A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs | SpringerLink
African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV.
3 days ago
A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion | Nature Communications
Here we use a Cancer rainbow (Crainbow) modelling system for fluorescently barcoding somatic mutations and directly visualizing the clonal expansion and spread of oncogenes. Crainbow shows that mutations of ß-catenin (Ctnnb1) within the intestinal stem cell results in widespread expansion of oncogenes during perinatal development but not in adults. In contrast, mutations that extrinsically disrupt the stem cell microenvironment can spread in adult intestine without delay. We observe the rapid spread of premalignant clones in Crainbow mice expressing oncogenic Rspondin-3 (RSPO3), which occurs by increasing crypt fission and inhibiting crypt fixation. Crainbow modelling provides insight into how somatic mutations rapidly spread and a plausible mechanism for predetermining the intratumor heterogeneity found in colon cancers.
4 days ago
Seven Teachings from the Tibetan Book of Living and Dying
How hollow and futile life can be when it’s founded on a false belief in continuity and permanence.
5 days ago
Iran Launched an App That Claimed to Diagnose Coronavirus. Instead, It Collected Location Data on Millions of People. - VICE
Dear compatriots, before going to the hospital or health center, install and use this software to determine if you or your loved ones have been infected with the coronavirus
5 days ago
Improvement of cognitive and motor performance with mitotherapy in aged mice
Here we intravenously injected the mitochondria isolated from young mice into aged mice and investigated the mitotherapy on biochemistry metabolism and animal behaviors. The results showed that heterozygous mitochondrial DNA (mtDNA) of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only provides a useful approach to study mitochondrial function associated with aging, but also a new insight into anti-aging through mitotherapy.
5 days ago
Four Vaccine Types That Could Stop the Coronavirus, Explained
Recombinant Vector: The Sheep in Wolf’s Clothing

Recombinant vector vaccines are made through genetic engineering. Similar to subunit vaccines, recombinant vector vaccines aim to expose the immune system to viral antigens. But instead of injecting the antigens directly, scientists take a snippet of the virus’ genetic code for the antigen and combine it with that of a harmless virus. The engineered virus can then express the antigen needed to generate an immune response without causing an infection.

China’s first experimental vaccine approved for human trials uses this technique, with the team of researchers from the Academy of Military Medical Sciences inoculating their first volunteers last week. The study is aiming to recruit 108 healthy volunteers aged 18 to 60, and to run from March 16 to Dec. 31.
6 days ago
Max Siedentopf apologises for coronavirus masks made of everyday items
Artist and designer Max Siedentopf has apologised for offending people with his photos of home-made coronavirus masks, adding that his work aims to take people "out of their comfort zone".

"I apologise to everyone that felt offended by the series, it was never my intention," the Namibian-German artist told Dezeen.

"Most of my work takes a critical and often ironical look at our surroundings," he added. "It's important for me to take people out of their comfort zone and see things from a different perspective, both positively and negatively."
6 days ago
Max Siedentopf presents alternative coronavirus masks
Global demand for surgical face masks is growing, as people try to protect themselves against the virus. However doctors don't advise using them for protection as research shows they have limited use in preventing the spread of viruses.
6 days ago
Sympoietic and autopoietic systems: A new distinction for self-organizing systems
Heuristics provide essential tools for understanding living systems, their characteristics and their behaviours. My intent in this paper is to describe a considerably different heuristic than the conventional tools. My motivation is a concern that heuristics based on the organism metaphor are often inappropriate and misleading for understanding complex systems. I propose a new concept based on an interpretation of ecosystems: sympoietic systems. These are complex, self-organizing but collectively producing, boundaryless systems. A subsequent distinction between sympoietic and autopoietic systems is discussed. This distinction arises from defining a difference between three key system characteristics: 1) autopoietic systems have self-defined boundaries, sympoietic systems do not; 2) autopoietic systems are self-produced, sympoietic systems are collectively-produced; and, 3) autopoietic systems are organizationally closed, sympoietic systems are organizationally ajar. A range of other characteristics arise from these differences. Autopoietic systems are homeostatic, development oriented, centrally controlled, predictable and efficient. Sympoietic systems are homeorhetic, evolutionary, distributively controlled, unpredictable and adaptive. Recognized as caricatures at ends of a conceptual continuum, these descriptions present a useful heuristic. By introducing an alternative to the organism metaphor, the conceptualization of sympoietic systems draws attention to many, often neglected, complex system characteristics. In addition, the heuristic provides a means for recognizing trade-offs between the two sets of characteristics that are associated with the two system types. These, and other distinctions, lead to a range of new questions that have significant implications relevant to understanding complex living systems. Since it is based on generic system descriptions, the heuristic can be applied to a wide range of situations, including social, political, economic and cultural systems.
7 days ago
Frontiers | Toward Biorecycling: Isolation of a Soil Bacterium That Grows on a Polyurethane Oligomer and Monomer | Microbiology
In order to examine bacterial biodegradability of polyurethanes, a soil bacterium was isolated from a site rich in brittle plastic waste. The strain, identified as Pseudomonas sp. by 16S rRNA gene sequencing and membrane fatty acid profile, was able to grow on a PU-diol solution, a polyurethane oligomer, as the sole source of carbon and energy. In addition, the strain was able to use 2,4-diaminotoluene, a common precursor and putative degradation intermediate of polyurethanes, respectively, as sole source of energy, carbon, and nitrogen. Whole genome sequencing of the strain revealed the presence of numerus catabolic genes for aromatic compounds. Growth on potential intermediates of 2,4-diaminotoluene degradation, other aromatic growth substrates and a comparison with a protein data base of oxygenases present in the genome, led to the proposal of a degradation pathway.
7 days ago
Pandemics Depress the Economy, Public Health Interventions Do Not: Evidence from the 1918 Flu by Sergio Correia, Stephan Luck, Emil Verner :: SSRN
We find that cities that intervened earlier and more aggressively do not perform worse and, if anything, grow faster after the pandemic is over. Our findings thus indicate that NPIs not only lower mortality; they also mitigate the adverse economic consequences of a pandemic.
8 days ago
COVID-19 Has Closed Nightclubs, But The Queer Party Goes On At Club Quarantine | HuffPost Canada Life
Nightlife across the nation has been indefinitely suspended, as bars and clubs shut down to help stifle the spread of COVID-19. But partying hasn’t been completely annihilated — it’s just gone digital.

“Honestly, it started out as a joke,” Casey MQ, one of many organizers of the Toronto-based virtual party Club Quarantine, told HuffPost Canada. “But then it just seemed so obvious. It’s like, of course you want to connect with people when you’re all alone at home. That’s just part of human nature.”
8 days ago
Sugata Mitra creates a School in the Cloud | Prize-winning wishes | TED Prize | Participate | TED
My wish is to help design the future of learning by supporting children all over the world to tap into their innate sense of wonder. Help me build the School in the Cloud, a learning lab in India, where children can embark on intellectual adventures by engaging and connecting with information and mentoring online. I also invite you, wherever you are, to create your own miniature child-driven learning environments and share your discoveries.
8 days ago
Spatially regulated editing of genetic information within a neuron | Nucleic Acids Research | Oxford Academic
In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can be tailored for different cellular regions, particularly in cells with complex morphologies like neurons. Although messenger RNAs (mRNAs), and the proteins that they encode, can be differentially sorted between cellular regions, the information itself does not change. RNA editing by adenosine deamination can alter the genome’s blueprint by recoding mRNAs; however, this process too is thought to be restricted to the nucleus. In this work, we show that ADAR2 (adenosine deaminase that acts on RNA), an RNA editing enzyme, is expressed outside of the nucleus in squid neurons. Furthermore, purified axoplasm exhibits adenosine-to-inosine activity and can specifically edit adenosines in a known substrate. Finally, a transcriptome-wide analysis of RNA editing reveals that tens of thousands of editing sites (>70% of all sites) are edited more extensively in the squid giant axon than in its cell bodies. These results indicate that within a neuron RNA editing can recode genetic information in a region-specific manner.
9 days ago
An Infrared Thermometer Inside A Smartphone | Futuristic NEWS
Thanks to Jacob Fraden, an inventor who has patented the smartphone thermometer, very soon manufacturers might equip phones with infrared sensors that will allow measuring the temperature in a second. Temperature-taking wouldn’t be limited to humans, it may be used on pets or even on inanimate objects like stoves or bathtubs. Results should be accurate, falling within International Organization for Standardization (ISO) standards. But so far we don’t know if the inventor’s patented smartphone thermometer will see the light of day.
10 days ago
That Discomfort You’re Feeling Is Grief
Anticipatory grief is that feeling we get about what the future holds when we’re uncertain. Usually it centers on death. We feel it when someone gets a dire diagnosis or when we have the normal thought that we’ll lose a parent someday. Anticipatory grief is also more broadly imagined futures. There is a storm coming. There’s something bad out there. With a virus, this kind of grief is so confusing for people. Our primitive mind knows something bad is happening, but you can’t see it. This breaks our sense of safety. We’re feeling that loss of safety. I don’t think we’ve collectively lost our sense of general safety like this. Individually or as smaller groups, people have felt this, but all together this is new. We are grieving on a micro and a macro level.
10 days ago
Disease as Political Metaphor | by Susan Sontag | The New York Review of Books
For more than a century and a half, tuberculosis provided a metaphoric equivalent for delicacy, sensitivity, sadness, powerlessness; while whatever seemed ruthless, implacable, predatory, could be analogized to cancer.
covid-readings  dart631 
11 days ago
Brave New Farm?, by Jim Mason
In our mind's eye the farm is a peaceful, pleasant place where calves nuzzle their mothers in a shady field, pigs loaf in the mudhole and chickens scratch and scramble about the barnyard. We comfort ourselves with these bucolic images - images that are implanted by calendars, colouring books and the countrified labelling and advertising of animal products.

The reality of modern animal production, however, is starkly different from these scenes. Now, virtually all of our poultry products and about half of our milk and red meat come from animals mass-produced in huge factory-like systems. In some of the more intensively managed 'confinement' operations, animals are crowded in pens and cages stacked up like so many shipping crates. On these factory farms there are no pastures, no streams, no seasons, not even day and night. Health and productivity come not from frolics in sunny meadows but from syringes and additive-laced feed.
animal  covid-readings 
11 days ago
Charles "Chuck" Trimble - SD Hall of Fame Programs
From 1961 to 1967 Trimble was a master scheduler with the General Dynamics Astronautics Division’s Atlas Missile program, then with the General Dynamics Electronics division on the TFX (F-111) program. Moving to Colorado in 1966, he worked with the Ball Brothers Research Corporation’s solar research projects for the Harvard College Observatory and the Naval Research Laboratory experiments on the Apollo Telescope Mount project.

In 1968 he began working in American Indian rights with the Mayor’s Commission on Community Relations for the City and County of Denver. There he became involved with the White Buffalo Council of American Indians, the Denver urban Indian organization, and edited and published the organization’s newsletter – the Denver Indian Times, which he converted to a full newspaper.

As published of the Indian Times, Trimble found it difficult to get any news regarding Indian policy development and tribal affairs. Most of what he was able to garner was from the mainstream media, which carried little news about Native people, except when Indians were demonstrating against the federal government. In 1969 he secured a small grant to pull together a meeting of editors of Indian news periodicals, representing a tribal and regional cross-section of the country, to discuss the common needs of Indian media, and the possibility of forming a national organization to represent them and to provide them with news services.

In 1969 he was principal founder of the American Indian Press Association, and served as the organization's Executive Director until 1972, when he was elected Executive Director of the National Congress of American Indians. In his tenure, the NCAI is generally credited with having effectively lobbied for enactment of the Indian Financing Act, the Indian Health Care Improvement Act, the Indian Self Determination Act, the Indian Religious Freedom Act, the Indian Child Welfare Act, and unprecedented return of land to Indian tribes.
14 days ago
Netflix Party - Chrome Web Store
Netflix Party is a Chrome extension for watching Netflix remotely with friends, e.g., for movie nights with that long-distance special someone. It synchronizes video playback and adds group chat.

As of Mar 2020, Version 1.7.4 of Netflix Party is up and running.
15 days ago
Implications of Endectocide Residues on the Survival of Aphodiine Dung Beetles: A Meta‐Analysis - Finch - - Environmental Toxicology and Chemistry - Wiley Online Library
Our results document a positive effect on the occurrence of adult beetles, indicating that adults tend to be attracted to dung with residues. Conversely, larvae are less likely to occur in the presence of residues. Thus, either adults that colonize dung with residues do not lay eggs or, more likely, the larvae that hatch from these eggs die early in development. Abundance of adult and larval stages was shown to be significantly reduced in dung containing residues. When individual endectocides were compared, only ivermectin demonstrated a significantly negative effect on the abundance of both adults and larvae, possibly owing to a small sample size for other agents. In laboratory studies, only dung “spiked” with endectocides reduced the abundance of larvae, whereas during field research, only pour‐on applications were shown to reduce the abundance of larvae. The present study further documents the nontarget effects of endectocide residues on dung‐dwelling organisms, provides robust evidence on the consequences of different application methods, and emphasizes the need for standardized methodological techniques in future studies.
17 days ago
Why outbreaks like coronavirus spread exponentially, and how to “flatten the curve” - Washington Post
“If you want this to be more realistic,” Harris said after seeing a preview of this story, “some of the dots should disappear.”
17 days ago
Researchers prepare COVID-19 diagnostic for human testing
Through experiments in the lab and clinical environment, she has reported that when a person coughs or sneezes, they do not emit a spray of individual droplets that quickly fall to the ground and evaporate, as scientists had once thought. Instead, they produce a complex cloud of hot and moist air that trap droplets of all sizes together, propelling them much further through the air than any individual droplet would travel on its own.

On average, her experiments have revealed that a cough can transmit droplets up to 13 to 16 feet, while a sneeze can eject them up to 26 feet away. Surrounding air conditions can act to further disperse the residual droplets in upper levels of rooms.
18 days ago
How to Install Matrix Synapse Chat on Ubuntu 18.04 LTS
Matrix is a new ecosystem for decentralized communication in real time for open federated instant messaging and VoIP services. It provides RESTful HTTP JSON APIs for building distributed and federated chat servers with no single point of control and failure and provides all references for the APIs.

Synapse is an implementation of the matrix homeserver that's created by matrix team and written in Python/Twisted. With this software, we can implement the matrix way for decentralized communication, we can create our own home server and store all user personal info, chat history, create the room for own use, etc.

In this tutorial, we will show you step-by-step how to install and configure Matrix Synapse on Ubuntu 18.04. We will configure Matrix Synapse on the local IP address, and configure the Nginx web server as a reverse proxy for it, and implement the HTTPS connection between clients and the front-end Nginx web server.
19 days ago
Le virus responsable de la COVID-19 évolue en temps réel | Le Devoir
Une étude chinoise vient de montrer que le nouveau coronavirus a subi des mutations et qu’il s’est différencié en un second type qui semble plus contagieux et plus agressif que celui d’origine. Pour le moment, les différences entre ces deux variantes sont minimes et ne compromettent pas les démarches en cours pour la mise au point d’un vaccin, affirment les experts.
19 days ago
Glial Cells - The University of Chicago | Coursera
And, in addition when synapses are formed,
the synapses are not or not maintained without some effort and
part of that is that the synapses are enveloped in the processes of Astrocytes.
So, there's a lot of structural and
metabolic support that the Astrocytes are providing for neurons.
And then there are these two different types of glia cells.
Both of these glia cells make myelin.
And the oligodendrocytes make myelin in the CNS and
the Schwann cells make it in the Peripheral Nervous System.
So all these demyelinating diseases will affect either central myelin or
peripheral myelin.
They will not affect both, central or peripheral.
Because they are made by two different types.
The Oligodendrocytes in the central nervous system and
a Schwann cells in the peripheral nervous system.
Now it turns out that this is about, Astrocytes can comprise about 20% of
all the Glia cells, and these Oligodendrocytes
comprise about 75% of the central glia cells.
The remainder are these microglia, and
microglia are the one exception to the rule that
nervous system, that the cells of the nervous system come from Ectoderm.
These are actually essentially immune cells coming from the blood lineage.
These are immune cells that have invaded into
the central nervous system and their job is to be quiet.
And if we're healthy and everything goes well, they are quiet.
But when there is a problem these microglia react,
they try to rectify things, they try and
bring some attention to areas of damage and
what is emerging is that sometimes they go overboard and
they start to participate in making the problem as well as solving the problem.
Microglia are a hot topic.
And  in  addition  when  synapses  are  formed  the  not  or  maintained  without  some  effort  part  of  that  is  enveloped  processes  Astrocytes.  So  there's  a  lot  structural  metabolic  support  Astrocytes  providing  for  neurons.  then  there  these  two  different  types  glia  cells.  Both  cells  make  myelin.  oligodendrocytes  myelin  CNS  Schwann  it  Peripheral  Nervous  System.  all  demyelinating  diseases  will  affect  either  central  They  peripheral.  Because  made  by  types.  system  Now  turns  out  this  about  can  comprise  20%  75%  remainder  microglia  one  exception  to  rule  come  from  Ectoderm.  actually  essentially  immune  coming  blood  lineage.  have  invaded  into  their  job  be  quiet.  if  we're  healthy  everything  goes  well  But  problem  react  try  rectify  things  bring  attention  areas  damage  what  emerging  sometimes  go  overboard  start  participate  making  as  solving  problem.  hot  topic. 
21 days ago
Biology works at nanoscale, with objects invisible to the human eye. With BioBlender it is possible to show some of the characters that populate our cells, based on scientific data and the highest standard of 3D manipulation. Scientists all over the world study proteins at atomic level and deposit information in the public repository Protein Data Bank, where each molecule is described as the list of its atoms and their 3D coordinates.

With BioBlender users can handle proteins in the 3D space, displaying their surface in a photorealistic way, and elaborate protein movements on the basis of known conformations.
21 days ago
Searching for discrete time crystals in classical many-body systems
Recently, studies focusing on systems outside of thermal equilibrium have led to the discovery of new phases in periodically driven quantum systems, the most well-known of which is the discrete time crystal (DTC) phase. This unique phase is characterized by collective subharmonic oscillations arising from the interplay between many-body interactions and non-equilibrium driving, which leads to a loss of ergodicity.

Interestingly, subharmonic oscillations are also known to be a characteristic of dynamical systems, such as predator-prey models and parametric resonances.
21 days ago
MCA – Exhibitions: I Was Raised on the Internet
Was Raised on the Internet focuses on how the internet has changed the way we experience the world. Due to new types of gaming and entertainment and the rise of social media and alternative modes of representation, the everyday is no longer what it used to be. The ways we interact with each other have shifted through the connected nature of telecommunications devices across the internet, including mobile applications, social media platforms, and large search engines that have become everyday tools for individuals from all walks of life. New modes, not only of seeing but also of feeling, have emerged in response to this.
21 days ago
Forward Thinking | The New Yorker
According to the tachyon trajectory of this message, you should receive it around thirty years ago. (E-mail-less as you were, I’m not sure how it will appear. Muttered through radio static? A string of 8s, 0s, 3s, 4s, 7s, and 5s on your pocket calculator, to be read upside-down?) You’ll probably ignore it as blather. Perhaps, though, you’ll stash it and come back to it when it’s of some use.

How did you get into this stuff?

You’re going to be asked this question a lot. Sometimes with a sneer, sometimes with friendly curiosity, generally with bewilderment. It’s impossible to answer, of course; you didn’t get into anything.
23 days ago
Lantern | Nord Projects - a design and technology consultancy
Android Things

Android Things is a new operating system from Google, designed for embedded devices and the Internet of Things. In contrast to other embedded platforms, Android Things lets you build on modern technology that is familiar to mobile app developers.

The Lantern code-base is written in Kotlin, a modern type-safe language that should be familiar to Android and Swift developers alike. In addition, it uses Google technology like Nearby Connection and Cast to accelerate development.
23 days ago
GSNI | Human Development Reports
The Gender Social Norms Index (GSNI) measures how social beliefs obstruct gender equality in areas like politics, work, and education, and contains data from 75 countries, covering over 80 percent of the world’s population.

The analysis reveals that, despite decades of progress closing the equality gap between men and women, close to 90 percent of men and women hold some sort of bias against women, providing new clues to the invisible barriers women face in achieving equality.

According to the index, about half of the world’s men and women feel that men make better political leaders, and over 40 percent feel that men make better business executives and that men have more right to a job when jobs are scarce. 28 percent think it is justified for a man to beat his wife.
23 days ago
QT.bot | Lucas LaRochelle – Residency Presentation | Studio XX
As part of its Slow Tech programming, Studio XX welcomes Lucas LaRochelle, in residency from November 1st to December 13. They are developing “QT.bot”, an artificial intelligence trained on the textual and visual data of Queering The Map, a community-generated mapping platform of 80 000+ stories of LGBTQ2+ experience, that produces an endless stream of speculative queer futures.
24 days ago
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