jm + genome   5

Modern Irish genome closely matches pre-Celt DNA, not Celtic
Radiocarbon dating shows that the bones discovered at McCuaig's go back to about 2000 B.C. That makes them hundreds of years older than the oldest artifacts generally considered to be Celtic — relics unearthed from Celt homelands of continental Europe, most notably around Switzerland, Austria and Germany.

For a group of scholars who in recent years have alleged that the Celts, beginning from the middle of Europe, may never have reached Ireland, the arrival of the DNA evidence provides the biological certitude that the science has sometimes brought to criminal trials.

“With the genetic evidence, the old model [of Celtic colonisation of Ireland] is completely shot,” John Koch, a linguist at the Center for Advanced Welsh and Celtic Studies at the University of Wales.
celts  ireland  history  dna  genetics  genome  carbon-dating  bronze-age  europe  colonisation 
march 2016 by jm
How I decoded the human genome - Salon.com
classic long-read article from John Sundman: 'We are becoming the masters of our own DNA. But does that give us the right to decide that my children should never have been born?' part two at http://www.salon.com/2003/10/22/genome_two/
human  genome  genomics  eugenics  politics  life  john-sundman  disability  health  dna  medicine  salon  long-reads  children 
may 2013 by jm
Comparing genomes to computer operating systems in terms of the topology and evolution of their regulatory control networks — PNAS
'we present a comparison between the transcriptional regulatory network of a well-studied bacterium (E. coli) and the call graph of a canonical OS (Linux) in terms of topology and evolution. ... both networks have a fundamentally hierarchical layout, but there is a key difference: The transcriptional regulatory network possesses a few global regulators at the top and many targets at the bottom; conversely, the call graph has many regulators controlling a small set of generic functions. This top-heavy organization leads to highly overlapping functional modules in the call graph, in contrast to the relatively independent modules in the regulatory network. ... These findings stem from the design principles of the two systems: robustness for biological systems and cost effectiveness (reuse) for software systems.' (via adulau)
via:adulau  papers  toread  genetics  genome  call-graph  linux  kernel  e-coli  operating-systems  transcriptional-regulatory-network  from delicious
may 2010 by jm
TCD researchers first to find genes unique to humans
go Aoife! “This is the first ever discovery of novel human-specific protein coding genes,” said Dr McLysaght. “They are found in humans and nowhere else.”
science  genetics  research  biology  evolution  tcd  sfi  genome  junk-dna  from delicious
september 2009 by jm

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