jm + immune-system   4

Boost your immunity: Cold and flu treatments suppress innate immune system
The next time you feel a cold coming on, maybe what you really want is just a little teensy bit of innate immune suppression, not an immunity boost. Over-the-counter medications like ibuprofen and antihistamines should help you feel better. Meanwhile, sit back while your acquired B and T cells do the rest. And if you aren't yet sick, stay up-to-date on your vaccines, including the yearly influenza vaccine. Most importantly, practice vigorous hand washing — after all, the skin is also a component of your natural defenses and one that actually can be enhanced by good hygiene. Take care of yourself by keeping a balanced diet, maintaining good sleep habits, and minimizing stress. These are interventions that have been shown to help keep your immune system at its best. These alone can "boost" your odds of staving off an infection this cold season.
immunity  health  immune-system  colds  b-cells  t-cells  flu 
4 days ago by jm
Novartis CAR-T immunotherapy strongly endorsed by FDA advisory panel
This is very exciting stuff, cytokine release syndrome risks notwithstanding.
The new treatment is known as CAR-T cell immunotherapy. It works by removing key immune system cells known as T cells from the patient so scientists can genetically modify them to seek out and attack only cancer cells. That's why some scientists refer to this as a "living drug."

Doctors then infuse millions of the genetically modified T cells back into the patient's body so they can try to obliterate the cancer cells and hopefully leave healthy tissue unscathed.

"It's truly a paradigm shift," said Dr. David Lebwohl, who heads the CAR-T Franchise Global Program at the drug company Novartis, which is seeking the FDA's approval for the treatment. "It represents a new hope for patients."

The drug endorsed by the advisory panel is known as CTL019 or tisagenlecleucel. It was developed to treat children and young adults ages 3 to 25 who have relapsed after undergoing standard treatment for B cell acute lymphoblastic leukemia, which is the most common childhood cancer in the United States.

While this blood cell cancer can be highly curable, some patients fail to respond to standard treatments; and a significant proportion of patients experience relapses that don't respond to follow-up therapies.
"There is a major unmet medical need for treatment options" for these patients, Dr. Stephen Hunger, who helped study at the Children's Hospital of Philadelphia, told the committee.

In the main study that the company submitted as evidence in seeking FDA approval, doctors at 25 sites in 11 countries administered the treatment to 88 patients. The patients, ages 3 to 23, had failed standard treatment or experienced relapses and failed to respond to follow-up standard treatment. CTL019 produced remissions in 83 percent of patients, the company told the committee.
car-t  immunotherapy  cancer  novartis  trials  fda  drugs  t-cells  immune-system  medicine  leukemia  ctl019 
july 2017 by jm
A gut microbe that stops food allergies
Actual scientific research showing that antibiotic use may be implicated in allergies:

'Nagler’s team first confirmed that mice given antibiotics early in life were far more susceptible to peanut sensitization, a model of human peanut allergy. Then, they introduced a solution containing Clostridia, a common class of bacteria that’s naturally found in the mammalian gut, into the rodents’ mouths and stomachs. The animals’ food allergen sensitization disappeared, the team reports online today in the Proceedings of the National Academy of Sciences. When the scientists instead introduced another common kind of healthy bacteria, called Bacteroides, into similarly allergy-prone mice, they didn’t see the same effect. Studying the rodents more carefully, the researchers determined that Clostridia were having a surprising effect on the mouse gut: Acting through certain immune cells, the bacteria helped keep peanut proteins that can cause allergic reactions out of the bloodstream. “The bacteria are maintaining the integrity of the [intestinal] barrier,” Nagler says.'
allergies  health  food  peanuts  science  research  clostridium  bacteria  gut  intestines  immune-system  mice  papers  pnas 
september 2014 by jm
A tick bite can make you allergic to red meat
The bugs harbor a sugar that humans don't have, called alpha-gal. The sugar is also is found in red meat — beef, pork, venison, rabbit — and even some dairy products. It's usually fine when people encounter it through food that gets digested.
But a tick bite triggers an immune system response, and in that high-alert state, the body perceives the sugar the tick transmitted to the victim's bloodstream and skin as a foreign substance, and makes antibodies to it. That sets the stage for an allergic reaction the next time the person eats red meat and encounters the sugar.


Via Shane Naughton
ticks  meat  food  allergies  immune-system  health  via:inundata  sugar  alpha-gal  red-meat 
august 2014 by jm

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