schizophrenia   1378

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Does autism arise because the brain is continually surprised? | Science | AAAS
Satsuki Ayaya remembers finding it hard to play with other children when she was young, as if a screen separated her from them. Sometimes she felt numb, sometimes too sensitive; sometimes sounds were muted, sometimes too sharp.
research  autism  schizophrenia  neuroscience 
11 weeks ago by dougleigh
A ‘Bright Light,’ Dimmed in the Shadows of Homelessness - The New York Times
Brilliant woman from New Jersey who went to Williams College but developed schizophrenia and died on the street in midtown
homelessness  mental_illness  schizophrenia  NYC 
12 weeks ago by jcretan
Lessons for human genetics from genetic screens in model organisms
> For many human traits or disorders, especially ones involving the human mind, that detailed understanding is lacking. Oftentimes the phenotype is simply a word on a form – like “schizophrenia”. Moreover, while in model organisms we can simply screen out the indirect and non-specific mutations and focus on the ones directly involved in the processes of interest, we don’t have that luxury in humans. The indirect and non-specific ones will contribute most of the variance in risk.

At one level, that’s okay – just identifying these genetic risk factors can be tremendously useful in a clinical setting. But it does make getting at the underlying biology much more challenging. Nature is under no obligation to make things simple for us. It is going to take a hell of a lot more work after the initial discovery of genetic variants to unravel the biology of complex traits and disorders.
kevin_mitchell  genetics  beyond_gwas  gene_expression  schizophrenia  causation 
february 2018 by porejide
Getting a Knack for NAC
In this edition of The Interface, we discuss N-acetyl-cysteine, or NAC, a precursor to the amino acid cysteine. Through cysteine, NAC plays a notable metabolic role in the body's general antioxidant activities as well as in regulating the glutamatergic system (i.e., reward/reinforcement). Because of these functions, NAC may have a therapeutic influence on psychiatric syndromes that are either characterized by oxidative stress or impulsivity/compulsivity.
N-Acetyl-Cysteine  NAC  cysteine  metabolism  schizophrenia  bipolar  antioxidants 
january 2018 by askium

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