jm + mice   2

One Man's Plan to Make Sure Gene Editing Doesn't Go Haywire - The Atlantic
Open science - radical transparency where gene-editing and CRISPR is involved. Sounds great.
“For gene drive, the closed-door model is morally unacceptable. You don’t have the right to go into your lab and build something that is ineluctably designed to affect entire ecosystems. If it escapes into the wild, it would be expected to spread and affect people’s lives in unknown ways. Doing that in secret denies people a voice.”

Also this is a little scary:

in 2015, he was shocked to read a paper, due to be published in ... Science, in which Californian researchers had inadvertently created a gene drive in fruit flies, without knowing what gene drives are. They developed it as a research tool for spreading a trait among lab populations, and had no ambitions to alter wild animals. And yet, if any of their insects had escaped, that’s what would have happened.
science  openness  open-source  visibility  transparency  crispr  gene-editing  mice  nantucket  gene-drive 
13 days ago by jm
A gut microbe that stops food allergies
Actual scientific research showing that antibiotic use may be implicated in allergies:

'Nagler’s team first confirmed that mice given antibiotics early in life were far more susceptible to peanut sensitization, a model of human peanut allergy. Then, they introduced a solution containing Clostridia, a common class of bacteria that’s naturally found in the mammalian gut, into the rodents’ mouths and stomachs. The animals’ food allergen sensitization disappeared, the team reports online today in the Proceedings of the National Academy of Sciences. When the scientists instead introduced another common kind of healthy bacteria, called Bacteroides, into similarly allergy-prone mice, they didn’t see the same effect. Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream. “The bacteria are maintaining the integrity of the [intestinal] barrier,” Nagler says.'
allergies  health  food  peanuts  science  research  clostridium  bacteria  gut  intestines  immune-system  mice  papers  pnas 
september 2014 by jm

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