nhaliday + nootropics   34

Links 2/17: Site Your Sources | Slate Star Codex
The United States not only does poorly on education benchmark PISA, but each decile of wealth also does poorly compared to equivalent deciles in other countries. I find this surprising. Does this torpedo the theory that each US ethnic group does as well as its foreign counterparts, and US underperformance is a Simpson’s Paradox on ethnic distribution?

Twitter: @EveryoneIsDril.

New Study Finds Performance-Enhancing Drugs For Chess. Okay, fine, just modafinil, which we already knew about, but the exact pattern is interesting. Modafinil makes people take longer to make their moves, but the moves are ultimately better. That suggests that its advantage is not increasing IQ per se, but in giving people the increased attention span/concentration to work harder on finding good moves. I think this elegantly ties together a lot of stuff into a good explanation of modafinil’s cognitive-enhancing properties.

New Zealand Wants To Know How Peter Thiel Became A Secret Citizen. Give up, New Zealand; Peter Thiel is a citizen of any country he wants to be a citizen of. Also: Peter Thiel Denies California Governor Run Despite Mysterious Group’s Backing.

I was going to link to the paper Physics Envy May Be Hazardous To Your Wealth, but the part that actually interested me is small enough that I’m just going to include it here as a jpg (h/t Julia Galef).

Nature: Prevalence And Architecture Of De Novo Mutations In Developmental Disorders. There’s been a lot of debate over paternal age effects, and this paper helps clarify that by actually counting people’s de novo mutations and finding that children of older fathers (and to a lesser degree older mothers) have more of them. I am not sure to what degree this answers the objection that fathers with worse genes will tend to get married later; my impression is that it’s circumstantial evidence against (de novo mutations are more specific to paternal age than just bad genes) but not complete disproof.

Psssst, kid, wanna buy a parasitic worm? Key quote: “Those who experience the ‘hookworm bounce’ tend to describe it as ‘feeling as if they are teenagers again'” (h/t pistachi0n).

New paper in Crime And Delinquency: “We find no evidence that the number of fatal police shootings either increased or decreased post-Ferguson. Claims to the contrary are based on weak analyses of short-term trends.” This is especially surprising in light of claims that increased inner-city crime is caused by police withdrawing in order to prevent further fatal shootings; if that’s the police’s plan, it doesn’t seem to be working very well.

Intranasal ghrelin vaccine prevents obesity in mice.

Gene drive testing thwarted when organisms quickly develop resistance. There goes that idea.

New poll: Majority of Europeans support banning Muslim immigration. It’s an Internet-based poll, which is always cause for suspicion, but they seem to be a reputable organization and not the sort of group whose results are 100% due to trolling by 4chan, plus it’s consistent with some other results. Still pretty shocking and an existential-terror-level reminder of partisan bubbles. Also: Rasmussen finds most Americans support Trump’s refugee ban order.

Closely related: M.G. Miles makes the case for banning Muslim immigration. Maybe the first person I have seen make this case in a principled way; everyone else just seems to be screaming about stuff and demanding their readers reinterpret it into argument form. Also, he uses the word “terrorism” zero times, which seems like the correct number of times for a case of this sort. This is what people should be debating and responding to. Rebuttals by Americans would probably want to start with the differences between Muslim immigrants to Europe and Muslim immigrants to the US – Miles discusses the European case, but by my understanding these are very different populations with very different outcomes).

Second Enumerations podcast: Grognor reading interesting essays.

SSRN: Extreme Protest Tactics Reduce Popular Support For Social Movements: “We find across three experiments that extreme protest tactics decreased popular support for a given cause because they reduced feelings of identification with the movement. Though this effect obtained in tests of popular responses to extreme tactics used by animal rights, Black Lives Matter, and anti-Trump protests (Studies 1-3), we found that self-identified political activists were willing to use extreme tactics because they believed them to be effective for recruiting popular support.” Cf. The Toxoplasma Of Rage. (h/t Dain)

The Cagots were an underclass of people in medieval France whom everyone hated, with various purity laws around how decent people weren’t allowed to associate with/marry/touch/go near them. In the 1500s, the Pope personally intervened to tell the French to stop persecuting them, but the French ignored him and persecuted them more than ever. As far as anyone can tell, they looked, spoke, and acted just like everyone else, and exactly how they became so despised is one of the minor mysteries of medieval history.
ratty  yvain  ssc  links  commentary  multi  education  psychometrics  class  usa  regularizer  twitter  memes(ew)  nootropics  study  summary  games  thiel  government  anglo  california  pic  physics  interdisciplinary  complex-systems  models  map-territory  epistemic  science  social-science  org:nat  paternal-age  genetics  genetic-load  genomics  parasites-microbiome  data  crime  trends  criminal-justice  politics  culture-war  medicine  obesity  model-organism  geoengineering  CRISPR  unintended-consequences  europe  poll  migrant-crisis  migration  policy  islam  rhetoric  attaq  audio  podcast  postrat  subculture  medieval  gallic  tribalism  thinking  tactics  anthropology  meta:rhetoric  persuasion 
february 2017 by nhaliday
Links 1/17: Inaugurl Address | Slate Star Codex
“Fanatics got into the Capitol building and committed a mass shooting on Congress while it was in session, and you’ve never heard of them…people have completely forgotten that in 1972 we had over nineteen hundred domestic bombings in the United States” A review of Days Of Rage and history lesson on the 1970s underground. Highly recommended.

New Yorker: The Mosul Dam in Iraq could fail soon, potentially causing a flash flood and hundreds of thousands of deaths.

An ecologist denounces calls to “drain the swamp” as an insult to swamps: “Given the sea of misinformation we currently find ourselves swimming in, I feel this is as good a time as any to clarify what swamps actually are and why they should be regarded as wonderful and valuable parts of nature rather than objects of derision and hatred.” If any of you are oceanographers, can you troll the Washington Post for me by denouncing their use of the term “sea of misinformation”?

The Seasteading Institute announces a deal with French Polynesia to build the first seastead in a lagoon there. I’m still confused on whether they’ve got funding or anything else besides the location. Still a big step.

80,000 Hours’ guide to what charities to give to this season. A good supplement to GiveWell’s Top Charities list

Vox: Why the war on poverty failed, and what to do now. In the form of a long and detailed history of Brooklyn’s Bedford-Stuyveysant neighborhood. Not clear that anyone actually knows what to do now beyond a few good common-sense suggestions.

RIP utilitarian philosopher Derek Parfit: “When I believed the non-reductionist view [of personal identity], I also cared more about my inevitable death. After my death, there will [be] no one living who will be me. I can now redescribe this fact. Though there will later be many experiences, none of these experiences will be connected to my present experiences by chains of such direct connections as those involved in experience-memory, or in the carrying out of an earlier intention. Some of these future experiences may be related to my present experiences in less direct ways. There will later be some memories about my life. And there may later be thoughts that are influenced by mine, or things done as the result of my advice. My death will break the more direct relations between my present experiences and future experiences, but it will not break various other relations. This is all there is to the fact that there will be no one living who will be me. Now that I have seen this, my death seems to me less bad.”

Alex K. Chen on Quora on the speculation that Ritalin may be long-term safer than Adderall. See also this review article. This is definitely not yet psychiatric common knowledge or consensus.

Meta-analysis in the American Journal Of Nutrition: Red meat does not increase risk of cardiovascular disease.

Acemoglu and Restropo: Economic stagnation is not due to aging populations.

User dogtasteslikechicken at the r/slatestarcodex subreddit gives a good summary of the Flynn Effect. But it looks like he is confused about some of the same things I am. For example, rich people and the nobility probably had good nutrition and education in the past. So we might expect a Flynn effect based on nutrition and education not to affect them as much. But if this were true, we would expect a skewed or bimodal distribution in the past (un-Flynned poor people with bad nutrition + Flynned rich people with good nutrition), which I don’t think ever clearly showed up.

Some fallout from the Buzzfeed story on growth mindset I linked last week. The Spectator published what I think is a really nasty and evidence-free denunciation of the phenomenon. Mindset researcher David Yeager has tried to set the record straight and argues that growth mindset actually replicates just fine, eg in this paper, and that several other large and rigorous replications are being attempted. Dweck herself has a reply up here. And Timothy Bates put his failed replications online here. Looks like it will be an interesting year in this field.

Does pupil size correlate with intelligence? (blog post, paper)
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january 2017 by nhaliday
Nootropics for Everyone | Nootrobox®
generally considered to be a ripoff by r/nootropics
nootropics  store  brands  drugs 
august 2016 by nhaliday
Zapping Their Brains at Home | Hacker News
interesting comments on the evolutionary heuristic in nootropics
nootropics  commentary  hn  news  critique  org:rec 
july 2016 by nhaliday
Nootropics and Cognitive Enhancers
more cutting-edge stuff, run by u/MisterYouAreSoDumb
nootropics  drugs  neuro  store  skunkworks  brands 
june 2016 by nhaliday
Buy The Best Nootropics Online Today at Nootropics Depot
high quality, cheap staples, run by u/MisterYouAreSoDumb
nootropics  drugs  neuro  store  brands  metabolic 
june 2016 by nhaliday
Nootropics | Otium
Bottom Lines

Caffeine, modafinil, amphetamine, methylphenidate, and maybe a discontinued nicotinic-receptor agonist drug called ispronicline, have really big effects on cognitive function in healthy people.

Caffeine and modafinil work significantly better in sleep-deprived than non-sleep-deprived people.

Caffeine, nicotine, and amphetamine, in contrast to methylphenidate and modafinil, do not improve memory performance or accuracy on cognitive tasks in healthy people, but only reaction time. In other words: caffeine, nicotine, and amphetamine make you more alert but not smarter; methylphenidate and modafinil also seem to improve memory.

Amphetamine and modafinil work better on people with the COMT val/val phenotype (who tend to be less intelligent) and may be ineffective or counterproductive on COMT met/met phenotype people.

All of the above (caffeine, nicotine, modafinil, amphetamine, and methylphenidate) cause some tolerance.

Cerebrolysin, a mixture of neural growth factors, apparently works really well on Alzheimer’s patients, though there’s fewer studies of it than more common Alzheimer’s drugs. It might extrapolate to people with other kinds of neurodegenerative problems, or to slow the effects of aging.

Cognitive training (memorization practice including spaced repetition) works moderately well on Alzheimer’s patients and schizophrenics. It’s quite plausible that it’s also good for healthy people.

Healthy people can get small positive effects from nicotine, possibly the herb Bacopa monniera, and from transcranial magnetic stimulation.

Alzheimer’s patients can get small effects from cholinesterase inhibitors (which are standard Alzheimer’s drugs); from a mixture of vitamins, fatty acids, choline, and uridine; from melatonin, the hormone which regulates sleep; and from the amino acid derivative acetyl-l-carnitine. Apart from the cholinesterase inhibitors (which have GI side effects) these are safe for healthy people to take, but it’s not known whether they affect cognitive function in healthy people.
summary  reflection  nootropics  neuro  drugs  list  survey  reference  yvain  hmm  len:long  ssc  ratty  🤖  faq  core-rats  big-picture  iteration-recursion  learning  retention  chart 
june 2016 by nhaliday
What is up with carbon dioxide and cognition? An offer - Less Wrong Discussion
study: http://ehp.niehs.nih.gov/1104789/
n=22, p-values < .001 generally, no multiple comparisons or anything, right?
chart: http://ehp.niehs.nih.gov/wp-content/uploads/2012/11/ehp.1104789.g002.png
- note it's CO2 not oxygen that's relevant
- some interesting debate in comments about whether you would find similar effects for similar levels of variation in oxygen, implications for high-altitude living, etc.
- CO2 levels can range quite to quite high levels indoors (~1500, and even ~7000 in some of Gwern's experiments); this seems to be enough to impact cognition to a significant degree
- outdoor air quality often better than indoor even in urban areas (see other studies)

the solution: houseplants, http://lesswrong.com/lw/nk0/what_is_up_with_carbon_dioxide_and_cognition_an/d956

https://twitter.com/menangahela/status/965167009083379712
https://archive.is/k0I0U
except that environmental instability tends to be harder on more 'complex' adaptations and co2 ppm directly correlates with decreased effectiveness of cognition-enhancing traits vis chronic low-grade acidosis
productivity  study  gotchas  workflow  money-for-time  neuro  gwern  embodied  hypochondria  hmm  lesswrong  🤖  spock  nootropics  embodied-cognition  evidence-based  ratty  clever-rats  atmosphere  rat-pack  psychology  cog-psych  🌞  field-study  multi  c:**  2016  human-study  acmtariat  embodied-street-fighting  biodet  objective-measure  decision-making  s:*  embodied-pack  intervention  iq  environmental-effects  branches  unintended-consequences  twitter  social  discussion  backup  gnon  mena4  land  🐸  environment  climate-change  intelligence  structure 
may 2016 by nhaliday
Modafinil - Gwern.net
I would describe its advantages over other common stimulants as: more powerful and less addictive & tolerating than caffeine or khat; much longer-lasting than nicotine; less likely to alter mood or produce ‘tweaking’ behavior than Adderall or Vyvanse; and much more legal & with almost no side-effects compared to methamphetamine or cocaine.
nootropics  drugs  analysis  longform  comparison  data  gwern  ratty  faq  guide  chart  cost-benefit  money  internet  brands  list  top-n  ranking  checking  chemistry 
may 2016 by nhaliday
Product Recommendations 2015 | Slate Star Codex
Not a product so much as a company. Nootropics Depot and Ceretropic are two online nootropics stores. They’re both owned by the same guy but have different branding: Nootropics Depot has nice gentle all-natural stuff, Ceretropic has new high-tech research chemicals.
drugs  nootropics  recommendations  list  rationality  yvain  len:short  ssc  ratty  2015  consumerism 
april 2016 by nhaliday
Double Blinded
group buys for nootropics w/ a focus on rigorous self-experimentation
quantified-self  science  nootropics  drugs 
december 2015 by nhaliday

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