nhaliday + interdisciplinary   163

Manifold – man·i·fold /ˈmanəˌfōld/ many and various.
https://infoproc.blogspot.com/2019/01/a-grand-experiment.html
Silicon Valley (Big Tech and startups and VC)
Financial Markets
Academia (Good, Bad, and Ugly)
The View from Europe
The View from Asia (Life in PRC? Fear and Loathing of PRC?)
Frontiers of Science (AI, Genomics, Physics, ...)
Frontiers of Rationality
The Billionaire Life
MMA / UFC
What Millennials think us old folks don't understand
True things that you are not allowed to say
Bubbles that are ready to pop?
Under-appreciated Genius?
Overrated Crap and Frauds?
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march 2019 by nhaliday
Contingent, Not Arbitrary | Truth is contingent on what is, not on what we wish to be true.
A vital attribute of a value system of any kind is that it works. I consider this a necessary (but not sufficient) condition for goodness. A value system, when followed, should contribute to human flourishing and not produce results that violate its core ideals. This is a pragmatic, I-know-it-when-I-see-it definition. I may refine it further if the need arises.

I think that the prevailing Western values fail by this standard. I will not spend much time arguing this; many others have already. If you reject this premise, this blog may not be for you.

I consider old traditions an important source of wisdom: they have proven their worth over centuries of use. Where they agree, we should listen. Where they disagree, we should figure out why. Where modernity departs from tradition, we should be wary of the new.

Tradition has one nagging problem: it was abandoned by the West. How and why did that happen? I consider this a central question. I expect the reasons to be varied and complex. Understanding them seems necessary if we are to fix what may have been broken.

In short, I want to answer these questions:

1. How do values spread and persist? An ideology does no good if no one holds it.
2. Which values do good? Sounding good is worse than useless if it leads to ruin.

The ultimate hope would be to find a way to combine the two. Many have tried and failed. I don’t expect to succeed either, but I hope I’ll manage to clarify the questions.

Christianity Is The Schelling Point: https://contingentnotarbitrary.com/2018/02/22/christianity-is-the-schelling-point/
Restoring true Christianity is both necessary and sufficient for restoring civilization. The task is neither easy nor simple but that’s what it takes. It is also our best chance of weathering the collapse if that’s too late to avoid.

Christianity is the ultimate coordination mechanism: it unites us with a higher purpose, aligns us with the laws of reality and works on all scales, from individuals to entire civilizations. Christendom took over the world and then lost it when its faith faltered. Historically and culturally, Christianity is the unique Schelling point for the West – or it would be if we could agree on which church (if any) was the true one.

Here are my arguments for true Christianity as the Schelling point. I hope to demonstrate these points in subsequent posts; for now I’ll just list them.

- A society of saints is the most powerful human arrangement possible. It is united in purpose, ideologically stable and operates in harmony with natural law. This is true independent of scale and organization: from military hierarchy to total decentralization, from persecuted minority to total hegemony. Even democracy works among saints – that’s why it took so long to fail.
- There is such a thing as true Christianity. I don’t know how to pinpoint it but it does exist; that holds from both secular and religious perspectives. Our task is to converge on it the best we can.
- Don’t worry too much about the existence of God. I’m proof that you don’t need that assumption in order to believe – it helps but isn’t mandatory.

Pascal’s Wager never sat right with me. Now I know why: it’s a sucker bet. Let’s update it.

If God exists, we must believe because our souls and civilization depend on it. If He doesn’t exist, we must believe because civilization depends on it.

Morality Should Be Adaptive: http://www.overcomingbias.com/2012/04/morals-should-be-adaptive.html
I agree with this
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april 2018 by nhaliday
Theory of Self-Reproducing Automata - John von Neumann
Fourth Lecture: THE ROLE OF HIGH AND OF EXTREMELY HIGH COMPLICATION

Comparisons between computing machines and the nervous systems. Estimates of size for computing machines, present and near future.

Estimates for size for the human central nervous system. Excursus about the “mixed” character of living organisms. Analog and digital elements. Observations about the “mixed” character of all componentry, artificial as well as natural. Interpretation of the position to be taken with respect to these.

Evaluation of the discrepancy in size between artificial and natural automata. Interpretation of this discrepancy in terms of physical factors. Nature of the materials used.

The probability of the presence of other intellectual factors. The role of complication and the theoretical penetration that it requires.

Questions of reliability and errors reconsidered. Probability of individual errors and length of procedure. Typical lengths of procedure for computing machines and for living organisms--that is, for artificial and for natural automata. Upper limits on acceptable probability of error in individual operations. Compensation by checking and self-correcting features.

Differences of principle in the way in which errors are dealt with in artificial and in natural automata. The “single error” principle in artificial automata. Crudeness of our approach in this case, due to the lack of adequate theory. More sophisticated treatment of this problem in natural automata: The role of the autonomy of parts. Connections between this autonomy and evolution.

- 10^10 neurons in brain, 10^4 vacuum tubes in largest computer at time
- machines faster: 5 ms from neuron potential to neuron potential, 10^-3 ms for vacuum tubes

https://en.wikipedia.org/wiki/John_von_Neumann#Computing
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april 2018 by nhaliday
Eternity in six hours: intergalactic spreading of intelligent life and sharpening the Fermi paradox
We do this by demonstrating that traveling between galaxies – indeed even launching a colonisation project for the entire reachable universe – is a relatively simple task for a star-spanning civilization, requiring modest amounts of energy and resources. We start by demonstrating that humanity itself could likely accomplish such a colonisation project in the foreseeable future, should we want to, and then demonstrate that there are millions of galaxies that could have reached us by now, using similar methods. This results in a considerable sharpening of the Fermi paradox.
pdf  study  article  essay  anthropic  fermi  space  expansionism  bostrom  ratty  philosophy  xenobio  ideas  threat-modeling  intricacy  time  civilization  🔬  futurism  questions  paradox  risk  physics  engineering  interdisciplinary  frontier  technology  volo-avolo  dirty-hands  ai  automation  robotics  duplication  iteration-recursion  von-neumann  data  scale  magnitude  skunkworks  the-world-is-just-atoms  hard-tech  ems  bio  bits  speedometer  nature  model-organism  mechanics  phys-energy  relativity  electromag  analysis  spock  nitty-gritty  spreading  hanson  street-fighting  speed  gedanken  nibble 
march 2018 by nhaliday
Antinomia Imediata – experiments in a reaction from the left
https://antinomiaimediata.wordpress.com/lrx/
So, what is the Left Reaction? First of all, it’s reaction: opposition to the modern rationalist establishment, the Cathedral. It opposes the universalist Jacobin program of global government, favoring a fractured geopolitics organized through long-evolved complex systems. It’s profoundly anti-socialist and anti-communist, favoring market economy and individualism. It abhors tribalism and seeks a realistic plan for dismantling it (primarily informed by HBD and HBE). It looks at modernity as a degenerative ratchet, whose only way out is intensification (hence clinging to crypto-marxist market-driven acceleration).

How come can any of this still be in the *Left*? It defends equality of power, i.e. freedom. This radical understanding of liberty is deeply rooted in leftist tradition and has been consistently abhored by the Right. LRx is not democrat, is not socialist, is not progressist and is not even liberal (in its current, American use). But it defends equality of power. It’s utopia is individual sovereignty. It’s method is paleo-agorism. The anti-hierarchy of hunter-gatherer nomads is its understanding of the only realistic objective of equality.

...

In more cosmic terms, it seeks only to fulfill the Revolution’s side in the left-right intelligence pump: mutation or creation of paths. Proudhon’s antinomy is essentially about this: the collective force of the socius, evinced in moral standards and social organization vs the creative force of the individuals, that constantly revolutionize and disrupt the social body. The interplay of these forces create reality (it’s a metaphysics indeed): the Absolute (socius) builds so that the (individualistic) Revolution can destroy so that the Absolute may adapt, and then repeat. The good old formula of ‘solve et coagula’.

Ultimately, if the Neoreaction promises eternal hell, the LRx sneers “but Satan is with us”.

https://antinomiaimediata.wordpress.com/2016/12/16/a-statement-of-principles/
Liberty is to be understood as the ability and right of all sentient beings to dispose of their persons and the fruits of their labor, and nothing else, as they see fit. This stems from their self-awareness and their ability to control and choose the content of their actions.

...

Equality is to be understood as the state of no imbalance of power, that is, of no subjection to another sentient being. This stems from their universal ability for empathy, and from their equal ability for reason.

...

It is important to notice that, contrary to usual statements of these two principles, my standpoint is that Liberty and Equality here are not merely compatible, meaning they could coexist in some possible universe, but rather they are two sides of the same coin, complementary and interdependent. There can be NO Liberty where there is no Equality, for the imbalance of power, the state of subjection, will render sentient beings unable to dispose of their persons and the fruits of their labor[1], and it will limit their ability to choose over their rightful jurisdiction. Likewise, there can be NO Equality without Liberty, for restraining sentient beings’ ability to choose and dispose of their persons and fruits of labor will render some more powerful than the rest, and establish a state of subjection.

https://antinomiaimediata.wordpress.com/2017/04/18/flatness/
equality is the founding principle (and ultimately indistinguishable from) freedom. of course, it’s only in one specific sense of “equality” that this sentence is true.

to try and eliminate the bullshit, let’s turn to networks again:

any nodes’ degrees of freedom is the number of nodes they are connected to in a network. freedom is maximum when the network is symmetrically connected, i. e., when all nodes are connected to each other and thus there is no topographical hierarchy (middlemen) – in other words, flatness.

in this understanding, the maximization of freedom is the maximization of entropy production, that is, of intelligence. As Land puts it:

https://antinomiaimediata.wordpress.com/category/philosophy/mutualism/
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march 2018 by nhaliday
Prisoner's dilemma - Wikipedia
caveat to result below:
An extension of the IPD is an evolutionary stochastic IPD, in which the relative abundance of particular strategies is allowed to change, with more successful strategies relatively increasing. This process may be accomplished by having less successful players imitate the more successful strategies, or by eliminating less successful players from the game, while multiplying the more successful ones. It has been shown that unfair ZD strategies are not evolutionarily stable. The key intuition is that an evolutionarily stable strategy must not only be able to invade another population (which extortionary ZD strategies can do) but must also perform well against other players of the same type (which extortionary ZD players do poorly, because they reduce each other's surplus).[14]

Theory and simulations confirm that beyond a critical population size, ZD extortion loses out in evolutionary competition against more cooperative strategies, and as a result, the average payoff in the population increases when the population is bigger. In addition, there are some cases in which extortioners may even catalyze cooperation by helping to break out of a face-off between uniform defectors and win–stay, lose–switch agents.[8]

https://alfanl.com/2018/04/12/defection/
Nature boils down to a few simple concepts.

Haters will point out that I oversimplify. The haters are wrong. I am good at saying a lot with few words. Nature indeed boils down to a few simple concepts.

In life, you can either cooperate or defect.

Used to be that defection was the dominant strategy, say in the time when the Roman empire started to crumble. Everybody complained about everybody and in the end nothing got done. Then came Jesus, who told people to be loving and cooperative, and boom: 1800 years later we get the industrial revolution.

Because of Jesus we now find ourselves in a situation where cooperation is the dominant strategy. A normie engages in a ton of cooperation: with the tax collector who wants more and more of his money, with schools who want more and more of his kid’s time, with media who wants him to repeat more and more party lines, with the Zeitgeist of the Collective Spirit of the People’s Progress Towards a New Utopia. Essentially, our normie is cooperating himself into a crumbling Western empire.

Turns out that if everyone blindly cooperates, parasites sprout up like weeds until defection once again becomes the standard.

The point of a post-Christian religion is to once again create conditions for the kind of cooperation that led to the industrial revolution. This necessitates throwing out undead Christianity: you do not blindly cooperate. You cooperate with people that cooperate with you, you defect on people that defect on you. Christianity mixed with Darwinism. God and Gnon meet.

This also means we re-establish spiritual hierarchy, which, like regular hierarchy, is a prerequisite for cooperation. It is this hierarchical cooperation that turns a household into a force to be reckoned with, that allows a group of men to unite as a front against their enemies, that allows a tribe to conquer the world. Remember: Scientology bullied the Cathedral’s tax department into submission.

With a functioning hierarchy, men still gossip, lie and scheme, but they will do so in whispers behind closed doors. In your face they cooperate and contribute to the group’s wellbeing because incentives are thus that contributing to group wellbeing heightens status.

Without a functioning hierarchy, men gossip, lie and scheme, but they do so in your face, and they tell you that you are positively deluded for accusing them of gossiping, lying and scheming. Seeds will not sprout in such ground.

Spiritual dominance is established in the same way any sort of dominance is established: fought for, taken. But the fight is ritualistic. You can’t force spiritual dominance if no one listens, or if you are silenced the ritual is not allowed to happen.

If one of our priests is forbidden from establishing spiritual dominance, that is a sure sign an enemy priest is in better control and has vested interest in preventing you from establishing spiritual dominance..

They defect on you, you defect on them. Let them suffer the consequences of enemy priesthood, among others characterized by the annoying tendency that very little is said with very many words.

https://contingentnotarbitrary.com/2018/04/14/rederiving-christianity/
To recap, we started with a secular definition of Logos and noted that its telos is existence. Given human nature, game theory and the power of cooperation, the highest expression of that telos is freely chosen universal love, tempered by constant vigilance against defection while maintaining compassion for the defectors and forgiving those who repent. In addition, we must know the telos in order to fulfill it.

In Christian terms, looks like we got over half of the Ten Commandments (know Logos for the First, don’t defect or tempt yourself to defect for the rest), the importance of free will, the indestructibility of evil (group cooperation vs individual defection), loving the sinner and hating the sin (with defection as the sin), forgiveness (with conditions), and love and compassion toward all, assuming only secular knowledge and that it’s good to exist.

Iterated Prisoner's Dilemma is an Ultimatum Game: http://infoproc.blogspot.com/2012/07/iterated-prisoners-dilemma-is-ultimatum.html
The history of IPD shows that bounded cognition prevented the dominant strategies from being discovered for over over 60 years, despite significant attention from game theorists, computer scientists, economists, evolutionary biologists, etc. Press and Dyson have shown that IPD is effectively an ultimatum game, which is very different from the Tit for Tat stories told by generations of people who worked on IPD (Axelrod, Dawkins, etc., etc.).

...

For evolutionary biologists: Dyson clearly thinks this result has implications for multilevel (group vs individual selection):
... Cooperation loses and defection wins. The ZD strategies confirm this conclusion and make it sharper. ... The system evolved to give cooperative tribes an advantage over non-cooperative tribes, using punishment to give cooperation an evolutionary advantage within the tribe. This double selection of tribes and individuals goes way beyond the Prisoners' Dilemma model.

implications for fractionalized Europe vis-a-vis unified China?

and more broadly does this just imply we're doomed in the long run RE: cooperation, morality, the "good society", so on...? war and group-selection is the only way to get a non-crab bucket civilization?

Iterated Prisoner’s Dilemma contains strategies that dominate any evolutionary opponent:
http://www.pnas.org/content/109/26/10409.full
http://www.pnas.org/content/109/26/10409.full.pdf
https://www.edge.org/conversation/william_h_press-freeman_dyson-on-iterated-prisoners-dilemma-contains-strategies-that

https://en.wikipedia.org/wiki/Ultimatum_game

analogy for ultimatum game: the state gives the demos a bargain take-it-or-leave-it, and...if the demos refuses...violence?

The nature of human altruism: http://sci-hub.tw/https://www.nature.com/articles/nature02043
- Ernst Fehr & Urs Fischbacher

Some of the most fundamental questions concerning our evolutionary origins, our social relations, and the organization of society are centred around issues of altruism and selfishness. Experimental evidence indicates that human altruism is a powerful force and is unique in the animal world. However, there is much individual heterogeneity and the interaction between altruists and selfish individuals is vital to human cooperation. Depending on the environment, a minority of altruists can force a majority of selfish individuals to cooperate or, conversely, a few egoists can induce a large number of altruists to defect. Current gene-based evolutionary theories cannot explain important patterns of human altruism, pointing towards the importance of both theories of cultural evolution as well as gene–culture co-evolution.

...

Why are humans so unusual among animals in this respect? We propose that quantitatively, and probably even qualitatively, unique patterns of human altruism provide the answer to this question. Human altruism goes far beyond that which has been observed in the animal world. Among animals, fitness-reducing acts that confer fitness benefits on other individuals are largely restricted to kin groups; despite several decades of research, evidence for reciprocal altruism in pair-wise repeated encounters4,5 remains scarce6–8. Likewise, there is little evidence so far that individual reputation building affects cooperation in animals, which contrasts strongly with what we find in humans. If we randomly pick two human strangers from a modern society and give them the chance to engage in repeated anonymous exchanges in a laboratory experiment, there is a high probability that reciprocally altruistic behaviour will emerge spontaneously9,10.

However, human altruism extends far beyond reciprocal altruism and reputation-based cooperation, taking the form of strong reciprocity11,12. Strong reciprocity is a combination of altruistic rewarding, which is a predisposition to reward others for cooperative, norm-abiding behaviours, and altruistic punishment, which is a propensity to impose sanctions on others for norm violations. Strong reciprocators bear the cost of rewarding or punishing even if they gain no individual economic benefit whatsoever from their acts. In contrast, reciprocal altruists, as they have been defined in the biological literature4,5, reward and punish only if this is in their long-term self-interest. Strong reciprocity thus constitutes a powerful incentive for cooperation even in non-repeated interactions and when reputation gains are absent, because strong reciprocators will reward those who cooperate and punish those who defect.

...

We will show that the interaction between selfish and strongly reciprocal … [more]
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march 2018 by nhaliday
Why Sex? And why only in Pairs? - Marginal REVOLUTION
The core conclusion is that mutations continue to rise with the number of sex-participating partners, but in simple Red Queen models the limiting features of the genotypes is the same whether there are two, three, or more partners.

Men Are Animals: http://www.overcomingbias.com/2018/06/men-are-animals.html
I agree with all the comments citing motility/sessility.
econotariat  marginal-rev  commentary  study  summary  economics  broad-econ  interdisciplinary  bio  biodet  deep-materialism  new-religion  eden  gender  sex  EGT  explanans  red-queen  parasites-microbiome  mutation  comparison  evolution  roots  🌞  population-genetics  genetics  marginal  equilibrium  number  ecology  whole-partial-many  uniqueness  parsimony  multi  cost-benefit  outcome-risk  uncertainty  moments  spatial  travel  explore-exploit  ratty  hanson 
january 2018 by nhaliday
Sacred text as cultural genome: an inheritance mechanism and method for studying cultural evolution: Religion, Brain & Behavior: Vol 7, No 3
Yasha M. Hartberg & David Sloan Wilson

Any process of evolution requires a mechanism of inheritance for the transmission of information across generations and the expression of phenotypes during each generation. Genetic inheritance mechanisms have been studied for over a century but mechanisms of inheritance for human cultural evolution are far less well understood. Sacred religious texts have the properties required for an inheritance system. They are replicated across generations with high fidelity and are transcribed into action every generation by the invocation and interpretation of selected passages. In this article we borrow concepts and methods from genetics and epigenetics to study the “expressed phenotypes” of six Christian churches that differ along a conservative–progressive axis. Their phenotypic differences, despite drawing upon the same sacred text, can be explained in part by differential expression of the sacred text. Since the invocation and interpretation of sacred texts are often well preserved, our methods allow the expressed phenotypes of religious groups to be studied at any time and place in history.
study  interdisciplinary  bio  sociology  cultural-dynamics  anthropology  religion  christianity  theos  protestant-catholic  politics  ideology  correlation  organizing  institutions  analogy  genetics  genomics  epigenetics  comparison  culture  pdf  piracy  density  flexibility  noble-lie  deep-materialism  new-religion  universalism-particularism  homo-hetero  hypocrisy  group-selection  models  coordination  info-dynamics  evolution  impact  left-wing  right-wing  time  tradition  spreading  sanctity-degradation  coalitions  trees  usa  social-capital  hari-seldon  wisdom  the-basilisk  frequency  sociality  ecology  analytical-holistic  phalanges 
january 2018 by nhaliday
What are the Laws of Biology?
The core finding of systems biology is that only a very small subset of possible network motifs is actually used and that these motifs recur in all kinds of different systems, from transcriptional to biochemical to neural networks. This is because only those arrangements of interactions effectively perform some useful operation, which underlies some necessary function at a cellular or organismal level. There are different arrangements for input summation, input comparison, integration over time, high-pass or low-pass filtering, negative auto-regulation, coincidence detection, periodic oscillation, bistability, rapid onset response, rapid offset response, turning a graded signal into a sharp pulse or boundary, and so on, and so on.

These are all familiar concepts and designs in engineering and computing, with well-known properties. In living organisms there is one other general property that the designs must satisfy: robustness. They have to work with noisy components, at a scale that’s highly susceptible to thermal noise and environmental perturbations. Of the subset of designs that perform some operation, only a much smaller subset will do it robustly enough to be useful in a living organism. That is, they can still perform their particular functions in the face of noisy or fluctuating inputs or variation in the number of components constituting the elements of the network itself.
scitariat  reflection  proposal  ideas  thinking  conceptual-vocab  lens  bio  complex-systems  selection  evolution  flux-stasis  network-structure  structure  composition-decomposition  IEEE  robust  signal-noise  perturbation  interdisciplinary  graphs  circuits  🌞  big-picture  hi-order-bits  nibble  synthesis 
november 2017 by nhaliday
Fortifications and Democracy in the Ancient Greek World by Josiah Ober, Barry Weingast :: SSRN
- Joshiah Ober, Barry Weingast

In the modern world, access-limiting fortification walls are not typically regarded as promoting democracy. But in Greek antiquity, increased investment in fortifications was correlated with the prevalence and stability of democracy. This paper sketches the background conditions of the Greek city-state ecology, analyzes a passage in Aristotle’s Politics, and assesses the choices of Hellenistic kings, Greek citizens, and urban elites, as modeled in a simple game. The paper explains how city walls promoted democracy and helps to explain several other puzzles: why Hellenistic kings taxed Greek cities at lower than expected rates; why elites in Greek cities supported democracy; and why elites were not more heavily taxed by democratic majorities. The relationship between walls, democracy, and taxes promoted continued economic growth into the late classical and Hellenistic period (4th-2nd centuries BCE), and ultimately contributed to the survival of Greek culture into the Roman era, and thus modernity. We conclude with a consideration of whether the walls-democracy relationship holds in modernity.

'Rulers Ruled by Women': An Economic Analysis of the Rise and Fall of Women's Rights in Ancient Sparta by Robert K. Fleck, F. Andrew Hanssen: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=788106
Throughout most of history, women as a class have possessed relatively few formal rights. The women of ancient Sparta were a striking exception. Although they could not vote, Spartan women reportedly owned 40 percent of Sparta's agricultural land and enjoyed other rights that were equally extraordinary. We offer a simple economic explanation for the Spartan anomaly. The defining moment for Sparta was its conquest of a neighboring land and people, which fundamentally changed the marginal products of Spartan men's and Spartan women's labor. To exploit the potential gains from a reallocation of labor - specifically, to provide the appropriate incentives and the proper human capital formation - men granted women property (and other) rights. Consistent with our explanation for the rise of women's rights, when Sparta lost the conquered land several centuries later, the rights for women disappeared. Two conclusions emerge that may help explain why women's rights have been so rare for most of history. First, in contrast to the rest of the world, the optimal (from the men's perspective) division of labor among Spartans involved women in work that was not easily monitored by men. Second, the rights held by Spartan women may have been part of an unstable equilibrium, which contained the seeds of its own destruction.
study  broad-econ  economics  polisci  political-econ  institutions  government  north-weingast-like  democracy  walls  correlation  polis  history  mediterranean  iron-age  the-classics  microfoundations  modernity  comparison  architecture  military  public-goodish  elite  civic  taxes  redistribution  canon  literature  big-peeps  conquest-empire  rent-seeking  defense  models  GT-101  incentives  urban  urban-rural  speculation  interdisciplinary  cliometrics  multi  civil-liberty  gender  gender-diff  equilibrium  cycles  branches  labor  interests  property-rights  unintended-consequences  explanation  explanans  analysis  econ-productivity  context  arrows  micro  natural-experiment 
november 2017 by nhaliday
Indiana Jones, Economist?! - Marginal REVOLUTION
In a stunningly original paper Gojko Barjamovic, Thomas Chaney, Kerem A. Coşar, and Ali Hortaçsu use the gravity model of trade to infer the location of lost cities from Bronze age Assyria! The simplest gravity model makes predictions about trade flows based on the sizes of cities and the distances between them. More complicated models add costs based on geographic barriers. The authors have data from ancient texts on trade flows between all the cities, they know the locations of some of the cities, and they know the geography of the region. Using this data they can invert the gravity model and, triangulating from the known cities, find the lost cities that would best “fit” the model. In other words, by assuming the model is true the authors can predict where the lost cities should be located. To test the idea the authors pretend that some known cities are lost and amazingly the model is able to accurately rediscover those cities.
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november 2017 by nhaliday
New Theory Cracks Open the Black Box of Deep Learning | Quanta Magazine
A new idea called the “information bottleneck” is helping to explain the puzzling success of today’s artificial-intelligence algorithms — and might also explain how human brains learn.

sounds like he's just talking about autoencoders?
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september 2017 by nhaliday
Medicine as a pseudoscience | West Hunter
The idea that venesection was a good thing, or at least not so bad, on the grounds that one in a few hundred people have hemochromatosis (in Northern Europe) reminds me of the people who don’t wear a seatbelt, since it would keep them from being thrown out of their convertible into a waiting haystack, complete with nubile farmer’s daughter. Daughters. It could happen. But it’s not the way to bet.

Back in the good old days, Charles II, age 53, had a fit one Sunday evening, while fondling two of his mistresses.

Monday they bled him (cupping and scarifying) of eight ounces of blood. Followed by an antimony emetic, vitriol in peony water, purgative pills, and a clyster. Followed by another clyster after two hours. Then syrup of blackthorn, more antimony, and rock salt. Next, more laxatives, white hellebore root up the nostrils. Powdered cowslip flowers. More purgatives. Then Spanish Fly. They shaved his head and stuck blistering plasters all over it, plastered the soles of his feet with tar and pigeon-dung, then said good-night.

...

Friday. The king was worse. He tells them not to let poor Nelly starve. They try the Oriental Bezoar Stone, and more bleeding. Dies at noon.

Most people didn’t suffer this kind of problem with doctors, since they never saw one. Charles had six. Now Bach and Handel saw the same eye surgeon, John Taylor – who blinded both of them. Not everyone can put that on his resume!

You may wonder how medicine continued to exist, if it had a negative effect, on the whole. There’s always the placebo effect – at least there would be, if it existed. Any real placebo effect is very small: I’d guess exactly zero. But there is regression to the mean. You see the doctor when you’re feeling worse than average – and afterwards, if he doesn’t kill you outright, you’re likely to feel better. Which would have happened whether you’d seen him or not, but they didn’t often do RCTs back in the day – I think James Lind was the first (1747).

Back in the late 19th century, Christian Scientists did better than others when sick, because they didn’t believe in medicine. For reasons I think mistaken, because Mary Baker Eddy rejected the reality of the entire material world, but hey, it worked. Parenthetically, what triggered all that New Age nonsense in 19th century New England? Hash?

This did not change until fairly recently. Sometime in the early 20th medicine, clinical medicine, what doctors do, hit break-even. Now we can’t do without it. I wonder if there are, or will be, other examples of such a pile of crap turning (mostly) into a real science.

good tweet: https://twitter.com/bowmanthebard/status/897146294191390720
The brilliant GP I've had for 35+ years has retired. How can I find another one who meets my requirements?

1 is overweight
2 drinks more than officially recommended amounts
3 has an amused, tolerant atitude to human failings
4 is well aware that we're all going to die anyway, & there are better or worse ways to die
5 has a healthy skeptical attitude to mainstream medical science
6 is wholly dismissive of "a|ternative” medicine
7 believes in evolution
8 thinks most diseases get better without intervention, & knows the dangers of false positives
9 understands the base rate fallacy

EconPapers: Was Civil War Surgery Effective?: http://econpapers.repec.org/paper/htrhcecon/444.htm
contra Greg Cochran:
To shed light on the subject, I analyze a data set created by Dr. Edmund Andrews, a Civil war surgeon with the 1st Illinois Light Artillery. Dr. Andrews’s data can be rendered into an observational data set on surgical intervention and recovery, with controls for wound location and severity. The data also admits instruments for the surgical decision. My analysis suggests that Civil War surgery was effective, and increased the probability of survival of the typical wounded soldier, with average treatment effect of 0.25-0.28.

Medical Prehistory: https://westhunt.wordpress.com/2016/03/14/medical-prehistory/
What ancient medical treatments worked?

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76878
In some very, very limited conditions, bleeding?
--
Bad for you 99% of the time.

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76947
Colchicine – used to treat gout – discovered by the Ancient Greeks.

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76973
Dracunculiasis (Guinea worm)
Wrap the emerging end of the worm around a stick and slowly pull it out.
(3,500 years later, this remains the standard treatment.)
https://en.wikipedia.org/wiki/Ebers_Papyrus

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76971
Some of the progress is from formal medicine, most is from civil engineering, better nutrition ( ag science and physical chemistry), less crowded housing.

Nurses vs doctors: https://westhunt.wordpress.com/2014/10/01/nurses-vs-doctors/
Medicine, the things that doctors do, was an ineffective pseudoscience until fairly recently. Until 1800 or so, they were wrong about almost everything. Bleeding, cupping, purging, the four humors – useless. In the 1800s, some began to realize that they were wrong, and became medical nihilists that improved outcomes by doing less. Some patients themselves came to this realization, as when Civil War casualties hid from the surgeons and had better outcomes. Sometime in the early 20th century, MDs reached break-even, and became an increasingly positive influence on human health. As Lewis Thomas said, medicine is the youngest science.

Nursing, on the other hand, has always been useful. Just making sure that a patient is warm and nourished when too sick to take care of himself has helped many survive. In fact, some of the truly crushing epidemics have been greatly exacerbated when there were too few healthy people to take care of the sick.

Nursing must be old, but it can’t have existed forever. Whenever it came into existence, it must have changed the selective forces acting on the human immune system. Before nursing, being sufficiently incapacitated would have been uniformly fatal – afterwards, immune responses that involved a period of incapacitation (with eventual recovery) could have been selectively favored.

when MDs broke even: https://westhunt.wordpress.com/2014/10/01/nurses-vs-doctors/#comment-58981
I’d guess the 1930s. Lewis Thomas thought that he was living through big changes. They had a working serum therapy for lobar pneumonia ( antibody-based). They had many new vaccines ( diphtheria in 1923, whopping cough in 1926, BCG and tetanus in 1927, yellow fever in 1935, typhus in 1937.) Vitamins had been mostly worked out. Insulin was discovered in 1929. Blood transfusions. The sulfa drugs, first broad-spectrum antibiotics, showed up in 1935.

DALYs per doctor: https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/
The disability-adjusted life year (DALY) is a measure of overall disease burden – the number of years lost. I’m wondering just much harm premodern medicine did, per doctor. How many healthy years of life did a typical doctor destroy (net) in past times?

...

It looks as if the average doctor (in Western medicine) killed a bunch of people over his career ( when contrasted with doing nothing). In the Charles Manson class.

Eventually the market saw through this illusion. Only took a couple of thousand years.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100741
That a very large part of healthcare spending is done for non-health reasons. He has a chapter on this in his new book, also check out his paper “Showing That You Care: The Evolution of Health Altruism” http://mason.gmu.edu/~rhanson/showcare.pdf
--
I ran into too much stupidity to finish the article. Hanson’s a loon. For example when he talks about the paradox of blacks being more sentenced on drug offenses than whites although they use drugs at similar rate. No paradox: guys go to the big house for dealing, not for using. Where does he live – Mars?

I had the same reaction when Hanson parroted some dipshit anthropologist arguing that the stupid things people do while drunk are due to social expectations, not really the alcohol.
Horseshit.

I don’t think that being totally unable to understand everybody around you necessarily leads to deep insights.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100744
What I’ve wondered is if there was anything that doctors did that actually was helpful and if perhaps that little bit of success helped them fool people into thinking the rest of it helped.
--
Setting bones. extracting arrows: spoon of Diocles. Colchicine for gout. Extracting the Guinea worm. Sometimes they got away with removing the stone. There must be others.
--
Quinine is relatively recent: post-1500. Obstetrical forceps also. Caesarean deliveries were almost always fatal to the mother until fairly recently.

Opium has been around for a long while : it works.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100839
If pre-modern medicine was indeed worse than useless – how do you explain no one noticing that patients who get expensive treatments are worse off than those who didn’t?
--
were worse off. People are kinda dumb – you’ve noticed?
--
My impression is that while people may be “kinda dumb”, ancient customs typically aren’t.
Even if we assume that all people who lived prior to the 19th century were too dumb to make the rational observation, wouldn’t you expect this ancient practice to be subject to selective pressure?
--
Your impression is wrong. Do you think that there some slick reason for Carthaginians incinerating their first-born?

Theodoric of York, bloodletting: https://www.youtube.com/watch?v=yvff3TViXmY

details on blood-letting and hemochromatosis: https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100746

Starting Over: https://westhunt.wordpress.com/2018/01/23/starting-over/
Looking back on it, human health would have … [more]
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august 2017 by nhaliday
It made their brown eyes blue.. | West Hunter
Assuming population continuity, the selective advantage of the alleles they examined must have been very high. In order to see if there had been population continuity, they looked at the mtDNA frequencies of the ancient populations and compared them with mtDNA frequencies of modern populations in the same areas. Since they’re different, but not wildly different, they conclude that there has been population continuity, which was their null assumption.

That null assumption might have been reasonable, if someone had burned every history book ever written, while at the same time suppressing all the ancient DNA evidence.

Since that has not yet happened, I think their assumption is downright embarrassing. People have been moving in and out of this area for all of recorded history (as Razib Khan has also pointed out) : Cimmerians, Scythians, Goths, Khazars, Kievian Rus, the Golden Horde, eventually Russians.

There is no logical reason for geneticists to ignore information outside their field. Ignorance is no excuse. I could say the same for every other discipline. Cross the streams – it would be good.
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august 2017 by nhaliday
Controversial New Theory Suggests Life Wasn't a Fluke of Biology—It Was Physics | WIRED
First Support for a Physics Theory of Life: https://www.quantamagazine.org/first-support-for-a-physics-theory-of-life-20170726/
Take chemistry, add energy, get life. The first tests of Jeremy England’s provocative origin-of-life hypothesis are in, and they appear to show how order can arise from nothing.
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august 2017 by nhaliday
Predicting the outcomes of organic reactions via machine learning: are current descriptors sufficient? | Scientific Reports
As machine learning/artificial intelligence algorithms are defeating chess masters and, most recently, GO champions, there is interest – and hope – that they will prove equally useful in assisting chemists in predicting outcomes of organic reactions. This paper demonstrates, however, that the applicability of machine learning to the problems of chemical reactivity over diverse types of chemistries remains limited – in particular, with the currently available chemical descriptors, fundamental mathematical theorems impose upper bounds on the accuracy with which raction yields and times can be predicted. Improving the performance of machine-learning methods calls for the development of fundamentally new chemical descriptors.
study  org:nat  papers  machine-learning  chemistry  measurement  volo-avolo  lower-bounds  analysis  realness  speedometer  nibble  🔬  applications  frontier  state-of-art  no-go  accuracy  interdisciplinary 
july 2017 by nhaliday
Economics empiricism - Wikipedia
Economics empiricism[1] (sometimes economic imperialism) in contemporary economics refers to economic analysis of seemingly non-economic aspects of life,[2] such as crime,[3] law,[4] the family,[5] prejudice,[6] tastes,[7] irrational behavior,[8] politics,[9] sociology,[10] culture,[11] religion,[12] war,[13] science,[14] and research.[14] Related usage of the term predates recent decades.[15]

The emergence of such analysis has been attributed to a method that, like that of the physical sciences, permits refutable implications[16] testable by standard statistical techniques.[17] Central to that approach are "[t]he combined postulates of maximizing behavior, stable preferences and market equilibrium, applied relentlessly and unflinchingly."[18] It has been asserted that these and a focus on economic efficiency have been ignored in other social sciences and "allowed economics to invade intellectual territory that was previously deemed to be outside the discipline’s realm."[17][19]

The Fluidity of Race: https://westhunt.wordpress.com/2015/01/26/the-fluidity-of-race/
So: what can we conclude about this paper? It’s a classic case of economic imperialism, informed by what ‘intellectuals’ [ those that have never been introduced to Punnet squares, Old Blue Light, the Dirac equation, or Melungeons] would like to hear.

It is wrong, not close to right.

Breadth-first search: https://westhunt.wordpress.com/2015/05/24/breadth-first-search/
When I complain about some egregious piece of research, particularly those that are in some sense cross-disciplinary, I often feel that that just knowing more would solve the problem. If Roland Fryer or Oded Galor understood genetics, they wouldn’t make these silly mistakes. If Qian and Nix understood genetics or American post-Civil War history, they would never have written that awful paper about massive passing. Or if paleoanthropologists and population geneticists had learned about mammalian hybrids, they would have been open to the idea of Neanderthal introgression.

But that really amounts to a demand that people learn about five times as much in college and grad school as they actually do. It’s not going to happen. Or, perhaps, find a systematic and effective way of collaborating with people outside their discipline without having their heads shaved. That doesn’t sound too likely either.

Hot enough for you?: https://westhunt.wordpress.com/2015/10/22/hot-enough-for-you/
There’s a new study out in Nature, claiming that economic productivity peaks at 13 degrees Centigrade and that global warming will therefore drastically decrease world GDP.

Singapore. Phoenix. Queensland. Air-conditioners!

Now that I’ve made my point, just how stupid are these people? Do they actually believe this shit? I keep seeing papers by economists – in prominent places – that rely heavily on not knowing jack shit about anything on Earth, papers that could only have been written by someone that didn’t know a damn thing about the subject they were addressing, from the influence of genetic diversity on civilization achievement (zilch) to the massive race-switching that happened after the Civil War (not). Let me tell you, there’s a difference between ‘economic imperialism’ and old-fashioned real imperialism: people like Clive of India or Raffles bothered to learn something about the territory they were conquering. They knew enough to run divide et impera in their sleep: while economists never say peccavi, no matter how badly they screw up.
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july 2017 by nhaliday
[1705.03394] That is not dead which can eternal lie: the aestivation hypothesis for resolving Fermi's paradox
If a civilization wants to maximize computation it appears rational to aestivate until the far future in order to exploit the low temperature environment: this can produce a 10^30 multiplier of achievable computation. We hence suggest the "aestivation hypothesis": the reason we are not observing manifestations of alien civilizations is that they are currently (mostly) inactive, patiently waiting for future cosmic eras. This paper analyzes the assumptions going into the hypothesis and how physical law and observational evidence constrain the motivations of aliens compatible with the hypothesis.

http://aleph.se/andart2/space/the-aestivation-hypothesis-popular-outline-and-faq/

simpler explanation (just different math for Drake equation):
Dissolving the Fermi Paradox: http://www.jodrellbank.manchester.ac.uk/media/eps/jodrell-bank-centre-for-astrophysics/news-and-events/2017/uksrn-slides/Anders-Sandberg---Dissolving-Fermi-Paradox-UKSRN.pdf
http://marginalrevolution.com/marginalrevolution/2017/07/fermi-paradox-resolved.html
Overall the argument is that point estimates should not be shoved into a Drake equation and then multiplied by each, as that requires excess certainty and masks much of the ambiguity of our knowledge about the distributions. Instead, a Bayesian approach should be used, after which the fate of humanity looks much better. Here is one part of the presentation:

Life Versus Dark Energy: How An Advanced Civilization Could Resist the Accelerating Expansion of the Universe: https://arxiv.org/abs/1806.05203
The presence of dark energy in our universe is causing space to expand at an accelerating rate. As a result, over the next approximately 100 billion years, all stars residing beyond the Local Group will fall beyond the cosmic horizon and become not only unobservable, but entirely inaccessible, thus limiting how much energy could one day be extracted from them. Here, we consider the likely response of a highly advanced civilization to this situation. In particular, we argue that in order to maximize its access to useable energy, a sufficiently advanced civilization would chose to expand rapidly outward, build Dyson Spheres or similar structures around encountered stars, and use the energy that is harnessed to accelerate those stars away from the approaching horizon and toward the center of the civilization. We find that such efforts will be most effective for stars with masses in the range of M∼(0.2−1)M⊙, and could lead to the harvesting of stars within a region extending out to several tens of Mpc in radius, potentially increasing the total amount of energy that is available to a future civilization by a factor of several thousand. We also discuss the observable signatures of a civilization elsewhere in the universe that is currently in this state of stellar harvesting.
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may 2017 by nhaliday
Interview Greg Cochran by Future Strategist
https://westhunt.wordpress.com/2016/08/10/interview/

- IQ enhancement (somewhat apprehensive, wonder why?)
- ~20 years to CRISPR enhancement (very ballpark)
- cloning as an alternative strategy
- environmental effects on IQ, what matters (iodine, getting hit in the head), what doesn't (schools, etc.), and toss-ups (childhood/embryonic near-starvation, disease besides direct CNS-affecting ones [!])
- malnutrition did cause more schizophrenia in Netherlands (WW2) and China (Great Leap Forward) though
- story about New Mexico schools and his children (mostly grad students in physics now)
- clever sillies, weird geniuses, and clueless elites
- life-extension and accidents, half-life ~ a few hundred years for a typical American
- Pinker on Harvard faculty adoptions (always Chinese girls)
- parabiosis, organ harvesting
- Chicago economics talk
- Catholic Church, cousin marriage, and the rise of the West
- Gregory Clark and Farewell to Alms
- retinoblastoma cancer, mutational load, and how to deal w/ it ("something will turn up")
- Tularemia and Stalingrad (ex-Soviet scientist literally mentioned his father doing it)
- germ warfare, nuclear weapons, and testing each
- poison gas, Haber, nerve gas, terrorists, Japan, Syria, and Turkey
- nukes at https://en.wikipedia.org/wiki/Incirlik_Air_Base
- IQ of ancient Greeks
- history of China and the Mongols, cloning Genghis Khan
- Alexander the Great vs. Napoleon, Russian army being late for meetup w/ Austrians
- the reason why to go into Iraq: to find and clone Genghis Khan!
- efficacy of torture
- monogamy, polygamy, and infidelity, the Aboriginal system (reverse aging wives)
- education and twin studies
- errors: passing white, female infanticide, interdisciplinary social science/economic imperialism, the slavery and salt story
- Jewish optimism about environmental interventions, Rabbi didn't want people to know, Israelis don't want people to know about group differences between Ashkenazim and other groups in Israel
- NASA spewing crap on extraterrestrial life (eg, thermodynamic gradient too weak for life in oceans of ice moons)
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march 2017 by nhaliday
[1604.03640] Bridging the Gaps Between Residual Learning, Recurrent Neural Networks and Visual Cortex
We discuss relations between Residual Networks (ResNet), Recurrent Neural Networks (RNNs) and the primate visual cortex. We begin with the observation that a shallow RNN is exactly equivalent to a very deep ResNet with weight sharing among the layers. A direct implementation of such a RNN, although having orders of magnitude fewer parameters, leads to a performance similar to the corresponding ResNet. We propose 1) a generalization of both RNN and ResNet architectures and 2) the conjecture that a class of moderately deep RNNs is a biologically-plausible model of the ventral stream in visual cortex. We demonstrate the effectiveness of the architectures by testing them on the CIFAR-10 dataset.
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february 2017 by nhaliday
Links 2/17: Site Your Sources | Slate Star Codex
The United States not only does poorly on education benchmark PISA, but each decile of wealth also does poorly compared to equivalent deciles in other countries. I find this surprising. Does this torpedo the theory that each US ethnic group does as well as its foreign counterparts, and US underperformance is a Simpson’s Paradox on ethnic distribution?

Twitter: @EveryoneIsDril.

New Study Finds Performance-Enhancing Drugs For Chess. Okay, fine, just modafinil, which we already knew about, but the exact pattern is interesting. Modafinil makes people take longer to make their moves, but the moves are ultimately better. That suggests that its advantage is not increasing IQ per se, but in giving people the increased attention span/concentration to work harder on finding good moves. I think this elegantly ties together a lot of stuff into a good explanation of modafinil’s cognitive-enhancing properties.

New Zealand Wants To Know How Peter Thiel Became A Secret Citizen. Give up, New Zealand; Peter Thiel is a citizen of any country he wants to be a citizen of. Also: Peter Thiel Denies California Governor Run Despite Mysterious Group’s Backing.

I was going to link to the paper Physics Envy May Be Hazardous To Your Wealth, but the part that actually interested me is small enough that I’m just going to include it here as a jpg (h/t Julia Galef).

Nature: Prevalence And Architecture Of De Novo Mutations In Developmental Disorders. There’s been a lot of debate over paternal age effects, and this paper helps clarify that by actually counting people’s de novo mutations and finding that children of older fathers (and to a lesser degree older mothers) have more of them. I am not sure to what degree this answers the objection that fathers with worse genes will tend to get married later; my impression is that it’s circumstantial evidence against (de novo mutations are more specific to paternal age than just bad genes) but not complete disproof.

Psssst, kid, wanna buy a parasitic worm? Key quote: “Those who experience the ‘hookworm bounce’ tend to describe it as ‘feeling as if they are teenagers again'” (h/t pistachi0n).

New paper in Crime And Delinquency: “We find no evidence that the number of fatal police shootings either increased or decreased post-Ferguson. Claims to the contrary are based on weak analyses of short-term trends.” This is especially surprising in light of claims that increased inner-city crime is caused by police withdrawing in order to prevent further fatal shootings; if that’s the police’s plan, it doesn’t seem to be working very well.

Intranasal ghrelin vaccine prevents obesity in mice.

Gene drive testing thwarted when organisms quickly develop resistance. There goes that idea.

New poll: Majority of Europeans support banning Muslim immigration. It’s an Internet-based poll, which is always cause for suspicion, but they seem to be a reputable organization and not the sort of group whose results are 100% due to trolling by 4chan, plus it’s consistent with some other results. Still pretty shocking and an existential-terror-level reminder of partisan bubbles. Also: Rasmussen finds most Americans support Trump’s refugee ban order.

Closely related: M.G. Miles makes the case for banning Muslim immigration. Maybe the first person I have seen make this case in a principled way; everyone else just seems to be screaming about stuff and demanding their readers reinterpret it into argument form. Also, he uses the word “terrorism” zero times, which seems like the correct number of times for a case of this sort. This is what people should be debating and responding to. Rebuttals by Americans would probably want to start with the differences between Muslim immigrants to Europe and Muslim immigrants to the US – Miles discusses the European case, but by my understanding these are very different populations with very different outcomes).

Second Enumerations podcast: Grognor reading interesting essays.

SSRN: Extreme Protest Tactics Reduce Popular Support For Social Movements: “We find across three experiments that extreme protest tactics decreased popular support for a given cause because they reduced feelings of identification with the movement. Though this effect obtained in tests of popular responses to extreme tactics used by animal rights, Black Lives Matter, and anti-Trump protests (Studies 1-3), we found that self-identified political activists were willing to use extreme tactics because they believed them to be effective for recruiting popular support.” Cf. The Toxoplasma Of Rage. (h/t Dain)

The Cagots were an underclass of people in medieval France whom everyone hated, with various purity laws around how decent people weren’t allowed to associate with/marry/touch/go near them. In the 1500s, the Pope personally intervened to tell the French to stop persecuting them, but the French ignored him and persecuted them more than ever. As far as anyone can tell, they looked, spoke, and acted just like everyone else, and exactly how they became so despised is one of the minor mysteries of medieval history.
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february 2017 by nhaliday
Information Processing: Learn to solve every problem that has been solved
While it may be impossible to achieve Feynman's goal, I'm surprised that more people don't attempt the importance threshold-modified version. Suppose we set the importance bar really, really high: what are the most important results that everyone should try to understand? Here's a very biased partial list: basic physics and mathematics (e.g., to the level of the Feynman Lectures); quantitative theory of genetics and evolution; information, entropy and probability; basic ideas about logic and computation (Godel and Turing?); ... What else? Dynamics of markets? Complex Systems? Psychometrics? Descriptive biology? Organic chemistry?
hsu  scitariat  feynman  giants  stories  aphorism  curiosity  interdisciplinary  frontier  signal-noise  top-n  discussion  caltech  problem-solving  big-picture  vitality  🎓  virtu  big-surf  courage  🔬  allodium  nietzschean  ideas  quixotic  accretion  learning  hi-order-bits 
february 2017 by nhaliday
Information Processing: Machine Dreams
This is a controversial book because it demolishes not just the conventional history of the discipline, but its foundational assumptions. For example, once you start thinking about the information processing requirements that each agent (or even the entire system) must satisfy to find the optimal neoclassical equilibrium points, you realize the task is impossible. In fact, in some cases it has been rigorously shown to be beyond the capability of any universal Turing machine. Certainly, it seems beyond the plausible capabilities of a primitive species like homo sapiens. Once this bounded rationality (see also here) is taken into account, the whole notion of optimality of market equilibrium becomes far-fetched and speculative. It cannot be justified in any formal sense, and therefore cries out for experimental justification, which is not to be found.

I like this quote: This polymath who prognosticated that "science and technology would shift from a past emphasis on subjects of motion, force and energy to a future emphasis on subjects of communications, organization, programming and control," was spot on the money.
hsu  scitariat  economics  cs  computation  interdisciplinary  map-territory  models  market-failure  von-neumann  giants  history  quotes  links  debate  critique  review  big-picture  turing  heterodox  complex-systems  lens  s:*  books  🎩  thinking  markets  bounded-cognition 
february 2017 by nhaliday
Information Processing: Big, complicated data sets
This Times article profiles Nick Patterson, a mathematician whose career wandered from cryptography, to finance (7 years at Renaissance) and finally to bioinformatics. “I’m a data guy,” Dr. Patterson said. “What I know about is how to analyze big, complicated data sets.”

If you're a smart guy looking for something to do, there are 3 huge computational problems staring you in the face, for which the data is readily accessible.

1) human genome: 3 GB of data in a single genome; most data freely available on the Web (e.g., Hapmap stores patterns of sequence variation). Got a hypothesis about deep human history (evolution)? Test it yourself...

2) market prediction: every market tick available at zero or minimal subscription-service cost. Can you model short term movements? It's never been cheaper to build and test your model!

3) internet search: about 10^3 Terabytes of data (admittedly, a barrier to entry for an individual, but not for a startup). Can you come up with a better way to index or search it? What about peripheral problems like language translation or picture or video search?

The biggest barrier to entry is, of course, brainpower and a few years (a decade?) of concentrated learning. But the necessary books are all in the library :-)

Patterson has worked in 2 of the 3 areas listed above! Substituting crypto for internet search is understandable given his age, our cold war history, etc.
hsu  scitariat  quotes  links  news  org:rec  profile  giants  stories  huge-data-the-biggest  genomics  bioinformatics  finance  crypto  history  britain  interdisciplinary  the-trenches  🔬  questions  genetics  dataset  search  web  internet  scale  commentary  apollonian-dionysian  magnitude  examples  open-problems  big-surf  markets  securities  ORFE  nitty-gritty  quixotic  google  startups  ideas  measure  space-complexity  minimum-viable  move-fast-(and-break-things) 
february 2017 by nhaliday
Information Processing: Epistasis vs additivity
On epistasis: why it is unimportant in polygenic directional selection: http://rstb.royalsocietypublishing.org/content/365/1544/1241.short
- James F. Crow

The Evolution of Multilocus Systems Under Weak Selection: http://www.genetics.org/content/genetics/134/2/627.full.pdf
- Thomas Nagylaki

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000008
The relative proportion of additive and non-additive variation for complex traits is important in evolutionary biology, medicine, and agriculture. We address a long-standing controversy and paradox about the contribution of non-additive genetic variation, namely that knowledge about biological pathways and gene networks imply that epistasis is important. Yet empirical data across a range of traits and species imply that most genetic variance is additive. We evaluate the evidence from empirical studies of genetic variance components and find that additive variance typically accounts for over half, and often close to 100%, of the total genetic variance. We present new theoretical results, based upon the distribution of allele frequencies under neutral and other population genetic models, that show why this is the case even if there are non-additive effects at the level of gene action. We conclude that interactions at the level of genes are not likely to generate much interaction at the level of variance.
hsu  scitariat  commentary  links  study  list  evolution  population-genetics  genetics  methodology  linearity  nonlinearity  comparison  scaling-up  nibble  lens  bounded-cognition  ideas  bio  occam  parsimony  🌞  summary  quotes  multi  org:nat  QTL  stylized-facts  article  explanans  sapiens  biodet  selection  variance-components  metabuch  thinking  models  data  deep-materialism  chart  behavioral-gen  evidence-based  empirical  mutation  spearhead  model-organism  bioinformatics  linear-models  math  magnitude  limits  physics  interdisciplinary  stat-mech 
february 2017 by nhaliday
Information Geometry (Part 16) | Azimuth
While preparing this talk, I discovered a cool fact. I doubt it’s new, but I haven’t exactly seen it elsewhere. I came up with it while trying to give a precise and general statement of ‘Fisher’s fundamental theorem of natural selection’. I won’t start by explaining that theorem, since my version looks rather different than Fisher’s, and I came up with mine precisely because I had trouble understanding his. I’ll say a bit more about this at the end.

Here’s my version:
The square of the rate at which a population learns information is the variance of its fitness.
baez  mathtariat  evolution  bio  genetics  population-genetics  bits  interdisciplinary  models  exposition  math.DS  giants  information-theory  entropy-like  org:bleg  nibble  fisher  EGT  dynamical 
february 2017 by nhaliday
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