schizophrenia   1411

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Altered growth trajectory of head circumference during infancy and schizophrenia in a National Birth Cohort. - PubMed - NCBI
> Adjusting for growth velocity of height and weight, and gestational age, there was significantly accelerated growth of head circumference in females with schizophrenia from birth to 2months; the findings remained significant following Bonferroni correction (p<0.0125). This is the first study to report abnormal HC growth acceleration, a more sensitive measure of somatic developmental deviation of this measure, in schizophrenia.
schizophrenia  development 
4 days ago by porejide
Early warning sign of psychosis detected | YaleNews
Cannon said the hyperconnectivity findings suggest that the affected brain network may reflect greater errors in integrative brain functioning, such as the mistiming in the convergence of information from different brain regions. Alternately, he noted, the pattern may reflect compensation for such errors, which are believed to underlie the disorganized thinking that is a hallmark psychosis.
Yale  schizophrenia  research  brain  2018 
8 days ago by suitable
Here's What Happened When Japan Renamed Schizophrenia | AllPsych Blog
> So JSPN decided to rename the disorder. After all, it couldn’t possibly make the situation any worse. Starting in late 2002, schizophrenia became known as Togo Shitcho Sho (“integration disorder”) in Japan.

Over the next few months, the new term spread rapidly through the psychiatric profession. Within seven months, 78 percent of psychiatrists in Japan were using it.

As usage of the new term grew, it got easier to tell people about their diagnosis. Thirteen months out, 86 percent of doctors surveyed said they found it easier to communicate with their patients using the new term.
schizophrenia  names  japan  psychiatry 
12 days ago by porejide
Treating The Prodrome | Slate Star Codex
> This theory fits the “duration of untreated psychosis” model very well. The longer you’re psychotic, with weird prediction errors popping up everywhere, the more thoroughly your brain is going to shift from its normal mode of evidence-processing to whatever mode of evidence-processing best suits receiving lots of random data. If you start antipsychotics as soon as the prediction errors start, you’ll have a few weird thoughts about how a buzzing fly might have been a sign from God, but then the weirdness will stop and you’ll end up okay. If you start antipsychotics after ten years of this kind of stuff, your brain will already have concluded that the world only makes sense in the context of a magic-wielding conspiracy plus also normal logic doesn’t work, and the sudden cessation of new weirdness won’t change that.
schizophrenia  prodrome  plasticity  neuroscience  scott_alexander 
4 weeks ago by porejide
Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 90,000 patients across three healthcare systems | bioRxiv
> PRSs were robustly associated with schizophrenia (odds ratio per standard deviation increase in PRS = 1.65 [95% confidence interval (CI), 1.5-1.8], p = 1.25 x 10-16) and patients in the highest risk decile of the PRS distribution had a four-fold increased odds of schizophrenia compared to those in the bottom decile (95% CI, 2.4-6.5, p = 4.43 x 10-8).
schizophrenia  genetics 
4 weeks ago by porejide

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