What if the Placebo Effect Isn’t a Trick? - The New York Times


61 bookmarks. First posted by aebraddy 12 days ago.


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4 days ago by jburkunk
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5 days ago by cspathis
You don’t even have to deceive the patients. You can hand a patient with irritable bowel syndrome a sugar pill, identify it as such and tell her that sugar pills are known to be effective when used as placebos, and she will get better, especially if you take the time to deliver that message with warmth and close attention. Depression, back pain, chemotherapy-related malaise, migraine, post-traumatic stress disorder: The list of conditions that respond to placebos — as well as they do to drugs, with some patients — is long and growing.
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6 days ago by mattrud
What if the Placebo Effect Isn’t a Trick?
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7 days ago by John-Dobbin
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7 days ago by mattl
The Chain of Office of the Dutch city of Leiden is a broad and colorful ceremonial necklace that, draped around the shoulders of Mayor Henri Lenferink, lends a magisterial air to official proceedings in this ancient university town. via Pocket
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7 days ago by michimaurer
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7 days ago by timwburch
New research is zeroing in on a biochemical basis for the placebo effect — possibly opening a Pandora’s box for Western medicine.
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8 days ago by noiseguy
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9 days ago by Devje
in depth review of placebo effects and biological basis?
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9 days ago by ElliotPsyIT
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9 days ago by johnrclark
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9 days ago by nzeribe
Wake a patient from surgery and tell him you’ve done an arthroscopic repair, and his knee gets better even if all you did was knock him out and put a couple of incisions in his skin. Give a drug a fancy name, and it works better than if you don’t. You don’t even have to deceive the patients.
health  science 
9 days ago by carlesbellver
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10 days ago by granth
It is not possible to assay levels of COMT directly in a living brain, but there is a snippet of the genome called rs4680 that governs the production of the enzyme, and that varies from one person to another: One variant predicts low levels of COMT, while another predicts high levels. When Hall analyzed the I.B.S. patients’ DNA, she found a distinct trend. Those with the high-COMT variant had the weakest placebo responses, and those with the opposite variant had the strongest. These effects were compounded by the amount of interaction each patient got: For instance, low-COMT, high-interaction patients fared best of all, but the low-COMT subjects who were placed in the no-treatment group did worse than the other genotypes in that group. They were, in other words, more sensitive to the impact of the relationship with the healer.

The discovery of this genetic correlation to placebo response set Hall off on a continuing effort to identify the biochemical ensemble she calls the placebome — the term reflecting her belief that it will one day take its place among the other important “-omes” of medical science, from the genome to the microbiome. The rs4680 gene snippet is one of a group that governs the production of COMT, and COMT is one of a number of enzymes that determine levels of catecholamines, a group of brain chemicals that includes dopamine and epinephrine. (Low COMT tends to mean higher levels of dopamine, and vice versa.) Hall points out that the catecholamines are associated with stress, as well as with reward and good feeling, which bolsters the possibility that the placebome plays an important role in illness and health, especially in the chronic, stress-related conditions that are most susceptible to placebo effects.
placebo  comt  health  healthcare  medicine  enzymes  brain 
10 days ago by jm
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10 days ago by robw
It’s an urgent subject for them, and only in part because, like all apostate professionals, they crave mainstream acceptance. More important, they are motivated by a conviction that the placebo is a powerful medical treatment that is ignored by doctors only at their patients’ expense.

Wake a patient from surgery and tell him you’ve done an arthroscopic repair, and his knee gets better even if all you did was knock him out and put a couple of incisions in his skin.
health  placebo 
11 days ago by craniac
100g But as many of the talks at the conference indicated, this might be about to change. Aided by functional magnetic resonance imaging (f.M.R.I.) and other precise surveillance techniques, Kaptchuk and his colleagues have begun to elucidate an ensemble of biochemical processes that may finally account for how placebos work and why they are more effective for some people, and some disorders, than others. The molecules, in other words, appear to be emerging. And their emergence may reveal fundamental flaws in the way we understand the body’s healing mechanisms, and the way we evaluate whether more standard medical interventions in those processes work, or don’t. Long a useful foil for medical science, the placebo effect might soon represent a more fundamental challenge to it.
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11 days ago by scritic
RT atmostbeautiful : 플라시보 효과. 속임수라 하기엔 치유 사례 많다. 주류 의학은 기대심리가 만드는 환각일 뿐이라며 배제. 최근엔 첨단기기로 효능을 생화학적으로 분석. 치유를 유전자-약-정신의 복합 작용으로 재조명. 의술의 과학화 과정에서 배제된 환자-의사 신뢰와 보살핌의 효능. 추천 http://bit.ly/2JRIydO November 08, 2018 at 09:32PM http://twitter.com/atmostbeautiful/status/1060510431242907650
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11 days ago by seoulrain
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11 days ago by WFreeland
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11 days ago by bkerr
What if the Placebo Effect Isn’t a Trick?
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12 days ago by KlasO
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12 days ago by dshack
“Rituals trigger specific neurobiological pathways that specifically modulate bodily sensations, symptoms and emotions,” he wrote. “It seems that if the mind can be persuaded, the body can sometimes act accordingly.”
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12 days ago by thinkling
The findings of the I.B.S. study were in keeping with a hypothesis Kaptchuk had formed over the years: that the placebo effect is a biological response to an act of caring; that somehow the encounter itself calls forth healing and that the more intense and focused it is, the more healing it evokes.
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12 days ago by seaugust
Hypnosis: What if the Placebo Effect Isn’t a Trick?
12 days ago by davie-
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12 days ago by archizoo
I knew it! Hand me more garlic cloves
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12 days ago by brunoboutot
I knew it! Hand me more garlic cloves
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12 days ago by Palafo
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12 days ago by mathewi
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12 days ago by toph
Her findings take their place among other results from neuroscientists that strengthen the placebo’s claim to a place at the medical table, in particular studies using f.M.R.I. machines that have found consistent patterns of brain activation in placebo responders. “For years, we thought of the placebo effect as the work of imagination,” Hall says. “Now through imaging you can literally see the brain lighting up when you give someone a sugar pill.”
12 days ago by spectrevision
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12 days ago by drewcaldwell
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12 days ago by robmcmyers