jm + drugs   14

‘This is not the end’: Using immunotherapy to target genes gives cancer patients hope - The Washington Post
Pembrolizumab, marketed by Merck as Keytruda, is an anti-PD-1 immunotherapy drug now going through US trials, targeting malignancies with certain molecular characteristics.

Good trial results vs melanoma here: http://www.nejm.org/doi/full/10.1056/NEJMoa1503093
cancer  trials  drugs  pembro  anti-pd-1  immunotherapy  merck 
28 days ago by jm
The Irish Ether Drinking Craze
Dr. Kelly, desperate to become intoxicated while maintaining The Pledge, realized that not only could ether vapors be inhaled, but liquid ether could be swallowed. Around 1845 he began consuming tiny glasses of ether, and then started dispensing these to his patients and friends as a nonalcoholic libation. It wasn't long before it became a popular beverage, with one priest going so far as to declare that ether was "a liquor on which a man could get drunk with a clean conscience." In some respects ingesting ether is less damaging to the system than severe alcohol intoxication. Its volatility - ether is a liquid at room temperature but a gas at body temperature -dramatically speeds its effects. Dr. Ernest Hart wrote that "the immediate effects of drinking ether are similar to those produced by alcohol, but everything takes place more rapidly; the stages of excitement, mental confusion, loss of muscular control, and loss of consciousness follow each other so quickly that they cannot be clearly separated." Recovery is similarly rapid. Not only were ether drunks who were picked up by the police on the street often completely sober by the time they reached the station, but they suffered no hangovers.

Ether drinking spread rapidly throughout Ireland, particularly in the North, and the substance soon could be purchased from grocers, druggists, publicans, and even traveling salesmen. Because ether was produced in bulk for certain industrial uses, it could also be obtained quite inexpensively. Its low price and rapid action meant than even the poorest could afford to get drunk several times a day on it. By the 1880s ether, distilled in England or Scotland, was being imported and widely distributed to even the smallest villages. Many Irish market towns would "reek of the mawkish fumes of the drug" on fair days when "its odor seems to cling to the very hedges and houses for some time."
ether  history  ireland  northern-ireland  ulster  drugs  bizarre 
january 2017 by jm
Illicit trade in prescription drugs a growing problem for Dublin’s north inner city
ughh. The latest scourge is Zopiclone, "zimmos", which are being dealt openly due to a bureaucratic loophole in enforcement.
zopiclone  zimmos  drugs  dublin  northside  drug-abuse 
april 2016 by jm
DRUG PUMP’S SECURITY FLAW LETS HACKERS RAISE DOSE LIMITS
The Hospira drug pump vulnerabilities described here sound pretty horrific
drugs  drug-pumps  hospira  exploits  vulnerabilities  security  root  dosage  limits 
may 2015 by jm
Totally Mexico! How the Nathan Barley nightmare came true | Television & radio | The Guardian
Nathan Barley was scarcely less prophetic when it came to TV itself. In one episode Nathan’s friend Claire makes a comically po-faced, self-righteous but secretly rather narcissistic documentary about a choir made up of drug addicts. Nine years later, Channel 4 made Addicts’ Symphony for real.
nathan-barley  well-weapon  vice  shoreditch  drugs  charlie-brooker  chris-morris  sitcoms  channel-4 
february 2015 by jm
Silk Road Mastermind Ross Ulbricht Convicted of All 7 Charges
The case’s decision will no doubt be seen by many as U.S. law enforcement striking a significant blow against the dark web’s burgeoning drug trade. More broadly, the case represents the limits of cryptographic anonymity tools like Tor and bitcoin against the surveillance powers of the U.S. government. In spite of his use of those crypto tools and others, Ulbricht couldn’t prevent the combined efforts of the FBI, DHS, and IRS from linking his pseudonym to his real-world identity.

But Ulbricht will nonetheless be remembered not just for his conviction, but also for ushering in a new age of online black markets. Today’s leading dark web drug sites like Agora and Evolution offer more narcotics listings than the Silk Road ever did, and have outlived law enforcement’s crackdown on their competitors. Tracking down and prosecuting those new sites’ operators, like prosecuting Ulbricht, will likely require the same intense, multi-year investigations by three-letter agencies.

If the feds do find the administrators of the next generation of dark web drug sites, as they found Ulbricht, don’t expect those online drug lords to let their unencrypted laptops be snatched in a public library, or to have kept assiduous journals of their criminal conspiracies. The Dread Pirate Roberts’ successors have no doubt been watching his trial unfold and learning from his mistakes. And the next guilty verdict may not be so easy.
ross-ulbricht  silk-road  drugs  tor  dark-web  law  convictions 
february 2015 by jm
Swiss Authorities Arrest Bot for Buying Drugs and Fake Passport
A bot created by a group of artists spent the last few months selecting items at random from a Silk Road-style darknet marketplace, buying them with Bitcoin, and having them shipped to a gallery in Switzerland. After the it bought some ecstasy pills and a counterfeit passport, we asked: How will authorities deal with the complex legal and moral issue of a piece of artificial intelligence breaking the law? It turns out, the answer was simple: just arrest the computer.
drugs  darknet  bitcoin  ecstasy  art  bots  law-enforcement  switzerland 
january 2015 by jm
Ebola: While Big Pharma Slept
We’ve had almost 40 years to develop, test and stockpile an Ebola vaccine. That has not happened because big pharma has been entirely focused on shareholder value and profits over safety and survival from a deadly virus. For the better part of Ebola’s 38 years ‒ big pharma has been asleep. The question ahead is what virus or superbug will wake them up?
pharma  ebola  ip  patents  health  drugs  africa  research 
october 2014 by jm
Ebola vaccine delayed by IP spat
This is the downside of publicly-funded labs selling patent-licensing rights to private companies:
Given the urgency, it's inexplicable that one of the candidate vaccines, developed at the Public Health Agency of Canada (PHAC) in Winnipeg, has yet to go in the first volunteer's arm, says virologist Heinz Feldmann, who helped develop the vaccine while at PHAC. "It’s a farce; these doses are lying around there while people are dying in Africa,” says Feldmann, who now works at the Rocky Mountain Laboratories of the U.S. National Institute of Allergy and Infectious Diseases (NIAID) in Hamilton, Montana.

At the center of the controversy is NewLink Genetics, a small company in Ames, Iowa, that bought a license to the vaccine's commercialization from the Canadian government in 2010, and is now suddenly caught up in what WHO calls "the most severe acute public health emergency seen in modern times.” Becker and others say the company has been dragging its feet the past 2 months because it is worried about losing control over the development of the vaccine.
ip  patents  drugs  ebola  canada  phac  newlink-genetics  health  epidemics  vaccines 
october 2014 by jm
How the feds took down the Dread Pirate Roberts | Ars Technica
Well-written, comprehensive writeup of the Silk Road takedown, and the libertarian craziness of Ross William Ulbricht, it's alleged owner and operator
silk-road  drugs  crazy  ross-william-ulbricht  fbi  libertarian  murder  tor 
october 2013 by jm
Silk Road busted
This is a pretty good summary of the salient points from the criminal complaint against Ross William Ulbricht -- I'd say it's pretty bad news for any users of the dodgy site, particularly given this:
"During the 60-day period from May 24, 2013 to July 23, 2013, there were approximately 1,217,218 communications sent between Silk Road users through Silk Road's private-message system."


According to the complaint, those are now in the FBI's hands -- likely unencrypted.
crime  silk-road  drugs  busts  tor  ross-william-ulbricht  fbi 
october 2013 by jm
The Rational Choices of Crack Addicts - NYTimes.com
“The key factor is the environment, whether you’re talking about humans or rats,” Dr. Hart said. “The rats that keep pressing the lever for cocaine are the ones who are stressed out because they’ve been raised in solitary conditions and have no other options. But when you enrich their environment, and give them access to sweets and let them play with other rats, they stop pressing the lever.”
crack  drugs  policy  science  addiction  society 
september 2013 by jm
Mail from the (Velvet) Cybercrime Underground
Brian Krebs manages to thwart an attempted framing for possession of Silk Road heroin. bloody hell
silk-road  drugs  bitcoin  ecommerce  brian-krebs  crime  framed  cybercrime  russia  scary  law-enforcement 
july 2013 by jm
drug cartel-controlled mobile comms networks
“The Mexican military has recently broken up several secret telecommunications networks that were built and controlled by drug cartels so they could coordinate drug shipments, monitor their rivals and orchestrate attacks on the security forces. A network that was dismantled just last week provided cartel members with cellphone and radio communications across four northeastern states. The network had coverage along almost 500 miles of the Texas border and extended nearly another 500 miles into Mexico’s interior. Soldiers seized 167 antennas, more than 150 repeaters and thousands of cellphones and radios that operated on the system. Some of the remote antennas and relay stations were powered with solar panels.”
mexico  drugs  networks  mobile-phones  crime 
february 2013 by jm

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