Michael.Massing + set   3

Cannabinoid-related agents in the... [Recent Pat CNS Drug Discov. 2012] - PubMed - NCBI
Rich evidence has shown that cannabis products exert a broad gamut of effects on emotional regulation. The main psychoactive ingredient of hemp, Δ9-tetrahydrocannabinol (THC), and its synthetic cannabinoid analogs have been reported to either attenuate or exacerbate anxiety and fear-related behaviors in humans and experimental animals.
The heterogeneity of cannabis-induced psychological outcomes reflects a complex network of molecular interactions...The high degree of interindividual variability in the responses to cannabis is contributed by a wide spectrum of factors, including genetic and environmental determinants, as well as differences in the relative concentrations of THC and other alkaloids (such as cannabidiol) within the plant itself.
The present article reviews the currently available knowledge on the herbal, synthetic and endogenous cannabinoids with respect to the modulation of anxiety responses, and highlights the challenges that should be overcome to harness the therapeutic potential of some of these compounds, all the while limiting the [adverse] effects associated with cannabis consumption. In addition the article presents some promising patents on cannabinoid-related agents.
medical  research  peer-reviewed  cannabis  marijuana  drug  effects  environment  set  brain  cognition  emotion  response  anxiety  cannabinoids  dosage  genetics  cannabidiol  literature  review  adverse  correlation 
april 2012 by Michael.Massing
Effects of endocannabinoid system modul... [Front Behav Neurosci. 2011] - PubMed - NCBI
Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive and emotional processes.
This review focuses on the effects of endocannabinoid system modulation in animal models of cognition (learning and memory) and emotion (anxiety and depression). We review studies in which natural or synthetic cannabinoid agonists were administered to directly stimulate cannabinoid receptors or, conversely, where cannabinoid antagonists were administered to inhibit the activity of cannabinoid receptors. In addition, studies are reviewed that involved genetic disruption of cannabinoid receptors or genetic or pharmacological manipulation of the endocannabinoid-degrading enzyme, fatty acid amide hydrolase (FAAH).
Endocannabinoids affect the function of many neurotransmitter systems, some of which play opposing roles. The diversity of cannabinoid roles and the complexity of task-dependent activation of neuronal circuits may lead to the effects of endocannabinoid system modulation being strongly dependent on environmental conditions. Recent findings are reviewed that raise the possibility that endocannabinoid signaling may change the impact of environmental influences on emotional and cognitive behavior rather than selectively affecting any specific behavior.
medical  research  peer-reviewed  cannabis  marijuana  drug  effects  environment  set  brain  cognition  emotion  response  in  vivo  animal  models  literature  reviews  correlation 
april 2012 by Michael.Massing

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