nhaliday + minimalism   31

I Want a New Drug | West Hunter
Big pharma has taken a new course over the past few years. In the past, most useful drugs originated in some kind of living organism – penicillin, quinine, insulin, etc etc. Nowadays, big pharmaceutical companies use combinatorial chemistry and computer modeling. Merck has sold off its biological-products research arm. This new approach, combined with doubled spending on drug R&D, has been a resounding failure. The rate of development of fundamentally new drugs – ‘new molecular entities’ – is running about 40% of that seen in the 1970s. Since big pharma makes its money from drugs that are still on patent, this slowed innovation is a real threat to their bottom line.


I think that this is an instance of a more general trend: often a modern, advanced approach shows up, and it persists long after it’s been shown to be a miserable failure. You can see some of the reasons why: the people trained in the new technique would lose out if it were abandoned. Hard to imagine combinatorial chemists rooting around in a garbage can looking for moldy fruit.
west-hunter  discussion  pharma  medicine  FDA  randy-ayndy  regularizer  critique  minimalism  bio  nature  low-hanging  drugs  error  scitariat  info-dynamics  innovation  ideas  discovery  meta:medicine  stagnation  parasites-microbiome  the-trenches  alt-inst  dirty-hands  regulation  civil-liberty  proposal  corporation  fashun 
february 2017 by nhaliday
A Bad Carver
decondensation and its malcontents
- condensation provided plausible deniability (so some people benefited from it)
- some recondensation happening, partially facilitated by technology

good take: https://twitter.com/lumenphosphor/status/794554089728249857
Personal image for the dangers of decondensation is "hidden micronutrients" - what if Soylent doesn't *really* contain everything you need?
postrat  carcinisation  essay  culture  society  trends  insight  things  aesthetics  vgr  meaningness  history  antiquity  🦀  water  unintended-consequences  2016  minimalism  multi  twitter  social  commentary 
november 2016 by nhaliday
Beauty is Fit | Carcinisation
Cage’s music is an example of the tendency for high-status human domains to ignore fit with human nervous systems in favor of fit with increasingly rarified abstract cultural systems. Human nervous systems are limited. Representation of existing forms, and generating pleasure and poignancy in human minds, are often disdained as solved problems. Domains unhinged from the desires and particularities of human nervous systems and bodies become inhuman; human flourishing, certainly, is not a solved problem. However, human nervous systems themselves create and seek out “fit” of the more abstract sort; the domain of abstract systems is part of the natural human environment, and the forms that exist there interact with humans as symbiotes. Theorems and novels and money and cathedrals rely on humans for reproduction, like parasites, but offer many benefits to humans in exchange. Humans require an environment that fits their nervous systems, but part of the definition of “fit” in this case is the need for humans to feel that they are involved in something greater (and perhaps more abstract) than this “animal” kind of fit.
essay  reflection  carcinisation  🦀  aesthetics  postrat  thinking  culture  insight  operational  minimalism  parsimony  beauty  elegance 
november 2016 by nhaliday
Ra | Otium
Ra = smooth, blank, prestigeful (or maybe just statusful) authority


Vagueness, mental fog, “underconfidence”, avoidance, evasion, blanking out, etc. are hallmarks of Ra. If cornered, a person embodying Ra will abruptly switch from blurry vagueness to anger and nihilism.

Ra is involved in the sense of “everyone but me is in on the joke, there is a Thing that I don’t understand myself but is the most important Thing, and I must approximate or imitate or cargo-cult the Thing, and anybody who doesn’t is bad.”

Ra causes persistent brain fog or confusion, especially around economic thinking or cost-benefit analysis or quantitative estimates.

Ra causes a disinclination to express oneself. An impression that a person who is unknown or mysterious is more attractive or favorably received than a person who is an “open book.”

Ra is fake Horus.
things  thinking  mystic  postrat  status  signaling  essay  civilization  society  power  insight  hmm  metabuch  🦀  hidden-motives  leviathan  models  2016  core-rats  minimalism  frisson  ratty  vague  cost-benefit  schelling  order-disorder  emotion  info-dynamics  elegance 
october 2016 by nhaliday
My Beautiful Bubble, Bryan Caplan | EconLog | Library of Economics and Liberty
funny rejoinder from Sailer:
Of course, if there were a big war, it would be nice to be defended by all those dreary Americans you despise.

And, the irony is, they'd do it, too, just because you are an American.
reflection  society  community  economics  contrarianism  lifestyle  philosophy  len:short  econotariat  cracker-econ  org:econlib  network-structure  minimalism  -_-  polarization  individualism-collectivism  isteveish  subculture  nationalism-globalism 
september 2016 by nhaliday
On Refusing to Read - The Chronicle of Higher Education
The activity of nonreading is something that scholars rarely discuss. When they — or others whose identities are bound up with books — do so, the discussions tend to have a shamefaced quality. Blame "cultural capital" — the sense of superiority associated with laying claim to books that mark one’s high social status. More entertainingly, blame Humiliation, the delicious game that a diabolical English professor invents in David Lodge’s 1975 academic satire, Changing Places. In a game of Humiliation, players win points for not having read canonical books that everyone else in the game has read. One hapless junior faculty member in the novel wins a departmental round but loses his tenure case. In real life, the game has been most happily played by the tenured professor secure in his reputation. Changing Places had apparently inspired my adviser’s confession to someone at some point, and the information then wound through the gossip mill to reach me, standing around in the mid-1990s with a beer, trying to hide my own growing list of unread books.

Consider, however, the fact that, as Matthew Wilkens points out, in 2011 more than 50,000 new novels were published in the United States alone. "The problem of abundance" is a problem for every person who has an internet connection, and it is a professional problem in every corner of literary study. Nonreading, seen in this light, is not a badge of shame, but the way of the future. Franco Moretti has been making this point for years about the literary production of the 18th and 19th centuries, inspiring a few labs-worth of scholars to turn to machine reading — for example, using algorithms to find patterns in a particular era’s literary works. This is a form of not reading that holds tight to the dream that our literary scholarship should be based on the activity of reading as much as humanly or inhumanly possible.
academia  literature  learning  attention  contrarianism  essay  rhetoric  len:long  org:mag  org:edu  minimalism  news  signal-noise  serene  culture  time-use  inhibition  info-foraging  prioritizing  explore-exploit 
september 2016 by nhaliday
The Awe Delusion
Art is a technology. If you did a Casablanca / Law & Order double feature you might notice that although Casablanca perhaps has more ‘artistic value’ (that horribly vague phrase), Law & Order tells its stories with a mind-boggling efficiency that vastly outstrips the former. Some time after 1960 filmmakers learned how to tell more story with less.
thinking  art  philosophy  vgr  postrat  literature  insight  mystic  essay  hmm  aesthetics  len:short  🦀  minimalism  beauty  parsimony  elegance 
june 2016 by nhaliday

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