jm + via:adulau + genome   1

Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks — PNAS
'we present a comparison between the transcriptional regulatory network of a well-studied bacterium (E. coli) and the call graph of a canonical OS (Linux) in terms of topology and evolution. ... both networks have a fundamentally hierarchical layout, but there is a key difference: The transcriptional regulatory network possesses a few global regulators at the top and many targets at the bottom; conversely, the call graph has many regulators controlling a small set of generic functions. This top-heavy organization leads to highly overlapping functional modules in the call graph, in contrast to the relatively independent modules in the regulatory network. ... These findings stem from the design principles of the two systems: robustness for biological systems and cost effectiveness (reuse) for software systems.' (via adulau)
via:adulau  papers  toread  genetics  genome  call-graph  linux  kernel  e-coli  operating-systems  transcriptional-regulatory-network  from delicious
may 2010 by jm

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