Dietary calcium induced cytological and biochemical changes in thyroid
Enlargement of thyroid with hypertrophic and hyperplastic changes, retarded TPO and 5′-DI but enhanced Na+–K+-ATPase activities, augmented serum total and free T4 and TSH but decreased total and free T3 levels and low T3/T4 ratio (T3:T4) were observed in the treated groups. All these findings indicate development of goitrogenesis upon exposure to excessive dietary calcium.

Highlights
▸ High calcium caused enlarged thyroid gland with hypertrophic/hyperplastic changes. ▸ Excess calcium decreased TPO and 5′ DI but increased Na+–K+-ATPase activities. ▸ Calcium altered serum total and free T4, total and free T3, T3/T4 ratio and TSH. ▸ Chronic calcium exposure exerted goitrogenic or antithyroidal action.
thyroid  calcium  hyperthyroidism 
3 days ago
Retinoids: Compounds important to hair growth
Although the mechanisms of follicular regression in androgenetic alopecia are not fully understood, retinoids may be important in changing the status of regressing follicles. There are many reports documenting reversal of epithelial dysplastic changes with retinoids. 13–18 Although none of the studies with retinoids have concentrated on the precise mechanisms of follicular growth (regression or regeneration), these limited observations1plt12 and our early studies2 suggest that further work should be done on the effect retinoids have on the hair follicle during the various growth and regression phases of the follicular life cycle in humans.

We propose that certain retinoids increase the rate of hair growth, prolong the anagen phase of the hair cycle, play a role in converting vellus to terminal hairs, and act synergistically with minoxidil to produce more dense hair regrowth from regressing follicles than either compound alone. Larger controlled studies and better methods for assessing hair growth are necessary to support these early results, Other retinoids as well as certain minoxidil analogs should also be studied.
retinoicAcid  retinol  hair  hairloss  alopecia 
8 days ago
Thyroid Dysfunction and Tinnitus
In some cases hypothyroidism is accompanied by iron deficiency. When this occurs, supplementing with iron will often produce the required therapeutic results. Patients with hypothyroidism should routinely be checked for iron deficiency.
HYPOTHYROIDISM  iron  tinnitus 
14 days ago
Supplementation with iron and riboflavin enhances dark adaptation response to vitamin A-fortified rice in iron-deficient, pregnant, nightblind Nepali women.
BACKGROUND:
Nightblindness affects 16-52% of pregnant women in areas of Nepal and in some cases persists after vitamin A treatment. Iron and riboflavin affect vitamin A utilization and photoreceptor function, respectively, and pilot data in the study population showed a high prevalence of iron and riboflavin deficiencies.

OBJECTIVE:
The objective was to assess the effect of supplemental iron and riboflavin on pupillary threshold (PT) and plasma retinol in nightblind, pregnant Nepali women given vitamin A-fortified rice.

DESIGN:
Nightblind pregnant women were randomly assigned to receive, 6 d/wk under supervision for 6 wk, a vitamin A-fortified rice curry dish providing 850 microg retinal activity equivalents/d with either a 30-mg Fe and 6-mg riboflavin (FeR + VA) capsule or a placebo control (VA only) capsule. Hemoglobin, erythrocyte riboflavin, and plasma ferritin and retinol were measured before and after the intervention. Dark adaptation was assessed by PT score.

RESULTS:
Women who were iron deficient at baseline (n=38) had significantly greater improvement in PT score with iron and riboflavin supplementation than without (P=0.05). Iron and riboflavin supplements significantly reduced the prevalences of riboflavin deficiency (from 60% to 6%; P<0.0001), iron deficiency anemia (from 35% to 15%; P<0.007), and abnormal PT (from 87% to 30%; P<0.05) from baseline. Mean increases in erythrocyte riboflavin (P<0.0001) and plasma ferritin (P=0.01) were greater in the FeR + VA group than in the VA only group.

CONCLUSIONS:
Iron deficiency may limit the efficacy of vitamin A to normalize dark adaptation in pregnant Nepali women. Further studies are needed to assess the effect of simultaneous delivery of iron and vitamin A for the treatment of nightblindness.
iron  riboflavin  vitaminA  retinol 
17 days ago
Topical tretinoin for hair growth promotion.
Topical all-trans-retinoic acid (tretinoin) alone and in combination with 0.5% minoxidil has been tested for the promotion of hair growth in 56 subjects with androgenetic alopecia. After 1 year, the combination of topical tretinoin with 0.5% minoxidil resulted in terminal hair regrowth in 66% of the subjects studied. Tretinoin was shown to stimulate some hair regrowth in approximately 58% of the subjects studied. One female subject with pronounced alopecia for more than 20 years had regrowth of hair using only tretinoin for a period of 18 months. Tretinoin has been shown to promote and regulate cell proliferation and differentiation in the epithelium and may promote vascular proliferation. These factors are important for hair growth promotion. These preliminary results indicate that more work should be done on the role of retinoids in hair growth. The synergistic effect of retinoids in combination with a low concentration of minoxidil should also be further investigated.
retinoicAcid  tretinoin  atra  hair  vita  riboflavin  hairloss  alopecia 
17 days ago
The additive effects of minoxidil and retinol on human hair growth in vitro.
retinol significantly improves scalp skin condition and promotes hair growth
retinol  vitaminA  hair  hairloss 
17 days ago
Regulation mechanisms of hair growth. in mice
Amongst all of the treatments that were applied, topical application of TPA was most able to accelerate hair regrowth, followed by UV irradiation and retinoic acid treatment.
vitaminA  hair  hairloss  alopecia  retinoicAcid 
24 days ago
Elevated aldosterone levels in patients with androgenetic alopecia
Background There is reported to be an elevated prevalence of hypertension among patients with androgenetic alopecia (AGA), and it has been proposed that both phenomena may be explained by the presence of hyperaldosteronism. However, no data on aldosterone levels in patients with AGA have been published to date.

Objectives The objective of this pilot study was to evaluate aldosterone levels and the presence of hypertension in patients with AGA and in healthy controls.

Methods This case–control study included 40 patients with AGA and 40 healthy controls from the Dermatology Department of San Cecilio Hospital, Granada, Spain.

Results Patients with AGA showed significantly higher systolic blood pressure values (136·23 vs. 124·10 mmHg, P = 0·01) and aldosterone levels (197·35 vs. 133·71 pg mL−1, P = 0·007) vs. controls.

Conclusion The elevated aldosterone values in these patients may contribute, together with other mechanisms, to the development of AGA and may also explain the higher prevalence of hypertension. Blood pressure screening of patients with AGA will permit earlier diagnosis of an unknown hypertension and initiation of appropriate treatment.
aldosterone  hair  hairloss  alopecia  baldness  bloodpressure 
5 weeks ago
Dumbbell lateral fly
proper way to do the lateral fly
exercise  weightLifting 
6 weeks ago
StrongLifts 5×5: Get Stronger Lifting Weights 3x/Week Read more https://stronglifts.com/5x5/
The StrongLifts 5×5 strength training program consists of two workout

Do three workouts per week. Never train two days in a row or do two workouts in a day. Wait one day before doing your next workout. This gives your body time to recover, get stronger and build muscle so you can lift heavier next workout. Alternate workout A and B each time you train.
weightTraining  exercise 
6 weeks ago
Evidence for anisotropy of cosmic acceleration
The observed acceleration of the Hubble expansion rate has been attributed to a mysterious "dark energy" which supposedly makes up about 70% of the universe. Professor Subir Sarkar from the Rudolf Peierls Centre for Theoretical Physics, Oxford along with collaborators at the Institut d'Astrophysique, Paris and the Niels Bohr Institute, Copenhagen have used observations of 740 Type Ia supernovae to show that this acceleration is a relatively local effect—it is directed along the direction we seem to be moving with respect to the cosmic microwave background (which exhibits a similar dipole anisotropy). While the physical reason for this acceleration is unknown, it cannot be ascribed to dark energy which would have caused equal acceleration in all directions.
darkEnergy  universeExpansion 
6 weeks ago
Clinical study finds eating within 10-hour window may help stave off diabetes, heart disease
Researchers have found that a 10-hour time-restricted eating intervention, when combined with traditional medications, resulted in weight loss, reduced abdominal fat, lower blood pressure and cholesterol for participants. The pilot study could lead to a new treatment option for metabolic syndrome patients who are at risk for developing life-altering and costly medical conditions such as diabetes.
fasting  intermittentFasting  diabetes  insulin 
6 weeks ago
EveryCircuit - Circuit Simulator/Animator
You can build and simulate circuits right on your phone or tablet, animate and understand how they work, check homework and test your designs. Best of all, you can join and interact with EveryCircuit's large online community of fellow circuit enthusiasts.
circuit  electronics 
6 weeks ago
Wearable sweat sensor detects gout-causing compounds
describe a mass-producible wearable sensor that can monitor levels of metabolites and nutrients in a person's blood by analyzing their sweat. Previously developed sweat sensors mostly target compounds that appear in high concentrations, such as electrolytes, glucose, and lactate. Gao's sweat sensor is more sensitive than current devices and can detect sweat compounds of much lower concentrations, in addition to being easier to manufacture, the researchers say.
sweat  sensor 
7 weeks ago
Laser-driven liquid marbles can push 150 times their own weight Read more: https://www.newscientist.com/article/2084124-laser-driven-liquid-marbles-can-push-150-times-their-own-weight/#ixzz65sXC5NiC
For their version, the team coated millimetre-sized drops of water in a nanometre-scale powder of polypyrrole, a plastic which heats up when illuminated and also repels water. The powder coating turned the drop into a liquid marble, trapping the fluid inside.

The team put one of these marbles in a pool of water and illuminated the marble with a laser. As the polypyrrole warmed up, it changed the surface tension on one side of the marble, propelling it across the water just like the beetles.
microfluidics  engine  pump 
8 weeks ago
studies on nutritional achromotrichia in rats: Three figures
liver extracts are more effective at protecting against achromotrichia than pantothenic acid alone
achromotrichia  copper  liver  pantothenicAcid 
8 weeks ago
Relation of cystine to achromotrichia
cystine with pantothenic acid enhances restoration of color
pantothenicAcid  achromotrichia  whitehair  greyhair 
8 weeks ago
achromotrichia due to copper deficiency
white hair due to copper deficiency, previously described.
achromotrichia  Copper  greyhair  whitehair 
8 weeks ago
“Folic Acid” in Nutritional Achromotrichia
Biotin and “folic acid” are growth factors for rats on synthetic diets containing sulfaguanidine. “Folic acid” is also a chromotrichial factor for these rats.
folicAcid  achromotrichia  greyhair  whitehair 
8 weeks ago
Pantothenic acid and nutritional achromotrichia in rats
Achromotrichia or greying of hair developed regularly in rats fed on a diet of casein 18, sucrose 68, butter fat 8, cod liver oil 2, salt 4, supplemented by daily doses of 20 γ each of vitamin B1, riboflavin and vitamin B6. The colour of the hair regularly returned to normal after administration of pantothenic acid, daily doses of 75 or 100 γ causing a definite change in 5 to 7 days and a complete cure in 5 to 7 weeks; a dose of 50 γ daily effected a partial cure.
pantothenicAcid  VitB5  achromotrichia  whitehair  greyhair 
8 weeks ago
Specific neurons that map memories now identified in the human brain
Neuroengineers have found the first evidence that individual neurons in the human brain target specific memories during recall. They studied recordings in neurosurgical patients who had electrodes implanted in their brains and examined how the patients' brain signals corresponded to their behavior while performing a virtual-reality object-location memory task. The researchers identified 'memory-trace cells' whose activity was spatially tuned to the location where subjects remembered encountering specific objects.
memory  memories  brain  neuroscience  neurons 
9 weeks ago
Sea-thru: A Method For Removing Water From Underwater Images
Colors bleed out of underwater images over distance, this corrects for it.
underwater  imaging  submarine  vision  robotics  robot 
9 weeks ago
Role of taurine accumulation in keratinocyte hydration.
Epidermal keratinocytes are exposed to a low water concentration at the stratum corneum-stratum granulosum interface. When epithelial tissues are osmotically perturbed, cellular protection and cell volume regulation is mediated by accumulation of organic osmolytes such as taurine. Previous studies reported the presence of taurine in the epidermis of several animal species. Therefore, we analyzed human skin for the presence of the taurine transporter (TAUT) and studied the accumulation of taurine as one potential mechanism protecting epidermal keratinocytes from dehydration. According to our results, TAUT is expressed as a 69 kDa protein in human epidermis but not in the dermis. For the epidermis a gradient was evident with maximal levels of TAUT in the outermost granular keratinocyte layer and lower levels in the stratum spinosum. No TAUT was found in the basal layer or in the stratum corneum. Keratinocyte accumulation of taurine was induced by experimental induction of skin dryness via application of silica gel to human skin. Cultured human keratinocytes accumulated taurine in a concentration- and osmolarity-dependent manner. TAUT mRNA levels were increased after exposure of human keratinocytes to hyperosmotic culture medium, indicating osmosensitive TAUT mRNA expression as part of the adaptation of keratinocytes to hyperosmotic stress. Keratinocyte uptake of taurine was inhibited by beta-alanine but not by other osmolytes such as betaine, inositol, or sorbitol. Accumulation of taurine protected cultured human keratinocytes from both osmotically induced and ultraviolet-induced apoptosis. Our data indicate that taurine is an important epidermal osmolyte required to maintain keratinocyte hydration in a dry environment.
taurine  skin  epidermis  drySkin 
12 weeks ago
Skin findings associated with nutritional deficiencies.
Certain vitamin and mineral deficiencies may be recognized by their cutaneous signs. This case-based article reviews deficiencies of zinc and vitamins A, B2, B3, B6, and C, discussing their consequences and skin findings.
skin  deficiency  zinc  riboflavin  niacin  b6  vitb6  vita 
october 2019
How To Make Oven-Roasted Corn: 3 Simple Methods
Roasting Corn in the Husk
30 minutes at 350 degrees in the oven. Remove outer husk, trim tassels.
cornOnCob  cooking 
august 2019
New cause of cell aging discovered
Many senescent cells have two nuclei and stop producing nucleotides.
aging  senescence 
july 2019
Biotin Is Required for the Zinc Homeostasis in the Skin.
Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previously shown that epidermal keratinocytes of mice fed zinc-deficient (ZD) diets secreted more adenosine triphosphate (ATP) than those of mice fed zinc-adequate (ZA) diets and that epidermal Langerhans cells are absent in ZD mice. Langerhans cells highly express CD39, which potently hydrolyzes ATP into adenosine monophosphate (AMP). Thus, a lack of Langerhans cells in ZD mice leads to non-hydrolysis of ATP, thereby leading to the development of ATP-mediated irritant contact dermatitis. In this study, we examined if biotin-deficient (BD) mice showed the same underlying mechanisms as those in ZD mice. BD mice showed reduced serum zinc levels, disappearance of epidermal Langerhans cells, and enhanced ATP production in the skin. Consequently, irritant contact dermatitis was significantly enhanced and prolonged in BD mice. In conclusion, the findings of our study showed that biotin deficiency leads to zinc deficiency because of which patients with biotin deficiency show similar symptoms as those with acrodermatitis enteropathica.
zinc  biotin 
july 2019
serum biotin and zinc in male androgenetic alopecia.
A positive significant correlation was found between serum zinc and serum biotin

Serum zinc showed subnormal value and adding zinc supplement in MAGA treatment is recommended. Serum biotin showed a suboptimal level in MAGA patients that is not correlated with patients' age or disease severity. Biotin supplement in MAGA treatment may add value to hair quality and texture. We recommend future biotin evaluation in serum combined with its metabolites in MAGA patients' urine.
zinc  biotin  hair  hairloss  malePatternBaldness 
july 2019
Mayor offers reward to first couple to have a boy in village where only girls are born – The First News
Over the last nine years, only girls have been born in the village of Miejsce Odrzańskie
genetics  poland 
july 2019
Subclinical zinc deficiency impairs pancreatic digestive enzyme activity and digestive capacity of weaned piglets
even slight zinc deficiency in an animal's diet impedes pancreatic digestive activity and results in significant digestive impairment, even at an early stage

In conclusion, (1) subclinical Zn deficiency impaired pancreatic exocrine enzymes, (2) this response was connected to pancreatic Zn metabolism and (3) the decline in catalytic activity impaired faecal digestibility already after 1 week of insufficient alimentary Zn supply and very early before clinical deficiency symptoms arise.
zinc  pancreas  pancreatitis 
july 2019
Effect of taurine supplementation on plasma homocysteine levels of the middle-aged Korean women. - PubMed - NCBI
The purpose of this study was to evaluate the effect of taurine supplementation on plasma homocysteine (Hcy) levels, an independent risk factor of cardiovascular disease. The subjects consisted of 22 healthy middle-aged women (33 to 54 years). Serum lipids, plasma taurine and plasma Hcy levels were measured before and after supplying 3 g taurine per day for 4 weeks. The concentration of plasma taurine was significantly increased from 63.7 +/- 14.2 micromol/L to 73.8 +/- 16.6 micromol/L after taurine supplementation (p < 0.001). On the other hand, the concentration of plasma Hcy was significantly decreased from 8.5 +/- 1.2 micromol/L to 7.6 +/- 1.1 micromol/L after taurine supplementation (p < 0.05). The effect of taurine on the levels of plasma Hcy was assessed by regression analysis (R2 = 0.304). After taurine supplementation, plasma taurine and Hcy concentration exhibited a significant negative correlation (p < 0.05). In conclusion, taurine is an effective nutrient that antagonizes Hcy levels. Therefore, this study suggests that sufficient taurine intake might be an effective way of preventing cardiovascular diseases, such as atherosclerosis.
taurine  homocysteine 
july 2019
Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment.
The plasma taurine levels of PD patients were decreased when compared with controls and negatively associated with motor severity but not non motor symptoms. Moreover, treated PD patients exhibited lower levels of plasma taurine than non treated PD patients. Interestingly, plasma taurine levels negatively correlated with cumulative levodopa dosage in treated PD. After controlling for potential confounders, the association between taurine and levodopa remained significant.
taurine  parkinson's 
july 2019
Randomised clinical trial: oral taurine supplementation versus placebo reduces muscle cramps in patients with chronic liver disease.
Oral supplementation with 2 g taurine/d results in a clinically significant reduction in the frequency, duration, and intensity of muscle cramps in patients with chronic liver disease.
taurine  cramps  musclecramp  magnesium 
july 2019
Role of Taurine Accumulation in Keratinocyte Hydration
Epidermal keratinocytes are exposed to a low water concentration at the stratum corneum-stratum granulosum interface. When epithelial tissues are osmotically perturbed, cellular protection and cell volume regulation is mediated by accumulation of organic osmolytes such as taurine. Previous studies reported the presence of taurine in the epidermis of several animal species. Therefore, we analyzed human skin for the presence of the taurine transporter (TAUT) and studied the accumulation of taurine as one potential mechanism protecting epidermal keratinocytes from dehydration. According to our results, TAUT is expressed as a 69 kDa protein in human epidermis but not in the dermis. For the epidermis a gradient was evident with maximal levels of TAUT in the outermost granular keratinocyte layer and lower levels in the stratum spinosum. No TAUT was found in the basal layer or in the stratum corneum. Keratinocyte accumulation of taurine was induced by experimental induction of skin dryness via application of silica gel to human skin. Cultured human keratinocytes accumulated taurine in a concentration- and osmolarity-dependent manner. TAUT mRNA levels were increased after exposure of human keratinocytes to hyperosmotic culture medium, indicating osmosensitive TAUT mRNA expression as part of the adaptation of keratinocytes to hyperosmotic stress. Keratinocyte uptake of taurine was inhibited by β-alanine but not by other osmolytes such as betaine, inositol, or sorbitol. Accumulation of taurine protected cultured human keratinocytes from both osmotically induced and ultraviolet-induced apoptosis. Our data indicate that taurine is an important epidermal osmolyte required to maintain keratinocyte hydration in a dry environment.
taurine  hyperosmolar  dryskin 
july 2019
Zinc absorption as a function of the dose of zinc sulfate in aqueous solution.
Increases in aqueous zinc doses >20 mg result in relatively small and progressively diminishing increases in absorbed zinc in healthy adults.

20 mg resulted in 11 absorbed while 30mg resulted in 11.2 absorbed
11.0 +/- 4.4, and 11.2 +/- 2.1 mg
zinc  absorption  zincUptake 
june 2019
A Descriptive Study of Alopecia Patterns and their Relation to Thyroid Dysfunction
Thyroid dysfunction is connected to alopecia and male pattern baldness above 40
thyroid  alopecia  hair  hairloss  malePatternBaldness 
june 2019
Retinoids Putting the “A” in Alopecia
Vitamin A (vitA) has many roles in human biology. With respect to hair, knockout mice for vitA receptor, hairless, and vitamin D genes have similar phenotypes, and follicle loss occurs during catagen. Hypovitaminosis A from inadequate vitA intake causes hair loss. This work suggests that dietary vitA may have a role in precipitating and maintaining alopecias as well.
alopecia  vita 
june 2019
The role of calcium in pancreatic secretion and disease.
Hypercalcemia stimulates enzyme secretion in the pancreas, hypocalcemia inhibits it.
calcium  pancreas  pancreatitis  bicarbonate 
june 2019
Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter.
We found that the enzyme binds all-trans- or 9-cis-retinoic acid and all-trans- or 13-cis-retinal, but not all-trans-retinol, with affinities (Kd of 70-80 nM) sufficient for function as a retinoid transporter. All-trans-retinoic acid inhibited the enzyme activity in a noncompetitive manner, suggesting that it binds to the same hydrophobic pocket as prostaglandin H2, the substrate for prostaglandin D synthase, but at a different site in this pocket. It is likely that this enzyme is a bifunctional protein that acts as both retinoid transporter and prostaglandin D2-producing enzyme.
retinol  retinolBindingProtein  prostaglandin  hair 
june 2019
Sertoli cell prostaglandin D2 synthetase is a multifunctional molecule: its expression and regulation.
As PGD-Synthetase is a known retinoid transporter, the effects of all-trans-retinoic acid and all-trans-retinal on Sertoli cell PGD-Synthetase expression were also assessed. Both compounds were found to induce Sertoli cell PGD-Synthetase expression. (From other articles: Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness )
prostaglandin  retinol  retinolBindingProtein  hair  vita 
may 2019
Vitamin E can reduce blood pressure in mild hypertensives.
, it was found that the vitamin E supplement had caused a remarkable decrease in SBP (-24% in DG versus -1.6% in PG) and a less remarkable decrease in DBP (-12.5% in DG versus -6.2% in PG) (p < 0.05). The change in heart rate was -4.3% in DG, and -14.0% in PG (p < 0.05). It is concluded that a vitamin E supplement of 200 IU/day can be effective in mild hypertensive patients in the long term, probably due to nitric oxide, and improve their blood pressure status.
vite  bloodpressure 
april 2019
Biochemical vitamin E deficiency in chronic pancreatitis.
patients without pancreatic steatorrhoea also had significantly lower levels of plasma vitamin E and the ratio vitamin E/total lipids when compared to controls. We conclude that biochemical vitamin E deficiency is common in chronic alcohol-induced pancreatitis, particularly in patients with steatorrhoea, and that factors other than fat malabsorption may be responsible for vitamin E deficiency in pancreatic non-steatorrhoea.
pancreatitis  steatorrhea  vite 
april 2019
Sniffing out Parkinson's disease
The data revealed the presence of hippuric acid, eicosane and octadecanal, which indicate the altered levels of neurotransmitters found in Parkinson's patients, along with several other biomarkers for the disease. Milne confirmed the signature musk of Parkinson's when presented with laboratory-prepared samples containing these compounds in a controlled olfactory environment.
parkinson's  scent  smell 
march 2019
Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
Other articles indicated that hyperthyroidism can lower gfr and raise vitamin A.

This article indicates ckd is associated with high vitamin A levels. But it sounds as though vitamin A is not being converted to the right form.
vita  kidney  kidneyFailure  gfr 
march 2019
Zinc Status in Chronic Pancreatitis and its Relationship with Exocrine and Endocrine Insufficiency
This study demonstrates zinc deficiency in chronic pancreatitis patients, and that zinc deficiency correlates with exocrine and endocrine insufficiency. Further studies may clarify the possible benefits of zinc supplementation in chronic pancreatitis.
zinc  pancreas  pancreatitis 
march 2019
Blood donations, iron stores, and risk of Parkinson's disease. - PubMed - NCBI
Multiple blood donations likely induce a deficiency in riboflavin. Which is why there is an increased risk of Parkinson's after multiple recent donations.
parkinson's  riboflavin  Iron 
march 2019
Artificial intelligence senses people through walls
Human bodies interfere with radio signals enough that a neural network cqan sense people through walls.
wireless  artificialIntelligence 
march 2019
Pancreatic acinar cell regeneration following copper deficiency-induced pancreatic necrosis. - PubMed - NCBI
Copper deficiency causes the pancreas to shrink to 30% in size. Copper supplementation causes it to regenerate.

This may be because of the large amount of endoplasmic reticulum and golgi in the pancreas due to its role in secreting a large number of substances. The ER and golgi are fragmented in cholesterol deficiency and cholesterol metabolism would be definitely inhibited by a copper deficiency.
copper  pancreas  cholesterol  hdl  ldl 
march 2019
Project Chrono: An Open Source Multi-physics Simulation Engine
Chrono is a physics-based modelling and simulation infrastructure based on a platform-independent open-source design implemented in C++. A PROJECTCHRONO library can be embedded in a software project to simulate, for instance, wheeled and tracked vehicles operating on deformable terrains, robots, mechatronic systems, compliant mechanisms, and fluid solid interaction phenomena. Systems can be made of rigid and flexible/compliant parts with constraints, motors and contacts; parts can have three-dimensional shapes for collision detection.
Robotics  dynamics  simulation  Physics  roboticsSimulation  physicsSimulation 
march 2019
Lower serum calcium levels are a risk factor for a decrease in eGFR in a general non-chronic kidney disease population
Lower serum Ca levels are a significant risk for rapid decrease in estimated glomerular filtration rate (GFR)
kidney  calcium  kidneyFailure 
march 2019
Niacin in patients with chronic kidney disease: Is it effective and safe?
niacin treatment improved the glomerular filtration rate compared to baseline values.

niacin administration improves renal tissue lipid metabolism, renal function and structure, hypertension, proteinuria, and histological tubulointerstitial injury in an animal model of 5/6 nephrecomized rats
niacin  kidney 
march 2019
Circulating Retinol-Binding Protein-4 Concentration Might Reflect Insulin Resistance–Associated Iron Overload
Serum RBP4 concentration decreased after iron depletion in type 2 diabetic patients 

iron supplementation significantly increased plasma retinol and RBP4
retinol  rbp4  iron 
february 2019
Nutrition effects on pancreas
zinc deficient diet leads to reduced pancreatic secretory volume and bicarbonate by large percentages.
pancreas  nutrition  zinc  selenium  iron  copper  bicarbonate 
february 2019
Exocrine pancreas ER stress is differentially induced by different fatty acids.
mono-unsaturated oleic acid attenuated the ER stress response of the pancreas. Oleic acid is most abundant in olive oil.
pancreas  pancreatitis  fattyAcids  oliveOil 
february 2019
Effects of niacin on biliary lipid output in the rat.
Thus, increased biliary secretion of cholesterol explains, at least in part, the hypocholesterolaemic action of niacin.

Niacin treatment for 2 or 4 weeks lowered serum cholesterol concentrations by 13% or 29%, respectively, with the greatest decrease occurring in the low density lipoprotein fraction. This was accompanied by relatively large increases in biliary cholesterol output (114% and 130% after 2 and 4 weeks treatment, respectively) with smaller increases in the biliary output of phospholipid (18% and 45%) and bile acid (26% and 14%).
bile  niacin  cholesterol  ldl 
february 2019
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