cessationoftime + neuroscience   18

ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide.
Protein kinase M ζ (PKMζ), an atypical isoform of protein kinase C, has been suggested to be necessary and sufficient for the maintenance of long-term potentiation (LTP) and long-term memory (LTM). This evidence is heavily based on the use of ζ inhibitory peptide (ZIP), a supposed specific inhibitor of PKMζ that interferes with both LTP and LTM. Problematically, both LTP and LTM are unaffected in both constitutive and conditional PKMζ knock-out mice, yet both are still impaired by ZIP application, suggesting a nonspecific mechanism of action. Because translational interference can disrupt neural activity, we assessed network activity after a unilateral intrahippocampal infusion of ZIP in anesthetized rats. ZIP profoundly reduced spontaneous hippocampal local field potentials, comparable in magnitude to infusions of lidocaine, but with a slower onset and longer duration. Our results highlight a serious confound in interpreting the behavioral effects of ZIP. We suggest that future molecular approaches in neuroscience consider the intervening level of cellular and systems neurophysiology before claiming influences on behavior.
memory  brain  neuroscience  neurons 
april 2018 by cessationoftime
Anxiety Cells in a Hippocampal-Hypothalamic Circuit
Anxiety cells stimulated to manipulate avoidance behavior with modified proteins triggered with light
anxiety  fear  brain  neuroscience  mind 
february 2018 by cessationoftime
'Cyborg' spinal implant could help paralysed walk again
It might seem like science fiction but a new implant which attaches directly to the spine could help paralysed people walk again
cyborg  implant  spine  prosthesis  neuroscience  paralysis 
january 2015 by cessationoftime
How Sleep Clears the Brain - National Institutes of Health (NIH)
The researchers next injected mice with labeled beta-amyloid and measured how long it lasted in their brains when they were asleep and awake. Beta-amyloid disappeared twice as quickly in the brains of mice that were asleep. The hormone noradrenaline, which increases alertness, is known to cause cells to swell.
alzheimer's  neuroscience  sleeping  sleep  amyloid  osmo  osmoticFragility  osmolarity  hyperosmolar  hyperosmotic  noradrenaline  glialCell  glymphatic 
december 2013 by cessationoftime

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