taz   1556

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Diskussion über Erbschaftsteuer: Pleite als Phantom (2015)
Die Erbschaftsteuer vernichte Firmen, so die Kritik großer Wirtschaftsverbände. Tatsächlich hat sie aber noch keinen Betrieb in den Konkurs getrieben.
erbschaftsteuer  taz  wirtschaft 
2 days ago by Cervus
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate | Nature Communications
Notch is a tumor suppressor for skin cancer so may work differently here than in mammary gland - still - matrix stiffness/cell stretching can activate YAP/TAZ which then suppresses expression of Notch ligands

"...several Notch ligands, such as DLL1, DLL3 and JAG226, are all associated with several YAP/TAZ-bound enhancers. Chromatin immunoprecipitation quantitative polymerase chain reaction (ChIP-qPCR) experiments confirmed that YAP/TAZ were specifically bound to these chromatin regions in epidermal progenitors cultured on stiff substrates but not in cells in which the F-actin cytoskeleton has been disrupted (Fig. 7a and Supplementary Fig. 5a). Consistently, by qRT–PCR, the expression of DLL1, DLL3 and JAG2 was mechano-dependent, being downregulated both in cells plated on soft ECM (Fig. 7b) or treated with F-actin inhibitors (Supplementary Fig. 5c) or upon YAP/TAZ knockdown (Fig. 7c). Thus these Delta-like ligands represent direct YAP/TAZ targets"
Notch  jag  dll1  taz  YAP  stiffness  differentiation 
3 days ago by Segalllab
Rechte Terrorzelle in Meck-Pomm: Reservisten im Verdacht
Nach der Razzia wegen rechtem Terror führen die Spuren der Verdächtigen in den Reservistenverband.
taz  rechtspopulismus  rechtsextremismus  bundeswehr  afd 
8 days ago by heartsforfools
Ex-Profi über Homophobie im Fußball „Das kann krank machen“
Die Ex-Bundesligaspielerin Friederike Wenner hatte ihr Coming-Out mit 20. Später hörte sie mit dem Fußball auf – das Umfeld war zu lesbenfeindlich.
taz  homophobie  lgbt  fußball  frauenfußball 
8 days ago by heartsforfools
Hakim Bey and pedophilia
Famous anarchist writer and his having sex with children
hakimbey  taz  pedophilia  anarchism 
12 days ago by nelson
head of the flock - teacuptaako - The Adventure Zone (Podcast) [Archive of Our Own]
Lup knows she's beautiful, and brilliant, and adored by everybody she meets. She has to know it because you can't leave shit like your worth up for discussion.

My beautiful, fierce Lup
taz  lup 
21 days ago by pearwaldorf
crack your bones with veins of gold - tardigradeschool - The Adventure Zone (Podcast) [Archive of Our Own]
In a hundred years, one tends to see their friends die a lot. It doesn't get easier, except it kind of does.

I love the slowly developing relationship Barry and Taako have.
taz  barrybluejeans  taako 
21 days ago by pearwaldorf
Transactive Memory - dimircharmer - The Adventure Zone (Podcast) [Archive of Our Own]
As it turns out, when you take someone's friends, their family, their memories from them, they aren't a better person for it.

I love the way this sets everything up, the way you can see the absence of everybody else, especially Lup
taz  taako 
21 days ago by pearwaldorf
it's kind of nice to just go home - altschmerzes - The Adventure Zone (Podcast) [Archive of Our Own]
Taako has a bad day, Magnus exercises his cuddling skills, the tables turn, and Merle is not prepared to deal with feelings today. A gen fic heavy on the affection, light on the plot, told in three parts.
taz  taako  magnus  merle 
21 days ago by pearwaldorf
in the quiet of the night - AnonymousPuzzler - The Adventure Zone (Podcast) [Archive of Our Own]
Elves don't need to sleep, so Taako sits awake in the long hours of the night. It turns out, those quiet hours are more full than he'd ever realized.

The one where Taako somehow becomes the one everybody calls at night
taz  taako 
21 days ago by pearwaldorf
because that's what love is (equivalent exchange) - teacuptaako - The Adventure Zone (Podcast) [Archive of Our Own]
In which Taako and Barry try to understand each other.

A gorgeous character study of Barry and the rest of the IPRE crew, with an especial emphasis on Lup and Taako.
taz  barry/lup 
21 days ago by pearwaldorf
Breakfast - anonymousAlchemist - The Adventure Zone (Podcast) [Archive of Our Own]
It’s doublethink in his head, it’s like being two different people at the same time. There is the elf who grew up alone and crystallized callous in his own loneliness, who was a chef before he was an enchanter, who only made close friends seventy-some years into his lifespan. And there is the elf who grew up hand in hand with the best damn sister a guy could ask for, who cooked as a hobby for his friends and spent years studying magicks, who joined a mission to explore the multiverse and ended up spending a century trying to save it. Who had a family.

Lovely little character study.
taz  taako 
21 days ago by pearwaldorf
Two Columns - goodnicepeople - The Adventure Zone (Podcast) [Archive of Our Own]
I didn’t plan to outlive you, Taako thinks.

I love this one, because I don't think Taako is somebody who's ever really wrestled with death much?
taz  taako  magnus 
21 days ago by pearwaldorf
Missing me, missing you - anonymousAlchemist - The Adventure Zone (Podcast) [Archive of Our Own]
Listen, it’s really hard to protect your brother when he insists on being a disaster, and also when you’re trapped in an umbrella and kind of sort of dead.

The one where Lup watches from the umbrella, because it's all she can do.
taz  lup 
21 days ago by pearwaldorf
diamond heart - possibilityleft - The Adventure Zone (Podcast) [Archive of Our Own]
Magnus and Taako start out sleeping together -- just sleeping. Magnus isn't sure what to do when he realizes he wants more than that.

I love this one, the way they slide into a relationship before they realize it and it turns out to be a thing they both miss when it's not there.
taz  magnus/taako 
21 days ago by pearwaldorf
Cinnamon Rolls - goldfishoflove - The Adventure Zone (Podcast) [Archive of Our Own]
The morning after the Eleventh Hour, Taako and Magnus are still rattled by what they've learned.

Sweet bit of teammate bonding. Also, it has the tag "voidfish innuendo"
taz  magnus  taako 
21 days ago by pearwaldorf

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