radiotherapy   49

Does Radioactive Iodine Post Reoperation Improve Thyroid Cancer Outcomes? | Cancer Network
Adjuvant radioactive iodine (RAI) after reoperation for recurrent or persisting papillary thyroid cancer following initial treatment might not improve clinical outcomes, according to findings from a retrospective cohort analysis of data for 102 patients treated at a tertiary referral center.

Post-reoperation thyroglobulin levels were similar between patients who received RAI and those who did not, study authors reported in JAMA Surgery.

“Structural recurrence after reoperation occurred in 18 of 50 patients (36%) in the reoperation with RAI group and 10 of 52 patients (19%) in the reoperation without RAI group,” noted senior study author Michael W. Yeh, MD, of the David Geffen School of Medicine at the University of California, Los Angeles. The difference was not statistically significant in the team’s multivariate analysis.

“This study admirably addresses a very challenging question where there is little established data,” Allen S. Ho, MD, director of the head & neck cancer program and co-director of the thyroid cancer program at Cedars-Sinai Medical Center in Los Angeles, told Cancer Network.

The study suggests that RAI after a reoperation should not be the default treatment, Ho noted. “Rather, it may be considered on a case-by-case basis, as already described in the 2015 American Thyroid Association Guidelines,” he said.

“The main established treatment for this population is surgery (reoperation). RAI, especially a second dose after reoperation, is considered an adjuvant treatment rather than the primary driver of outcomes in this scenario,” said Ho.

The patients who received RAI had more advanced disease, cautioned Ho and Robert Udelsman, MD, FACS, FACE, director of the Endocrine Neoplasia Institute at the Miami Cancer Institute, Baptist Health South Florida.
cancer  radiotherapy 
august 2018 by cnk
Twitter
RT : Is there a better way to celebrate the last day of your treatment? I think not..
Just look at that li…
radiotherapy  from twitter
august 2018 by Geek13
Harnessing the Immunomodulatory Effects of Radiation Therapy | Cancer Network
Abstract / Synopsis: 
In this article, we discuss the immunogenicity of radiation-induced cell death and describe the innate immune signaling pathways that precede adaptive antitumoral immunity. The innate and adaptive immune systems work in concert to generate systemic immune responses. In the setting of cancer, DNA damage caused by radiotherapy activates the innate immune system while tumor cell death liberates antigen that serves as a target for adaptive immunity. The immunomodulatory effects of radiation have been investigated in preclinical models; here we summarize the available data, with particular attention to the effects of radiotherapy timing, location, dose, and fractionation strategy on the antitumoral immune response. We synthesize preclinical and clinical information regarding the potential superiority of hypofractionated radiation for induction of proinflammatory responses. Although many questions remain, early successes with combining immunotherapy and radiotherapy merit further inquiry into the dose and fractionation strategies best able to activate and sustain an antitumoral response.

Introduction
Since x-rays were first used to treat cancer in the 1890s,[1] the field of radiation oncology has evolved clinically toward dose and fractionation strategies that maximize tumor control while minimizing side effects. Most of these side effects—inflammation, fibrosis, necrosis—are immunologically mediated. As we have learned more about the way cells die, and the way the immune system preserves self-tolerance to protect us from autoimmunity while fighting foreign pathogens, it has become clear that cell death occurs on a spectrum from immunogenic to tolerogenic. Current clinical dose and fractionation strategies likely lie in the middle of this spectrum because we have empirically selected treatment regimens over decades for the express purpose of killing tumor cells while minimizing attendant inflammation.


Recent successes in combining immunotherapy and radiotherapy have prompted consideration of the role radiation might play in augmenting the antitumoral immune response. Because radiation can kill cells and liberate tumor antigen, it functions as a complete vaccine: both antigen and adjuvant.[2] In the setting of checkpoint inhibition, which removes barriers to activation of the adaptive immune response, all the ingredients of a successful immunologic defense are present: innate immune activation lays the groundwork for a T-cell–mediated systemic defense. In this article, we discuss radiation’s immunomodulatory effects, with particular attention to the impact of dose and fractionation on the antitumoral response.
immunotherapy  immunology  radiotherapy  radiation 
august 2018 by cnk
Radiation Therapy in Renal Cell Carcinoma | PracticeUpdate
Renal cell carcinoma (RCC) is classically regarded as extremely resistant to classical fractionated radiation therapy (RT). Nowadays, there is convincing data supporting RCC radiosensitivity to high fraction doses, which may represent an ideal issue for new treatment strategies in primary and oligometastatic RCC disease. This review discusses the role of RT in RCC and its potential therapeutic scenario focusing on the most interesting clinical trials.
RCC  stereotactic-radiation  radiotherapy 
august 2018 by cnk
Twitter
RT : Ben has just completed his for a , he was unable to walk and talk before his treatment bu…
radiotherapy  braintumour  from twitter
july 2018 by userX
Twitter
I love it when our patients come up with challenging designs for their mask. This one was probably th…
radiotherapy  from twitter_favs
april 2018 by oliver.turner
The wounded healer: how my father’s cancer led me to a life of helping others
The language of cancer echoes that of war: fights and battles, bravery and resistance. But, like soldiers, patients can develop shell shock. The strength of their reactions can be overwhelming, making re-engagement with the enemy impossible. Sometimes surrender seems the only thing to do. [...] [... RADIOTHERAPY LONG-TERM CONSEQUENCES ...] I was a partner in a practice by the time new difficulties arose. The skin over the bottom of his back – in the area of his old radiotherapy field – started to break down and refused to heal despite a plastic surgeon’s best efforts at grafting. Then a routine blood test picked up a problem with his liver. An ultrasound scan found extensive metastases. A biopsy revealed an aggressive, poorly differentiated cancer that might have arisen originally from squamous skin cells. It’s a long-recognised problem with radiotherapy: some 35 years after treatment, the radiation that once saved a life can prove to have caused a new cancer to form.
Cancer  Radiotherapy 
april 2018 by asterisk2a
Twitter
The first ever mask I painted was for a 4 yr old Spiderman fan. When he first saw his painted mask an…
radiotherapy  from twitter_favs
march 2018 by mattedgar
Twitter
The first ever mask I painted was for a 4 yr old Spiderman fan. When he first saw his painted mask an…
radiotherapy  from twitter_favs
march 2018 by bperrier
(429) https://twitter.com/i/web/status/976947928626552832
RT : I’ve shared this before and will probably share this again.
Our patients are left on their own for t…
radiotherapy  from twitter_favs
march 2018 by jmkorhonen
Twitter
RT @lobke_marsden: This Monday I’ve been painting #radiotherapy masks for exactly one year. Thirty six masks to be precise. 😊
I hope i…
via:packrati.us  radiotherapy 
december 2017 by pigsonthewing
Twitter
RT : This Monday I’ve been painting masks for exactly one year. Thirty six masks to be precise. 😊
I hope i…
radiotherapy  from twitter
december 2017 by pigsonthewing
Twitter
This Monday I’ve been painting masks for exactly one year. Thirty six masks to be precise. 😊
I hope i…
radiotherapy  from twitter_favs
december 2017 by mattedgar
Twitter
RT : ✨”Magic String”✨

Children will be in the treatment room by themselves during

To help ease separati…
radiotherapy  from twitter
november 2017 by CamiloEL
Twitter
✨”Magic String”✨

Children will be in the treatment room by themselves during

To help ease separati…
radiotherapy  from twitter_favs
november 2017 by freerange_inc
ASTRO 2017: Maximum Radiation Dose to the Left Hippocampus Predicts Neurocognitive Decline in Patients With Brain Tumors | PracticeUpdate
She continued, “In this preliminary analysis of our prospective study, we showed that dose to the left hippocampus predicted for decline in memory. Patients are continuing to be accrued to this study and further neurocognitive data is being gathered. With a larger number of patients, we expect that future analyses will show other correlations between dose to other brain structures and cognitive decline.”

“As survival of patients with brain tumors continues to increase,” she said, “with advances in combined-modality therapy including surgery, chemotherapy, and radiotherapy, greater attention is being paid to quality-of-life measures including neurocognitive decline.”

She noted, “No guidelines exist for how to best preserve cognition when giving brain radiotherapy. We wanted to define these guidelines. This research is directly translatable to the clinic as radiation oncologists worldwide will be able to avoid critical brain regions to spare neurocognition.”
brain  radiotherapy  stereotactic-radiation 
october 2017 by cnk
Optimizing Radiotherapy With Immunotherapy in Lung Cancer Treatment | Cancer Network
Several reports have described how the use of radiation therapy in patients on immunotherapy can trigger immunogenic cell death.

In this video, Ramesh Rengan, MD, PhD, of the University of Washington in Seattle, highlights research aiming to optimize this combination of radiation therapy and immunotherapy, and discusses unwanted immune responses from radiotherapy and the challenge of utilizing this combination in patients with brain metastases. - info at about 4:23 on video
immunotherapy  cancer  radiation  radiotherapy 
july 2017 by cnk

related tags

advances  american  anti-inflammatory  austerity  autoimmune  awareness  big  blood  brain  braintumour  brca-1  brca-2  budget  cancer-research-uk  cancer  carcinogen  carcinogenic  care  chemotherapy  chronic  clinical-trial  coi  columbia-university  complex  cost  counterpoint  crisis  debate  demand  diabetes  dicom  diet-related  diet  dietary  discourse  disease  diseases  door  dosimetry  epidemic  epigenetics  errors  ethics  fiber  fiducialmarkers  glioma  gold  health  healthcare  heart  high  htaioslo2015  image  immune  immunology  immunotherapy  industry  inflammation  lobby  lobbying  lobbyist  low-grade  margins  medical-industrial  medical  medical_physics  nhs  nihr  nihrtips  obesity  oncology  opinion  overweight  pancreas  pancreatic  pattern  perception  pharma  pharmaceutical  plant-based  policy  population  pressure  profession  public  qa  radiation  radiation_physics  radiation_protection  radiobiology  radiology  rationing  rcc  research  response  revolving  safety  sbrt  science  serie  sick  spending  standard  statin  statins  stereotactic-radiation  stress  surgery  system  tumor  varian  webline  western  whole-food 

Copy this bookmark:



description:


tags: