nhaliday + embodied   335

Comparing within- and between-family polygenic score prediction | bioRxiv
https://twitter.com/StuartJRitchie/status/1116074740475736066
https://archive.is/bQnjM
See this thread for our new study on polygenic scores within fraternal twin pairs! Main point: take extra care with polygenic scores for traits like IQ & education, because they're confounded by (what seem to be) socioeconomic status effects. Not so for traits like height & BMI.
The idea is that the parenting is caused by the parental genotype, so it gets (mis)classified as a genetic effect on the children. It's really another way of looking at "genetic nurture" - see the papers from last year.
study  bio  preprint  biodet  behavioral-gen  genetics  sib-study  GWAS  class  s-factor  iq  education  attention  disease  psychiatry  embodied  health  environmental-effects  parenting  regularizer  spearhead  multi  twitter  social  commentary  backup 
13 days ago by nhaliday
An adaptability limit to climate change due to heat stress
Despite the uncertainty in future climate-change impacts, it is often assumed that humans would be able to adapt to any possible warming. Here we argue that heat stress imposes a robust upper limit to such adaptation. Peak heat stress, quantified by the wet-bulb temperature TW, is surprisingly similar across diverse climates today. TW never exceeds 31 °C. Any exceedence of 35 °C for extended periods should induce hyperthermia in humans and other mammals, as dissipation of metabolic heat becomes impossible. While this never happens now, it would begin to occur with global-mean warming of about 7 °C, calling the habitability of some regions into question. With 11–12 °C warming, such regions would spread to encompass the majority of the human population as currently distributed. Eventual warmings of 12 °C are possible from fossil fuel burning. One implication is that recent estimates of the costs of unmitigated climate change are too low unless the range of possible warming can somehow be narrowed. Heat stress also may help explain trends in the mammalian fossil record.

Trajectories of the Earth System in the Anthropocene: http://www.pnas.org/content/early/2018/07/31/1810141115
We explore the risk that self-reinforcing feedbacks could push the Earth System toward a planetary threshold that, if crossed, could prevent stabilization of the climate at intermediate temperature rises and cause continued warming on a “Hothouse Earth” pathway even as human emissions are reduced. Crossing the threshold would lead to a much higher global average temperature than any interglacial in the past 1.2 million years and to sea levels significantly higher than at any time in the Holocene. We examine the evidence that such a threshold might exist and where it might be.
study  org:nat  environment  climate-change  humanity  existence  risk  futurism  estimate  physics  thermo  prediction  temperature  nature  walls  civilization  flexibility  rigidity  embodied  multi  manifolds  plots  equilibrium  phase-transition  oscillation  comparison  complex-systems  earth 
august 2018 by nhaliday
Moravec's paradox - Wikipedia
Moravec's paradox is the discovery by artificial intelligence and robotics researchers that, contrary to traditional assumptions, high-level reasoning requires very little computation, but low-level sensorimotor skills require enormous computational resources. The principle was articulated by Hans Moravec, Rodney Brooks, Marvin Minsky and others in the 1980s. As Moravec writes, "it is comparatively easy to make computers exhibit adult level performance on intelligence tests or playing checkers, and difficult or impossible to give them the skills of a one-year-old when it comes to perception and mobility".[1]

Similarly, Minsky emphasized that the most difficult human skills to reverse engineer are those that are unconscious. "In general, we're least aware of what our minds do best", he wrote, and added "we're more aware of simple processes that don't work well than of complex ones that work flawlessly".[2]

...

One possible explanation of the paradox, offered by Moravec, is based on evolution. All human skills are implemented biologically, using machinery designed by the process of natural selection. In the course of their evolution, natural selection has tended to preserve design improvements and optimizations. The older a skill is, the more time natural selection has had to improve the design. Abstract thought developed only very recently, and consequently, we should not expect its implementation to be particularly efficient.

As Moravec writes:

Encoded in the large, highly evolved sensory and motor portions of the human brain is a billion years of experience about the nature of the world and how to survive in it. The deliberate process we call reasoning is, I believe, the thinnest veneer of human thought, effective only because it is supported by this much older and much more powerful, though usually unconscious, sensorimotor knowledge. We are all prodigious olympians in perceptual and motor areas, so good that we make the difficult look easy. Abstract thought, though, is a new trick, perhaps less than 100 thousand years old. We have not yet mastered it. It is not all that intrinsically difficult; it just seems so when we do it.[3]

A compact way to express this argument would be:

- We should expect the difficulty of reverse-engineering any human skill to be roughly proportional to the amount of time that skill has been evolving in animals.
- The oldest human skills are largely unconscious and so appear to us to be effortless.
- Therefore, we should expect skills that appear effortless to be difficult to reverse-engineer, but skills that require effort may not necessarily be difficult to engineer at all.
concept  wiki  reference  paradox  ai  intelligence  reason  instinct  neuro  psychology  cog-psych  hardness  logic  deep-learning  time  evopsych  evolution  sapiens  the-self  EEA  embodied  embodied-cognition  abstraction  universalism-particularism  gnosis-logos  robotics 
june 2018 by nhaliday
The Religions of the Three Castes – The Neo-Ciceronian Times
The sudra caste is that which is most fitted to physical labor and bodily exercise and, as noted above, occupies the lowest position in the social hierarchy. The sudra soul is characterized by a sensual approach to life and tends to exhibit short time preferences. Thus, sudra are most often concerned with gross physical satisfaction and instant gratification. It is not surprising that it is among individuals of this caste that drug addiction, property crimes, and alcoholism are the most prevalent.

As a result, sudra religion tends to focus on feedbacks relating to the body and to the satisfaction of felt needs. It tends to be characterized the most by fleshly music, swaying, rhythmic movements, and the like. It also inclines toward specific concerns about health and physical safety, day by day provision, and so forth. Again, keep in mind that there is nothing about this that is necessarily “bad.” These are things appropriate to this caste which reflect its character and which enable it to fulfill its roles in society.

The vaisya caste is that which is most fitted to the soulish/psychical occupations which involve money and finance, technics, science, and production. The psychology of this caste involves a propensity toward materialism, empiricism, and a focus on what can be seen and felt over the intangible and faith-oriented. This caste emphasizes the pragmatic benefits provided by entrepreneurship and science, as well as exhibiting the long time preferences which enable those fields of endeavor to be successful.

The vaisya carry these concentrations over into the religious realm. Religion for the vaisya consists primarily in what can be seen and touched, whether as tangible benefits deriving from religious piety or as aids in worship itself. The intercession of gods or demigods into specific areas of life (usually pertaining to wealth or business) is considered necessary for success in those fields. Vaisya religion tends to require the reification of religious experience, rather than taking matters of religion on faith. Indeed, pure spiritualism or symbolism in religion is considered unreal, and therefore not truly efficacious.

The aristocratic caste (brahman and kshatriyan considered together) is the noble caste, and thus its tendencies are those that concern leadership and guidance, a desire to guide others in the right way. This caste tends to be focused more on eternal truths (whether specifically pertaining to religion or otherwise), and is subconsciously, and perhaps even divinely, guided toward the polar and axial tendencies which have been described by Evola in numerous places. As such, the aristocratic caste eschews materialism and the grasping for pecuniary gain and democratic political power. Instead, its focus tends to be on intangible qualities of excellence and spiritual alignment with divine and eternal realities.

Thus, aristocratic religion tends to focus more on faith and accord with spiritual realities and truths. This caste attempts to see “the reality behind the image” and is concerned with direct connection with the Divine. It will often emphasize the role of written and spoken revelation (holy books and preaching) as the means of bridging the gap between the Divine and man, ways which are used by the Divine to express His eternal laws and truths, with which man is expected to come into accord and which must be accepted through spiritual faith. The aristocratic caste, whether as priest or as king/ruler, seeks to lead and guide their people into harmony with the eternal truths espoused by religion. This caste is scrupulous to uphold the rites, while at the same time grasping and teaching the deeper spiritual realities represented by those rites.
gnon  religion  theos  gavisti  class  egalitarianism-hierarchy  military  martial  aristos  labor  things  phalanges  mystic  ascetic  empirical  new-religion  pragmatic  time-preference  embodied  realness  leadership  leviathan  sanctity-degradation  elite  social-structure  culture  society  paganism 
may 2018 by nhaliday
Who We Are | West Hunter
I’m going to review David Reich’s new book, Who We Are and How We Got Here. Extensively: in a sense I’ve already been doing this for a long time. Probably there will be a podcast. The GoFundMe link is here. You can also send money via Paypal (Use the donate button), or bitcoins to 1Jv4cu1wETM5Xs9unjKbDbCrRF2mrjWXr5. In-kind donations, such as orichalcum or mithril, are always appreciated.

This is the book about the application of ancient DNA to prehistory and history.

height difference between northern and southern europeans: https://westhunt.wordpress.com/2018/03/29/who-we-are-1/
mixing, genocide of males, etc.: https://westhunt.wordpress.com/2018/03/29/who-we-are-2-purity-of-essence/
rapid change in polygenic traits (appearance by Kevin Mitchell and funny jab at Brad Delong ("regmonkey")): https://westhunt.wordpress.com/2018/03/30/rapid-change-in-polygenic-traits/
schiz, bipolar, and IQ: https://westhunt.wordpress.com/2018/03/30/rapid-change-in-polygenic-traits/#comment-105605
Dan Graur being dumb: https://westhunt.wordpress.com/2018/04/02/the-usual-suspects/
prediction of neanderthal mixture and why: https://westhunt.wordpress.com/2018/04/03/who-we-are-3-neanderthals/
New Guineans tried to use Denisovan admixture to avoid UN sanctions (by "not being human"): https://westhunt.wordpress.com/2018/04/04/who-we-are-4-denisovans/
also some commentary on decline of Out-of-Africa, including:
"Homo Naledi, a small-brained homonin identified from recently discovered fossils in South Africa, appears to have hung around way later that you’d expect (up to 200,000 years ago, maybe later) than would be the case if modern humans had occupied that area back then. To be blunt, we would have eaten them."

Live Not By Lies: https://westhunt.wordpress.com/2018/04/08/live-not-by-lies/
Next he slams people that suspect that upcoming genetic genetic analysis will, in most cases, confirm traditional stereotypes about race – the way the world actually looks.

The people Reich dumps on are saying perfectly reasonable things. He criticizes Henry Harpending for saying that he’d never seen an African with a hobby. Of course, Henry had actually spent time in Africa, and that’s what he’d seen. The implication is that people in Malthusian farming societies – which Africa was not – were selected to want to work, even where there was no immediate necessity to do so. Thus hobbies, something like a gerbil running in an exercise wheel.

He criticized Nicholas Wade, for saying that different races have different dispositions. Wade’s book wasn’t very good, but of course personality varies by race: Darwin certainly thought so. You can see differences at birth. Cover a baby’s nose with a cloth: Chinese and Navajo babies quietly breathe through their mouth, European and African babies fuss and fight.

Then he attacks Watson, for asking when Reich was going to look at Jewish genetics – the kind that has led to greater-than-average intelligence. Watson was undoubtedly trying to get a rise out of Reich, but it’s a perfectly reasonable question. Ashkenazi Jews are smarter than the average bear and everybody knows it. Selection is the only possible explanation, and the conditions in the Middle ages – white-collar job specialization and a high degree of endogamy, were just what the doctor ordered.

Watson’s a prick, but he’s a great prick, and what he said was correct. Henry was a prince among men, and Nick Wade is a decent guy as well. Reich is totally out of line here: he’s being a dick.

Now Reich may be trying to burnish his anti-racist credentials, which surely need some renewal after having pointing out that race as colloquially used is pretty reasonable, there’s no reason pops can’t be different, people that said otherwise ( like Lewontin, Gould, Montagu, etc. ) were lying, Aryans conquered Europe and India, while we’re tied to the train tracks with scary genetic results coming straight at us. I don’t care: he’s being a weasel, slandering the dead and abusing the obnoxious old genius who laid the foundations of his field. Reich will also get old someday: perhaps he too will someday lose track of all the nonsense he’s supposed to say, or just stop caring. Maybe he already has… I’m pretty sure that Reich does not like lying – which is why he wrote this section of the book (not at all logically necessary for his exposition of the ancient DNA work) but the required complex juggling of lies and truth required to get past the demented gatekeepers of our society may not be his forte. It has been said that if it was discovered that someone in the business was secretly an android, David Reich would be the prime suspect. No Talleyrand he.

https://westhunt.wordpress.com/2018/04/12/who-we-are-6-the-americas/
The population that accounts for the vast majority of Native American ancestry, which we will call Amerinds, came into existence somewhere in northern Asia. It was formed from a mix of Ancient North Eurasians and a population related to the Han Chinese – about 40% ANE and 60% proto-Chinese. Is looks as if most of the paternal ancestry was from the ANE, while almost all of the maternal ancestry was from the proto-Han. [Aryan-Transpacific ?!?] This formation story – ANE boys, East-end girls – is similar to the formation story for the Indo-Europeans.

https://westhunt.wordpress.com/2018/04/18/who-we-are-7-africa/
In some ways, on some questions, learning more from genetics has left us less certain. At this point we really don’t know where anatomically humans originated. Greater genetic variety in sub-Saharan African has been traditionally considered a sign that AMH originated there, but it possible that we originated elsewhere, perhaps in North Africa or the Middle East, and gained extra genetic variation when we moved into sub-Saharan Africa and mixed with various archaic groups that already existed. One consideration is that finding recent archaic admixture in a population may well be a sign that modern humans didn’t arise in that region ( like language substrates) – which makes South Africa and West Africa look less likely. The long-continued existence of homo naledi in South Africa suggests that modern humans may not have been there for all that long – if we had co-existed with homo naledi, they probably wouldn’t lasted long. The oldest known skull that is (probably) AMh was recently found in Morocco, while modern humans remains, already known from about 100,000 years ago in Israel, have recently been found in northern Saudi Arabia.

While work by Nick Patterson suggests that modern humans were formed by a fusion between two long-isolated populations, a bit less than half a million years ago.

So: genomics had made recent history Africa pretty clear. Bantu agriculuralists expanded and replaced hunter-gatherers, farmers and herders from the Middle East settled North Africa, Egypt and northeaat Africa, while Nilotic herdsmen expanded south from the Sudan. There are traces of earlier patterns and peoples, but today, only traces. As for questions back further in time, such as the origins of modern humans – we thought we knew, and now we know we don’t. But that’s progress.

https://westhunt.wordpress.com/2018/04/18/reichs-journey/
David Reich’s professional path must have shaped his perspective on the social sciences. Look at the record. He starts his professional career examining the role of genetics in the elevated prostate cancer risk seen in African-American men. Various social-science fruitcakes oppose him even looking at the question of ancestry ( African vs European). But they were wrong: certain African-origin alleles explain the increased risk. Anthropologists (and human geneticists) were sure (based on nothing) that modern humans hadn’t interbred with Neanderthals – but of course that happened. Anthropologists and archaeologists knew that Gustaf Kossina couldn’t have been right when he said that widespread material culture corresponded to widespread ethnic groups, and that migration was the primary explanation for changes in the archaeological record – but he was right. They knew that the Indo-European languages just couldn’t have been imposed by fire and sword – but Reich’s work proved them wrong. Lots of people – the usual suspects plus Hindu nationalists – were sure that the AIT ( Aryan Invasion Theory) was wrong, but it looks pretty good today.

Some sociologists believed that caste in India was somehow imposed or significantly intensified by the British – but it turns out that most jatis have been almost perfectly endogamous for two thousand years or more…

It may be that Reich doesn’t take these guys too seriously anymore. Why should he?

varnas, jatis, aryan invastion theory: https://westhunt.wordpress.com/2018/04/22/who-we-are-8-india/

europe and EEF+WHG+ANE: https://westhunt.wordpress.com/2018/05/01/who-we-are-9-europe/

https://www.nationalreview.com/2018/03/book-review-david-reich-human-genes-reveal-history/
The massive mixture events that occurred in the recent past to give rise to Europeans and South Asians, to name just two groups, were likely “male mediated.” That’s another way of saying that men on the move took local women as brides or concubines. In the New World there are many examples of this, whether it be among African Americans, where most European ancestry seems to come through men, or in Latin America, where conquistadores famously took local women as paramours. Both of these examples are disquieting, and hint at the deep structural roots of patriarchal inequality and social subjugation that form the backdrop for the emergence of many modern peoples.
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march 2018 by nhaliday
Strategic height adjustment - Marginal REVOLUTION
Professor Bogin’s study, carried out in collaboration with Dr Christiane Scheffler, at the University of Potsdam, and Professor Michael Hermanussen, from the University of Kiel, also explored a second phenomenon called competitive growth — where the ruling social classes adjust their height to exceed the subordinate population.

Prof Bogin said: “This is when the mean height of colonial or military migrants, who become the socially dominant group in the conquered country, surpasses the average height of the both the conquered people and the origin population.”

In one example, the researchers found that the height of Dutch colonial masters in Indonesia in the 19th and early 20th centuries was greater than the Indonesians they ruled, and also greater than social upper classes back in the Netherlands.

“This was also the case for English colonial masters in North America,” said Prof Bogin.

“We find that it is the superior social status of the conquerors that promotes their greater height.
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march 2018 by nhaliday
Reid Hofmann and Peter Thiel and technology and politics - Marginal REVOLUTION
econotariat  marginal-rev  links  video  interview  thiel  barons  randy-ayndy  cryptocurrency  ai  communism  individualism-collectivism  civil-liberty  sv  tech  automation  speedometer  stagnation  technology  politics  current-events  trends  democracy  usa  malthus  zero-positive-sum  china  asia  stanford  news  org:local  polarization  economics  cycles  growth-econ  zeitgeist  housing  urban-rural  california  the-west  decentralized  privacy  anonymity  inequality  multi  winner-take-all  realpolitik  machiavelli  error  order-disorder  leviathan  dirty-hands  the-world-is-just-atoms  heavy-industry  embodied  engineering  reflection  trump  2016-election  pessimism  definite-planning  optimism  left-wing  right-wing  steel-man  managerial-state  orwellian  vampire-squid  contrarianism  age-generation  econ-productivity  compensation  time-series  feudal  gnosis-logos 
february 2018 by nhaliday
The Space Trilogy - Wikipedia
Out of the Silent Planet:

Weston makes a long speech justifying his proposed invasion of Malacandra on "progressive" and evolutionary grounds, which Ransom attempts to translate into Malacandrian, thus laying bare the brutality and crudity of Weston's ambitions.

Oyarsa listens carefully to Weston's speech and acknowledges that the scientist is acting out of a sense of duty to his species, and not mere greed. This renders him more mercifully disposed towards the scientist, who accepts that he may die while giving Man the means to continue. However, on closer examination Oyarsa points out that Weston's loyalty is not to Man's mind – or he would equally value the intelligent alien minds already inhabiting Malacandra, instead of seeking to displace them in favour of humanity; nor to Man's body – since, as Weston is well aware of and at ease with, Man's physical form will alter over time, and indeed would have to in order to adapt to Weston's programme of space exploration and colonisation. It seems then that Weston is loyal only to "the seed" – Man's genome – which he seeks to propagate. When Oyarsa questions why this is an intelligible motivation for action, Weston's eloquence fails him and he can only articulate that if Oyarsa does not understand Man's basic loyalty to Man then he, Weston, cannot possibly instruct him.

...

Perelandra:

The rafts or floating islands are indeed Paradise, not only in the sense that they provide a pleasant and care-free life (until the arrival of Weston) but also in the sense that Ransom is for weeks and months naked in the presence of a beautiful naked woman without once lusting after her or being tempted to seduce her. This is because of the perfection in that world.

The plot thickens when Professor Weston arrives in a spaceship and lands in a part of the ocean quite close to the Fixed Land. He at first announces to Ransom that he is a reformed man, but appears to still be in search of power. Instead of the strictly materialist attitude he displayed when first meeting Ransom, he asserts he had become aware of the existence of spiritual beings and pledges allegiance to what he calls the "Life-Force." Ransom, however, disagrees with Weston's position that the spiritual is inherently good, and indeed Weston soon shows signs of demonic possession.

In this state, the possessed Weston finds the Queen and tries to tempt her into defying Maleldil's orders by spending a night on the Fixed Land. Ransom, perceiving this, believes that he must act as a counter-tempter. Well versed in the Bible and Christian theology, Ransom realises that if the pristine Queen, who has never heard of Evil, succumbs to the tempter's arguments, the Fall of Man will be re-enacted on Perelandra. He struggles through day after day of lengthy arguments illustrating various approaches to temptation, but the demonic Weston shows super-human brilliance in debate (though when "off-duty" he displays moronic, asinine behaviour and small-minded viciousness) and moreover appears never to need sleep.

With the demonic Weston on the verge of winning, the desperate Ransom hears in the night what he gradually realises is a Divine voice, commanding him to physically attack the Tempter. Ransom is reluctant, and debates with the divine (inner) voice for the entire duration of the night. A curious twist is introduced here; whereas the name "Ransom" is said to be derived from the title "Ranolf's Son", it can also refer to a reward given in exchange for a treasured life. Recalling this, and recalling that his God would (and has) sacrificed Himself in a similar situation, Ransom decides to confront the Tempter outright.

Ransom attacks his opponent bare-handed, using only physical force. Weston's body is unable to withstand this despite the Tempter's superior abilities of rhetoric, and so the Tempter flees. Ultimately Ransom chases him over the ocean, Weston fleeing and Ransom chasing on the backs of giant and friendly fish. During a fleeting truce, the "real" Weston appears to momentarily re-inhabit his body, and recount his experience of Hell, wherein the damned soul is not consigned to pain or fire, as supposed by popular eschatology, but is absorbed into the Devil, losing all independent existence.
fiction  scifi-fantasy  tip-of-tongue  literature  big-peeps  religion  christianity  theos  space  xenobio  analogy  myth  eden  deep-materialism  new-religion  sanctity-degradation  civil-liberty  exit-voice  speaking  truth  realness  embodied  fighting  old-anglo  group-selection  war  paying-rent  counter-revolution  morality  parable  competition  the-basilisk  gnosis-logos  individualism-collectivism  language  physics  science  evolution  conquest-empire  self-interest  hmm  intricacy  analytical-holistic  tradeoffs  paradox  heterodox  narrative  philosophy  expansionism  genetics  duty  us-them  interests  nietzschean  parallax  the-devil  the-self 
january 2018 by nhaliday
The Roman Virtues
These are the qualities of life to which every citizen should aspire. They are the heart of the Via Romana--the Roman Way--and are thought to be those qualities which gave the Roman Republic the moral strength to conquer and civilize the world:
Auctoritas--"Spiritual Authority": The sense of one's social standing, built up through experience, Pietas, and Industria.
Comitas--"Humor": Ease of manner, courtesy, openness, and friendliness.
Clementia--"Mercy": Mildness and gentleness.
Dignitas--"Dignity": A sense of self-worth, personal pride.
Firmitas--"Tenacity": Strength of mind, the ability to stick to one's purpose.
Frugalitas--"Frugalness": Economy and simplicity of style, without being miserly.
Gravitas--"Gravity": A sense of the importance of the matter at hand, responsibility and earnestness.
Honestas--"Respectibility": The image that one presents as a respectable member of society.
Humanitas--"Humanity": Refinement, civilization, learning, and being cultured.
Industria--"Industriousness": Hard work.
Pietas--"Dutifulness": More than religious piety; a respect for the natural order socially, politically, and religiously. Includes the ideas of patriotism and devotion to others.
Prudentia--"Prudence": Foresight, wisdom, and personal discretion.
Salubritas--"Wholesomeness": Health and cleanliness.
Severitas--"Sternness": Gravity, self-control.
Veritas--"Truthfulness": Honesty in dealing with others.

THE ROMAN CONCEPT OF FIDES: https://www.csun.edu/~hcfll004/fides.html
"FIDES" is often (and wrongly) translated 'faith', but it has nothing to do with the word as used by Christians writing in Latin about the Christian virute (St. Paul Letter to the Corinthians, chapter 13). For the Romans, FIDES was an essential element in the character of a man of public affairs, and a necessary constituent element of all social and political transactions (perhaps = 'good faith'). FIDES meant 'reliablilty', a sense of trust between two parties if a relationship between them was to exist. FIDES was always reciprocal and mutual, and implied both privileges and responsibilities on both sides. In both public and private life the violation of FIDES was considered a serious matter, with both legal and religious consequences. FIDES, in fact, was one of the first of the 'virtues' to be considered an actual divinity at Rome. The Romans had a saying, "Punica fides" (the reliability of a Carthaginian) which for them represented the highest degree of treachery: the word of a Carthaginian (like Hannibal) was not to be trusted, nor could a Carthaginian be relied on to maintain his political elationships.

Some relationships governed by fides:

VIRTUS
VIRTUS, for the Roman, does not carry the same overtones as the Christian 'virtue'. But like the Greek andreia, VIRTUS has a primary meaning of 'acting like a man' (vir) [cf. the Renaissance virtù ), and for the Romans this meant first and foremost 'acting like a brave man in military matters'. virtus was to be found in the context of 'outstanding deeds' (egregia facinora), and brave deeds were the accomplishments which brought GLORIA ('a reputation'). This GLORIA was attached to two ideas: FAMA ('what people think of you') and dignitas ('one's standing in the community'). The struggle for VIRTUS at Rome was above all a struggle for public office (honos), since it was through high office, to which one was elected by the People, that a man could best show hi smanliness which led to military achievement--which would lead in turn to a reputation and votes. It was the duty of every aristocrat (and would-be aristocrat) to maintain the dignitas which his family had already achieved and to extend it to the greatest possible degree (through higher political office and military victories). This system resulted in a strong built-in impetus in Roman society to engage in military expansion and conquest at all times.
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january 2018 by nhaliday
The Politics of Mate Choice
TABLE 1 Spousal Concordance on 16 Traits Pearson’s r (n)

Church attendance .714 (4950)
W-P Index (28 items) .647 (3984)
Drinking frequency .599 (4984)
Political party support .596 (4547)
Education .498 (4957)
Height .227 (4964)
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december 2017 by nhaliday
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries
We report a set of tools to estimate the number of susceptibility loci and the distribution of their effect sizes for a trait on the basis of discoveries from existing genome-wide association studies (GWASs). We propose statistical power calculations for future GWASs using estimated distributions of effect sizes. Using reported GWAS findings for height, Crohn’s disease and breast, prostate and colorectal (BPC) cancers, we determine that each of these traits is likely to harbor additional loci within the spectrum of low-penetrance common variants. These loci, which can be identified from sufficiently powerful GWASs, together could explain at least 15–20% of the known heritability of these traits. However, for BPC cancers, which have modest familial aggregation, our analysis suggests that risk models based on common variants alone will have modest discriminatory power (63.5% area under curve), even with new discoveries.

later paper:
Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants: http://www.pnas.org/content/108/44/18026.full

Recent discoveries of hundreds of common susceptibility SNPs from genome-wide association studies provide a unique opportunity to examine population genetic models for complex traits. In this report, we investigate distributions of various population genetic parameters and their interrelationships using estimates of allele frequencies and effect-size parameters for about 400 susceptibility SNPs across a spectrum of qualitative and quantitative traits. We calibrate our analysis by statistical power for detection of SNPs to account for overrepresentation of variants with larger effect sizes in currently known SNPs that are expected due to statistical power for discovery. Across all qualitative disease traits, minor alleles conferred “risk” more often than “protection.” Across all traits, an inverse relationship existed between “regression effects” and allele frequencies. Both of these trends were remarkably strong for type I diabetes, a trait that is most likely to be influenced by selection, but were modest for other traits such as human height or late-onset diseases such as type II diabetes and cancers. Across all traits, the estimated effect-size distribution suggested the existence of increasingly large numbers of susceptibility SNPs with decreasingly small effects. For most traits, the set of SNPs with intermediate minor allele frequencies (5–20%) contained an unusually small number of susceptibility loci and explained a relatively small fraction of heritability compared with what would be expected from the distribution of SNPs in the general population. These trends could have several implications for future studies of common and uncommon variants.

...

Relationship Between Allele Frequency and Effect Size. We explored the relationship between allele frequency and effect size in different scales. An inverse relationship between the squared regression coefficient and f(1 − f) was observed consistently across different traits (Fig. 3). For a number of these traits, however, the strengths of these relationships become less pronounced after adjustment for ascertainment due to study power. The strength of the trend, as captured by the slope of the fitted line (Table 2), markedly varies between traits, with an almost 10-fold change between the two extremes of distinct types of traits. After adjustment, the most pronounced trend was seen for type I diabetes and Crohn’s disease among qualitative traits and LDL level among quantitative traits. In exploring the relationship between the frequency of the risk allele and the magnitude of the associated risk coefficient (Fig. S4), we observed a quadratic pattern that indicates increasing risk coefficients as the risk-allele frequency diverges away from 0.50 either toward 0 or toward 1. Thus, it appears that regression coefficients for common susceptibility SNPs increase in magnitude monotonically with decreasing minor-allele frequency, irrespective of whether the minor allele confers risk or protection. However, for some traits, such as type I diabetes, risk alleles were predominantly minor alleles, that is, they had frequencies of less than 0.50.
pdf  nibble  study  article  org:nat  🌞  biodet  genetics  population-genetics  GWAS  QTL  distribution  disease  cancer  stat-power  bioinformatics  magnitude  embodied  prediction  scale  scaling-up  variance-components  multi  missing-heritability  effect-size  regression  correlation  data 
november 2017 by nhaliday
Random Thought Depository — digging-holes-in-the-river: This is a video about...
“Much of the science of modern orthodontics is devoted to creating - through rubber bands, wires, and braces - the perfect “overbite.” An overbite refers to the way our top layer of incisors hang over the bottom layer, like a lid on a box. This is the ideal human occlusion. The opposite of an overbite is an “edge-to-edge” bite seen in primates such as chimpanzees, where the top incisors clash against the bottom ones, like a guillotine blade.

What the orthodontists don’t tell you is that the overbite is a very recent aspect of human anatomy and probably results from the way we use our table knives. Based on surviving skeletons, this has only been a “normal” alignment of the human jaw for 200 to 250 years in the Western world. Before that, most human beings had an edge-to-edge bite, comparable to apes. The overbite is not a product of evolution - the time frame is far too short. Rather, it seems likely to be a response to the way we cut our food during our formative years. The person who worked this out is Professor Charles Loring Brace (born 1930), a remarkable American anthropologist whose main intellectual passion was Neanderthal man. Over decades, Brace built up the world’s largest database on the evolution of hominid teeth. He possibly held more ancient human jaws in his hand than anyone else in the twentieth century.

It’s not that your teeth are too big: your jaw is too small: https://aeon.co/ideas/its-not-that-your-teeth-are-too-big-your-jaw-is-too-small
tumblr  social  trivia  cocktail  quotes  dental  embodied  history  medieval  early-modern  sapiens  archaeology  europe  comparison  china  asia  food  multi  news  org:mag  org:popup 
november 2017 by nhaliday
Static electricity - Wikipedia
Electrons can be exchanged between materials on contact; materials with weakly bound electrons tend to lose them while materials with sparsely filled outer shells tend to gain them. This is known as the triboelectric effect and results in one material becoming positively charged and the other negatively charged. The polarity and strength of the charge on a material once they are separated depends on their relative positions in the triboelectric series. The triboelectric effect is the main cause of static electricity as observed in everyday life, and in common high-school science demonstrations involving rubbing different materials together (e.g., fur against an acrylic rod). Contact-induced charge separation causes your hair to stand up and causes "static cling" (for example, a balloon rubbed against the hair becomes negatively charged; when near a wall, the charged balloon is attracted to positively charged particles in the wall, and can "cling" to it, appearing to be suspended against gravity).
nibble  wiki  reference  article  physics  electromag  embodied  curiosity  IEEE  dirty-hands  phys-energy  safety  data  magnitude  scale 
november 2017 by nhaliday
Stretching and injury prevention: an obscure relationship. - PubMed - NCBI
Sports involving bouncing and jumping activities with a high intensity of stretch-shortening cycles (SSCs) [e.g. soccer and football] require a muscle-tendon unit that is compliant enough to store and release the high amount of elastic energy that benefits performance in such sports. If the participants of these sports have an insufficient compliant muscle-tendon unit, the demands in energy absorption and release may rapidly exceed the capacity of the muscle-tendon unit. This may lead to an increased risk for injury of this structure. Consequently, the rationale for injury prevention in these sports is to increase the compliance of the muscle-tendon unit. Recent studies have shown that stretching programmes can significantly influence the viscosity of the tendon and make it significantly more compliant, and when a sport demands SSCs of high intensity, stretching may be important for injury prevention. This conjecture is in agreement with the available scientific clinical evidence from these types of sports activities. In contrast, when the type of sports activity contains low-intensity, or limited SSCs (e.g. jogging, cycling and swimming) there is no need for a very compliant muscle-tendon unit since most of its power generation is a consequence of active (contractile) muscle work that needs to be directly transferred (by the tendon) to the articular system to generate motion. Therefore, stretching (and thus making the tendon more compliant) may not be advantageous. This conjecture is supported by the literature, where strong evidence exists that stretching has no beneficial effect on injury prevention in these sports.
study  survey  health  embodied  fitness  fitsci  biomechanics  sports  soccer  running  endurance  evidence-based  null-result  realness  contrarianism  homo-hetero  comparison  embodied-pack 
november 2017 by nhaliday
Dr. Pribut on Runner's Knee (Patellofemoral Pain Syndrome)
Abnormal knee joint moments
Abnormal pronation of the foot
Weak Vastus Medialis
Weak Quadriceps Muscles
Tight Hamstrings or calf muscles
Weak Hip Abductors
Canted Surface

Do posterior muscle stretches (hamstrings and calf muscles)
Do Straight Leg Lifts (Start with 3 sets of 10, work up to 10 sets of 10)
Supine bridges 10-15, Later single leg bridges 8-12
Check Your Feet and Shoes, overpronation often contributes to this problem
org:junk  org:health  health  embodied  fitness  fitsci  running  endurance  biomechanics 
november 2017 by nhaliday
The Evil Dead | West Hunter
Someone asked me to go over a chapter he wrote, about the impact of certain customs on human health. One of them was the health advantages of quick burial: the problem is, usually there aren’t any.   People seem to think that the organisms causing decomposition are pathogenic, but they’re not.  People killed by trauma (earthquakes,  floods, bullets) are dead enough, but not a threat.  Sometimes, the body of someone that died of an infectious disease is contagious – smallpox scabs have been known to remain infectious for a long, long time – but most causative agents are unable to survive for long after the host’s death. Now if you’re dissecting someone,  especially if they’re fresh, you probably don’t want to nick yourself with the scalpel – but if you just walk past the corpse and refrain from playing with it, you’re usually OK.
west-hunter  scitariat  ideas  trivia  death  embodied  disease  parasites-microbiome  spreading  public-health  epidemiology  medicine  sanctity-degradation 
november 2017 by nhaliday
The Science of Roman History: Biology, Climate, and the Future of the Past (Hardcover and eBook) | Princeton University Press
Forthcoming April 2018

How the latest cutting-edge science offers a fuller picture of life in Rome and antiquity
This groundbreaking book provides the first comprehensive look at how the latest advances in the sciences are transforming our understanding of ancient Roman history. Walter Scheidel brings together leading historians, anthropologists, and geneticists at the cutting edge of their fields, who explore novel types of evidence that enable us to reconstruct the realities of life in the Roman world.

Contributors discuss climate change and its impact on Roman history, and then cover botanical and animal remains, which cast new light on agricultural and dietary practices. They exploit the rich record of human skeletal material--both bones and teeth—which forms a bio-archive that has preserved vital information about health, nutritional status, diet, disease, working conditions, and migration. Complementing this discussion is an in-depth analysis of trends in human body height, a marker of general well-being. This book also assesses the contribution of genetics to our understanding of the past, demonstrating how ancient DNA is used to track infectious diseases, migration, and the spread of livestock and crops, while the DNA of modern populations helps us reconstruct ancient migrations, especially colonization.

Opening a path toward a genuine biohistory of Rome and the wider ancient world, The Science of RomanHistory offers an accessible introduction to the scientific methods being used in this exciting new area of research, as well as an up-to-date survey of recent findings and a tantalizing glimpse of what the future holds.

Walter Scheidel is the Dickason Professor in the Humanities, Professor of Classics and History, and a Kennedy-Grossman Fellow in Human Biology at Stanford University. He is the author or editor of seventeen previous books, including The Great Leveler: Violence and the History of Inequality from the Stone Age to the Twenty-First Century (Princeton).
books  draft  todo  broad-econ  economics  anthropology  genetics  genomics  aDNA  measurement  volo-avolo  environment  climate-change  archaeology  history  iron-age  mediterranean  the-classics  demographics  health  embodied  labor  migration  walter-scheidel  agriculture  frontier  malthus  letters  gibbon  traces 
november 2017 by nhaliday
Places, not Programs – spottedtoad
1. There has to be a place for people to go.
2. It has to be safe.
3. There preferably needs to be bathrooms and water available there.
Schools fulfill this list, which is one reason they are still among our few remaining sources of shared meaning and in-person community. As Christ Arnade has often remarked, McDonalds fast-food restaurants fulfill this list, and are therefore undervalued sources of community in low-income communities. (The young black guys in my Philadelphia Americorps program would not-entirely-jokingly allude to McDonalds as the central hub of the weekend social/dating scene, where only one’s most immaculate clothing- a brand-new shirt, purchased just for the occasion- would suffice.) Howard Schultz, for all his occasional bouts of madness, understood from the beginning that Starbucks would succeed by becoming a “third space” between work and home, which the coffee chain for all its faults has indubitably become for many people. Ivan Illich argued that the streets themselves in poor countries once, but no longer, acted as the same kind of collective commons.
ratty  unaffiliated  institutions  community  alt-inst  metabuch  rhetoric  contrarianism  policy  wonkish  realness  intervention  education  embodied  order-disorder  checklists  cost-disease 
november 2017 by nhaliday
Injury prevention in runners - "skimpy research" | RunningPhysio
Wherever possible RunningPhysio tries to be evidence based but in many cases there is a lack of high quality research. Extensive advice exists on injury prevention in runners and yet the research underpinning that advice is very limited, so limited in fact that one recent study described it as “skimpy”! So we decided we'd examine this “skimpy research”.
org:health  health  fitness  fitsci  evidence-based  running  embodied  analysis  survey  endurance 
october 2017 by nhaliday
Two theories of home heat control - ScienceDirect
People routinely develop their own theories to explain the world around them. These theories can be useful even when they contradict conventional technical wisdom. Based on in-depth interviews about home heating and thermostat setting behavior, the present study presents two theories people use to understand and adjust their thermostats. The two theories are here called the feedback theory and the valve theory. The valve theory is inconsistent with engineering knowledge, but is estimated to be held by 25% to 50% of Americans. Predictions of each of the theories are compared with the operations normally performed in home heat control. This comparison suggests that the valve theory may be highly functional in normal day-to-day use. Further data is needed on the ways this theory guides behavior in natural environments.
study  hci  ux  hardware  embodied  engineering  dirty-hands  models  thinking  trivia  cocktail  map-territory  realness  neurons  psychology  cog-psych  social-psych  error  usa  poll  descriptive  temperature  protocol 
september 2017 by nhaliday
Accurate Genomic Prediction Of Human Height | bioRxiv
Stephen Hsu's compressed sensing application paper

We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning). Replication tests show that these predictors capture, respectively, ~40, 20, and 9 percent of total variance for the three traits. For example, predicted heights correlate ~0.65 with actual height; actual heights of most individuals in validation samples are within a few cm of the prediction.

https://infoproc.blogspot.com/2017/09/accurate-genomic-prediction-of-human.html

http://infoproc.blogspot.com/2017/11/23andme.html
I'm in Mountain View to give a talk at 23andMe. Their latest funding round was $250M on a (reported) valuation of $1.5B. If I just add up the Crunchbase numbers it looks like almost half a billion invested at this point...

Slides: Genomic Prediction of Complex Traits

Here's how people + robots handle your spit sample to produce a SNP genotype:

https://drive.google.com/file/d/1e_zuIPJr1hgQupYAxkcbgEVxmrDHAYRj/view
study  bio  preprint  GWAS  state-of-art  embodied  genetics  genomics  compressed-sensing  high-dimension  machine-learning  missing-heritability  hsu  scitariat  education  🌞  frontier  britain  regression  data  visualization  correlation  phase-transition  multi  commentary  summary  pdf  slides  brands  skunkworks  hard-tech  presentation  talks  methodology  intricacy  bioinformatics  scaling-up  stat-power  sparsity  norms  nibble  speedometer  stats  linear-models  2017  biodet 
september 2017 by nhaliday
Plastic fibres found in tap water around the world, study reveals | Environment | The Guardian
Scores of tap water samples from more than a dozen nations were analysed by scientists for an investigation by Orb Media, who shared the findings with the Guardian. Overall, 83% of the samples were contaminated with plastic fibres.

We are living on a plastic planet. What does it mean for our health?
New studies reveal that tiny plastic fibres are everywhere, not just in our oceans but on land too. Now we urgently need to find out how they enter our food, air and tap water and what the effects are on all of us

The US had the highest contamination rate, at 94%, with plastic fibres found in tap water sampled at sites including Congress buildings, the US Environmental Protection Agency’s headquarters, and Trump Tower in New York. Lebanon and India had the next highest rates.

...

Current standard water treatment systems do not filter out all of the microplastics, Mahon said: “There is nowhere really where you can say these are being trapped 100%. In terms of fibres, the diameter is 10 microns across and it would be very unusual to find that level of filtration in our drinking water systems.”

Bottled water may not provide a microplastic-free alternative to tapwater, as the they were also found in a few samples of commercial bottled water tested in the US for Orb.

Sea salt around the world is contaminated by plastic, studies show: https://www.theguardian.com/environment/2017/sep/08/sea-salt-around-world-contaminated-by-plastic-studies
news  org:lite  org:anglo  data  hypochondria  fluid  embodied  endocrine  environment  public-health  multi  food  science-anxiety 
september 2017 by nhaliday
House O’Rats | West Hunter
Not content with our simple selection experiment, we also install complicated mazes with flaming hoops that the rats have to jump through in order to get extra food and mates: we want rats with different brains, and eventually we get them. They’re maze-bright and flaming-hoop-bright. We install treadmills and feed the rats according to their work output, and eventually they produce more work per amount of food eaten. They’ve maximized efficiency rather than surge power, which was more useful back when they were wild and free. Not only that, they eventually come to like being on the treadmill, almost as if it’s some sort of race.

There are other silos – one full of rice and another full of maize. They have different mazes and flaming hoops, built at different times: and there are still wild rats, too, although not as many as in the silos.

But no matter how much they change, they’re still just a bunch of rats.
west-hunter  scitariat  discussion  ideas  gedanken  analogy  comparison  parable  sapiens  pop-diff  recent-selection  agriculture  farmers-and-foragers  population  metabolic  nutrition  diet  immune  disease  parasites-microbiome  egalitarianism-hierarchy  ethanol  iq  intelligence  eden  embodied  fitness  efficiency  race  conceptual-vocab  🌞  biodet  behavioral-gen  agri-mindset  realness 
september 2017 by nhaliday
National Greatness | West Hunter
As production rose, availability increased. At first, penicillin was largely reserved for US and British military needs. Later, it became available to US and British civilians, and soon after for general usage.

But there was a time window of several months in which American-produced penicillin was available for American wounded but not for French casualties. Fortunately, it happens that penicillin is rapidly excreted in urine. It can be recovered. Between January and April 1945, Rhône-Poulenc extracted penicillin from the urine of wounded American servicemen being treated in hospitals around Paris, penicillin which was then used to treat the wounded of the French Army. They typically recovered about 100 doses from 300 liters of urine.

When American piss is the elixir of life – that is national greatness.

USSR, innovation, and Japan: https://westhunt.wordpress.com/2013/04/10/national-greatness/#comment-11653
west-hunter  scitariat  medicine  pharma  drugs  low-hanging  history  mostly-modern  the-trenches  britain  usa  world-war  military  multi  poast  russia  communism  japan  asia  innovation  stories  trivia  cocktail  embodied  nationalism-globalism 
september 2017 by nhaliday
What kills, current or voltage? - Quora
Its an oversimplification to say that voltage kills or current kills and the cause of much misunderstanding.
 
You cannot have one without the other, therefore one could claim that answering one or the other is correct.
 
However, it is the current THROUGH key parts of the body that can be lethal. BUT even a lot of Current in a wire won't harm you if the current is constrained to the wire..
 
Specifically in order for you to be electrocuted, the voltage must be high enough to drive a lethal amount of current through your body over coming body resistance, the voltage must be applied in the right places so that the current path is through your (usually) heart muscle, and it must be long enough duration to stop the heart muscle due to fibrillation.

another good answer:
As I write this note, I’m looking at the textbook Basic Engineering Circuit Analysis by Irwin and Nelms (ISBN 0-471-48728-7). On page 449 the authors reference the work of Dr. John G. Webster who suggests the body resistance values that I have taken the liberty to sketch into this poor character.
nibble  q-n-a  qra  physics  electromag  dirty-hands  embodied  safety  short-circuit  IEEE  data  objektbuch  death 
september 2017 by nhaliday
electricity - Why is AC more "dangerous" than DC? - Physics Stack Exchange
One of the reasons that AC might be considered more dangerous is that it arguably has more ways of getting into your body. Since the voltage alternates, it can cause current to enter and exit your body even without a closed loop, since your body (and what ground it's attached to) has capacitance. DC cannot do that. Also, AC is quite easily stepped up to higher voltages using transformers, while with DC that requires some relatively elaborate electronics. Finally, while your skin has a fairly high resistance to protect you, and the air is also a terrific insulator as long as you're not touching any wires, sometimes the inductance of AC transformers can cause high-voltage sparks that break down the air and I imagine can get through your skin a bit as well.

Also, like you mentioned, the heart is controlled by electric pulses and repeated pulses of electricity can throw this off quite a bit and cause a heart attack. However, I don't think that this is unique to alternating current. I read once about an unfortunate young man that was learning about electricity and wanted to measure the resistance of his own body. He took a multimeter and set a lead to each thumb. By accident or by stupidity, he punctured both thumbs with the leads, and the small (I imagine it to be 9 V) battery in the multimeter caused a current in his bloodstream, and he died on the spot. So maybe ignorance is more dangerous than either AC or DC.
nibble  q-n-a  overflow  physics  electromag  dirty-hands  embodied  safety  short-circuit  IEEE  death 
september 2017 by nhaliday
Mechanisms of microbial traversal of the blood–brain barrier
A journey into the brain: insight into how bacterial pathogens cross blood–brain barriers: http://sci-hub.tw/10.1038/nrmicro.2016.178
How do extracellular pathogens cross the blood-brain barrier?: https://www.ncbi.nlm.nih.gov/pubmed/11973156
Defense at the border: the blood–brain barrier versus bacterial foreigners: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589978/
study  bio  medicine  health  embodied  neuro  neuro-nitgrit  disease  parasites-microbiome  metabolic  🌞  pdf  piracy  org:nat  multi  red-queen  epidemiology 
september 2017 by nhaliday
Medicine as a pseudoscience | West Hunter
The idea that venesection was a good thing, or at least not so bad, on the grounds that one in a few hundred people have hemochromatosis (in Northern Europe) reminds me of the people who don’t wear a seatbelt, since it would keep them from being thrown out of their convertible into a waiting haystack, complete with nubile farmer’s daughter. Daughters. It could happen. But it’s not the way to bet.

Back in the good old days, Charles II, age 53, had a fit one Sunday evening, while fondling two of his mistresses.

Monday they bled him (cupping and scarifying) of eight ounces of blood. Followed by an antimony emetic, vitriol in peony water, purgative pills, and a clyster. Followed by another clyster after two hours. Then syrup of blackthorn, more antimony, and rock salt. Next, more laxatives, white hellebore root up the nostrils. Powdered cowslip flowers. More purgatives. Then Spanish Fly. They shaved his head and stuck blistering plasters all over it, plastered the soles of his feet with tar and pigeon-dung, then said good-night.

...

Friday. The king was worse. He tells them not to let poor Nelly starve. They try the Oriental Bezoar Stone, and more bleeding. Dies at noon.

Most people didn’t suffer this kind of problem with doctors, since they never saw one. Charles had six. Now Bach and Handel saw the same eye surgeon, John Taylor – who blinded both of them. Not everyone can put that on his resume!

You may wonder how medicine continued to exist, if it had a negative effect, on the whole. There’s always the placebo effect – at least there would be, if it existed. Any real placebo effect is very small: I’d guess exactly zero. But there is regression to the mean. You see the doctor when you’re feeling worse than average – and afterwards, if he doesn’t kill you outright, you’re likely to feel better. Which would have happened whether you’d seen him or not, but they didn’t often do RCTs back in the day – I think James Lind was the first (1747).

Back in the late 19th century, Christian Scientists did better than others when sick, because they didn’t believe in medicine. For reasons I think mistaken, because Mary Baker Eddy rejected the reality of the entire material world, but hey, it worked. Parenthetically, what triggered all that New Age nonsense in 19th century New England? Hash?

This did not change until fairly recently. Sometime in the early 20th medicine, clinical medicine, what doctors do, hit break-even. Now we can’t do without it. I wonder if there are, or will be, other examples of such a pile of crap turning (mostly) into a real science.

good tweet: https://twitter.com/bowmanthebard/status/897146294191390720
The brilliant GP I've had for 35+ years has retired. How can I find another one who meets my requirements?

1 is overweight
2 drinks more than officially recommended amounts
3 has an amused, tolerant atitude to human failings
4 is well aware that we're all going to die anyway, & there are better or worse ways to die
5 has a healthy skeptical attitude to mainstream medical science
6 is wholly dismissive of "a|ternative” medicine
7 believes in evolution
8 thinks most diseases get better without intervention, & knows the dangers of false positives
9 understands the base rate fallacy

EconPapers: Was Civil War Surgery Effective?: http://econpapers.repec.org/paper/htrhcecon/444.htm
contra Greg Cochran:
To shed light on the subject, I analyze a data set created by Dr. Edmund Andrews, a Civil war surgeon with the 1st Illinois Light Artillery. Dr. Andrews’s data can be rendered into an observational data set on surgical intervention and recovery, with controls for wound location and severity. The data also admits instruments for the surgical decision. My analysis suggests that Civil War surgery was effective, and increased the probability of survival of the typical wounded soldier, with average treatment effect of 0.25-0.28.

Medical Prehistory: https://westhunt.wordpress.com/2016/03/14/medical-prehistory/
What ancient medical treatments worked?

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76878
In some very, very limited conditions, bleeding?
--
Bad for you 99% of the time.

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76947
Colchicine – used to treat gout – discovered by the Ancient Greeks.

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76973
Dracunculiasis (Guinea worm)
Wrap the emerging end of the worm around a stick and slowly pull it out.
(3,500 years later, this remains the standard treatment.)
https://en.wikipedia.org/wiki/Ebers_Papyrus

https://westhunt.wordpress.com/2016/03/14/medical-prehistory/#comment-76971
Some of the progress is from formal medicine, most is from civil engineering, better nutrition ( ag science and physical chemistry), less crowded housing.

Nurses vs doctors: https://westhunt.wordpress.com/2014/10/01/nurses-vs-doctors/
Medicine, the things that doctors do, was an ineffective pseudoscience until fairly recently. Until 1800 or so, they were wrong about almost everything. Bleeding, cupping, purging, the four humors – useless. In the 1800s, some began to realize that they were wrong, and became medical nihilists that improved outcomes by doing less. Some patients themselves came to this realization, as when Civil War casualties hid from the surgeons and had better outcomes. Sometime in the early 20th century, MDs reached break-even, and became an increasingly positive influence on human health. As Lewis Thomas said, medicine is the youngest science.

Nursing, on the other hand, has always been useful. Just making sure that a patient is warm and nourished when too sick to take care of himself has helped many survive. In fact, some of the truly crushing epidemics have been greatly exacerbated when there were too few healthy people to take care of the sick.

Nursing must be old, but it can’t have existed forever. Whenever it came into existence, it must have changed the selective forces acting on the human immune system. Before nursing, being sufficiently incapacitated would have been uniformly fatal – afterwards, immune responses that involved a period of incapacitation (with eventual recovery) could have been selectively favored.

when MDs broke even: https://westhunt.wordpress.com/2014/10/01/nurses-vs-doctors/#comment-58981
I’d guess the 1930s. Lewis Thomas thought that he was living through big changes. They had a working serum therapy for lobar pneumonia ( antibody-based). They had many new vaccines ( diphtheria in 1923, whopping cough in 1926, BCG and tetanus in 1927, yellow fever in 1935, typhus in 1937.) Vitamins had been mostly worked out. Insulin was discovered in 1929. Blood transfusions. The sulfa drugs, first broad-spectrum antibiotics, showed up in 1935.

DALYs per doctor: https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/
The disability-adjusted life year (DALY) is a measure of overall disease burden – the number of years lost. I’m wondering just much harm premodern medicine did, per doctor. How many healthy years of life did a typical doctor destroy (net) in past times?

...

It looks as if the average doctor (in Western medicine) killed a bunch of people over his career ( when contrasted with doing nothing). In the Charles Manson class.

Eventually the market saw through this illusion. Only took a couple of thousand years.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100741
That a very large part of healthcare spending is done for non-health reasons. He has a chapter on this in his new book, also check out his paper “Showing That You Care: The Evolution of Health Altruism” http://mason.gmu.edu/~rhanson/showcare.pdf
--
I ran into too much stupidity to finish the article. Hanson’s a loon. For example when he talks about the paradox of blacks being more sentenced on drug offenses than whites although they use drugs at similar rate. No paradox: guys go to the big house for dealing, not for using. Where does he live – Mars?

I had the same reaction when Hanson parroted some dipshit anthropologist arguing that the stupid things people do while drunk are due to social expectations, not really the alcohol.
Horseshit.

I don’t think that being totally unable to understand everybody around you necessarily leads to deep insights.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100744
What I’ve wondered is if there was anything that doctors did that actually was helpful and if perhaps that little bit of success helped them fool people into thinking the rest of it helped.
--
Setting bones. extracting arrows: spoon of Diocles. Colchicine for gout. Extracting the Guinea worm. Sometimes they got away with removing the stone. There must be others.
--
Quinine is relatively recent: post-1500. Obstetrical forceps also. Caesarean deliveries were almost always fatal to the mother until fairly recently.

Opium has been around for a long while : it works.

https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100839
If pre-modern medicine was indeed worse than useless – how do you explain no one noticing that patients who get expensive treatments are worse off than those who didn’t?
--
were worse off. People are kinda dumb – you’ve noticed?
--
My impression is that while people may be “kinda dumb”, ancient customs typically aren’t.
Even if we assume that all people who lived prior to the 19th century were too dumb to make the rational observation, wouldn’t you expect this ancient practice to be subject to selective pressure?
--
Your impression is wrong. Do you think that there some slick reason for Carthaginians incinerating their first-born?

Theodoric of York, bloodletting: https://www.youtube.com/watch?v=yvff3TViXmY

details on blood-letting and hemochromatosis: https://westhunt.wordpress.com/2018/01/22/dalys-per-doctor/#comment-100746

Starting Over: https://westhunt.wordpress.com/2018/01/23/starting-over/
Looking back on it, human health would have … [more]
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august 2017 by nhaliday
Let George Do It | West Hunter
I was thinking about how people would have adapted to local differences in essential micronutrients, stuff like iodine, selenium, manganese, molybdenum, zinc, etc. Australia, for example,  hasn’t had much geological activity in ages and generally has mineral-poor soils. At first I thought that Aboriginals, who have lived in such places for a long time,  might have developed better transporters, etc – ways of eking out scarce trace elements.

Maybe they have, but on second thought, they may not have needed to.  Sure, the Aboriginals were exposed to these conditions for tens of thousands of years, but not nearly as long as kangaroos and wombats have been.  If those animals had effective ways of accumulating the necessary micronutrients,  hunter-gatherers could have solved their problems by consuming local fauna. Let George do it, and then eat George.

The real problems should occur in people who rely heavily on plant foods (European farmers) and in their livestock, which are generally not adapted to the mineral-poor environments. If I’m right, even in areas where sheep without selenium supplements get white muscle disease (nutritional muscular dystrophy), indigenous wildlife should not.
west-hunter  scitariat  discussion  ideas  speculation  sapiens  pop-diff  embodied  metabolic  nutrition  diet  food  farmers-and-foragers  agriculture  nature  tricks  direct-indirect 
august 2017 by nhaliday
Genetic Architectures | West Hunter
Dairy cattle eventually graduate to McDonalds, so there is some interest in the genetics of beef production in dairy breeds. There is course more interest in the genetics of beef production in beef breeds of cattle.

Usually you don’t find a single allele that makes a lot of difference, but in some beef breeds, there are myostatin mutations that result in a ridiculous-looking, ‘double-muscled’ beast. Homozygosity for myostatin mutations causes difficulties in birth, so it takes really strong selection for beef production to make a myostatin null common. I don’t think you ever see this in dairy breeds.

But, as it turns out, there is a deletion that is pretty common in some dairy breeds that significantly increases milk production while killing homozygotes before birth.

Breeds under weaker selection for single traits, your typical cow of the past, probably have neither.

The point is that the genetic architecture of a quantitative trait does not have to be the same in different populations of the same species. For example, I have the impression that height is not as highly polygenic in Pygmies as it is most other human populations. There’s a particular region on chromosome 3 that seems to influence height- you don’t see such a concentration in Europeans.
west-hunter  scitariat  discussion  ideas  speculation  sapiens  pop-diff  genetics  population-genetics  QTL  homo-hetero  analogy  agriculture  nature  food  comparison  embodied  archaics  africa  genomics 
august 2017 by nhaliday
Ethiopian altitude adaptations | West Hunter
I said a while ago that the altitude adaptations in Tibet were too damn good, more effective than those seen in Andean Amerindians, and so must have originated in a population that lived at high altitude for a long time.  This seems to be the case.

The same must be true of Ethiopia. Their altitude adaptations also work well. There is a genetic component in Ethiopia that seems to correspond to the original hunter-gatherers, and the altitude alleles must have originated in that population, not the later components that look like East Africans or Levantines.

In both cases, there’s a fair chance that the ultimate origin could be some archaic group.

https://westhunt.wordpress.com/2014/02/27/ethiopian-adaptations/#comment-22644
You know, I don’t think that is the problem.

I’ve paid attention to the Falasha story for a long time. I think it’s funny as hell.

...

The Falasha are (best guess based on recent genetic studies) locals who converted to an old-fashioned, non-rabbinic Judaism. Genetically pretty much like other highland Ethiopians, definitely so in mtDNA.
On the other hand, the non-African component is probably similar to what we see in the Levant today, as with other Ethiopian highlanders speaking Semitic languages.
west-hunter  scitariat  discussion  ideas  speculation  asia  developing-world  africa  sapiens  pop-diff  archaics  gene-flow  embodied  atmosphere  sky  comparison  archaeology  multi  poast  judaism  prudence  israel 
august 2017 by nhaliday
Demography of the Roman Empire - Wikipedia
There are few recorded population numbers for the whole of antiquity, and those that exist are often rhetorical or symbolic. Unlike the contemporaneous Han Dynasty, no general census survives for the Roman Empire. The late period of the Roman Republic provides a small exception to this general rule: serial statistics for Roman citizen numbers, taken from census returns, survive for the early Republic through the 1st century CE.[41] Only the figures for periods after the mid-3rd century BCE are reliable, however. Fourteen figures are available for the 2nd century BCE (from 258,318 to 394,736). Only four figures are available for the 1st century BCE, and are feature a large break between 70/69 BCE (910,000) and 28 BCE (4,063,000). The interpretation of the later figures—the Augustan censuses of 28 BCE, 8 BCE, and 14 CE—is therefore controversial.[42] Alternate interpretations of the Augustan censuses (such as those of E. Lo Cascio[43]) produce divergent population histories across the whole imperial period.[44]

Roman population size: the logic of the debate: https://www.princeton.edu/~pswpc/pdfs/scheidel/070706.pdf
- Walter Scheidel (cited in book by Vaclav Smil, "Why America is Not a New Rome")

Our ignorance of ancient population numbers is one of the biggest obstacles to our understanding of Roman history. After generations of prolific scholarship, we still do not know how many people inhabited Roman Italy and the Mediterranean at any given point in time. When I say ‘we do not know’ I do not simply mean that we lack numbers that are both precise and safely known to be accurate: that would surely be an unreasonably high standard to apply to any pre-modern society. What I mean is that even the appropriate order of magnitude remains a matter of intense dispute.

Historical urban community sizes: https://en.wikipedia.org/wiki/Historical_urban_community_sizes

World population estimates: https://en.wikipedia.org/wiki/World_population_estimates
As a general rule, the confidence of estimates on historical world population decreases for the more distant past. Robust population data only exists for the last two or three centuries. Until the late 18th century, few governments had ever performed an accurate census. In many early attempts, such as in Ancient Egypt and the Persian Empire, the focus was on counting merely a subset of the population for purposes of taxation or military service.[3] Published estimates for the 1st century ("AD 1") suggest an uncertainty of the order of 50% (estimates range between 150 and 330 million). Some estimates extend their timeline into deep prehistory, to "10,000 BC", i.e. the early Holocene, when world population estimates range roughly between one and ten million (with an uncertainty of up to an order of magnitude).[4][5]

Estimates for yet deeper prehistory, into the Paleolithic, are of a different nature. At this time human populations consisted entirely of non-sedentary hunter-gatherer populations, with anatomically modern humans existing alongside archaic human varieties, some of which are still ancestral to the modern human population due to interbreeding with modern humans during the Upper Paleolithic. Estimates of the size of these populations are a topic of paleoanthropology. A late human population bottleneck is postulated by some scholars at approximately 70,000 years ago, during the Toba catastrophe, when Homo sapiens population may have dropped to as low as between 1,000 and 10,000 individuals.[6][7] For the time of speciation of Homo sapiens, some 200,000 years ago, an effective population size of the order of 10,000 to 30,000 individuals has been estimated, with an actual "census population" of early Homo sapiens of roughly 100,000 to 300,000 individuals.[8]
history  iron-age  mediterranean  the-classics  demographics  fertility  data  europe  population  measurement  volo-avolo  estimate  wiki  reference  article  conquest-empire  migration  canon  scale  archaeology  multi  broad-econ  pdf  study  survey  debate  uncertainty  walter-scheidel  vaclav-smil  urban  military  economics  labor  time-series  embodied  health  density  malthus  letters  urban-rural  database  list  antiquity  medieval  early-modern  mostly-modern  time  sequential  MENA  the-great-west-whale  china  asia  sinosphere  occident  orient  japan  britain  germanic  gallic  summary  big-picture  objektbuch  confidence  sapiens  anthropology  methodology  farmers-and-foragers  genetics  genomics  chart 
august 2017 by nhaliday
How to estimate distance using your finger | Outdoor Herbivore Blog
1. Hold your right arm out directly in front of you, elbow straight, thumb upright.
2. Align your thumb with one eye closed so that it covers (or aligns) the distant object. Point marked X in the drawing.
3. Do not move your head, arm or thumb, but switch eyes, so that your open eye is now closed and the other eye is open. Observe closely where the object now appears with the other open eye. Your thumb should appear to have moved to some other point: no longer in front of the object. This new point is marked as Y in the drawing.
4. Estimate this displacement XY, by equating it to the estimated size of something you are familiar with (height of tree, building width, length of a car, power line poles, distance between nearby objects). In this case, the distant barn is estimated to be 100′ wide. It appears 5 barn widths could fit this displacement, or 500 feet. Now multiply that figure by 10 (the ratio of the length of your arm to the distance between your eyes), and you get the distance between you and the thicket of blueberry bushes — 5000 feet away(about 1 mile).

- Basically uses parallax (similar triangles) with each eye.
- When they say to compare apparent shift to known distance, won't that scale with the unknown distance? The example uses width of an object at the point whose distance is being estimated.

per here: https://www.trails.com/how_26316_estimate-distances-outdoors.html
Select a distant object that the width can be accurately determined. For example, use a large rock outcropping. Estimate the width of the rock. Use 200 feet wide as an example here.
outdoors  human-bean  embodied  embodied-pack  visuo  spatial  measurement  lifehack  howto  navigation  prepping  survival  objektbuch  multi  measure  estimate 
august 2017 by nhaliday
Born that way | West Hunter
In the Atlantic Monthly , which no longer has any reason for existence, since there’s really no point in placing a computer screen on the bottom of a birdcage, Jason Silverstein  – a doctoral candidate in anthropology at Harvard –  has a piece explaining that genes don’t cause racial health disparities – society does! Moreover,  it’s immoral to even look for such genetic explanations.

I guess he should have gotten this published earlier, since we’ve already found some of those naughty genes – pretty important ones. So it’s too late.

...

Which means that Silverstein is a jackass. Nothing stopped him from digging into biomedical research to see if his thesis was substantially true: he didn’t bother. But why is he a jackass? Born that way, probably.
west-hunter  scitariat  discussion  ideas  rant  critique  race  medicine  pop-diff  health  genetics  embodied  attaq  prudence  straussian 
august 2017 by nhaliday
CURRENT CONCEPTS IN MUSCLE STRETCHING FOR EXERCISE AND REHABILITATION
Three muscle stretching techniques are frequently described in the literature: Static, Dynamic, and Pre-Contraction stretches (Figure 2).

Static stretching is effective at increasing ROM.

Unfortunately, however, static stretching as part of a warm-up immediately prior to exercise has been shown detrimental to dynamometer-measured muscle strength19–29 and performance in running and jumping.30–39 The loss of strength resulting from acute static stretching has been termed, “stretch-induced strength loss.”3 The specific causes for this type of stretch induced loss in strength is not clear; some suggest neural factors,31,40 while others suggest mechanical factors.19,23

In general, it appears that static stretching is most beneficial for athletes requiring flexibility for their sports (e.g. gymnastics, dance, etc.). Dynamic stretching may be better suited for athletes requiring running or jumping performance30 during their sport such as basketball players or sprinters.

Stretching has not been shown to be effective at reducing the incidence of overall injuries.88 While there is some evidence of stretching reducing musculotendinous injuries,88 more evidence is needed to determine if stretching programs alone can reduce muscular injuries.3
study  health  fitness  fitsci  evidence-based  running  embodied  sports  survey  summary  biomechanics  endurance  embodied-pack 
august 2017 by nhaliday
Whole Health Source: Palatability, Satiety and Calorie Intake
The more palatable the food, the less filling per calorie, and the relationship was quite strong for a study of this nature. This is consistent with the evidence that highly palatable foods shut down the mechanisms in the brain that constrain food intake. Croissants had the lowest SI (47), while potatoes had the highest (323). Overall, baked goods and candy had the lowest SI. They didn't test sweet potatoes, but I suspect they would have been similar to potatoes. Other foods with a high SI include meat/fish, whole grain foods, fruit and porridge.
taubes-guyenet  org:health  fitsci  health  embodied  food  diet  nutrition  metabolic  constraint-satisfaction  wire-guided  correlation  emotion 
july 2017 by nhaliday
Polygenic Adaptation has Impacted Multiple Anthropometric Traits | bioRxiv
By comparing these polygenic scores to a null distribution under genetic drift, we identify strong signals of selection for a suite of anthropometric traits including height, infant head circumference (IHC), hip circumference (HIP) and waist-to-hip ratio (WHR), as well as type 2 diabetes (T2D). In addition to the known north-south gradient of polygenic height scores within Europe, we find that natural selection has contributed to a gradient of decreasing polygenic height scores from West to East across Eurasia, and that this gradient is consistent with selection on height in ancient populations who have contributed ancestry broadly across Eurasia. We find that the signal of selection on HIP can largely be explained as a correlated response to selection on height. However, our signals in IHC and WC/WHR cannot, suggesting a response to selection along multiple axes of body shape variation. Our observation that IHC, WC, and WHR polygenic scores follow a strong latitudinal cline in Western Eurasia support the role of natural selection in establishing Bergmann's Rule in humans, and are consistent with thermoregulatory adaptation in response to latitudinal temperature variation.

http://infoproc.blogspot.com/2017/07/natural-selection-and-body-shape-in.html
study  bio  preprint  biodet  genetics  evolution  sapiens  pop-diff  embodied  recent-selection  survey  🌞  europe  asia  shift  GWAS  population-genetics  pop-structure  spearhead  environment  temperature  correlation  multi  hsu  scitariat  commentary 
july 2017 by nhaliday
Information Processing: Genetic variation in Han Chinese population
Largest component of genetic variation is a N-S cline (phenotypic N-S gradient discussed here). Variance accounted for by second (E-W) PC vector is much smaller and the Han population is fairly homogeneous in genetic terms: ...while we revealed East-to-West structure among the Han Chinese, the signal is relatively weak and very little structure is discernible beyond the second PC (p.24).

Neandertal ancestry does not vary significantly across provinces, consistent with admixture prior to the dispersal of modern Han Chinese.

http://infoproc.blogspot.com/2014/01/china-1793.html
My fellow officers informed me, that while the negotiation was going on, the ships were constantly crowded with all kinds of refreshments, and that when they were first boarded by the Chinese they received every attention from them that could be shown; and that the presents received by the different officers belonging to the embassy, were of immense value. That the natives of this part of China were of different complexions and manners from those in and near Canton; their colour being nearly white; and in their manners were much more free and candid; and that they were of a larger stature, and more athletic than the southern Chinese—they were much more sociable, and not so particular respecting their women being seen by the men. And were even fond of receiving the officers into their houses, when on shore, provided it could be done without the knowledge of the mandarins.

http://infoproc.blogspot.com/2014/06/large-scale-psychological-differences.html
The study below discusses a psychological/cognitive/personality gradient between N and S China, possibly driven by a history of wheat vs rice cultivation.

https://en.wikipedia.org/wiki/Northern_and_southern_China
http://shanghaiist.com/2015/07/01/average-heights-men-women.php
https://www.quora.com/Why-are-Northern-Chinese-people-generally-taller-than-Southern-Chinese

https://gnxp.nofe.me/2017/08/01/the-great-genetic-map-of-china/
hsu  scitariat  commentary  study  summary  pic  maps  china  asia  sinosphere  things  pop-structure  multi  individualism-collectivism  extra-introversion  old-anglo  history  early-modern  usa  ethnography  n-factor  exploratory  shift  archaics  gene-flow  news  org:foreign  embodied  data  q-n-a  qra  wiki  reference  stereotypes  matrix-factorization  open-closed  alien-character  agriculture  gnxp  medieval  gavisti  sapiens  fluid  leviathan  decentralized  cultural-dynamics  anthropology  courage 
july 2017 by nhaliday
Alzheimers | West Hunter
Some disease syndromes almost have to be caused by pathogens – for example, any with a fitness impact (prevalence x fitness reduction) > 2% or so, too big to be caused by mutational pressure. I don’t think that this is the case for AD: it hits so late in life that the fitness impact is minimal. However, that hardly means that it can’t be caused by a pathogen or pathogens – a big fraction of all disease syndromes are, including many that strike in old age. That possibility is always worth checking out, not least because infectious diseases are generally easier to prevent and/or treat.

There is new work that strongly suggests that pathogens are the root cause. It appears that the amyloid is an antimicrobial peptide. amyloid-beta binds to invading microbes and then surrounds and entraps them. ‘When researchers injected Salmonella into mice’s hippocampi, a brain area damaged in Alzheimer’s, A-beta quickly sprang into action. It swarmed the bugs and formed aggregates called fibrils and plaques. “Overnight you see the plaques throughout the hippocampus where the bugs were, and then in each single plaque is a single bacterium,” Tanzi says. ‘

obesity and pathogens: https://westhunt.wordpress.com/2016/05/29/alzheimers/#comment-79757
not sure about this guy, but interesting: https://westhunt.wordpress.com/2016/05/29/alzheimers/#comment-79748
http://perfecthealthdiet.com/2010/06/is-alzheimer%E2%80%99s-caused-by-a-bacterial-infection-of-the-brain/

https://westhunt.wordpress.com/2016/12/13/the-twelfth-battle-of-the-isonzo/
All too often we see large, long-lasting research efforts that never produce, never achieve their goal.

For example, the amyloid hypothesis [accumulation of amyloid-beta oligomers is the cause of Alzheimers] has been dominant for more than 20 years, and has driven development of something like 15 drugs. None of them have worked. At the same time the well-known increased risk from APOe4 has been almost entirely ignored, even though it ought to be a clue to the cause.

In general, when a research effort has been spinning its wheels for a generation or more, shouldn’t we try something different? We could at least try putting a fraction of those research dollars into alternative approaches that have not yet failed repeatedly.

Mostly this applies to research efforts that at least wish they were science. ‘educational research’ is in a special class, and I hardly know what to recommend. Most of the remedial actions that occur to me violate one or more of the Geneva conventions.

APOe4 related to lymphatic system: https://en.wikipedia.org/wiki/Apolipoprotein_E

https://westhunt.wordpress.com/2012/03/06/spontaneous-generation/#comment-2236
Look,if I could find out the sort of places that I usually misplace my keys – if I did, which I don’t – I could find the keys more easily the next time I lose them. If you find out that practitioners of a given field are not very competent, it marks that field as a likely place to look for relatively easy discovery. Thus medicine is a promising field, because on the whole doctors are not terribly good investigators. For example, none of the drugs developed for Alzheimers have worked at all, which suggests that our ideas on the causation of Alzheimers are likely wrong. Which suggests that it may (repeat may) be possible to make good progress on Alzheimers, either by an entirely empirical approach, which is way underrated nowadays, or by dumping the current explanation, finding a better one, and applying it.

You could start by looking at basic notions of field X and asking yourself: How do we really know that? Is there serious statistical evidence? Does that notion even accord with basic theory? This sort of checking is entirely possible. In most of the social sciences, we don’t, there isn’t, and it doesn’t.

Hygiene and the world distribution of Alzheimer’s disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden: https://academic.oup.com/emph/article/2013/1/173/1861845/Hygiene-and-the-world-distribution-of-Alzheimer-s

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease: http://stm.sciencemag.org/content/8/340/340ra72

Fungus, the bogeyman: http://www.economist.com/news/science-and-technology/21676754-curious-result-hints-possibility-dementia-caused-fungal
Fungus and dementia
paper: http://www.nature.com/articles/srep15015
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july 2017 by nhaliday
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