radiation   3296

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Grand Canyon tourists exposed for years to radiation in museum building, safety manager says
For nearly two decades at the Grand Canyon, tourists, employees, and children on tours passed by three paint buckets stored in the National Park's museum collection building, unaware that they were being exposed to radiation.

Although federal officials learned last year that the 5-gallon containers were brimming with uranium ore, then removed the radioactive specimens, the park's safety director alleges nothing was done to warn park workers or the public that they might have been exposed to unsafe levels of radiation.

In a rogue email sent to all Park Service employees on Feb. 4, Elston "Swede" Stephenson — the safety, health and wellness manager — described the alleged cover-up as "a top management failure" and warned of possible health consequences.

"If you were in the Museum Collections Building (2C) between the year 2000 and June 18, 2018, you were 'exposed' to uranium by OSHA's definition," Stephenson wrote. "The radiation readings, at first blush, exceeds (sic) the Nuclear Regulatory Commission's safe limits. … Identifying who was exposed, and your exposure level, gets tricky and is our next important task."

In a Feb. 11 email to Acting Interior Secretary David Bernhardt and Deputy Inspector General Mary Kendall, Stephenson said he had repeatedly asked National Park executives to inform the public, only to get stonewalled.
us_AZ  public  discovery  environmental  radiation  uranium 
59 minutes ago by dchas
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma | Cancer Research
radiation increases MRCK (which is up at the edges of invasive tumors also) and cdc42 to mrck may lead to mesenchymal invasion

Glioblastoma (GBM) is an aggressive and incurable primary brain tumor that causes severe neurologic, cognitive, and psychologic symptoms. Symptoms are caused and exacerbated by the infiltrative properties of GBM cells, which enable them to pervade the healthy brain and disrupt normal function. Recent research has indicated that although radiotherapy (RT) remains the most effective component of multimodality therapy for patients with GBM, it can provoke a more infiltrative phenotype in GBM cells that survive treatment. Here, we demonstrate an essential role of the actin-myosin regulatory kinase myotonic dystrophy kinase-related CDC42-binding kinase (MRCK) in mediating the proinvasive effects of radiation. MRCK-mediated invasion occurred via downstream signaling to effector molecules MYPT1 and MLC2. MRCK was activated by clinically relevant doses per fraction of radiation, and this activation was concomitant with an increase in GBM cell motility and invasion. Furthermore, ablation of MRCK activity either by RNAi or by inhibition with the novel small-molecule inhibitor BDP-9066 prevented radiation-driven increases in motility both in vitro and in a clinically relevant orthotopic xenograft model of GBM. Crucially, treatment with BDP-9066 in combination with RT significantly increased survival in this model and markedly reduced infiltration of the contralateral cerebral hemisphere.
mrck  Glioblastoma  invasion  mesenchymal_motion  radiation  cdc42 
5 days ago by Segalllab
Inhibition of Notch signaling pathway enhanced the radiosensitivity of breast cancer cells - Peng - 2018 - Journal of Cellular Biochemistry - Wiley Online Library
4Gy induced NOTCH1 protein and activation in MCF7/T47D as well as invasion. No analysis of ligands. Possibly look at radiation effects on macrophages?

This study aimed to investigate the effect of inhibiting the Notch signaling pathway on the radiosensitivity of breast cancer cells. Human breast cancer cell lines (MCF‐7 and T47D) were selected and treated with radiation of different doses. Cells were treated with Gamma secretase inhibitor (GSI) to analyze the effects of GSI on the Notch signaling, which were detected by Immunofluorescence assay, RT‐qPCR, and Western blot analysis. Besides, Transwell assay, Scratch test, colony formation assay, MTT assay, and flow cytometry were conducted to show the effects of GSI on the invasion and migration, survival fraction, cell viability, and apoptosis of MCF‐7 and T47D cells after radiation therapy. Moreover, cell transfection with a dominant negative mutant of RBPJ, the key transcription factor of Notch signaling pathway, were also applied to show the inhibition of Notch signaling pathway. Initially, we found that the 4 Gy radiation activated Notch signaling pathway, and enhanced the invasion and migration of MCF‐7 and T47D cells. However, GSI inhibited the Notch signaling pathway, and reversed the enhancement of radiation on the migration and invasion, promoted the enhancement of apoptosis and inhibition of proliferation of MCF‐7 and T47D cells induced by radiation. Except that, we also determined that GSI and dnRBPJ suppressed the upregulation of Notch signaling after radiation therapy. Our study demonstrated that inhibition of the Notch signaling pathway enhanced the radiosensitivity of breast cancer cells, which may provide evident for a beneficial adjuvant therapy in the breast cancer treatment.
Notch  radiation  radiosensitivity  MCF-7  T47D  GSI  invasion 
6 days ago by Segalllab
Které telefony vyzařují nejvíce radiace do hlavy? Úřad zveřejnil žebříček
SAR hodnota určuje škodlivost záření telefonů. Několikrát do roka pak můžeme vidět výsledky toho, Které telefony vyzařují nejvíce radiace do hlavy.
phone  radiation 
7 days ago by andreok
Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation | Oncogene
I wonder if macrophages could provide the IL1A to trigger HA to stimulate CD44...

Ionizing radiation is widely used for patient with glioblastoma (GBM). However, the effect of radiation on patient survival is marginal and upon recurrence tumors frequently shift toward mesenchymal subtype adopting invasiveness. Here, we show that ionizing radiation affects biomechanical tension in GBM microenvironment and provides proinvasive extracellular signaling cue, hyaluronic acid (HA)-rich condition. In response to radiation, HA production was increased in GBM cells by HA synthase-2 (HAS2) that was transcriptionally upregulated by NF-ĸB. Notably, NF-ĸB was persistently activated by IL-1α-feedback loop, making HA abundance in tumor microenvironment after radiation. Radiation-induced HA abundance causally has been linked to invasiveness of GBM cells by generating movement track as an extracellular matrix, and by acting as a signaling ligand for CD44 receptor, leading to SRC activation, which is sufficient for mesenchymal shift of GBM cells. Collectively, our findings provide an explanation for the frequent brain tumor relapse after radiotherapy, and potential therapeutic targets to block mesenchymal shift upon relapse.
radiation  il1alpha  nfkb  hyaluronic_acid  U87 
11 days ago by Segalllab
Dirt Cheap Muon Detector Puts Particle Physics Within DIY Reach | Hackaday
Subatomic physics is pretty neat stuff, but not generally considered within the reach of the home-gamer. With cavernous labs filled with racks of expensive gears and miles-wide accelerators, playing with the subatomic menagerie has been firmly in the hands of the pros for pretty much as long as the field has been in existence. But that could change with this sub-$100 DIY muon detector.
hackaday  muon  radiation  sensor  diy  embedded  arduino 
4 weeks ago by cyberchucktx
Hearing planned on barrel ruptures at E. Idaho nuclear site
BOISE, Idaho (AP) — A government board that makes recommendations on U.S. Department of Energy facilities plans to hold a public hearing concerning the rupture of four barrels containing radioactive sludge at an eastern Idaho nuclear site.
The Defense Nuclear Facilities Safety Board will meet in May in Washington, D.C., to discuss the ruptures at the Energy Department's 890-square-mile (2,300-square-kilometer) site in eastern Idaho that includes the Idaho National Laboratory.
The board in a closed meeting last month opted for the public hearing involving the April barrel ruptures at the Radioactive Waste Management Complex.
Three of the four board members voted in favor of holding the meeting, while Bruce Hamilton abstained, citing his concerns about the location of the meeting. "The recent event at Idaho National Laboratory is worthy of further information gathering which could be facilitated by a hearing. Whether that hearing is best accomplished in Washington, D.C., instead of in Idaho is questionable," he wrote.
Officials say there were no injuries and no threat to the public because of the barrel ruptures. Work later resumed at the facility.
U.S. Department of Energy contractor Fluor Idaho in a statement Thursday said it appreciated the board's interest in the problems with the barrels and said it "will lend our technical assistance as needed. We have worked with the board over the past several years on technical issues associated with the cleanup mission in Idaho and have always welcomed their input."
us_ID  industrial  follow-up  response  radiation  waste 
5 weeks ago by dchas
5G: The Complete WIRED Guide | WIRED
Millimeter wave signals are less reliable over long distances and are easily disrupted by obstacles like trees, people, and even rain. To make it practical for mobile use, carriers will need to deploy huge numbers of small access points in cities, instead of relying on a few big cell towers as they do today.

working on an antenna called Terragraph, which would let wireless access points connect with each other instead of relying exclusively on wired connections for backhaul.

FCC gutted its net neutrality protections in 2017, dubiously arguing that fewer regulations would lead to more investment in 5G and other broadband infrastructure. In 2018, it voted to override state and local regulations governing the placement of wireless equipment in the name of helping carriers build 5G networks faster. Meanwhile, T-Mobile and Sprint are pushing regulators to approve the merger between the two companies by arguing that they would be able to deploy 5G more quickly and efficiently together.
5g  cellular  radiation  internet  fcc  wireless 
6 weeks ago by bwiese
How Big Wireless Made Us Think That Cell Phones Are Safe: A Special Investigation | The Nation
The Internet of Things will require augmenting today’s 4G technology with 5G, thus “massively increasing” the general population’s exposure to radiation, according to a petition signed by 236 scientists worldwide who have published more than 2,000 peer-reviewed studies and represent “a significant portion of the credentialed scientists in the radiation research field,” according to Joel Moskowitz, the director of the Center for Family and Community Health at the University of California, Berkeley, who helped circulate the petition. Nevertheless, like cell phones, 5G technology is on the verge of being introduced without pre-market safety testing....

The wireless industry’s determination to bring about the Internet of Things, despite the massive increase in radiation exposure this would unleash, raises the stakes exponentially. Because 5G radiation can only travel short distances, antennas roughly the size of a pizza box will have to be installed approximately every 250 feet to ensure connectivity. “Industry is going to need hundreds of thousands, maybe millions, of new antenna sites in the United States alone,” said Moskowitz, the UC Berkeley researcher. “So people will be bathed in a smog of radiation 24/7.”...

The scientists’ petition discussed earlier urges government regulators to apply the precautionary principle to 5G technology. Current safety guidelines “protect industry—not health,” contends the petition, which “recommend[s] a moratorium on the roll-out of [5G]…until potential hazards for human health and the environment have been fully investigated by scientists independent from industry.”
telecommunications  infrastructure  5G  health  radiation 
7 weeks ago by shannon_mattern
Under a fermium sky : The Sceptical Chymist
In the summer of 1953, Kuroda and his co-worker Paul Damon noticed high concentrations of fission products in the Arkansas rain. They published their results quickly5. Their publication ”On the artificial radioactivity of rainfall”, did not go unnoticed. In the autumn of 1953, they were ordered to stop studying fallout, because ”the study of radioactive fallout by non-authorized scientists was strictly forbidden by the U.S. government as a classified military secret” (ref. 4). Damon and Kuroda apparently were mostly silent about the order to stop, but in 1954, they published a report titled ”On the natural radioactivity of rainfall”, which included the pithy statement about artificial radioactivity in rainfall: ”Presumably, considerable work is underway, but has not yet been published.” (ref. 6).
history  radiation  nuclear 
7 weeks ago by itrasbiel
Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge | Nature Communications
Detailed evaluation of bone marrow derived microglia in irradiated mice.


"Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persistently contribute to the parenchymal brain macrophage compartment. Here we establish that graft-derived macrophages acquire, over time, microglia characteristics, including ramified morphology, longevity, radio-resistance and clonal expansion. However, even after prolonged CNS residence, transcriptomes and chromatin accessibility landscapes of engrafted, BM-derived macrophages remain distinct from yolk sac-derived host microglia. Furthermore, engrafted BM-derived cells display discrete responses to peripheral endotoxin challenge, as compared to host microglia. In human HSC transplant recipients, engrafted cells also remain distinct from host microglia, extending our finding to clinical settings. Collectively, our data emphasize the molecular and functional heterogeneity of parenchymal brain macrophages and highlight potential clinical implications for HSC gene therapies aimed to ameliorate lysosomal storage disorders, microgliopathies or general monogenic immuno-deficiencies.
microglia  radiation  bone_marrow_cells 
7 weeks ago by Segalllab

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