asterisk2a + models   5

DNA editing in human embryos reveals role of fertility "master gene" | Science | The Guardian
The failures of fertility treatments could be down, in part, to a reliance on mouse studies, which until now have been seen as the best way to work out the role of genes during embryonic development – and why things sometimes go wrong. The latest work highlights the shortcomings with this approach, showing that the OCT4 gene appears to play a different role in early human embryos than in mice.

“This is in a way unexpected, because of the dogma that the earliest stages of development are common for all mammalian and even some non-mammalian species,” said Dusko Ilic, reader in stem cell science at King’s College London. “The study is another proof that the findings from experimental animal models cannot be always extrapolated to humans.”
chronic  sick  population  premature  ageing  IVF  fertility  DNA  Crispr  mouse  models  Crispr-Cas9  epigenetics 
september 2017 by asterisk2a
Zerstört der Klimawandel unsere Denkmäler? | Zwischen Spessart & Karwendel | BR - YouTube
- rising temperatures also inside buildings, historic buildings. micro climates in buildings. further - the extreme winds and storms in the future; steep pitched roofs from the past, especially old ones from historic buildings, can't hand that kind of force that is coming. those historic pitched roofs have to be refitted with diagonal ?battens? ... further - historical buildings have to be refitted with climate control systems to keep humidity low during summer days to prevent mould not only on walls, but also on paintings and other stuff inside of historical buildings.. another expense.
weather  extreme  extreme  weather  unintended  consequences  complexity  unknown  unknowns  climate  change  climate  science  climate  system  global  warming  drought  flooding  weather  system  climate  models  historic  buildings  pitched  roof  economic  damage  humidity 
july 2014 by asterisk2a
Franchise redux: The professionalization of the sharing economy has deep implications | PandoDaily
But for all Airbnb and Uber’s much deserved “disruptive” acclaim, these businesses have older roots than the hype cycle suggests. According to conventional wisdom, Airbnb and Uber enable “regular individuals” to make a few extra bucks renting out an extra bedroom or giving fellow travelers a ride. They unlock a new class of assets, where fellow consumers share in collaborative consumption. In fact, while these businesses nailed rapidly changing consumer preferences  –  buying services at time of usage, rather than owning assets fits the post-recession, Millennial sensibility of the moment –  the supply side of their businesses does not match the narrative. Supply in these marketplaces is increasingly delivered by entrepreneurial, small business owners, not fellow consumers. Uber and Airbnb are best understood as reimagined franchise operations that leverage mobile data, the social graph, and continuous feedback loops to deliver a better consumer experience.
Airbnb  Millennials  GFC  post-recession  2014  Consumerism  consumerist  zombie  consumer  sharing  is  caring  sharing  economy  marketplace  marketplace  efficiencies  marketplace  inefficiencies  Technology  convenience  disrupting  markets  disruption  franchise  business  Platform  Open  Platform  franchising  redux  service  delivery  mobile  first  digital  natives  adoption  adoption  curve  trends  youthification  unintended  consequences  complexity  unknown  unknowns  self-regulation  regulation  deregulation  vested  interest  interest  groups  operating  performance  Start-Up  Start-Ups  Lean  Start-Up  Silicon  Valley  entrepreneurial  entrepreneurship  feedback  loop  transparency  Models  Social  Media  recovery  productivity  output-gap  underemployed  working  poor  squeezed  middle  class  disposable  income  Debt  Super  Cycle  USA  UK  Europe  consumer 
may 2014 by asterisk2a
BBC News - Charlotte Church attacks 'sexist' music industry
The music industry has a "culture of demeaning women" that forces stars to sell themselves as sex objects. The business is "a male dominated industry with a juvenile perspective on gender and sexuality" and increasingly wants "sex objects that appear child-like", Church claimed. [...] Sinead O'Connor wrote an open letter to the pop star, warning her not to be exploited by the music business. [...] "Short burst messaging." (Shallow Content with no Context. Cheap. Meaningless. Disappearing in the ether.) + http://www.bbc.co.uk/news/entertainment-arts-24382051 + Look what the entertainment industry did to so many people (ie Germany Gina-Lisa Lohfink & Co https://www.facebook.com/photo.php?v=338916486255060) http://www.bbc.co.uk/news/entertainment-arts-24432329 + http://www.bbc.co.uk/news/entertainment-arts-24395755 + !!! http://amandapalmer.net/blog/20131003/ !!!
social  role  gender  inequality  Lady  Gaga  Music  Industry  Miley  Cyrus  cultural  beauty  standard  psychology  gender  childhood  gender  politics  Nicki  Minaj  celebrity  culture  short-term  thinking  sex-sells  image  social  science  ageing  Facebook  social  study  branding  gender  policing  sex  sells  everyday  sexism  plastic  surgery  Madonna  Entertainment  Industry  Twitter  role  models  Explicit  Pornographic  Amanda  Palmer  internet  culture  mass  culture  Rihanna  Britney  Spears  stereotype  sexualität  income  inequality  civil  society  Twerking  Sinead  O'Connor  sexuality  childhood  development  Annie  Lennox  marketing  society  social  media  gender  norms  Hollywood  sexism  gender  role  sexismus  superficial  beauty  standard  brand  western  society  inequality  Charlotte  Church  male  privilege 
october 2013 by asterisk2a
Spreadsheet programs
You will find a revenue growth estimator as well as a generic valuation model for high growth firms in this section.
Valuation  models  model  value  revenue  growth  estimator  finance  Investing  equity  resources  patent  spreadsheets  spreadsheet  reference  asset  business  tools  excel  education 
november 2009 by asterisk2a

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