nhaliday + pharma   38

Existential Risks: Analyzing Human Extinction Scenarios
https://archive.is/dUTD5
Would you endorse choosing policy to max the expected duration of civilization, at least as a good first approximation?
Can anyone suggest a different first approximation that would get more votes?

https://archive.is/RpygO
How useful would it be to agree on a relatively-simple first-approximation observable-after-the-fact metric for what we want from the future universe, such as total life years experienced, or civilization duration?

We're Underestimating the Risk of Human Extinction: https://www.theatlantic.com/technology/archive/2012/03/were-underestimating-the-risk-of-human-extinction/253821/
An Oxford philosopher argues that we are not adequately accounting for technology's risks—but his solution to the problem is not for Luddites.

Anderson: You have argued that we underrate existential risks because of a particular kind of bias called observation selection effect. Can you explain a bit more about that?

Bostrom: The idea of an observation selection effect is maybe best explained by first considering the simpler concept of a selection effect. Let's say you're trying to estimate how large the largest fish in a given pond is, and you use a net to catch a hundred fish and the biggest fish you find is three inches long. You might be tempted to infer that the biggest fish in this pond is not much bigger than three inches, because you've caught a hundred of them and none of them are bigger than three inches. But if it turns out that your net could only catch fish up to a certain length, then the measuring instrument that you used would introduce a selection effect: it would only select from a subset of the domain you were trying to sample.

Now that's a kind of standard fact of statistics, and there are methods for trying to correct for it and you obviously have to take that into account when considering the fish distribution in your pond. An observation selection effect is a selection effect introduced not by limitations in our measurement instrument, but rather by the fact that all observations require the existence of an observer. This becomes important, for instance, in evolutionary biology. For instance, we know that intelligent life evolved on Earth. Naively, one might think that this piece of evidence suggests that life is likely to evolve on most Earth-like planets. But that would be to overlook an observation selection effect. For no matter how small the proportion of all Earth-like planets that evolve intelligent life, we will find ourselves on a planet that did. Our data point-that intelligent life arose on our planet-is predicted equally well by the hypothesis that intelligent life is very improbable even on Earth-like planets as by the hypothesis that intelligent life is highly probable on Earth-like planets. When it comes to human extinction and existential risk, there are certain controversial ways that observation selection effects might be relevant.
bostrom  ratty  miri-cfar  skunkworks  philosophy  org:junk  list  top-n  frontier  speedometer  risk  futurism  local-global  scale  death  nihil  technology  simulation  anthropic  nuclear  deterrence  environment  climate-change  arms  competition  ai  ai-control  genetics  genomics  biotech  parasites-microbiome  disease  offense-defense  physics  tails  network-structure  epidemiology  space  geoengineering  dysgenics  ems  authoritarianism  government  values  formal-values  moloch  enhancement  property-rights  coordination  cooperate-defect  flux-stasis  ideas  prediction  speculation  humanity  singularity  existence  cybernetics  study  article  letters  eden-heaven  gedanken  multi  twitter  social  discussion  backup  hanson  metrics  optimization  time  long-short-run  janus  telos-atelos  poll  forms-instances  threat-modeling  selection  interview  expert-experience  malthus  volo-avolo  intel  leviathan  drugs  pharma  data  estimate  nature  longevity  expansionism  homo-hetero  utopia-dystopia
march 2018 by nhaliday
National Greatness | West Hunter
As production rose, availability increased. At first, penicillin was largely reserved for US and British military needs. Later, it became available to US and British civilians, and soon after for general usage.

But there was a time window of several months in which American-produced penicillin was available for American wounded but not for French casualties. Fortunately, it happens that penicillin is rapidly excreted in urine. It can be recovered. Between January and April 1945, Rhône-Poulenc extracted penicillin from the urine of wounded American servicemen being treated in hospitals around Paris, penicillin which was then used to treat the wounded of the French Army. They typically recovered about 100 doses from 300 liters of urine.

When American piss is the elixir of life – that is national greatness.

USSR, innovation, and Japan: https://westhunt.wordpress.com/2013/04/10/national-greatness/#comment-11653
west-hunter  scitariat  medicine  pharma  drugs  low-hanging  history  mostly-modern  the-trenches  britain  usa  world-war  military  multi  poast  russia  communism  japan  asia  innovation  stories  trivia  cocktail  embodied  nationalism-globalism
september 2017 by nhaliday
Low-Hanging Fruit: Nyekulturny | West Hunter
The methodology is what’s really interesting.  Kim Lewis and Slava Epstein sorted individual soil bacteria into chambers of a device they call the iChip, which is then buried in the ground – the point being that something like 98% of soil bacteria cannot be cultured in standard media, while in this approach, key compounds (whatever they are) can diffuse in from the soil, allowing something like 50% of soil bacteria species to grow.  They then tested the bacterial colonies (10,000 of them) to see if any slammed S. aureus – and some did.

...

I could be wrong, but I wonder if part of the explanation is that microbiology – the subject – is in relative decline, suffering because of funding and status competition with molecular biology and genomics (sexier and less useful than microbiology) . That and the fact that big pharma is not enthusiastic about biological products.
west-hunter  scitariat  discussion  ideas  speculation  bio  science  medicine  meta:medicine  low-hanging  error  stagnation  disease  parasites-microbiome  pharma  innovation  info-dynamics  the-world-is-just-atoms  discovery  the-trenches  alt-inst  dirty-hands  fashun
july 2017 by nhaliday
Vioxx | West Hunter
The Vigor study was submitted in February 2001. The New England Journal of Medicine, a few months later, found that the authors had failed to mention some strokes and heart attacks near the end of the trial. The authors used a cutoff for cardiovascular effects (bad news) that was earlier than the cutoff for gastrointestinal effects (good news). why? Because they were weasels, of course. There was a lot of money riding on this drug’s success.

Other people began to notice the increased heart risks – looking at data from HMOs and such. Merck fought back. There was an MD at Stanford that was concerned about Vioxx: Merck called up the dean of Stanford Medical School at home and warned him about possible loss of financial support: he told them to go fuck themselves.

...

Now it is true that there were studies that showed greater efficacy: 21 such were reported by Scott S. Reuben, former chief of acute pain at Baystate medical Center in Springfield Mass. But as it turns out, he made them all up. There’s is no evidence that Merck knew about this, but it does perhaps say something about the general climate in big pharma.

Merck knew the gist of this for four years before they pulled the plug on the drug. They had their their drug reps lie about cardio risks, threatened researchers and sued journals that talked about the emerging cardio risks. Few physicians were aware of these risks, even though a close reading of the journals would have suggested it – because hardly any physicians read the journals.

Epidemiologists think that Vioxx caused something like 40,000 deaths.

...

In the 70s corporations were the bad guys, whether they were or not. Today, billionaires are your friend.
west-hunter  scitariat  discussion  reflection  stories  history  mostly-modern  drugs  medicine  meta:medicine  rent-seeking  cardio  public-health  epidemiology  vampire-squid  corporation  madisonian  domestication  pharma  track-record  randy-ayndy  aphorism  interests
july 2017 by nhaliday
SPIEGEL Interview with Singapore's Lee Kuan Yew: "It's Stupid to be Afraid" - SPIEGEL ONLINE
SPIEGEL: How so?

Mr. Lee: The social contract that led to workers sitting on the boards of companies and everybody being happy rested on this condition: I work hard, I restore Germany's prosperity, and you, the state, you have to look after me. I'm entitled to go to Baden Baden for spa recuperation one month every year. This old system was gone in the blink of an eye when two to three billion people joined the race -- one billion in China, one billion in India and over half-a-billion in Eastern Europe and the former Soviet Union.

SPIEGEL: The question is: How do you answer that challenge?

Mr. Lee: Chancellor Kohl tried to do it. He did it halfway then he had to pause. Schroeder tried to do it, now he's in a jam and has called an election. Merkel will go in and push, then she will get hammered before she can finish the job, but each time, they will push the restructuring a bit forward.

SPIEGEL: You think it's too slow?

Mr. Lee: It is painful because it is so slow. If your workers were rational they would say, yes, this is going to happen anyway, let's do the necessary things in one go. Instead of one month at the spa, take one week at the spa, work harder and longer for the same pay, compete with the East Europeans, invent in new technology, put more money into your R&amp;D, keep ahead of the Chinese and the Indians.

...

SPIEGEL: During your career, you have kept your distance from Western style democracy. Are you still convinced that an authoritarian system is the future for Asia?

Mr. Lee: Why should I be against democracy? The British came here, never gave me democracy, except when they were about to leave. But I cannot run my system based on their rules. I have to amend it to fit my people's position. In multiracial societies, you don't vote in accordance with your economic interests and social interests, you vote in accordance with race and religion. Supposing I'd run their system here, Malays would vote for Muslims, Indians would vote for Indians, Chinese would vote for Chinese. I would have a constant clash in my Parliament which cannot be resolved because the Chinese majority would always overrule them. So I found a formula that changes that...
news  org:euro  interview  lee-kuan-yew  statesmen  foreign-policy  realpolitik  polisci  asia  developing-world  china  sinosphere  government  thucydides  expansionism  leviathan  property-rights  big-peeps  nationalism-globalism  europe  japan  korea  geopolitics  usa  democracy  antidemos  labor  temperance  trade  competition  germanic  pharma  peace-violence  latin-america  iran  nuclear  deterrence  india  russia  great-powers
june 2017 by nhaliday
Is Pharma Research Worse Than Chance? | Slate Star Codex
Here’s one hypothesis: at the highest level, the brain doesn’t have that many variables to affect, or all the variables are connected. If you smack the brain really really hard in some direction or other, you will probably treat some psychiatric disease. Drugs of abuse are ones that smack the brain really hard in some direction or other. They do something. So find the psychiatric illness that’s treated by smacking the brain in that direction, and you’re good.

Actual carefully-researched psychiatric drugs are exquisitely selected for having few side effects. The goal is something like an SSRI – mild stomach discomfort, some problems having sex, but overall you can be on them forever and barely notice their existence. In the grand scheme of things their side effects are tiny – in most placebo-controlled studies, people have a really hard time telling whether they’re in the experimental or the placebo group.

...

But given that we’re all very excited to learn about ketamine and MDMA, and given that if their original promise survives further testing we will consider them great discoveries, it suggests we chose the wrong part of the tradeoff curve. Or at least it suggests a different way of framing that tradeoff curve. A drug that makes you feel extreme side effects for a few hours – but also has very strong and lasting treatment effects – is better than a drug with few side effects and weaker treatment effects. That suggests a new direction pharmaceutical companies might take: look for the chemicals that have the strongest and wackiest effects on the human mind. Then see if any of them also treat some disease.

I think this is impossible with current incentives. There’s too little risk-tolerance at every stage in the system. But if everyone rallied around the idea, it might be that trying the top hundred craziest things Alexander Shulgin dreamed up on whatever your rat model is would be orders of magnitude more productive than whatever people are doing now.
ratty  yvain  ssc  reflection  psychiatry  medicine  pharma  drugs  error  efficiency  random  meta:medicine  flexibility  outcome-risk  incentives  stagnation  innovation  low-hanging  tradeoffs  realness  perturbation  degrees-of-freedom  volo-avolo  null-result
june 2017 by nhaliday
Antibiotic feed/food supplementation | West Hunter
Many domesticated animals show increased growth and improved feed efficiency when given low doses of antibiotics.  In fact, this is by far the biggest use of antibiotics.  Mostly you hear about this in the context of worries about how this may select for resistant bacteria (which may well be true), but one interesting question is why it even works – and what other applications this technique might have.

It strikes me that it might be useful in food emergencies – famines and so forth.  The dosage is low (200 g per ton) and can increase feed efficiency over 10% in some cases.  Assuming that antibiotic supplementation works in humans (which is likely, considering that it works in a wide spectrum of domestic animals), you might be able to save 5 or 10% more people with a given food supply. Now if we ever bothered to learn exactly how this works, we might be able to find an equivalent approach that didn’t use antibiotics, some other way of knocking out certain pathogens (phage therapy?) or altering the gut flora.
west-hunter  scitariat  discussion  speculation  ideas  agriculture  food  efficiency  disease  parasites-microbiome  medicine  drugs  pharma  retrofit  questions  dirty-hands
may 2017 by nhaliday
Annotating Greg Cochran’s interview with James Miller
https://westhunt.wordpress.com/2017/04/05/interview-2/
opinion of Scott and Hanson: https://westhunt.wordpress.com/2017/04/05/interview-2/#comment-90238
Greg's methodist: https://westhunt.wordpress.com/2017/04/05/interview-2/#comment-90256
https://westhunt.wordpress.com/2017/04/05/interview-2/#comment-90299
You have to consider the relative strengths of Japan and the USA. USA was ~10x stronger, industrially, which is what mattered. Technically superior (radar, Manhattan project). Almost entirely self-sufficient in natural resources. Japan was sure to lose, and too crazy to quit, which meant that they would lose after being smashed flat.
--
There’s a fairly common way of looking at things in which the bad guys are not at fault because they’re bad guys, born that way, and thus can’t help it. Well, we can’t help it either, so the hell with them. I don’t think we had to respect Japan’s innate need to fuck everybody in China to death.

https://westhunt.wordpress.com/2017/03/25/ramble-on/
https://westhunt.wordpress.com/2017/03/24/topics/
https://soundcloud.com/user-519115521/greg-cochran-part-1
2nd part: https://pinboard.in/u:nhaliday/b:9ab84243b967

- political correctness, the Cathedral and the left (personnel continuity but not ideology/value) at start
- joke: KT impact = asteroid mining, every mass extinction = intelligent life destroying itself
- Alawites: not really Muslim, women liberated because "they don't have souls", ended up running shit in Syria because they were only ones that wanted to help the British during colonial era
- solution to Syria: "put the Alawites in NYC"
- Zimbabwe was OK for a while, if South Africa goes sour, just "put the Boers in NYC" (Miller: left would probably say they are "culturally incompatible", lol)
- story about Lincoln and his great-great-great-grandfather
- skepticism of free speech
- free speech, authoritarianism, and defending against the Mongols
- Scott crazy (not in a terrible way), LW crazy (genetics), ex.: polyamory
- TFP or microbio are better investments than stereotypical EA stuff
- just ban AI worldwide (bully other countries to enforce)
- bit of a back-and-forth about macroeconomics
- not sure climate change will be huge issue. world's been much warmer before and still had a lot of mammals, etc.
- he quite likes Pseudoerasmus
- shits on modern conservatism/Bret Stephens a bit

- mentions Japan having industrial base a tenth the size of the US's and no chance of winning WW2 around 11m mark
- describes himself as "fairly religious" around 20m mark
- 27m30s: Eisenhower was smart, read Carlyle, classical history, etc.

The Scandals of Meritocracy. Virtue vs. competence. Would you rather have a boss who is evil but competent, or good but incompetent? The reality is you have to balance the two. Richard Nixon was probably smarter that Dwight Eisenhower in raw g, but Eisenhower was probably a better person.
org:med  west-hunter  scitariat  summary  links  podcast  audio  big-picture  westminster  politics  culture-war  academia  left-wing  ideology  biodet  error  crooked  bounded-cognition  stories  history  early-modern  africa  developing-world  death  mostly-modern  deterrence  japan  asia  war  meta:war  risk  ai  climate-change  speculation  agriculture  environment  prediction  religion  islam  iraq-syria  gender  dominant-minority  labor  econotariat  cracker-econ  coalitions  infrastructure  parasites-microbiome  medicine  low-hanging  biotech  terrorism  civil-liberty  civic  social-science  randy-ayndy  law  polisci  government  egalitarianism-hierarchy  expression-survival  disease  commentary  authoritarianism  being-right  europe  nordic  cohesion  heuristic  anglosphere  revolution  the-south  usa  thinking  info-dynamics  yvain  ssc  lesswrong  ratty  subculture  values  descriptive  epistemic  cost-disease  effective-altruism  charity  econ-productivity  technology  rhetoric  metameta  ai-control  critique  sociology  arms  paying-rent  parsimony  writing  realness  migration  eco
april 2017 by nhaliday
hmm...:
If toxo naturally can make people like cat piss, it’s already preadapted to become (with suitable genetic engineering) the model system for many kinds of infectious behavior modifiers.
west-hunter  sapiens  parasites-microbiome  disease  toxo-gondii  neuro  psychiatry  nature  discussion  commentary  gwern  medicine  🌞  embodied  scitariat  hmm  biotech  biohacking  retrofit  public-health  model-organism  pro-rata  epidemiology  drugs  pharma
march 2017 by nhaliday
I Want a New Drug | West Hunter
Big pharma has taken a new course over the past few years. In the past, most useful drugs originated in some kind of living organism – penicillin, quinine, insulin, etc etc. Nowadays, big pharmaceutical companies use combinatorial chemistry and computer modeling. Merck has sold off its biological-products research arm. This new approach, combined with doubled spending on drug R&D, has been a resounding failure. The rate of development of fundamentally new drugs – ‘new molecular entities’ – is running about 40% of that seen in the 1970s. Since big pharma makes its money from drugs that are still on patent, this slowed innovation is a real threat to their bottom line.

...

I think that this is an instance of a more general trend: often a modern, advanced approach shows up, and it persists long after it’s been shown to be a miserable failure. You can see some of the reasons why: the people trained in the new technique would lose out if it were abandoned. Hard to imagine combinatorial chemists rooting around in a garbage can looking for moldy fruit.
west-hunter  discussion  pharma  medicine  FDA  randy-ayndy  regularizer  critique  minimalism  bio  nature  low-hanging  drugs  error  scitariat  info-dynamics  innovation  ideas  discovery  meta:medicine  stagnation  parasites-microbiome  the-trenches  alt-inst  dirty-hands  regulation  civil-liberty  proposal  corporation  fashun
february 2017 by nhaliday
Why 23andMe is no longer leading on personal genomics - The Unz Review
I think one way to understand what’s going on is that though the firm’s consumer face is still as a DTC personal genomics outfit, it is really banking on becoming a genetically savvy pharmaceutical corporation. Genomics is the future, but pharm is the present.
tech  sv  genetics  biotech  news  business  genomics  gnxp  scitariat  brands  pharma
november 2016 by nhaliday
weaponizing smallpox | West Hunter
As I have said before, it seems likely to me that the Soviet Union put so much effort into treaty-violating biological warfare because the guys at the top believed in it – because they had seen it work, the same reason that they were such tank enthusiasts. One more point on the likely use of tularemia at Stalingrad: in the summer of ’42 the Germans had occupied regions holding 40% of the Soviet Union’s population. The Soviets had a tularemia program: if not then [“Not One Step Back!”], when would they have used it? When would Stalin have used it? Imagine that someone intent on the destruction of the American republic and the extermination of its people [remember the Hunger Plan?] had taken over everything west of the Mississippi: would be that too early to pull out all the stops? Reminds me of of an old Mr Boffo cartoon: you see a monster, taller than skyscrapers, stomping his way through the city. That’s trouble. But then you notice that he’s a hand puppet: that’s serious trouble. Perhaps Stalin was waiting for serious trouble, for example if the Norse Gods had come in on the side of the Nazis.

Anyhow, the Soviets had a big smallpox program. In some ways smallpox is almost the ultimate biological weapon – very contagious, while some strains are highly lethal. And it’s controllable – you can easily shield your own guys via vaccination. Of course back in the 1970s, almost everyone was vaccinated, so it was also completely useless.

We kept vaccinating people as long as smallpox was still running around in the Third World. But when it was eradicated in 1978, people stopped. There seemed to be no reason – and so, as new unvaccinated generations arose, the military efficacy of smallpox has gone up and up and up. It got to the point where the World Health organization threw away its stockpile of vaccine, a couple hundred million units, just to save on the electric bill for the refrigerators.

Consider that the Soviet Union was always the strongest proponent of worldwide eradication of smallpox, dating back to the 1950s. Successful eradication would eventually make smallpox a superweapon: does it seem possible that the people running the Soviet Union had this in mind as a long term-goal ? Potentiation through ‘eradication’? Did the left hand know what the strangling hand had in mind, and shape policies accordingly? Of course.

D.A. Henderson, the man that led the eradication campaign, died just a few days ago. He was aware of this possibility.

Dr. Henderson strenuously argued that the samples should be destroyed because, in his view, any amount of smallpox was too dangerous to tolerate. A side effect of the eradication program — and one of the “horrendous ironies of history,” said “Hot Zone” author Preston — is that since no one in generations has been exposed to the virus, most of the world’s population would be vulnerable to it in the event of an outbreak.

“I feel very — what should we say? — dispirited,” Dr. Henderson told the Times in 2002. “Here we are, regressing to defend against something we thought was permanently defeated. We shouldn’t have to be doing this.”

http://www.bbc.co.uk/history/worldwars/coldwar/pox_weapon_01.shtml#four
Ken Alibek believes that, following the collapse of the Soviet Union in 1991, unemployed or badly-paid scientists are likely to have sold samples of smallpox clandestinely and gone to work in rogue states engaged in illicit biological weapons development. DA Henderson agrees that this is a plausible scenario and is upset by the legacy it leaves. 'If the [Russian bio-weapons] programme had not taken place we would not I think be worrying about smallpox in the same way. One can feel extremely bitter and extremely angry about this because I think they've subjected the entire world to a risk which was totally unnecessary.'

also:
War in the East: https://westhunt.wordpress.com/2012/02/02/war-in-the-east/
The books generally say that biological warfare is ineffective, but then they would say that, wouldn’t they? There is reason to think it has worked, and it may have made a difference.

...

We know of course that this offensive eventually turned into a disaster in which the German Sixth Army was lost. But nobody knew that then. The Germans were moving forward with little to stop them: they were scary SOBs. Don’t let anyone tell you otherwise. The Soviet leadership was frightened, enough so that they sent out a general backs-to-the-wall, no-retreat order that told the real scale of losses. That was the Soviet mood in the summer of 42.

That’s the historical background. Now for the clues. First, Ken Alibek was a bioweapons scientist back in the USSR. In his book, Biohazard, he tells how, as a student, he was given the assignment of explaining a mysterious pattern of tularemia epidemics back in the war. To him, it looked artificial, whereupon his instructor said something to the effect of “you never thought that, you never said that. Do you want a job?” Second, Antony Beevor mentions the mysteriously poor health of German troops at Stalingrad – well before being surrounded (p210-211). Third, the fact that there were large tularemia epidemics in the Soviet Union during the war – particularly in the ‘oblasts temporarily occupied by the Fascist invaders’, described in History and Incidence of Tularemia in the Soviet Union, by Robert Pollitzer.

Fourth, personal communications from a friend who once worked at Los Alamos. Back in the 90’s, after the fall of the Soviet Union, there was a time when you could hire a whole team of decent ex-Soviet physicists for the price of a single American. My friend was having a drink with one of his Russian contractors, son of a famous ace, who started talking about how his dad had dropped tularemia here, here, and here near Leningrad (sketching it out on a napkin) during the Great Patriotic War. Not that many people spontaneously bring up stories like that in dinner conversation…

Fifth, the huge Soviet investment in biowarfare throughout the Cold War is a hint: they really, truly, believed in it, and what better reason could there be than decisive past successes? In much the same way, our lavish funding of the NSA strongly suggested that cryptanalysis and sigint must have paid off handsomely for the Allies in WWII – far more so than publicly acknowledged, until the revelations about Enigma in the 1970s and later.

We know that tularemia is an effective biological agent: many countries have worked with it, including the Soviet Union. If the Russians had had this capability in the summer of ’42 (and they had sufficient technology: basically just fermentation) , it is hard to imagine them not using it. I mean, we’re talking about Stalin. You think he had moral qualms? But we too would have used germ warfare if our situation had been desperate.

https://westhunt.wordpress.com/2012/02/02/war-in-the-east/#comment-1330
Sean, you don’t know what you’re talking about. Anybody exposed to an aerosol form of tularemia is likely to get it: 10-50 bacteria are enough to give a 50% probability of infection. You do not need to be sickly, starved, or immunosuppressed in order to contract it, although those factors probably influence its lethality. The same is true of anthrax: if it starts growing in your lungs, you get sick. You’re not born immune. There are in fact some diseases that you _are_ born immune to (most strains of sleeping sickness, for example), or at least have built-in defenses against (Epstein-Barr, cf TLRs).

A few other facts I’ve just found: First, the Soviets had a tularemia vaccine, which was used to an unclear extent at Stalingrad. At the time nobody else did.

Next, as far as I can tell, the Stalingrad epidemic is the only large-scale pneumonic tularemia epidemic that has ever occurred.

Next cool fact: during the Cold War, the Soviets were somewhat more interested in tularemia than other powers. At the height of the US biowarfare program, we produced less than two tons per year. The Soviets produced over one thousand tons of F. tularensis per year in that period.

Next question, one which deserves a serious, extended treatment. Why are so many people so very very good at coming up with wrong answers? Why do they apply Occam’s razor backwards? This is particularly common in biology. I’m not talking about Croddy in Military Medicine: he probably had orders to lie, and you can see hints of that if you read carefully.

https://archive.is/tEcgK
Joining the Army might work. In general not available to private individuals, for reasons that are largely bullshit.
war  disease  speculation  military  russia  history  len:long  west-hunter  technology  multi  c:**  parasites-microbiome  mostly-modern  arms  scitariat  communism  maxim-gun  biotech  ideas  world-war  questions  poast  occam  parsimony  trivia  data  stylized-facts  scale  bio  epidemiology  🌞  nietzschean  food  death  nihil  axioms  morality  strategy  unintended-consequences  risk  news  org:rec  prepping  profile  postmortem  people  crooked  org:anglo  thick-thin  alt-inst  flux-stasis  flexibility  threat-modeling  twitter  social  discussion  backup  prudence  government  spreading  gender  sex  sexuality  elite  ability-competence  rant  pharma  drugs  medicine  politics  ideology  impetus  big-peeps  statesmen
september 2016 by nhaliday
Personnel decision | West Hunter
https://westhunt.wordpress.com/2016/09/20/personnel-decision/#comment-83814
I think we are about due for a career civil servant within the agency or relatively recently retired from it (ideally to academia), with a PhD or M.D. and probably a pay grade of either GS-15 or Senior Executive Service (SES), who has a reputation for integrity, for intelligence, and for getting things done bureaucratically, with some low profile political connections (at least to the ruling party but ideally to both political parties) in private life as well (e.g. through friendships made at a top college, a politician or top political aide parent, or friendships made while attending a top D.C. private school like Sidwell Friends or St. Albion’s or National Cathedral School).

Few federal agencies call for more subject-matter competence to understand its functions well enough to run it well.
--
The problem is that the typical member of the set you describe is nuts. Members have a lot of incorrect ideas in their heads: in fact, you have to express support of those ideas or you are expelled. So, that means that every educational improvement plan pushed by the Feds fails: you can’t do anything realistic, or you would be a bad person. Every intervention in the Middle East fails: same reason. AIDs shows up, so we abandon quarantine: Fidel Castro deals with the situation 50 times better than we did.

The Aztecs thought that the world would end if they didn’t keep cutting people’s hearts out on an industrial scale. They were crazy. But were they crazier than we are?
FDA  regulation  discussion  government  rhetoric  commentary  west-hunter  pharma  policy  meta:medicine  scitariat  proposal  counter-revolution  innovation  stagnation  randy-ayndy  trump  2016-election  alt-inst  money  elections  politics  polisci  variance-components  data  corruption  gilens-page  questions  multi  poast  info-dynamics  institutions  elite  ability-competence  truth  westminster  roots  usa  virginia-DC  is-ought  education  MENA  iraq-syria  disease  spreading  gender  sex  sexuality  prudence  ideology  social-science  empirical  evidence-based  religion
september 2016 by nhaliday
Eroom's Law - Wikipedia, the free encyclopedia
drug discovery is becoming slower and more expensive over time

While some suspect a lack of "low hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades worth of new potential drug targets relative to the number of drugged targets, even if the industry exploits 4-5 new targets per year.[2] There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.[4]
healthcare  medicine  concept  street-fighting  wiki  trends  drugs  pharma  hmm  meta:medicine  stylized-facts  low-hanging  stagnation  discovery  info-dynamics
september 2016 by nhaliday
EpiPenomenon – Put A Number On It!
I am no longer confident that the FDA harms more lives than it saves, and thus I no longer endorse setting fire to it, pending further investigation. What changed my mind was not the commenters disparaging me as a “101 economist” in the comments. What changed my mind was my mom, a long-time professional in the pharmaceutics industry, explaining in detail the rules the FDA plays by and the exact procedures and standards they follow.
ratty  healthcare  drugs  regularizer  policy  len:long  ssc  FDA  regulation  pharma
september 2016 by nhaliday
Reverse Voxsplaining: Drugs vs. Chairs | Slate Star Codex
Let me ask Vox a question: when was the last time that America’s chair industry hiked the price of chairs 400% and suddenly nobody in the country could afford to sit down? When was the last time that the mug industry decided to charge \$300 per cup, and everyone had to drink coffee straight from the pot or face bankruptcy? When was the last time greedy shoe executives forced most Americans to go barefoot? And why do you think that is?
medicine  critique  regularizer  drugs  policy  regulation  healthcare  ssc  unintended-consequences  nl-and-so-can-you  media  pharma  wonkish  meta:medicine  ratty  yvain
august 2016 by nhaliday
Blue or Green on Regulation? - Less Wrong
The FDA prevents 5,000 casualties per year but causes at least 20,000-120,000 casualties by delaying approval of beneficial medications. The second number is calculated only by looking at delays in the introduction of medications eventually approved - not medications never approved, or medications for which approval was never sought. FDA fatalities are comparable to the annual number of fatal car accidents, but the noneffects of medications not approved don't make the evening news. A bureaucrat's chief incentive is not to approve anything that will ever harm anyone in a way that makes it into the newspaper; no other cost-benefit calculus is involved as an actual career incentive. The bureaucracy as a whole may have an incentive to approve at least some new products - if the FDA never approved a new medication, Congress would become suspicious - but any individual bureaucrat has an unlimited incentive to say no. Regulators have no career motive to do any sort of cost-benefit calculation - except of course for the easy career-benefit calculation. A product with a failure mode spectacular enough to make the newspapers will be banned regardless of what other good it might do; one-reason decisionmaking. As with the FAA banning toenail clippers on planes, "safety precautions" are primarily an ostentatious display of costly efforts so that, when a catastrophe does occur, the agency will be seen to have tried its hardest.
policy  government  drugs  medicine  rationality  arbitrage  regulation  lesswrong  healthcare  FDA  unintended-consequences  ratty  pharma  cost-benefit  incentives
august 2016 by nhaliday

bundles : embodiedframe

Copy this bookmark:

description:

tags: