Michael.Massing + diabetes + remission   52

What Matters in Diabetes Care: Responding
We all rely on carbohydrates, macronutrients that are often misunderstood—especially when people talk, rather carelessly, about “carbs.” Carbohydrate-rich foods carry and/or readily convert to glucose: the carbohydrate cells burn for energy and the exclusive food of the brain. Carbohydrates are the most efficient way to get glucose our bodies need to keep going.

Insulin resistance and deficiency hamper glucose metabolism and complicate carbohydrate metabolism. Those of us living with diabetes need to be conscious of all carbohydrate intake, not just “empty,” “cheap,” or “net” carbs. Nonetheless, starting by minimizing sweetened and refined baked goods in my diet while increasing vegetables, turned out to be a good strategy to reduce and manage overall dietary carbohydrates. I found to my delight that as I ate fewer “cheap” carbs—actually quite costly in terms of their burden on our bodies—not only did the craving for them decrease, but the sense of hunger that is the diabetic body’s response to both low and high blood sugar also decreased. In surprisingly short order as I sought to space and pace my eating throughout the day, I went from, “Is it time to eat yet?” to, “Oh, look at the time. Guess I’d better eat.” Turns out, the bounty of the industrial bakery, so good at producing cravings and feeding false diabetic “hunger,” is pretty bad at satiety—the sense of fullness and satisfaction that comes from eating whole foods.

Want to kill hunger? Eat what’s hard to overeat.

Vegetables, on the other hand, are nature’s gift to satiety. When I’ve eaten a plateful of vegetables, I know I’ve eaten. With the possible exception of some starchier vegetables like corn (really a grain) and peas (a legume), it’s practically impossible to eat too many. While refined-carb baked goods are so laden with or readily converted to glucose that we might as well be mainlining the stuff, vegetables come cleverly packaged with a high proportion of satiety-inducing fiber among their carbohydrates, slowing and regulating digestion and fostering healthy gut flora.
Michael  Massing  diabetes  Douglas  self  care  treatment  remission  vegetables  satiety  fiber  carbohydrates  T2D 
november 2016 by Michael.Massing
What Matters in Diabetes Care: Forming a Strategy
I reduced my fat intake and started looking to carbs. I’d always been fond not only of sweets but of just about any bread I ever met. In retrospect, it seems likely that the three months of runaway gluttony and weight gain that preceded my diagnosis represented marked progression of longstanding insulin resistance that fed both habitual and intensified cravings. As Dr. Peter Attia, founder of the Nutrition Science Initiative, and others point out, it is perfectly logical for the insulin-resistant body to respond to its energy-starved state by both ramping up insulin production and demanding more fuel (calories and carbohydrates)—even when more and more of that fuel is unavailable and gets stored as fat.

Luckily, back when I had been being heedlessly warned of type 2 diabetes, I’d been referred to a nutritionist, and she had played a trick on me. Looking over my food diary, she had said, “It looks like you have to eat more…” then paused for the surprise to register before concluding “…vegetables.” And so I did. Mounds of them. Funny thing, it turns out that mounds of vegetables contain far fewer carbohydrates and calories, and far more fiber than mounds of baked goods. And thereby hangs my next installment: the success story.
Michael  Massing  diabetes  Douglas  self  care  treatment  remission  type  2  T2D  weight  loss  control  maintenance  vegetables  diet  carbohydrates  fiber 
november 2016 by Michael.Massing
Why Very Low Calorie Diets (VLCD) won’t solve the diabetes crisis | HealthInsightUK
“We believe this shows that Type 2 diabetes is all about energy balance in the body,” explained Professor Taylor, “if you are eating more than you burn, then the excess is stored in the liver and pancreas as fat which can lead to Type 2 diabetes in some people. What we need to examine further is why some people are more susceptible to developing diabetes than others.”

Clearly Prof Taylor did not think that the lack of carbohydrate in the diet was in any way relevant – only weight loss and keeping it off. Even though the low carbs would mean that the patients’ blood sugars were regularised. We know they went into a state known as ketosis when the body switches from burning glucose from carbohydrates to using fat from the diet and from storage for energy.

Some of this gets turned into energy packets called ketones in the liver. It is the state of ketosis that results in fast and substantial weight loss. What is really odd is that at no point did Prof Taylor or Diabetes UK ask whether the critical issue was the low calories or the ketosis or the lack of carbohydrate. This lack of critical thinking may be linked to the fact that weight-loss shakes maker Optifast part funded the original study and may not want people to know that you can get into a state of ketosis with just food from the local store.
diabetes  type  2  T2D  caloric  restriction  peer-reviewed  research  criticism  body  fat  organ  weight  loss  Newcastle  protocol  treatment  remission  symptom  reversal  ketosis 
may 2016 by Michael.Massing
Michael: “Data save lives and limbs” | AkibaH Health
Data save lives and limbs. Learn how diet and exercise affect your glucose levels, and develop habits that nurture good levels. Nag, beg, wheedle, plead, demand, and save your pennies for adequate testing supplies to manage your condition. Accept additional medical help if your particular diabetes cannot be managed with diet and activity alone.
diabetes  type  2  T2D  remission  Douglas  Michael  Massing  weight  loss  control  glucose  monitoring  management  SMBG  self  monitored  blood  humansofdiabetes 
september 2015 by Michael.Massing
Diabetes Remission? | Jane K. Dickinson, RN, PhD, CDE
I have had many patients – with type 2 diabetes – ask if they can get rid of it. I always explain that by making healthy food choices, exercising, managing their stress and losing weight they can get their blood glucose level down. Once their numbers are consistently in the “normal” range (70-110 mg/dL before meals and less than 140 mg/dL 2 hours after meals) they will feel better, have a greatly reduced risk of long-term complications, and they will appear to not have diabetes. However, diabetes is still lurking there: if they were to return to their old habits/lifestyle, their numbers would go right back up....

Just as type 2 diabetes can be prevented with a healthy lifestyle, diabetes remission can be prolonged the same way. Regardless, I think it’s risky to call this a “cure” or even “reversal”. I worry that people might truly believe it’s gone, whereas even “remission” implies that it could come back.
diabetes  remission  type  2  T2D  cure  reversal  expert  consensus  weight  loss  control  maintenance 
may 2015 by Michael.Massing
Road To Remission: Michael's Story | Diabetic Connect
What are your thoughts on the term #diabetes remission? See what @T2DRemission has to say.
diabetes  type  2  T2D  remission  Douglas  Michael  Massing 
may 2015 by Michael.Massing
Brain may play key role in development of type 2 diabetes - Medical News Today
One brain-centered mechanism uses a process called "glucose effectiveness" to promote glucose uptake in tissues. As this process accounts for nearly half of normal glucose uptake, it is on par with the insulin-dependent processes of the pancreatic islet cells.

The researchers propose a two-system model - the pancreatic islet system reacts to rising blood glucose by releasing insulin, and the brain-centered system enhances insulin-dependent glucose metabolism while also stimulating glucose effectiveness independently of insulin.

They say type 2 diabetes appears to be the result of failure of both systems.

According to the research, the brain system is the one most likely to fail first. This puts pressure on the islet system, which can compensate and carry on for a while, but then also fails, causing further decompensation in the brain system. The result is a vicious cycle of deterioration that ends in type 2 diabetes.

Introducing insulin reduces blood sugar back to normal levels but is only half the problem, say the researchers. You also need to tackle the brain-centered system failure. It may be possible not only to keep blood glucose under control, but also to cause a reversal of the type 2 diabetes, they write.

Medical News Today reported that in another Nature paper published recently, US researchers describe how they discovered a biological link between diabetes and heart disease. They found a biological pathway through which abnormally high blood sugar can trigger irregular heartbeats.
brain  diabetes  etiology  type  2  correlation  peer-reviewed  research  T2D  remission  heart  disease  neuroendocrine  system  type2  factor  risk 
november 2013 by Michael.Massing
@T2DRemission
I read clinical research to save my life. I edit it to make a living. I write about it because I must. My medical knowledge is self-taught, limited & extensive.
web  presence  Literacy  T2D  remission  diabetes  type  2  news  peer-reviewed  research  feed  Editorial 
september 2013 by Michael.Massing
Diabetes Remission: what they don't say (enough)
Diabetes is complicated. Volumes of research produce inconclusive and contradictory results.
Diabetes-related research may be badly reported, or just plain bad.
Evaluating research, assessing risks and benefits, and devising a working strategy for self care are not helped by the cognitive deficits, depression, and fatigue associated with blood sugar highs and lows.
Drugs used to treat diabetes and/or its comorbidities may increase the risk of death or morbidity, including onset of diabetes itself and incidence of comorbidities.
Blacks, Hispanics, American Indians, and Pacific Islanders are known to be at higher risk for developing diabetes. Less discussed are the risks conferred by a range of circumstances: socioeconomic status, stress, sleep, inadequate health literacy and education, location, and exposure to plastics and to environmental pollution. These factors often trump genetics; they can increase diabetes incidence and/or worsen outcomes.
Lack of professional consensus, balky insurance plans, and physicians' disregard of patient-reported data may all interfere with getting adequate testing supplies to carry out tight glucose control.
T2D  diabetes  type  2  etiology  correlation  research  peer-reviewed  remission  factor  tight  control  glucose  benefit  self-monitored  blood  self  monitoring  SMBG  plastics  depression  comorbidities  stress  distress  risk  management  treatment 
august 2013 by Michael.Massing
Diabetes Remission: remission? cure? control?
2003/12/16—I was diagnosed as a type 2 diabetic in December of 2002, after at least three frustrating years of debilitating, bloody, scary symptoms. In January, 2003, I started an aggressive, measured program of self-treatment through diet and exercise. My health improved dramatically. Over the course of a year, I lost about a hundred pounds. Since June of that year, my blood sugar readings were consistently good enough that I began to have vague hopes that I might someday hear the word "remission"—so vague that as I made up my list of things to take up with the doctor a year after my diagnosis, that question literally didn't even enter my mind.

Suddenly I was hearing "cured yourself" and "not diabetic anymore". Sweet Jesus!

2009/01/14—"[Y]ou are not diabetic, but you aren't cured of diabetes either. It could be said that you have diabetes but you're not diabetic—but that sounds too ridiculous."
diabetes  remission  cure  control  T2D  research  management  type  2  peer-reviewed  diet  diagnosis 
june 2013 by Michael.Massing
Diabetes Remission? | Jane K. Dickinson, RN, PhD, CDE
I have had many patients – with type 2 diabetes – ask if they can get rid of it. I always explain that by making healthy food choices, exercising, managing their stress and losing weight they can get their blood glucose level down. Once their numbers are consistently in the “normal” range (70-110 mg/dL before meals and less than 140 mg/dL 2 hours after meals) they will feel better, have a greatly reduced risk of long-term complications, and they will appear to not have diabetes. However, diabetes is still lurking there: if they were to return to their old habits/lifestyle, their numbers would go right back up.

The article linked above discusses the “remission” of diabetes after gastric bypass/banding. It is very common for diabetes to go away after someone has this type of weight loss surgery. If the person follows a healthy lifestyle consistently – healthy eating and regular exercise – they can keep their blood glucose levels down. Unfortunately, even in these people, returning to unhealthy eating habits and/or lack of exercise can land them back in diabetes-ville. I’ve had patients for whom this has happened.

Healthcare professionals historically used the term, “borderline” to describe what is now called “pre-diabetes”. To those of us in the field, this means type 2 diabetes is knocking on the door, and without sufficient lifestyle adjustments (changes), it’s going to come right in. We no longer say “borderline”, because people just didn’t take it seriously. How many times have you heard someone say, “I’m just borderline. I don’t have to worry about it.” Just as type 2 diabetes can be prevented with a healthy lifestyle, diabetes remission can be prolonged the same way. Regardless, I think it’s risky to call this a “cure” or even “reversal”. I worry that people might truly believe it’s gone, whereas even “remission” implies that it could come back.
diabetes  remission  self  care  diet  exercise  stress  blood  glucose  management  control  what.I'm.reading  body  fat  weight  loss  earnest  T2D  research  type  2  peer-reviewed  maintenance 
april 2012 by Michael.Massing
Massing - Diabetes remission data 2003
This Excel database documents - and also provided a tracking and management tool for - the process by which I lost 100 pounds of fat and rendered myself, according to my doctor, "no longer diabetic" within a year of a diagnosis of type 2 diabetes. Please note that I do not claim, despite my doctor's use of the word, to have "cured" myself of diabetes. I believe I have documented putting myself into remission - normoglycemia - an asymptomatic state. Day-to-day data are self-reported. All medical outcomes are documented by Kaiser-Permanente.
diabetes  management  data  remission  burden  diagnosis 
february 2012 by Michael.Massing
Bariatric Surgery Not a Cure for Diabetes | Pournaras D. Br J Surg. 2012:88:100-103.,
"Bariatric surgery (gastric bypass, sleeve gastrectomy, or gastric banding) leads to complete remission in only about one third of patients with type 2 diabetes, and should be viewed as a means for improving glycemic control, not as a cure."
Using the recently updated American Diabetes Association (ADA) standard, which defined diabetes remission as hemoglobin (Hb) A1c levels below 6% and fasting glucose levels less than 100mg/dL.(5.6 mmol/L ) at least 1 year after bariatric surgery without hypoglycemic medication, the researchers found remission to be substantially lower than had been reported with earlier criteria[:] 40.6% after gastric bypass (65/160 patients), 26% after sleeve gastrectomy (5/19 patients), and 7% after gastric banding (2/30 patients). "The remission rate for gastric bypass was significantly lower with the new definition than with the previously used definition (40.6 versus 57.5%...)." Remission rates for the other 2 procedures were not significantly different according to the new vs the old criteria...
[O]n average, patients remained obese after surgery (preoperative body mass index [BMI], 48 kg/m2 vs postoperative BMI, 35 kg/m2). After surgery, oral hypoglycemic medications were still used by 29.4% of gastric bypass patients, 63% of sleeve gastrectomy patients, and 83% of gastric banding patients.
HbA1c levels were significantly lower after surgery in all 3 surgical groups, with mean levels of 6.2% (compared with 8.1% before gastric bypass), 6.8% (7.5% before sleeve gastrectomy), and 6.3% (7.7% before gastric banding...
The authors [recommend] "establishing realistic expectations among patients, clinicians, and policy-makers" regarding bariatric surgery in the management of type 2 diabetes. They suggest that emphasis should shift to bariatric surgery as an aid in achieving glycemic control, rather than as a tool for achieving remission...
"The principal benefit of surgery, however, would not be to improve glycemic control per se but rather to reduce microvascular and macrovascular complications associated with diabetes. [We] emphasize the need for intensive follow-up of patients with type II diabetes following bariatric surgery, in order to review pharmacological treatment, monitor for complications of diabetes, and ensure that adequate glycemic control is achieved."
gastric  surgery  diabetes  remission  medical  research  peer-reviewed  definition  risk  benefit  glucose  blood  glycemic  control  what.I'm.reading  A1c  fasting  bariatric  T2D 
january 2012 by Michael.Massing
Three-week diet curbs diabetes - health - 13 January 2006 - New Scientist | Roberts C. Journal of Applied Physiology (DOI: 10.1152/japplphysiol.01292.2005)
Just three weeks of a high-fibre, low-fat diet and moderate exercise could slow key changes in the body crucial to the development of diabetes... <br />
The new study, along with previous work on the so-called Pritkin diet and exercise programme, found that just 3 weeks of the programme reversed the clinical diagnosis of type 2 diabetes - or its precursor, called metabolic syndrome. The programme worked in half of the overweight patients following it. <br />
"[Contrary to common belief,] type 2 diabetes and metabolic syndrome can be reversed solely through lifestyle changes," says Christian Roberts [of UCLA], who led the study. <br />
The prevailing view is that such an improvement could take place only in months or years rather than weeks, Roberts told New Scientist. "The effect can be very dramatic given that, of the vast majority of people who go through the programme, at least 50% are no longer clinically defined as diabetic after three weeks, which suggests this disease is reversible."
diabetes  remission  diet  fiber  fats  dietary  medical  research  heart  cardiovascular  endothelium  blood  sugar  glucose  links  what.I'm.reading  self  care  earnest  T2D  diagnosis  from delicious
august 2011 by Michael.Massing
Guidance for Industry - Powered by Google Docs
The treatment goals for patients with diabetes have evolved significantly over the last 80 years, from preventing imminent mortality, to alleviating symptoms, to the now recognized objective of normalization or near normalization of glucose levels with the intent of forestalling diabetic complications....
remission  normal  treatment  blood  glucose  sugar  progression  benefit  risk  cardiovascular  medical  research  drug  effects  regulation  via:FDA.gov  references  consensus  mortality  morbidity  diabetes  standards  normoglycemia  links  what.I'm.reading  prediabetes  self  care  management  T2D  diagnosis  from delicious
april 2011 by Michael.Massing
Weight-Loss Surgery Cuts Risks for Severely Obese, Heart Association Says | Poirier P. Circulation | via American Diabetes Association
The American Heart Association (AHA) has concluded that severely obese people can benefit from weight–loss surgery. <br />
[T]he AHA said that gastric bypass and gastric–banding operations may lead to weight loss and improvements in diabetes‚ cholesterol‚ and blood pressure that could outweigh the hazards of surgery. "At the moment‚ bariatric surgery should be reserved for patients who can undergo surgery safely‚ have severe obesity‚ and have failed attempts at medical therapy‚" says Paul Poirier‚ lead author...More studies should be conducted to look into the weight–loss procedures in adults and children. This is the first time that the AHA has directly addressed the issue‚ and it now considers the surgery a "treatment of choice" for people with a body–mass index of 40 or higher‚ says Robert Eckel‚ past AHA president and a professor of medicine at the University of Colorado Anschutz Medical Campus. These surgeries have also been found to reverse diabetes in many patients.
bariatric  surgery  obesity  risk  benefit  via:heart.org  via:diabetes.org  diabetes  cholesterol  blood  pressure  threshold  BMI  remission  hypertension  high  correlation  treatment  peer-reviewed  research  from delicious
april 2011 by Michael.Massing
Bariatric Surgery Is Highly Cost-Effective Treatment for Type 2 Diabetes in the Obese
[Is cost of surgery—some $15-24K in the US—justified by effectiveness and the potential to save future costs?].... <br />
[The US threshold for benefit is $50,000 per quality-adjusted life year (QALY): a year of human life adjusted] for disease or disability.<br />
[Bariatric surgery is very cost effective in the morbidly obese and 2x as cost effective in obese type 2 diabetics.]<br />
[Untreated Type 2 diabetics face lifelong disease and escalating costs for symptoms affecting eyes, heart, kidneys and limbs—outpatient care, medications, hospitalization and] surgeries, including amputation... <br />
[Surgery for Type 2 diabetes diagnosed < 5 years prior is more cost effective than for established diabetes. One study found] cost-effectiveness ratios of $7,000/QALY and $12,000/QALY for newly diagnosed and established diabetics, respectively... <br />
"Diabetes remission [is higher in the newly diagnosed. Costs of surgery may be fully recouped through prevention of future] costs. This excellent result is fairly rare."
healthcare  diabetes  obesity  surgery  treatment  benefit  cost  via:dLife.com  medical  research  economics  remission  from delicious
april 2011 by Michael.Massing
A1C
HbA1c [shows average blood sugar control over several months. A value o≥ 6.5% is used] as a diagnosis for diabetes....
The ADA recommends that the HbA1c be performed at least twice annually, and up to [4 times a year for individuals adjusting treatment or missing treatment goals;] the AACE recommends [type 2 diabetics test] at least quarterly. Patients who use insulin to control their type 1 or type 2 diabetes should have the test performed quarterly....
In [non-diabetics, some] 5.5 to 9% of total hemoglobin is glycated (around 5% when measuring HbA1c). [well-controlled diabetics can achieve levels within this range]...
[The American Association of Clinical Endocrinologists recommends diabetics aim for a target HbA1c of ≤ 6.5%]....
[Average HbA1c in diabetics] at diagnosis is 10.9 to 15.5%. HbA1c levels usually range from 8 to 11.9% in uncontrolled diabetes. With proper treatment, and tight control techniques, people with diabetes can attain the "normal" [HbA1c levels].
A1c  ADA  AACE  normal  remission  blood  glucose  target  management  via:dLife.com  control  self  care  tight  diabetes  diagnosis  treatment  from delicious
march 2011 by Michael.Massing
New Guidelines Issued on Optimal Hemoglobin A1C Targets for Type 2 Diabetes
Below 7%, below 6.5% OR NORMAL?
When do we [tell the public the honest truth]? To reduce your risks as if you did not have diabetes, then you need an A1c that represents a healthy individual without diabetes. [A] normal A1c for a healthy person without diabetes should be 4.3 to 4.6%. In the Epic-Norfolk study they showed that an A1c of 5% compared to an individual with an A1c of 6% had an increased risk of cardiovascular death of 28% higher.
In all of the recommendations they say that the A1c should be as low as possible without hypoglycemia. The ADA sticks with 7% or below, AACE stays with 6.5% or below, what does below mean? When we say it should be 7 or below then that is usually where most medical professionals stop being aggressive. We hear 7% we hear 6.5 % we even sometimes hear 6%.
If your child had diabetes, would you be satisfied at 6.5% or would you want it Normal, as if they did not have diabetes? Or would you like to wait 15 years and see what the studies tell us?
blood  glucose  target  management  normal  Richard  Bernstein  remission  diabetes  tight  control  A1c  medical  research  risk  comorbidities  symptoms  late-stage  complications  standards  morbidity  prediabetes  self  care  benefit  threshold  self-monitored  monitoring  SMBG  late  end-stage  diagnosis  treatment  from delicious
march 2011 by Michael.Massing
What We’re Reading: The Longest Walk :: Diabetes Self-Management
Native Americans have the highest prevalence of diabetes [of any ethnic group in the US: nearly 17%. T]o raise awareness of diabetes, several Native American tribes, together with health advocates and other participants, are [making a] 5-month-long, 5,000-mile walk from California to Washington, DC.
The founder of “The Longest Walk,” Dennis Banks, created the event in 2009...After he was hospitalized for serious diabetes-related complications, Dennis made drastic changes to his diet and exercise. These changes helped to reverse his diabetes, and he has become an advocate for exercise....
Native American leaders and participants starting in San Diego may choose to walk all or part of the journey, and will be joined by others in [14] other states. Each day, they will walk 15–25 miles, or run 50–100 miles as part of relay teams. Edwin Romero [of the Barona Band of Mission Indians, says "]We want to do everything we can to enhance the health and well-being of our people, young and old.”
Native  American  Indian  remission  reversal  diabetes  exercise  activism  health  education  walking  disparities  demographics  race  ethnicity  epidemiology  racism  geography  socioeconomics  socioeconomic  status  literacy  from delicious
march 2011 by Michael.Massing
The Normal A1C Level - Diabetes
[Every 3 or 4 years The NGSP lab studies] people who don't have diabetes to scientifically determine what a normal A1C level is. The results from one study to the next are always close...<br />
I asked how they knew if the people they tested didn't have diabetes. "Because we did fasting glucose tests on them, they had no prior history of diabetes, and none of them were obese"... <br />
[Levels ranged from 4.5 to 6] at plus or minus 3 standard deviations[, i.e. including] about 99% of the values.<br />
The range is narrower—4.7 to 5.7—at plus or minus 2 standard deviations. This includes about 95% of the values.<br />
"The upper limit is the more important one...The lower limit doesn't convey as much meaning."<br />
They also see "a little skew toward the high end of the range, a bit of tailing at the high side"...In fact, levels below 4.5 are "quite unusual," and usually are only when people have anemia or other abnormalities of the red blood cells.
diabetes  A1c  blood  glucose  norm  target  remission  standards  diagnosis  from delicious
february 2011 by Michael.Massing
The Benefits of Tight Control (Show All) :: Diabetes Self-Management
The way primary care is organized and reimbursed by insurance companies probably serves as a barrier to achieving optimal blood glucose control....
Before [Maine's] program existed, 80% of people with diabetes had received an HbA1c test within the past year. After a year, 93% of people had received one. The percentage of people with HbA1c values less than 7% rose from 41% to 49%—a 20% increase. The percentage of people with HbA1c values above 8% decreased from 31% to 24%, and the percentage of people with HbA1c values above 9.5% decreased from 13% to 9%. There were similar results in measures of LDL (or “bad”) cholesterol and blood pressure.
“This is not a question of bad doctors or bad patients...It is a question of a care model that is focused on illness instead of prevention, and systems that have been created that don’t accommodate a change in focus. We’re changing the focus, including offering financial incentives for physicians whose patients do better.”
delivery  system  illness  management  diabetes  treatment  remission  A1c  comorbidities  blood  glucose  eyes  neuropathy  kidneys  prevention  tight  control  chronic  health  care  healthcare  Maine  model  self  what.I'm.reading  burden  risk  benefit  T2D  research  kidney  disease  nephropathy  from delicious
february 2011 by Michael.Massing
How Do We Define Cure of Diabetes? — Buse JB et al. Diabetes Care. 2009;32:2133-2135.
[Our definitions] are the same for type 1 and type 2 diabetes: Remission is defined as achieving glycemia below the diabetic range in the absence of active pharmacologic (anti-hyperglycemic medications, immunosuppressive medications) or surgical (ongoing procedures such as repeated replacements of endoluminal devices) therapy. A remission can be characterized as partial or complete. <br />
Partial remission is sub-diabetic hyperglycemia (A1C not diagnostic of diabetes [<6.5%], fasting glucose 100–125 mg/dl [5.6–6.9 mmol/l]) [for at least a year] in the absence of active pharmacologic therapy or ongoing procedures. <br />
Complete remission is a return to “normal” measures of glucose metabolism (A1C in the normal range, fasting glucose <100 mg/dl [5.6 mmol/l]) [for at least a year] in the absence of active pharmacologic therapy or ongoing procedures. <br />
Remission of type 2 diabetes could be attained...after bariatric/metabolic surgery or with lifestyle efforts such as weight loss and exercise.
diabetes  remission  treatment  cure  language  diet  exercise  diagnosis  prognosis  self  care  hyperglycemia  dysglycemia  morbidity  risk  medical  research  correlation  activity  standards  threshold  from delicious
february 2011 by Michael.Massing
Diabetes Remission
Remission of type 2 diabetes is defined as reaching and sustaining normal levels of blood glucose (blood sugar). At least some type 2 diabetics can achieve remission, or normoglycemia; this is as close as we have to a cure for a disease considered chronic and incurable. Remission can vastly improve quality of life and can delay - perhaps even prevent - T2D's usual progression toward comorbidities and premature death.
diabetes  remission  T2D  earnest  from delicious
february 2011 by Michael.Massing
Diabetes Support Forum• View topic - Diabetic or Not ?
'I've had blood sugars in excess of 400, today they are usually in the seventies or eighties. If I ate a loaf of bread, I'd wind up closer to 200 than 100. Am I cured? As far as I'm concerned, it's just semantics, as long as I maintain normal blood sugars, I believe I'll avoid complications. I've been diabetic for 30 years, did develop complications, they've been reversed. There are people who've been diabetic for over 50 years, and they're complications free. There are people in their 60s who are not yet diabetic, but will be and who will develop complications. It's all in how you manage your life after diagnosis. As far as I'm concerned, it's just a word, "cure". If you mean can you live a normal life expectancy with no complications, yes, diabetes can be cured. If you mean, can you eat whatever you want, stop being physically active, and still remain healthy, no, diabetes is not "curable".'
diabetes  remission  standards  diagnosis 
december 2008 by Michael.Massing
Chili Extract A Possible Cure for Diabetes - Cell, 2008-12-15
After injecting capsaicin, a chili extract, [into diabetic mice] insulin levels increased and restored blood glucose levels to normal virtually overnight....Researchers...found that diabetes is controlled by abnormalities in the sensory nociceptor (pain-related) nerve endings in the pancreatic islet cells that produce insulin. This...breakthrough that has long been the elusive goal of diabetes research, has led to new treatment strategies for diabetes, achieving reversal of the disease without severe, toxic immunosuppression....Trials on humans...are expected to begin within the next six months...[W]ith similar results in humans, one injection could keep diabetes at bay for years....Insulin deficiency is fatal...current insulin replacement therapies cannot prevent many side effects such as heart attacks, blindness, strokes, loss of limbs and kidney function....[T]reating the islet-sensory nerve circuit...dramatically normalize[sType 2 diabetes' even stronger] insulin resistance.
diabetes  remission  nerves  research  medical  biological  capsaicin  insulin  resistance  T2D  type  2  peer-reviewed 
november 2008 by Michael.Massing
Terminally Ill Rodents With Type 1 Diabetes Restored To Full Health With Single Dose Of Leptin
'The fact that these animals don’t die and are restored to normal health despite a total lack of insulin is hard for many researchers and clinicians to believe,' said Dr. Roger Unger...senior author of the study. 'Many scientists, including us, thought it would be a waste of time to give leptin in the absence of insulin. We’ve been brainwashed into thinking that insulin is the only substance that can correct the consequences of insulin deficiency.'
The mechanism of leptin’s glucose-lowering action appears to involve the suppression of glucagon, a hormone produced by the pancreas that raises glucose levels. Normally, glucagon is released when the glucose, or sugar, level in the blood is low. In insulin deficiency, however, glucagon levels are inappropriately high and cause the liver to release excessive amounts of glucose into the bloodstream. This action is opposed by insulin, which tells the body’s cells to remove sugar from the bloodstream.
leptin  endocrine  remission  diabetes  glucagon  liver  risk  fatty  body  fat  metabolic  syndrome  disorder  etiology  T2D  peer-reviewed  research  correlation  T1D  type  1  2  factor 
august 2008 by Michael.Massing
[Aerobic/Resistance Training Combo Improve Glycemic Control and Decrease Mortality] by 25% for Type 2's
Aerobic and resistance training each improve glycemic control for patients with type 2 diabetes, but the improvement is greatest when both forms of exercise are combined, according to the results of a randomized controlled trial.
exercise  blood  glucose  diabetes  aerobics  strength  resistance  self  care  control  survival  mitigate  morbidity  remission  what.I'm.reading  mortality  type  2  T2D  training  research 
september 2007 by Michael.Massing
Early Tight Control and Aggressive Treatment of Diabetes Pays Off
Medical scientists have discovered how the body's metabolism is "locked" into a diabetic state after only limited high glucose exposure....their finding confirms the need for very early tight control of glucose levels to avoid diabetic complication.
diabetes  blood  glucose  remission  antioxidants  treatment  self  care  tight  control  management 
july 2007 by Michael.Massing
Recent Developments Regarding Risk Factors For Heart Disease (Part 2)
'When we reduce dietary carbohydrate, blood sugars improve dramatically. After several months of improved blood sugars, we repeat our studies of lipid profiles and thrombotic risk factors...the great majority of cases [show] normalization or improvement.'
diabetes  glucose  blood  pressure  cholesterol  carbohydrates  thyroid  endocrine  remission  fats  lipids  self  care  hypertension  high  risk  correlation 
june 2007 by Michael.Massing
diabetes reversal data
health indices and trends 2003: This Excel database documents - and also provided a tracking and management tool for - the process by which I lost 100 pounds of fat and reversed a diagnosis of type 2 diabetes in under a year.
diabetes  remission  database 
march 2007 by Michael.Massing

bundles : diabetes

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