vitamin_d   212

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Vitamin D Toxicity–A Clinical Perspective
Vitamin D toxicity appears to be exceptionally rare. > Regardless of additional risk factors for VDT, many studies provided evidence that vitamin D is probably one of the least toxic fat-soluble vitamins, much less toxic than vitamin A (4). Dudenkov et al. (2) researched more than 20,000 serum 25(OH)D measurements performed at the Mayo Clinic from 2002 to 2011 to determine the prevalence of VDT, demonstrated by the presence of hypercalcemia. The number of individuals with a serum 25(OH)D concentration >50 ng/ml (>75 nmol/l) had increased by 20 times during that period. However, relatively high 25(OH)D concentrations coincided with a normal serum calcium concentration. Only one patient, with a25(OH)D concentration of 364 ng/ml (910 nmol/l), was diagnosed with hypercalcemia. Pietras et al. (16) reported that healthy adults in a clinical setting, receiving 50,000 IU of vitamin D2 once every 2 weeks (equivalent to approximately 3,300 IU/day) for up to 6 years, maintained 25(OH)D concentrations of 40–60 ng/ml (100–150 nmol/l) without any evidence of VDT. Those findings were consistent with the observation by Ekwaru et al. (17) that Canadian adults who ingested up to 20,000 IU of vitamin D3 per day had a significant increase of 25(OH)D concentrations, up to 60 ng/ml (150 nmol/l), but without any evidence of toxicity.
vitamin_d  diet  calcium 
may 2019 by porejide
Is Sunscreen the New Margarine? | Outside Online
Is it possible that we've been wrong about sunscreen all along?
sunscreen  vitamin_d  sun  cancer 
february 2019 by zethraeus
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts | JNCI: Journal of the National Cancer Institute | Oxford Academic
From 2011 IOM: For vitamin D, RDAs of 600 IU/d for ages 1–70 yr and 800 IU/d for ages 71 yr and older, corresponding to a serum 25-hydroxyvitamin D level of at least 20 ng/ml (50 nmol/liter), meet the requirements of at least 97.5% of the population. So probably 1000 IU/d is good

Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non–statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations.
vitamin_D  colorectal_cancer 
february 2019 by Segalllab
Calcitriol - Wikipedia
> The main adverse drug reaction associated with calcitriol therapy is hypercalcemia – early symptoms include: nausea, vomiting, constipation, anorexia, apathy, headache, thirst, pruritus, sweating, and/or polyuria. Compared to other vitamin D compounds in clinical use (cholecalciferol, ergocalciferol), calcitriol has a higher risk of inducing hypercalcemia.
vitamin_d  hypercalcemia 
april 2018 by porejide
Human skin color - Wikipedia
> Natural selection has led to females with lighter skin than males in all indigenous populations because women must get enough vitamin D and calcium to support the development of fetus and nursing infant and to maintain their own health.[7] The sexes also differ in how they change their skin color with age. Men and women are not born with different skin color, they begin to diverge during puberty with the influence of sex hormones.
gender  skin  vitamin_d 
january 2018 by porejide
The effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control group. - PubMed - NCBI
RCT showing that vit D supplements help sleep. > Based on the results of the present study, at the end of the study sleep score (PSQI) reduced significantly in vitamin recipients as compared with placebo recipients (P < 0.05). This difference was significant even after modifying confounding variables (P < 0.05).
sleep  vitamin_d 
december 2017 by porejide
The Big Vitamin D Mistake. - PubMed - NCBI
This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter.
nutrition  vitamin_d 
december 2017 by berendes

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