nhaliday + obesity   57

Who We Are | West Hunter
I’m going to review David Reich’s new book, Who We Are and How We Got Here. Extensively: in a sense I’ve already been doing this for a long time. Probably there will be a podcast. The GoFundMe link is here. You can also send money via Paypal (Use the donate button), or bitcoins to 1Jv4cu1wETM5Xs9unjKbDbCrRF2mrjWXr5. In-kind donations, such as orichalcum or mithril, are always appreciated.

This is the book about the application of ancient DNA to prehistory and history.

height difference between northern and southern europeans: https://westhunt.wordpress.com/2018/03/29/who-we-are-1/
mixing, genocide of males, etc.: https://westhunt.wordpress.com/2018/03/29/who-we-are-2-purity-of-essence/
rapid change in polygenic traits (appearance by Kevin Mitchell and funny jab at Brad Delong ("regmonkey")): https://westhunt.wordpress.com/2018/03/30/rapid-change-in-polygenic-traits/
schiz, bipolar, and IQ: https://westhunt.wordpress.com/2018/03/30/rapid-change-in-polygenic-traits/#comment-105605
Dan Graur being dumb: https://westhunt.wordpress.com/2018/04/02/the-usual-suspects/
prediction of neanderthal mixture and why: https://westhunt.wordpress.com/2018/04/03/who-we-are-3-neanderthals/
New Guineans tried to use Denisovan admixture to avoid UN sanctions (by "not being human"): https://westhunt.wordpress.com/2018/04/04/who-we-are-4-denisovans/
also some commentary on decline of Out-of-Africa, including:
"Homo Naledi, a small-brained homonin identified from recently discovered fossils in South Africa, appears to have hung around way later that you’d expect (up to 200,000 years ago, maybe later) than would be the case if modern humans had occupied that area back then. To be blunt, we would have eaten them."

Live Not By Lies: https://westhunt.wordpress.com/2018/04/08/live-not-by-lies/
Next he slams people that suspect that upcoming genetic genetic analysis will, in most cases, confirm traditional stereotypes about race – the way the world actually looks.

The people Reich dumps on are saying perfectly reasonable things. He criticizes Henry Harpending for saying that he’d never seen an African with a hobby. Of course, Henry had actually spent time in Africa, and that’s what he’d seen. The implication is that people in Malthusian farming societies – which Africa was not – were selected to want to work, even where there was no immediate necessity to do so. Thus hobbies, something like a gerbil running in an exercise wheel.

He criticized Nicholas Wade, for saying that different races have different dispositions. Wade’s book wasn’t very good, but of course personality varies by race: Darwin certainly thought so. You can see differences at birth. Cover a baby’s nose with a cloth: Chinese and Navajo babies quietly breathe through their mouth, European and African babies fuss and fight.

Then he attacks Watson, for asking when Reich was going to look at Jewish genetics – the kind that has led to greater-than-average intelligence. Watson was undoubtedly trying to get a rise out of Reich, but it’s a perfectly reasonable question. Ashkenazi Jews are smarter than the average bear and everybody knows it. Selection is the only possible explanation, and the conditions in the Middle ages – white-collar job specialization and a high degree of endogamy, were just what the doctor ordered.

Watson’s a prick, but he’s a great prick, and what he said was correct. Henry was a prince among men, and Nick Wade is a decent guy as well. Reich is totally out of line here: he’s being a dick.

Now Reich may be trying to burnish his anti-racist credentials, which surely need some renewal after having pointing out that race as colloquially used is pretty reasonable, there’s no reason pops can’t be different, people that said otherwise ( like Lewontin, Gould, Montagu, etc. ) were lying, Aryans conquered Europe and India, while we’re tied to the train tracks with scary genetic results coming straight at us. I don’t care: he’s being a weasel, slandering the dead and abusing the obnoxious old genius who laid the foundations of his field. Reich will also get old someday: perhaps he too will someday lose track of all the nonsense he’s supposed to say, or just stop caring. Maybe he already has… I’m pretty sure that Reich does not like lying – which is why he wrote this section of the book (not at all logically necessary for his exposition of the ancient DNA work) but the required complex juggling of lies and truth required to get past the demented gatekeepers of our society may not be his forte. It has been said that if it was discovered that someone in the business was secretly an android, David Reich would be the prime suspect. No Talleyrand he.

The population that accounts for the vast majority of Native American ancestry, which we will call Amerinds, came into existence somewhere in northern Asia. It was formed from a mix of Ancient North Eurasians and a population related to the Han Chinese – about 40% ANE and 60% proto-Chinese. Is looks as if most of the paternal ancestry was from the ANE, while almost all of the maternal ancestry was from the proto-Han. [Aryan-Transpacific ?!?] This formation story – ANE boys, East-end girls – is similar to the formation story for the Indo-Europeans.

In some ways, on some questions, learning more from genetics has left us less certain. At this point we really don’t know where anatomically humans originated. Greater genetic variety in sub-Saharan African has been traditionally considered a sign that AMH originated there, but it possible that we originated elsewhere, perhaps in North Africa or the Middle East, and gained extra genetic variation when we moved into sub-Saharan Africa and mixed with various archaic groups that already existed. One consideration is that finding recent archaic admixture in a population may well be a sign that modern humans didn’t arise in that region ( like language substrates) – which makes South Africa and West Africa look less likely. The long-continued existence of homo naledi in South Africa suggests that modern humans may not have been there for all that long – if we had co-existed with homo naledi, they probably wouldn’t lasted long. The oldest known skull that is (probably) AMh was recently found in Morocco, while modern humans remains, already known from about 100,000 years ago in Israel, have recently been found in northern Saudi Arabia.

While work by Nick Patterson suggests that modern humans were formed by a fusion between two long-isolated populations, a bit less than half a million years ago.

So: genomics had made recent history Africa pretty clear. Bantu agriculuralists expanded and replaced hunter-gatherers, farmers and herders from the Middle East settled North Africa, Egypt and northeaat Africa, while Nilotic herdsmen expanded south from the Sudan. There are traces of earlier patterns and peoples, but today, only traces. As for questions back further in time, such as the origins of modern humans – we thought we knew, and now we know we don’t. But that’s progress.

David Reich’s professional path must have shaped his perspective on the social sciences. Look at the record. He starts his professional career examining the role of genetics in the elevated prostate cancer risk seen in African-American men. Various social-science fruitcakes oppose him even looking at the question of ancestry ( African vs European). But they were wrong: certain African-origin alleles explain the increased risk. Anthropologists (and human geneticists) were sure (based on nothing) that modern humans hadn’t interbred with Neanderthals – but of course that happened. Anthropologists and archaeologists knew that Gustaf Kossina couldn’t have been right when he said that widespread material culture corresponded to widespread ethnic groups, and that migration was the primary explanation for changes in the archaeological record – but he was right. They knew that the Indo-European languages just couldn’t have been imposed by fire and sword – but Reich’s work proved them wrong. Lots of people – the usual suspects plus Hindu nationalists – were sure that the AIT ( Aryan Invasion Theory) was wrong, but it looks pretty good today.

Some sociologists believed that caste in India was somehow imposed or significantly intensified by the British – but it turns out that most jatis have been almost perfectly endogamous for two thousand years or more…

It may be that Reich doesn’t take these guys too seriously anymore. Why should he?

varnas, jatis, aryan invastion theory: https://westhunt.wordpress.com/2018/04/22/who-we-are-8-india/

europe and EEF+WHG+ANE: https://westhunt.wordpress.com/2018/05/01/who-we-are-9-europe/

The massive mixture events that occurred in the recent past to give rise to Europeans and South Asians, to name just two groups, were likely “male mediated.” That’s another way of saying that men on the move took local women as brides or concubines. In the New World there are many examples of this, whether it be among African Americans, where most European ancestry seems to come through men, or in Latin America, where conquistadores famously took local women as paramours. Both of these examples are disquieting, and hint at the deep structural roots of patriarchal inequality and social subjugation that form the backdrop for the emergence of many modern peoples.
west-hunter  scitariat  books  review  sapiens  anthropology  genetics  genomics  history  antiquity  iron-age  world  europe  gavisti  aDNA  multi  politics  culture-war  kumbaya-kult  social-science  academia  truth  westminster  environmental-effects  embodied  pop-diff  nordic  mediterranean  the-great-west-whale  germanic  the-classics  shift  gene-flow  homo-hetero  conquest-empire  morality  diversity  aphorism  migration  migrant-crisis  EU  africa  MENA  gender  selection  speed  time  population-genetics  error  concrete  econotariat  economics  regression  troll  lol  twitter  social  media  street-fighting  methodology  robust  disease  psychiatry  iq  correlation  usa  obesity  dysgenics  education  track-record  people  counterexample  reason  thinking  fisher  giants  old-anglo  scifi-fantasy  higher-ed  being-right  stories  reflection  critique  multiplicative  iteration-recursion  archaics  asia  developing-world  civil-liberty  anglo  oceans  food  death  horror  archaeology  gnxp  news  org:mag  right-wing  age-of-discovery  latin-america  ea 
march 2018 by nhaliday
The Falling Price of Fat | Pseudoerasmus
Summary : There are too many baroque explanations for the increased prevalence of obesity. I suggest a simple mechanism : falling food prices, rising incomes.
econotariat  broad-econ  pseudoE  economics  supply-demand  food  obesity  trends  explanans  cynicism-idealism  money  compensation  cost-benefit  backup  epidemiology  public-health  roots  regularizer  parsimony 
february 2018 by nhaliday
Why has the prevalence of obesity doubled? | SpringerLink
The prevalence of obesity has doubled over the last 25 years. We estimate the effects of multiple socio-environmental factors (e.g., physical demands at work, restaurants, food prices, cigarette smoking, food stamps, and urban sprawl) on obesity using NLSY data. Then we use the Oaxaca–Blinder decomposition technique to approximate the contribution of each socio-environmental factor to the increase during this time. Many socio-environmental factors significantly affect weight, but none are able to explain a large portion of the obesity increase. Decreases in cigarette smoking consistently explains about 2–4 % of the increase in obesity and BMI. Food stamp receipt also consistently affects the measures of weight, but the small decrease in food stamp program participation during the period we examine actually dampened the increases in obesity and BMI. Collectively, the socio-environmental factors we examine never explain more than about 6.5 % of the weight increases.
study  sociology  medicine  health  epidemiology  public-health  obesity  trends  roots  explanans  labor  supply-demand  food  welfare-state  urban-rural  variance-components  volo-avolo  questions 
february 2018 by nhaliday
Scanners Live in Vain | West Hunter
Of course, finding that the pattern already exists at the age of one month seriously weakens any idea that being poor shrinks the brain: most of the environmental effects you would consider haven’t even come into play in the first four weeks, when babies drink milk, sleep, and poop. Genetics affecting both parents and their children would make more sense, if the pattern shows up so early (and I’ll bet money that, if real,  it shows up well before one month);  but Martha Farah, and the reporter from Nature, Sara Reardon, ARE TOO FUCKING DUMB to realize this.

Correlation between brain volume and IQ is about 0.4 . Shows up clearly in studies with sufficient power.

“poverty affects prenatal environment a lot.” No it does not. “poverty” in this country means having plenty to eat.

The Great IQ Depression: https://westhunt.wordpress.com/2014/03/07/the-great-iq-depression/
We hear that poverty can sap brainpower, reduce frontal lobe function, induce the fantods, etc. But exactly what do we mean by ‘poverty’? If we’re talking about an absolute, rather than relative, standard of living, most of the world today must be in poverty, as well as almost everyone who lived much before the present. Most Chinese are poorer than the official US poverty level, right? The US had fairly rapid economic growth until the last generation or so, so if you go very far back in time, almost everyone was poor, by modern standards. Even those who were considered rich at the time suffered from zero prenatal care, largely useless medicine, tabletless high schools, and slow Internet connections. They had to ride horses that had lousy acceleration and pooped all over the place.

In particular, if all this poverty-gives-you-emerods stuff is true, scholastic achievement should have collapsed in the Great Depression – and with the miracle of epigenetics, most of us should still be suffering those bad effects.

But somehow none of this seems to have gone through the formality of actually happening.
west-hunter  scitariat  commentary  study  org:nat  summary  rant  critique  neuro  neuro-nitgrit  brain-scan  iq  class  correlation  compensation  pop-diff  biodet  behavioral-gen  westminster  experiment  attaq  measure  multi  discussion  ideas  history  early-modern  pre-ww2  usa  gedanken  analogy  comparison  time  china  asia  world  developing-world  economics  growth-econ  medicine  healthcare  epigenetics  troll  aphorism  cycles  obesity  poast  nutrition  hypochondria  explanans 
august 2017 by nhaliday
Alzheimers | West Hunter
Some disease syndromes almost have to be caused by pathogens – for example, any with a fitness impact (prevalence x fitness reduction) > 2% or so, too big to be caused by mutational pressure. I don’t think that this is the case for AD: it hits so late in life that the fitness impact is minimal. However, that hardly means that it can’t be caused by a pathogen or pathogens – a big fraction of all disease syndromes are, including many that strike in old age. That possibility is always worth checking out, not least because infectious diseases are generally easier to prevent and/or treat.

There is new work that strongly suggests that pathogens are the root cause. It appears that the amyloid is an antimicrobial peptide. amyloid-beta binds to invading microbes and then surrounds and entraps them. ‘When researchers injected Salmonella into mice’s hippocampi, a brain area damaged in Alzheimer’s, A-beta quickly sprang into action. It swarmed the bugs and formed aggregates called fibrils and plaques. “Overnight you see the plaques throughout the hippocampus where the bugs were, and then in each single plaque is a single bacterium,” Tanzi says. ‘

obesity and pathogens: https://westhunt.wordpress.com/2016/05/29/alzheimers/#comment-79757
not sure about this guy, but interesting: https://westhunt.wordpress.com/2016/05/29/alzheimers/#comment-79748

All too often we see large, long-lasting research efforts that never produce, never achieve their goal.

For example, the amyloid hypothesis [accumulation of amyloid-beta oligomers is the cause of Alzheimers] has been dominant for more than 20 years, and has driven development of something like 15 drugs. None of them have worked. At the same time the well-known increased risk from APOe4 has been almost entirely ignored, even though it ought to be a clue to the cause.

In general, when a research effort has been spinning its wheels for a generation or more, shouldn’t we try something different? We could at least try putting a fraction of those research dollars into alternative approaches that have not yet failed repeatedly.

Mostly this applies to research efforts that at least wish they were science. ‘educational research’ is in a special class, and I hardly know what to recommend. Most of the remedial actions that occur to me violate one or more of the Geneva conventions.

APOe4 related to lymphatic system: https://en.wikipedia.org/wiki/Apolipoprotein_E

Look,if I could find out the sort of places that I usually misplace my keys – if I did, which I don’t – I could find the keys more easily the next time I lose them. If you find out that practitioners of a given field are not very competent, it marks that field as a likely place to look for relatively easy discovery. Thus medicine is a promising field, because on the whole doctors are not terribly good investigators. For example, none of the drugs developed for Alzheimers have worked at all, which suggests that our ideas on the causation of Alzheimers are likely wrong. Which suggests that it may (repeat may) be possible to make good progress on Alzheimers, either by an entirely empirical approach, which is way underrated nowadays, or by dumping the current explanation, finding a better one, and applying it.

You could start by looking at basic notions of field X and asking yourself: How do we really know that? Is there serious statistical evidence? Does that notion even accord with basic theory? This sort of checking is entirely possible. In most of the social sciences, we don’t, there isn’t, and it doesn’t.

Hygiene and the world distribution of Alzheimer’s disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden: https://academic.oup.com/emph/article/2013/1/173/1861845/Hygiene-and-the-world-distribution-of-Alzheimer-s

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease: http://stm.sciencemag.org/content/8/340/340ra72

Fungus, the bogeyman: http://www.economist.com/news/science-and-technology/21676754-curious-result-hints-possibility-dementia-caused-fungal
Fungus and dementia
paper: http://www.nature.com/articles/srep15015
west-hunter  scitariat  disease  parasites-microbiome  medicine  dementia  neuro  speculation  ideas  low-hanging  todo  immune  roots  the-bones  big-surf  red-queen  multi  🌞  poast  obesity  strategy  info-foraging  info-dynamics  institutions  meta:medicine  social-science  curiosity  🔬  science  meta:science  meta:research  wiki  epidemiology  public-health  study  arbitrage  alt-inst  correlation  cliometrics  path-dependence  street-fighting  methodology  nibble  population-genetics  org:nat  health  embodied  longevity  aging  org:rec  org:biz  org:anglo  news  neuro-nitgrit  candidate-gene  nutrition  diet  org:health  explanans  fashun  empirical  theory-practice  ability-competence  dirty-hands  education  aphorism  truth  westminster  innovation  evidence-based  religion  prudence  track-record  problem-solving 
july 2017 by nhaliday
The Effect of Smoking on Obesity: Evidence from a Randomized Trial
These results imply that the drop in smoking in recent decades explains 14% of the concurrent rise in obesity.
study  lol  economics  sociology  epidemiology  public-health  obesity  🐸  gnon  mena4  health  embodied  trends  variance-components  roots  explanans 
june 2017 by nhaliday
The Genomic Health Of Ancient Hominins | bioRxiv
On a broad scale, hereditary disease risks are similar for ancient hominins and modern-day humans, and the GRS percentiles of ancient individuals span the full range of what is observed in present day individuals. In addition, there is evidence that ancient pastoralists may have had healthier genomes than hunter-gatherers and agriculturalists. We also observed a temporal trend whereby genomes from the recent past are more likely to be healthier than genomes from the deep past.

Gwern has interesting take (abstract is misleading): https://twitter.com/gwern/status/871061144152178688

here it is in conclusion (and cf Figure 3A):
The genomic health of ancient individuals appears to have improved over time (Figure 3B). This calls into question the idea that genetic load has been increasing in human populations (Lynch 2016). However, there exists a perplexing pattern: ancient individuals who lived within the last few thousand years have healthier genomes, on average, than present day humans.

After controlling for age, BMI, and other variables, knee OA prevalence was 2.1-fold higher (95% confidence interval, 1.5–3.1) in the postindustrial sample than in the early industrial sample. Our results indicate that increases in longevity and BMI are insufficient to explain the approximate doubling of knee OA prevalence that has occurred in the United States since the mid-20th century. Knee OA is thus more preventable than is commonly assumed, but prevention will require research on additional independent risk factors that either arose or have become amplified in the postindustrial era.
study  bio  preprint  sapiens  genetics  biodet  disease  health  history  antiquity  aDNA  farmers-and-foragers  agriculture  anthropology  GWAS  genetic-load  multi  twitter  social  commentary  gwern  dysgenics  trends  mutation  embodied  org:nat  obesity  public-health  epidemiology  🌞  science-anxiety 
june 2017 by nhaliday
Secular decline in testosterone levels - Rogue Health and Fitness
A Population-Level Decline in Serum Testosterone Levels in American Men: http://sci-hub.tw/10.1210/jc.2006-1375
Secular trends in sex hormones and fractures in men and women: http://www.eje-online.org/content/166/5/887.full.pdf
Small n and older sample, but interesting that while testosterone decreases have been large for men they’ve been even larger (in % terms) for women; wonder if this contributes to declining pregnancy and sexual frequency, rising depression.

Strangelove: https://youtu.be/N1KvgtEnABY?t=67

People offering human-centric explanations like cell phones: Note also that the sperm quality of dogs has decreased 30% since 1988.

mendelian rand.:
1 SD genetically instrumented increase in BMI was associated with a 0.25 SD decrease in serum testosterone

Ibuprofen linked to male infertility: study: https://nypost.com/2018/01/08/ibuprofen-linked-to-male-infertility-study/

Tucker Carlson: "Men Seem To Be Becoming Less Male": https://www.realclearpolitics.com/video/2018/03/08/tucker_carlson_men_seem_to_be_becoming_less_male.html
Carlson interviewed Dr. Jordan Peterson who blamed the "insidious" movement being driven by the "radical left" that teaches there a problem of "toxic masculinity." He said ideological policies focus on "de-emphasizing masculinity may be part of the problem."


Those are the numbers. They paint a very clear picture: American men are failing, in body, mind and spirit. This is a crisis. Yet our leaders pretend it’s not happening. They tell us the opposite is true: Women are victims, men are oppressors. To question that assumption is to risk punishment. Even as women far outpace men in higher education, virtually every college campus supports a women’s studies department, whose core goal is to attack male power. Our politicians and business leaders internalize and amplify that message. Men are privileged. Women are oppressed. Hire and promote and reward accordingly.

But it also hints at an almost opposite take: average testosterone levels have been falling for decades, so at this point these businessmen would be the only “normal” (by 1950s standards) men out there, and everyone else would be unprecedently risk-averse and boring.
org:health  fitsci  health  endocrine  trends  public-health  science-anxiety  gender  commentary  multi  study  pdf  data  piracy  white-paper  gnon  news  org:mag  right-wing  fertility  dysgenics  drugs  psychiatry  stress  politics  government  hypochondria  idk  embodied  FDA  externalities  epidemiology  video  film  classic  org:lite  org:anglo  genetics  endo-exo  mendel-randomization  obesity  fitness  scitariat  🌞  medicine  correlation  intervention  causation  GWAS  environmental-effects  hn  org:sci  popsci  model-organism  embodied-cognition  hmm  org:davos  communism  memes(ew)  fluid  endogenous-exogenous  roots  explanans  org:local  summary  modernity  rot  org:nat  chart  the-bones  albion  canada  journos-pundits  philosophy  iq  coming-apart  malaise  gender-diff  attention  disease  opioids  death  interview  current-events  tv  higher-ed  labor  management  compensation  grad-school  law  twitter  social  backup  ratty  unaffiliated  yvain  ssc 
may 2017 by nhaliday
Book Review: The Hungry Brain | Slate Star Codex
The research of James Levine, an endocrinologist who works with the Mayo Clinic and Arizona State University, explains this puzzling phenomenon. In a carefully controlled overfeeding study, his team showed that the primary reason some people readily burn off excess calories is that they ramp up a form of calorie-burning called “non-exercise activity thermogenesis” (NEAT). NEAT is basically a fancy term for fidgeting. When certain people overeat, their brains boost calorie expenditure by making them fidget, change posture frequently, and make other small movements throughout the day. It’s an involuntary process, and Levine’s data show that it can incinerate nearly 700 calories per day. The “most gifted” of Levine’s subjects gained less than a pound of body fat from eating 1,000 extra calories per day for eight weeks. Yet the strength of the response was highly variable, and the “least gifted” of Levine’s subjects didn’t increase NEAT at all, shunting all the excess calories into fat tissue and gaining over nine pounds of body fat…
ratty  yvain  ssc  books  review  taubes-guyenet  nutrition  diet  food  health  obesity  epidemiology  public-health  fitsci  summary  genetics  biodet  variance-components  behavioral-gen 
april 2017 by nhaliday
‘How dare you work on whites’: Professors under fire for research on white mortality - The Washington Post
the paper: http://www.pnas.org/content/112/49/15078

The Nobel laureate Angus Deaton discusses extreme poverty, opioid addiction, Trump voters, robots, and rent-seeking.

co-authored the "dead white people paper" w/ wife

point about expansion of education seems important


Diverging Life Expectancies and Voting Patterns in the 2016 US Presidential Election.: https://www.ncbi.nlm.nih.gov/pubmed/28817322
Changes in county life expectancy from 1980 to 2014 were strongly negatively associated with Trump's vote share, with less support for Trump in counties experiencing greater survival gains. Counties in which life expectancy stagnated or declined saw a 10-percentage-point increase in the Republican vote share between 2008 and 2016.

DESPAIR AND DECADES-LONG DEINDUSTRIALIZATION: https://spottedtoad.wordpress.com/2018/01/10/despair-and-decades-long-deindustrialization/

WE’VE BEEN HERE BEFORE: https://spottedtoad.wordpress.com/2018/01/12/weve-been-here-before/
A concept that seems to me to be missing from the Ruhm vs. Case/Deaton debate on “deaths of despair” is that of social crisis.

This seems to me to be the case for American Indians, who began experiencing what looks like a similar social crisis to non-college educated whites about a decade beforehand: rapidly escalating rates of suicide, drug overdoses, exit from the workforce, and even alcohol-related deaths (which were already very high for American Indians well before 2000, of course):


The common thread here would seem to be replacement of workforce participation with transfer payments, particularly cash transfers (since, my own reservations about Medicaid aside, increases in in-kind payments and SNAP since the 80s haven’t seemed to exert the same disruptive effect.) As I’ve said before, it seems very likely to me that technology will push an ever larger segment of society out of the economy, sooner or later, but how to prevent this from tearing apart our social fabric I don’t know.

Once It Was Overdue Books. Now Librarians Fight Overdoses.: https://www.nytimes.com/2018/02/28/nyregion/librarians-opioid-heroin-overdoses.html
news  org:rec  current-events  sociology  academia  society  race  managerial-state  patho-altruism  class  clown-world  malaise  death  longevity  education  stagnation  wonkish  autor  opioids  public-health  coming-apart  dignity  org:mag  labor  usa  trends  age-generation  politics  social-capital  health  demographics  study  summary  anomie  economics  inequality  rent-seeking  automation  2016-election  drugs  interview  comparison  developing-world  midwest  northeast  trump  gelman  scitariat  gender  confounding  media  regularizer  class-warfare  medicine  polisci  disease  org:nat  epidemiology  data  spock  causation  analysis  ratty  unaffiliated  obesity  correlation  critique  debate  chart  🎩  visualization  time-series  multi  nihil  speculation  roots  impetus  trade  nationalism-globalism  china  asia  monetary-fiscal  money  debt  investing  heavy-industry  world  the-bones  rot  unintended-consequences  farmers-and-foragers  africa  reflection  welfare-state  futurism  books  urban-rural 
april 2017 by nhaliday
Meta-analysis: Impact of carbohydrate vs. fat calories on energy expenditure and body fatness
They identified 28 studies that met their criteria for energy expenditure.  Combining the data of these 28 studies, they found that calorie-matched diets predominating in fat vs. carbohydrate have almost identical effects, but higher-carbohydrate diets do lead to a slightly higher energy expenditure.  This difference was statistically significant but of little medical or practical relevance, since it only amounted to 26 Calories per day.  This slightly higher energy expenditure is consistent with the fact that the metabolism of carbohydrate is slightly less efficient than the metabolism of fat, meaning that a bit more energy is wasted*.

Examining the data, the paper’s result is not hard to believe because only 8 of the 28 studies reported that lower-carbohydrate diets led to a higher energy expenditure than higher-carbohydrate diets, and among those 8, the results were only statistically significant in four.  In contrast, 20 studies reported higher energy expenditure with higher-carbohydrate diets, and that was statistically significant in 14.  One can choose individual studies that support either belief, but the overall evidence suggests that the relative carbohydrate and fat content of the diet has little impact on energy expenditure.

Onward to body fatness.  Hall and Guo identified 20 controlled feeding studies that reported changes in body fatness on equal-calorie diets differing in fat and carbohydrate content.  Echoing the energy expenditure finding, they found that diets predominating in carbohydrate or fat have similar effects on body fatness.  Yet higher-carbohydrate diets do lead to a slightly greater loss of body fat per calorie, amounting to a 16 gram per day difference.  This is actually a larger difference than one would predict from the difference in energy expenditure, which would only be 2.8 g/day.
taubes-guyenet  org:health  health  diet  nutrition  fitsci  commentary  study  summary  meta-analysis  field-study  intervention  obesity  comparison  metabolic 
march 2017 by nhaliday
Whole Health Source: The Glycemic Index: A Critical Evaluation
Overall, these studies do not support the idea that lowering the glycemic index of carbohydrate foods is useful for weight loss, insulin or glucose control, or anything else besides complicating your life. I'll keep my finger on the pulse of this research as it expands, but for the time being I don't see the glycemic index per se as a significant way to combat fat gain or metabolic disease.
critique  concept  diet  nutrition  stamina  embodied-cognition  embodied  health  taubes-guyenet  org:health  contrarianism  fitsci  obesity  metrics 
march 2017 by nhaliday
Whole Health Source: The Potato Diet
1. Potatoes have a low calorie density and a high satiety value per calorie.
2. Eating a diet that is composed almost exclusively of one food is low in reward, low-moderate palatability, low in variety, and has a high sensory-specific satiety. Even if you dress up your potatoes as well as you can, you're still eating potatoes. This tends to reduce calorie intake.
3. Potatoes are nutritious enough (including complete protein) that they can be the sole source of calories for an extended period of time. However, they are not a complete source of all micronutrients and deficiencies will eventually arise.
diet  nutrition  food  rhetoric  analysis  models  taubes-guyenet  org:health  health  obesity  fitsci  prepping  minimum-viable  efficiency 
march 2017 by nhaliday
Social Epistasis Amplifies the Fitness Costs of Deleterious Mutations, Engendering Rapid Fitness Decline Among Modernized Populations | SpringerLink
- Michael A. Woodley

We argue that in social species, interorganismal gene-gene interactions, which in previous literatures have been termed social epistasis, allow genomes carrying deleterious mutations to reduce via group-level pleiotropy the fitness of others, including noncarriers. This fitness reduction occurs by way of degradation of group-level processes that optimize the reproductive ecology of a population for intergroup competition through, among other mechanisms, suppression of free-riding.


Fitness indicators theory (Houle 2000; Miller 2000) predicts that the behavioral and physiological condition of prospective partners strongly influences female mate choice in particular, as these constitute honest indicators of underlying genetic quality. Furthermore, as deleterious mutations are pleiotropic (i.e., they can influence the development of multiple traits simultaneously), they are a source of genetic correlation among diverse behavioral and physiological domains, yielding a latent general fitness factor( f ). This optimizes the efficiency of sexual selection, as selection for quality with respect to one domain will increase the probability of selection for quality “across the board” (Houle 2000; Miller 2000). If purifying selection is primarily cryptic—working by virtue of those lower in f simply being less successful in competition for mates and therefore producing fewer offspring relative to those higher in the factor—then considerably less reproductive failure is needed to solve the mutation load paradox (19% instead of 88% based on simulations in Leseque et al. 2012).


Theoretical work involving humans suggests a loss of intrinsic fitness of around 1% per generation in the populations of modernized countries (Lynch 2016; Muller 1950). Thus, these might yet be undergoing mutational meltdown, albeit very gradually (i.e., over the course of centuries)


An interesting observation is that the fitness of the populations of modernized nations does appear to be rapidly decreasing—although not in a manner consonant with the direct action of deleterious mutations on the fitness of individuals (as per the mutation load paradox).


Increased education has furthermore encouraged individuals to trade fertility against opportunities to enhance their social status and earning power, with the largest fitness losses occurring among those with high status who potentially carry fewer deleterious mutations (i.e., by virtue of possessing higher levels of traits that exhibit some sensitivity to mutation load, such as general intelligence; Spain et al. 2015; Woodley of Menie et al. 2016a). Hitherto not considered is the possibility that the demographic transition represents a potential change in the fitness characteristics of the group-level extended phenotype of modernized populations, indicating that there might exist pathways through which deleterious mutations that accumulate due to ecological mildness could pathologically alter fertility tradeoffs in ways that might account for the maladaptive aspects of the fertility transition (e.g., subreplacement fertility; Basten, Lutz and Scherbov, 2013).


Cooperation, though offering significant fitness benefits to individual organisms and groups, involves some costs for cooperators in order to realize mutual gains for all parties. Free riders are individuals that benefit from cooperation without suffering any of the costs needed to sustain it. Hence, free riders enjoy a fitness advantage relative to cooperators via the former’s parasitism on the latter.


The balance of selection can alternate between the different levels depending on the sorts of selective challenges that a population encounters. For example, group selection may operate on human populations during times of intergroup conflict (i.e., warfare), whereas during times of peace, selection may tend to favor the fitness of individuals instead (Woodley and Figueredo 2013; Wilson 2002). A major factor that seems to permit group-level selection to be viable under certain ecological regimes is the existence of free-rider controls, i.e., features of the group’s social ecology that curb the reproductive fitness of the carriers of “selfish” genetic variants (MacDonald 1994; Wilson 2002).


High-status individuals participate in the generation and vertical cultural transmission of free-rider controls—these take the form of religious and ideological systems which make a virtue out of behaviors that overtly benefit the group, and a vice out of those that only favor individual-level fitness, via the promotion of ethnocentrism, martyrdom, and displays of commitment (MacDonald 1994, 2009, 2010; Wilson 2002). Humans are furthermore equipped with specialized mental adaptations for coordinating as part of a group, such as effortful control—the ability to override implicit behavioral drives via the use of explicit processing systems, which allow them to regulate their behavior based on what is optimal for the group (MacDonald 2008). The interaction between individuals of different degrees of status, i.e., those that generate and maintain cultural norms and those who are merely subject to them, therefore constitutes a form of social epistasis, as the complex patterns of interactions among genomes that characterize human culture have the effect of regulating both individual- and group-level (via the curbing of free-riding) fitness (MacDonald 2009, 2010).

Mutations that push the behavior of high-status individuals away from the promotion of group-selected norms may promote a breakdown of or otherwise alter these social epistatic interactions, causing dysregulation of the group’s reproductive ecology. Behavioral changes are furthermore a highly likely consequence of mutation accumulation, as “behavior” (construed broadly) is a large potential target for new mutations (Miller 2000; Lynch 2016) 1 owing to the fact that approximately 84% of all genes in the human genome are involved in some aspect of brain development and/or maintenance (Hawrylycz et al. 2012).

Consistent with the theorized role of group-level (cultural) regulatory processes in the maintenance of fitness optima, positive correlations exist between religiosity (a major freerider control; MacDonald 1994; Wilson 2002) and fertility, both at the individual differences and cross-cultural levels (Meisenberg 2011). Religiosity has declined in modernized nations—a process that has gone hand-in-hand with the rise of a values system called postmaterialism (Inglehart 1977), which is characterized by the proliferation of individualistic, secular, and antihierarchical values (Welzel 2013). The holding of these values is negatively associated with fertility, both at the individual level (when measured as political liberalism; Goldstone et al. 2011) and across time and cultures (Inglehart and Appel 1989). The rise of postmaterialist values is also associated with increasingly delayed onset of reproduction (Klien 1990) which directly increases the (population) mutation load.

Pathological Altruism

Some of the values embodied in postmaterialism have been linked to the pathological altruism phenomenon, i.e., forms of altruism that damage the intended recipients or givers of largesse (Oakley et al. 2012; Oakley 2013). Virtues associated with altruism such as kindness, fidelity, magnanimity, and heroism, along with quasi-moral traits associated with personality and mental health, may be under sexual selection and might therefore be sensitive, through the f factor, to the deleterious effects of accumulating mutations (Miller 2007).


Another form of pathologically altruistic behavior that Oakley (2013) documents is self-righteousness, which may be increasing, consistent with secular trend data indicating elevated levels of self-regarding behavior among Western populations (sometimes called the narcissism epidemic; Twenge and Campbell 2009). This sort of behavior constitutes a key component of the clever silly phenomenon in which the embrace of counterfactual beliefs is used to leverage social status via virtue signaling (e.g., the conflation of moral equality among individuals, sexes, and populations with biological equality) (Dutton and van der Linden 2015; Charlton 2009; Woodley 2010). There may be a greater number of influential persons inclined to disseminate such beliefs, in that the prevalence of phenotypes disposed toward egoistic behaviors may have increased in Western populations (per Twenge and coworkers’ research), and because egoists, specifically Machiavellians and narcissists, appear advantaged in the acquisition of elite societal stations (Spurk et al. 2015).

[Do Bad Guys Get Ahead or Fall Behind? Relationships of the Dark Triad of Personality With Objective and Subjective Career Success: http://sci-hub.tw/http://journals.sagepub.com/doi/abs/10.1177/1948550615609735

After controlling for other relevant variables (i.e., gender, age, job tenure, organization size, education, and work hours), narcissism was positively related to salary, Machiavellianism was positively related to leadership position and career satisfaction, and psychopathy was negatively related to all analyzed outcomes.]


By altering cultural norms, elite egoists may encourage the efflorescence of selfish behaviors against which some older and once highly influential cultural systems acted. For example, Christianity in various forms strongly promoted personal sacrifice for the good of groups and proscribed egoistic behaviors (Rubin 2015), but has declined significantly in terms of cultural power following modernization (Inglehart 1977). Thus, it is possible that a feedback loop exists wherein deleterious mutation accumulation raises population levels of egoism, either directly or indirectly, via the breakdown of developmental constraints on personality canalization; the resultantly greater number of egoists are then able to exploit relevant personality traits to attain positions of sociocultural influence; and through these … [more]
study  speculation  models  biodet  bio  sapiens  evolution  genetic-load  paternal-age  the-monster  slippery-slope  society  social-structure  free-riding  coordination  EGT  dynamical  🌞  fertility  dysgenics  eh  self-control  obesity  altruism  mutation  multi  twitter  social  commentary  perturbation  gnon  new-religion  science-anxiety  population-genetics  biophysical-econ  hmm  discipline  autism  scitariat  clown-world  epidemiology  malaise  sociology  demographic-transition  blowhards  model-organism  nonlinearity  civilization  expression-survival  universalism-particularism  order-disorder  trends  deep-materialism  values  ideology  domestication  cohesion  christopher-lasch  scale  patho-altruism  social-capital  behavioral-gen  madisonian  chart  nihil  aristos  piracy  theos  cultural-dynamics  roots  zeitgeist  rot  the-bones  counter-revolution  pdf  modernity  microfoundations  video  presentation  religion  christianity  health  longevity  ethnocentrism  genetic-correlation  👽  instinct 
march 2017 by nhaliday
Links 2/17: Site Your Sources | Slate Star Codex
The United States not only does poorly on education benchmark PISA, but each decile of wealth also does poorly compared to equivalent deciles in other countries. I find this surprising. Does this torpedo the theory that each US ethnic group does as well as its foreign counterparts, and US underperformance is a Simpson’s Paradox on ethnic distribution?

Twitter: @EveryoneIsDril.

New Study Finds Performance-Enhancing Drugs For Chess. Okay, fine, just modafinil, which we already knew about, but the exact pattern is interesting. Modafinil makes people take longer to make their moves, but the moves are ultimately better. That suggests that its advantage is not increasing IQ per se, but in giving people the increased attention span/concentration to work harder on finding good moves. I think this elegantly ties together a lot of stuff into a good explanation of modafinil’s cognitive-enhancing properties.

New Zealand Wants To Know How Peter Thiel Became A Secret Citizen. Give up, New Zealand; Peter Thiel is a citizen of any country he wants to be a citizen of. Also: Peter Thiel Denies California Governor Run Despite Mysterious Group’s Backing.

I was going to link to the paper Physics Envy May Be Hazardous To Your Wealth, but the part that actually interested me is small enough that I’m just going to include it here as a jpg (h/t Julia Galef).

Nature: Prevalence And Architecture Of De Novo Mutations In Developmental Disorders. There’s been a lot of debate over paternal age effects, and this paper helps clarify that by actually counting people’s de novo mutations and finding that children of older fathers (and to a lesser degree older mothers) have more of them. I am not sure to what degree this answers the objection that fathers with worse genes will tend to get married later; my impression is that it’s circumstantial evidence against (de novo mutations are more specific to paternal age than just bad genes) but not complete disproof.

Psssst, kid, wanna buy a parasitic worm? Key quote: “Those who experience the ‘hookworm bounce’ tend to describe it as ‘feeling as if they are teenagers again'” (h/t pistachi0n).

New paper in Crime And Delinquency: “We find no evidence that the number of fatal police shootings either increased or decreased post-Ferguson. Claims to the contrary are based on weak analyses of short-term trends.” This is especially surprising in light of claims that increased inner-city crime is caused by police withdrawing in order to prevent further fatal shootings; if that’s the police’s plan, it doesn’t seem to be working very well.

Intranasal ghrelin vaccine prevents obesity in mice.

Gene drive testing thwarted when organisms quickly develop resistance. There goes that idea.

New poll: Majority of Europeans support banning Muslim immigration. It’s an Internet-based poll, which is always cause for suspicion, but they seem to be a reputable organization and not the sort of group whose results are 100% due to trolling by 4chan, plus it’s consistent with some other results. Still pretty shocking and an existential-terror-level reminder of partisan bubbles. Also: Rasmussen finds most Americans support Trump’s refugee ban order.

Closely related: M.G. Miles makes the case for banning Muslim immigration. Maybe the first person I have seen make this case in a principled way; everyone else just seems to be screaming about stuff and demanding their readers reinterpret it into argument form. Also, he uses the word “terrorism” zero times, which seems like the correct number of times for a case of this sort. This is what people should be debating and responding to. Rebuttals by Americans would probably want to start with the differences between Muslim immigrants to Europe and Muslim immigrants to the US – Miles discusses the European case, but by my understanding these are very different populations with very different outcomes).

Second Enumerations podcast: Grognor reading interesting essays.

SSRN: Extreme Protest Tactics Reduce Popular Support For Social Movements: “We find across three experiments that extreme protest tactics decreased popular support for a given cause because they reduced feelings of identification with the movement. Though this effect obtained in tests of popular responses to extreme tactics used by animal rights, Black Lives Matter, and anti-Trump protests (Studies 1-3), we found that self-identified political activists were willing to use extreme tactics because they believed them to be effective for recruiting popular support.” Cf. The Toxoplasma Of Rage. (h/t Dain)

The Cagots were an underclass of people in medieval France whom everyone hated, with various purity laws around how decent people weren’t allowed to associate with/marry/touch/go near them. In the 1500s, the Pope personally intervened to tell the French to stop persecuting them, but the French ignored him and persecuted them more than ever. As far as anyone can tell, they looked, spoke, and acted just like everyone else, and exactly how they became so despised is one of the minor mysteries of medieval history.
ratty  yvain  ssc  links  commentary  multi  education  psychometrics  class  usa  regularizer  twitter  memes(ew)  nootropics  study  summary  games  thiel  government  anglo  california  pic  physics  interdisciplinary  complex-systems  models  map-territory  epistemic  science  social-science  org:nat  paternal-age  genetics  genetic-load  genomics  parasites-microbiome  data  crime  trends  criminal-justice  politics  culture-war  medicine  obesity  model-organism  geoengineering  CRISPR  unintended-consequences  europe  poll  migrant-crisis  migration  policy  islam  rhetoric  attaq  audio  podcast  postrat  subculture  medieval  gallic  tribalism  thinking  tactics  anthropology  meta:rhetoric  persuasion 
february 2017 by nhaliday
A New Germ Theory: https://www.theatlantic.com/magazine/archive/1999/02/a-new-germ-theory/377430/
The dictates of evolution virtually demand that the causes of some of humanity's chronic and most baffling "noninfectious" illnesses will turn out to be pathogens -- that is the radical view of a prominent evolutionary biologist

A LATE-SEPTEMBER heat wave enveloped Amherst College, and young people milled about in shorts or sleeveless summer frocks, or read books on the grass. Inside the red-brick buildings framing the leafy quadrangle students listened to lectures on Ellison and Emerson, on Paul Verlaine and the Holy Roman Empire. Few suspected that strains of the organism that causes cholera were growing nearby, in the Life Sciences Building. If they had known, they would probably not have grasped the implications. But these particular strains of cholera make Paul Ewald smile; they are strong evidence that he is on the right track. Knowing the rules of evolutionary biology, he believes, can change the course of infectious disease.

I HAVE a motto," Gregory Cochran told me recently. "'Big old diseases are infectious.' If it's common, higher than one in a thousand, I get suspicious. And if it's old, if it has been around for a while, I get suspicious."

pdf  study  speculation  bio  evolution  sapiens  parasites-microbiome  red-queen  disease  west-hunter  🌞  unit  nibble  len:long  biodet  EGT  wild-ideas  big-picture  epidemiology  deep-materialism  🔬  spearhead  scitariat  maxim-gun  ideas  lens  heterodox  darwinian  equilibrium  medicine  heuristic  spreading  article  psychiatry  QTL  distribution  behavioral-gen  genetics  population-genetics  missing-heritability  gender  sex  sexuality  cardio  track-record  aging  popsci  natural-experiment  japan  asia  meta:medicine  profile  ability-competence  empirical  theory-practice  data  magnitude  scale  cost-benefit  is-ought  occam  parsimony  stress  GWAS  roots  explanans  embodied  obesity  geography  canada  britain  anglo  trivia  cocktail  shift  aphorism  stylized-facts  evidence  inference 
february 2017 by nhaliday
Link: Guyenet On Taubes | Slate Star Codex
I’m recommending this review more strongly than usual because I’ve previously praised Taubes. He did a good job explaining how the pop wisdom of the ’90s – that fat was uniquely bad – wasn’t true. He did a good job showing the ways in which the old “just diet and exercise, nothing can go wrong” idea was simplistic and needed to be replaced with a good understanding of obesity set points. I learned some useful things from his books and I had positive feelings about him.

But from the first time I talked about him almost five years ago, I’ve stressed that his views about sugar are really, really wrong. I was previously willing to excuse this on the grounds that he wrote about a lot of other useful things and everybody’s allowed a bit of crazy speculation once in a while before a field is completely settled. But at this point things seem pretty settled and I no longer think his behavior is excusable. The ’90s are over, the pop wisdom that Taubes set out to debunk is sufficiently debunked, and he’s doubling down on his sugar theory despite an increasing pile of evidence against it.

I apologize if my past praise for Taubes’ writing have helped create a climate where people listen to his theories. His good qualities aren’t enough to justify the increasing amount of misinformation he’s putting out, and I don’t recommend him on any level as a source of nutritional advice.

yvain  ssc  links  commentary  books  critique  nutrition  diet  epistemic  heterodox  ratty  health  fitness  review  science  multi  debate  twitter  social  discussion  obesity  epidemiology  taubes-guyenet  info-dynamics 
january 2017 by nhaliday
Ten Putative Contributors to the Obesity Epidemic
The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects, as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors.
study  meta-analysis  survey  obesity  health  hypochondria  assortative-mating  sleep  model-organism  human-study  🐸  endocrine  metabolic  biodet  epigenetics  epidemiology  sociology  public-health  recent-selection 
january 2017 by nhaliday
Is Healthy Food a Luxury for the Low-Income Households in the U.S.?
- not sure about https://twitter.com/St_Rev/status/814960958938447873

Using induced changes in the household budget due to exogenous variation in the winter temperature that directly affects heating bills, I show that households do not improve the nutritional quality of their food purchases. Households below 130 percent of the poverty threshold increase total calorie amount without changing the composition of food purchases. Households above 130 percent of the poverty threshold purchase different products, but these products are of mixed nutritional quality. My findings suggest that policies that provide food subsidies face a trade-off subsidizing not just the increased consumption of healthy food but also the increased consumption of unhealthy food.
study  economics  polisci  policy  obesity  food  natural-experiment  class  multi  pdf  wonkish  urban  epidemiology  endo-exo  intervention  public-health  endogenous-exogenous  urban-rural 
december 2016 by nhaliday
More doubt cast on food deserts | City Observatory
after controlling for differences in educational attainment and income, variations in physical access to food explain less than ten percent of the variation in consumption of healthy foods
news  org:mag  study  summary  polisci  policy  urban  food  obesity  class  wonkish  epidemiology  intervention  public-health  urban-rural 
december 2016 by nhaliday
International Journal of Obesity - Genetic and environmental correlations between obesity phenotypes and age at menarche
Our results for the first time suggested that significant phenotypic association between obesity phenotypes and AAM is mainly attributable to shared genetic rather than environmental factors
study  genetics  obesity  genetic-correlation  org:nat  biodet  epidemiology  embodied  gender  sex 
december 2016 by nhaliday
Population attributable risks and costs of diabetogenic chemical exposures in the elderly -- Trasande et al. -- Journal of Epidemiology & Community Health
Reduction of chemical exposures was associated with a 13% (95% CI 2% to 22%) reduction in prevalent diabetes, compared with 40% resulting from an identical (25%) reduction in body mass index (BMI) in cross-sectional analyses.
study  embodied  hypochondria  health  fitness  disease  obesity  🐸  medicine  embodied-street-fighting  prediction  human-study  metabolic  biodet  epidemiology  intervention  comparison  effect-size  public-health 
december 2016 by nhaliday
Childhood forecasting of a small segment of the population with large economic burden : Nature Human Behaviour
A segment comprising 22% of the cohort accounted for 36% of the cohort’s injury insurance claims; 40% of excess obese kilograms; 54% of cigarettes smoked; 57% of hospital nights; 66% of welfare benefits; 77% of fatherless child-rearing; 78% of prescription fills; and 81% of criminal convictions. Childhood risks, including poor brain health at three years of age, predicted this segment with large effect sizes. Early-years interventions that are effective for this population segment could yield very large returns on investment.
study  crime  class  policy  arbitrage  economics  anthropology  org:nat  health  stylized-facts  obesity  🎩  🌞  redistribution  pareto  low-hanging  biodet  epidemiology  sociology  distribution  healthcare  wonkish  society  objektbuch  s-factor  behavioral-gen  criminology  public-health  chart  welfare-state 
december 2016 by nhaliday
Thin Air | Slate Star Codex
So my guess is that Hersoug is wrong and CO2 doesn’t cause appreciable weight gain in normal concentrations. We should abandon the beautiful theory of climate-change-induced obesity and go down a level of contrarianism to blaming boring normal-person things like xenoestrogens and gut microbiota.

(I’ve heard there are theories of obesity even less contrarian than those, but I’ve never been to such low contaranianism levels and wouldn’t be able to tell you what they might be.)

so high altitude can cause weight loss, CO2 can't cause weight gain
ratty  yvain  ssc  essay  atmosphere  environment  health  contrarianism  regularizer  analysis  obesity  biodet  epidemiology  intervention  public-health  correlation  speculation  ideas 
december 2016 by nhaliday
Physical Activity, Fitness, Glucose Homeostasis, and Brain Morphology in Twins
twin study (N=10) shows exercise increases grey matter, lowers body fat

[Rottensteiner et al, 2016]: http://www.ncbi.nlm.nih.gov.sci-hub.cc/pubmed/27112070
Inactive twins had 31% more intra-abdominal fat than their active co-twins (mean difference 0.52 kg, 95% CI 0.12 to 0.91, P = 0.016), whereas the difference in subcutaneous abdominal fat was only 13% (P = 0.21) and 3% in body mass index (P = 0.28). Intraperitoneal fat mass was 41% higher among inactive twins compared to their active co-twins (mean difference 0.41 kg, 95% CI 0.11 to 0.70, P = 0.012). Dietary intake did not differ between co-twins.

same study: https://twitter.com/timothycbates/status/880326920491106304
Visible changes to body, but zero effect of exercise on mortality (p=.94) in MZ differences lifespan studies... #BGA2017
gwern  pdf  study  fitness  health  genetics  neuro  regularizer  🐸  fitsci  embodied-cognition  variance-components  🌞  twin-study  environmental-effects  c:**  hmm  biodet  virtu  oscillation  brain-scan  intervention  multi  obesity  twitter  social  commentary  scitariat  longevity  null-result  effect-size  piracy  europe  nordic  evidence-based  human-study  solid-study 
september 2016 by nhaliday
Hillary Clinton's Immigration Position Doesn't Consider the Interests of Americans - The Atlantic
later: https://www.theatlantic.com/politics/archive/2017/01/an-immigration-order-as-stupid-as-it-is-counterproductive/514847/
- David Frum

When liberals insist that only fascists will defend borders, then voters will hire fascists to do the job liberals won’t do. This weekend’s shameful chapter in the history of the United States is a reproach not only to Trump, although it is that too, but to the political culture that enabled him. Angela Merkel and Donald Trump may be temperamental opposites. They are also functional allies.

America's Immigration Challenge: https://www.theatlantic.com/politics/archive/2015/12/refugees/419976/
Coming to the United States would benefit millions—but policymakers seldom ask whether their arrival would benefit the United States.
critique  usa  2016-election  news  rhetoric  org:mag  migration  clinton  current-events  neocons  multi  politics  policy  trump  culture-war  wonkish  ideology  cost-benefit  human-capital  class  latin-america  asia  obesity  life-history  data  pro-rata  migrant-crisis  iraq-syria  judaism  elite  vampire-squid 
september 2016 by nhaliday
Helpless to Prevent Cancer? Actually, Quite a Bit Is in Your Control - The New York Times
nchelluri on HN:
Interesting article. I don't know that I'd take too much to heart given some of the obvious caveats the author has been nice enough to make explicit, but it sounds like I'd be hard pressed to argue the suggestions contained within.
For the tl;dr crowd:
- written by a physician
- people often think that heart disease is controllable by our actions whereas they feel that cancer is not
- > people can’t change many risk factors of heart disease like age, race and family genetics
- > A more recent study published in Nature argues that there is a lot we can do. [about cancer]
- > Using sophisticated modeling techniques, the researchers argued that less than 30 percent of the lifetime risk of getting cancer was because of intrinsic risk factors, or the “bad luck.”
- > [another study] identified four domains that are often noted to be related to disease prevention: smoking, drinking, obesity and exercise
- if you limit that stuff, and not meaning 0 smoking, but "having quit within the last 5 years", no more than 1 drink a day (women) or 2 drinks a day (men), your BMI is >= 18.5 and <= 27.5 (BMI is such a shit and antiquated metric, IMO, incidentally), and perform 150mins/wk moderate intensity excercise or 75mins/wk vigorous intensity exercise, then you're in the low risk group. so the barrier to entry is not super high.
> No study is perfect, and this is no exception. These cohorts are overwhelmingly white and consist of health professionals, who are not necessarily like the population at large. But the checks against the national data showed that if anything, these results might be underestimating how much cancer is preventable by healthy behaviors.
Optimistic conclusion, for a skeptical cheapskate like myself,
> As we talk about cancer “moonshots” that will most likely cost billions of dollars and might not achieve results, it’s worth considering that — as in many cases — prevention is not only the cheapest course, but also the most effective.
Hard to fault this article. I'm glad you posted it, thank you.
fitness  health  longevity  advice  expert  embodied  aging  cancer  habit  long-term  org:rec  obesity  multi  org:data  epidemiology  fitsci  expert-experience 
july 2016 by nhaliday

bundles : embodied

related tags

2016-election  ability-competence  academia  accuracy  aDNA  advice  africa  age-generation  age-of-discovery  aging  agriculture  albion  alignment  alt-inst  altruism  analogy  analysis  anglo  anglosphere  anomie  anthropology  antiquity  aphorism  arbitrage  archaeology  archaics  aristos  article  ascetic  asia  assortative-mating  atmosphere  attaq  attention  audio  autism  automation  autor  backup  beauty  behavioral-gen  being-right  benevolence  big-picture  big-surf  bio  biodet  biophysical-econ  blog  blowhards  books  brain-scan  branches  britain  broad-econ  c:**  california  canada  cancer  candidate-gene  cardio  career  causation  charity  chart  china  christianity  christopher-lasch  civil-liberty  civilization  class  class-warfare  classic  clinton  cliometrics  clown-world  cocktail  cog-psych  cohesion  coming-apart  commentary  communism  comparison  compensation  complex-systems  composition-decomposition  concept  concrete  confounding  conquest-empire  contrarianism  cooperate-defect  coordination  corporation  correlation  cost-benefit  counter-revolution  counterexample  courage  creative  crime  criminal-justice  criminology  CRISPR  critique  crooked  cultural-dynamics  culture  culture-war  curiosity  current-events  cybernetics  cycles  cynicism-idealism  dark-arts  darwinian  data  dataviz  death  debate  debt  deep-materialism  dementia  demographic-transition  demographics  developing-world  developmental  diet  dignity  dirty-hands  discipline  discussion  disease  distribution  diversity  domestication  drama  dropbox  drugs  duty  dynamic  dynamical  dysgenics  early-modern  ecology  economics  econotariat  eden  education  EEA  effect-size  efficiency  egalitarianism-hierarchy  EGT  eh  elite  embodied  embodied-cognition  embodied-street-fighting  emotion  empirical  endo-exo  endocrine  endogenous-exogenous  environment  environmental-effects  epidemiology  epigenetics  epistemic  equilibrium  error  essay  ethanol  ethics  ethnocentrism  EU  europe  evidence  evidence-based  evolution  evopsych  experiment  expert  expert-experience  explanans  explore-exploit  expression-survival  externalities  farmers-and-foragers  fashun  FDA  fertility  field-study  film  fisher  fitness  fitsci  fluid  food  foreign-lang  free-riding  futurism  gallic  games  gavisti  gedanken  gelman  gender  gender-diff  gene-flow  genetic-correlation  genetic-load  genetics  genomics  geoengineering  geography  germanic  giants  gibbon  gnon  gnxp  good-evil  government  grad-school  group-selection  growth-econ  guilt-shame  GWAS  gwern  habit  hari-seldon  health  healthcare  heavy-industry  heterodox  heuristic  higher-ed  history  hmm  hn  homo-hetero  horror  human-capital  human-study  humility  hypochondria  ideas  ideology  idk  immune  impetus  increase-decrease  india  individualism-collectivism  industrial-org  inequality  inference  info-dynamics  info-foraging  innovation  insight  instinct  institutions  interdisciplinary  interpretation  intervention  interview  intricacy  investing  iq  iraq-syria  iron-age  is-ought  islam  iteration-recursion  japan  journos-pundits  judaism  kumbaya-kult  labor  language  large-factor  latin-america  law  leadership  learning  left-wing  len:long  len:short  lens  lesswrong  let-me-see  lexical  life-history  links  lol  long-term  longevity  longitudinal  love-hate  low-hanging  machiavelli  madisonian  magnitude  malaise  malthus  management  managerial-state  map-territory  maps  maxim-gun  measure  measurement  media  medicine  medieval  mediterranean  memes(ew)  MENA  mena4  mendel-randomization  meta-analysis  meta:medicine  meta:research  meta:rhetoric  meta:science  metabolic  methodology  metrics  microfoundations  midwest  migrant-crisis  migration  minimum-viable  missing-heritability  model-organism  models  modernity  monetary-fiscal  money  morality  mostly-modern  multi  multiplicative  mutation  n-factor  nascent-state  nationalism-globalism  natural-experiment  nature  neocons  neuro  neuro-nitgrit  neurons  new-religion  news  nibble  nihil  nonlinearity  nootropics  nordic  northeast  null-result  nutrition  obesity  objektbuch  occam  oceans  old-anglo  open-things  opioids  order-disorder  org:anglo  org:biz  org:data  org:davos  org:gov  org:health  org:lite  org:local  org:mag  org:nat  org:popup  org:rec  org:sci  oscillation  parasites-microbiome  pareto  parsimony  paternal-age  path-dependence  patho-altruism  pdf  people  personality  persuasion  perturbation  pessimism  philosophy  physics  pic  piracy  poast  podcast  policy  polisci  politics  poll  pop-diff  pop-structure  popsci  population-genetics  postrat  pre-ww2  prediction  prepping  preprint  presentation  pro-rata  problem-solving  profile  prudence  pseudoE  psychiatry  psychology  psychometrics  public-health  QTL  questions  race  random  rant  rationality  ratty  reason  recent-selection  red-queen  reddit  redistribution  reflection  regression  regularizer  reinforcement  religion  rent-seeking  replication  retention  review  rhetoric  rhythm  right-wing  robust  roots  rot  russia  s-factor  sapiens  scale  science  science-anxiety  scifi-fantasy  scitariat  selection  self-control  self-interest  self-report  sex  sexuality  shift  signal-noise  signaling  sinosphere  sleep  slippery-slope  social  social-capital  social-norms  social-psych  social-science  social-structure  sociality  society  sociology  solid-study  spearhead  speculation  speed  spock  spreading  ssc  stagnation  stamina  status  stereotypes  stories  strategy  stream  street-fighting  stress  study  stylized-facts  subculture  summary  supply-demand  survey  symmetry  systematic-ad-hoc  tactics  taubes-guyenet  temperance  the-bones  the-classics  the-devil  the-great-west-whale  the-monster  theory-practice  theos  thiel  thinking  time  time-series  todo  traces  track-record  trade  trends  tribalism  trivia  troll  trump  truth  tv  twin-study  twitter  unaffiliated  unintended-consequences  unit  universalism-particularism  urban  urban-rural  us-them  usa  values  vampire-squid  variance-components  video  virtu  visualization  volo-avolo  war  weird  welfare-state  west-hunter  westminster  white-paper  wiki  wild-ideas  wonkish  world  world-war  yvain  zeitgeist  🌞  🎩  🐝  🐸  👽  🔬 

Copy this bookmark: