContentInterface) {

if ($content['#block_content']->bundle() == 'xxx') {
// ...

8  drupal8  drupal  web  dev  cms  computing  module  theme  block  update  refresh  force  cache  disable  twig  specific  howto  question  answer  problem  solution  time  computed  generated  calculated 
3 days ago by therobyouknow
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis | Nature
Not sure how relevant really but looks at actin/myosin contraction in tumor formation for pancreatic ducts

Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1,2,3,4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical parameters that underlie the adoption of abnormal tumour tissue shapes are unknown. Here we show in the pancreas of mice that the morphology of epithelial tumours is determined by the interplay of cytoskeletal changes in transformed cells and the existing tubular geometry. To analyse the morphological changes in tissue architecture during the initiation of cancer, we developed a three-dimensional whole-organ imaging technique that enables tissue analysis at single-cell resolution. Oncogenic transformation of pancreatic ducts led to two types of neoplastic growth: exophytic lesions that expanded outwards from the duct and endophytic lesions that grew inwards to the ductal lumen. Myosin activity was higher apically than basally in wild-type cells, but upon transformation this gradient was lost in both lesion types. Three-dimensional vertex model simulations and a continuum theory of epithelial mechanics, which incorporate the cytoskeletal changes observed in transformed cells, indicated that the diameter of the source epithelium instructs the morphology of growing tumours. Three-dimensional imaging revealed that—consistent with theory predictions—small pancreatic ducts produced exophytic growth, whereas large ducts deformed endophytically. Similar patterns of lesion growth were observed in tubular epithelia of the liver and lung; this finding identifies tension imbalance and tissue curvature as fundamental determinants of epithelial tumorigenesis.
tumorigenesis  myosin  ACTIN  force 
7 days ago by Segalllab
zxcvbn/ at master · dropbox/zxcvbn · GitHub
_________________________________________________/\/\___________________ _/\/\/\/\/\__/\/\__/\/\____/\/\/\/\__/\/\__/\/\__/\/\________/\/\/\/\___ _____/\/\______/\/\/\____/\/\________/\/\__/\/\__/\/\/\/\____/\/\__/\/\_ ___/\/\________/\/\/\____/\/\__________/\/\/\____/\/\__/\/\__/\/\__/\/\_ _/\/\/\/ via Pocket
IFTTT  Pocket  brute  cryptography  force  password  passwords  random  security 
19 days ago by ChristopherA
Can we measure force using an accelerometer ?
The main problem that you will face is not getting a pure measurement of acceleration; rather, you will get by an accelerometer what is called "proper acceleration" which is the acceleration vector and projection of gravity on accelerometer axes. There are some methods to separate but it requires accurate knowledge of the orientation of the accelerometer to compensate for gravity components. To get an estimate of the orientation accurately you need to combine the accelerometer with a gyroscope which is needed in dynamic scenarios.
accelerometer  force  fma 
4 weeks ago by imaginaryfriend
Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro | Journal of Cell Science
Cancer cell invasion is influenced by various biomechanical forces found within the microenvironment. We have previously found that invasion is enhanced in fibrosarcoma cells when transient mechanical stimulation is applied within an in vitro mechano-invasion assay. This enhancement of invasion is dependent on cofilin (CFL1), a known regulator of invadopodia maturation. Invadopodia are actin-rich structures present in invasive cancer cells that are enzymatically active and degrade the surrounding extracellular matrix to facilitate invasion. In this study, we examine changes in gene expression in response to tugging on matrix fibers. Interestingly, we find that integrin β3 expression is downregulated and leads to an increase in cofilin activity, as evidenced by a reduction in its Ser3 phosphorylation levels. As a result, invadopodia lengthen and have increased enzymatic activity, indicating that transient mechanical stimulation promotes the maturation of invadopodia leading to increased levels of cell invasion. Our results are unique in defining an invasive mechanism specific to the invasive process of cancer cells that is triggered by tugging forces in the microenvironment, as opposed to rigidity, compression or stretch forces.
force  invadopodia  invasion  cofilin 
4 weeks ago by Segalllab
Active Directory: Force replication of all Domain Controllers on all Sites at once – SID-500.COM
Active Directory Domain Services uses pull replication to replicate Active Directory Partitions. This means that the Domain Controller on which replication is started receives the data from the source Domain Controller. It's like a one way ticket. If you want to replicate all Domain Controllers, then you have to start replication on each of them separately. This…
force  replication  powershell  windows  server 
5 weeks ago by jgear

« earlier    

related tags

#metoo  'black/white'  'cocoa  'de  'don't  'right  'unjustifiable'  "pink  -  1  11  12  13  1722  1969  1984  1s  2.2  2  201  2012  2013  2018  2019:  5000  5g  8  9/11  911  a-cold-wall's  a  abloh's  abuse  acceleration  accelerometer  account  actin  activist  addon  afghanistan  again  agents  air  alcohol  allows  almost  alyx  americans  amid  an  and  android  another  answer  aparatus  app  applause  apple  are  army  around  art  as  ask  asylum  at  attempt  baltimore  bank  barriers  be  being  bethangilmer  bicycle  big  bill  blackface  block  blog  body  border  boys  boyz  brakes  breaking  brightest  brodycondon  browser  brute  buckles  burns  business  but  butler  by  c2h4  cache  cadaver  cadence  calculated  california  camp  can  cannot  can’t  captions  car  case’  cause  cdc:  censorship  certificate  ces  change  change:  charges  christineborland  chrome  chrysler  clashes  class  classic  clay  climate  closed  closer  closure  cms  code  coding  cofilin  collab  collaborated  college  come  coming  compactified  companies  complexcon  components  computed  computing  concerns  conference  configuration  cops  copy  coraopolis-pa  corpse  costs  could  counter  country  courts  cozy  cracker  cracking  crafted  crew  cristiano  cruz's  cryptography  culture  cursor  customs  d3-force  d3  dangling  dataviz  dc  deadly  death  decline  defence  design  dev  developming  dignity  dimension  directs  disable  discharged  discoverability  dodge  domesticviolence  dominican  don’t  dropping  drops  drupal  drupal8  dutch  e-mail  earlier  eff  elliott's  elon  elonmusk  emotionally  endorses  ends  example  expected  expects  experiment  explanation  extension  face  fall  fallexperiment  falling  features  federal  female  financial  fine  finger  firmware  flyleather  fma  for  formerly  free  free_speech  freedom  fundraiser  game  gathers  generated  get  git  government  gravity  guide  gun  gurkha  gwynne  gwynneshotwell  halloween  hampden  hang  hard  harrassment  hasbro  helmandprovince  here  high  history  hiv+  honors  hoping  house  how  how_to  howto  hsts  http  https  idapoole  ieds  ifttt  ii'  illness  implement  impression  in  inc  incandescent  india  info  initiatives  introduced  intuitive  invadopodia  invasion  investigation  ios  ipad  iphone  iron  is  its  jazz  jimgibson  jimmy  john  just  karlharris  kayciemader  ke  keep  key  keyboard  kickstarter  kill  known  kraft  labor  law  layouts  leaders  lebanese  leonardsusskind  lightsaber  like  limits  line  link  linked  linkedin  liveforce  living  livingforce  lo  look  looks  lows  madness  magic  magnum  mall  march  mass  math  members  mentalillness  mexico.  michaelbaker  mifare  migrate  military  million  mio'  mobile  module  money.laundering  monitoring  month  months  mopars  more  move?  multiverse  music  musk  myosin  mystic  nai  national  neolithic  new  next  nike  no  nodes  now  nyc  nz  obj's  object  observer  of  off-white  offer  official  oil  on  once  one  onkyo  onto  opd  operation  or  out  overwrite  palestinians  panama.papers  panic  participation  particle  password  passwords  pasts  pay  pedal  people  philosophy  phone  physics  pilots  playstation  plugin  plymouth  pocket  police  polio-like  political  portugal  portugal:  post-election  power  powershell  presentations  prime-working-age  problem  problems  programming  propublica  protect  psy  public  pull  purest  putting  question  quiet  quilt  race  racing  random  rape  rapist  rate  ready  reality  reckon  recovery  reference  reflective  refresh  release  releasing  repair'  replace  replication  reportedly  research  reset  residential  restart  return  returning  reveal  reveals  rising  rjwilliams  robert  ronaldo  roper  rumored  rural  ryankuzma  safety  sales  salesforce  salute  save  scandals  school  science  scotland  sculpture  section  security  seekers  seeks  server  setting  sexual  shooting  shotwell  show  shutdown  sitting  sizes  smoke  snake'  software  solution  soon  space  spacex  specific  ssl  starwars  state  statistics  steady  steadying  stephenmader  stick  still  strategy  strict  strike  strings  stringtheory  suicide  surface  survive  suspension  sustainability  swooshes  task  tax":  telepathy  than  that  the  their  them  theme  these  they  think  this  tiemencocquyt  time  tls  to.  to  toddler  top  touch  town  trade  training  trance  transport  tries  troop  troops  trump  tumorigenesis  turkey  tutorial  twig  tx-nr535/636/737/838  un  unavailable's  unlock  up  update  updates  us  use  used  uses  using  v  variant  velocity  vet  vibration  victor  video  videos  violence  virgil  wants  war-making  war  way  web  weirton-wv  west  wheeling-wv  when  white  white’  will  willemgravesande  windows  winter  wireless  with  withdrawal  women  work  workers  world  x  xtreme  yemen  you  your  youtube  zimbabwe  ‘ash  ‘just 

Copy this bookmark: