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Genome Editing
This collection of articles from the Nature Research journals provides an overview of current progress in developing targeted genome editing technologies. A selection of protocols for using and adapting these tools in your own lab is also included.
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2 days ago by nhaliday
New Theory Cracks Open the Black Box of Deep Learning | Quanta Magazine
A new idea called the “information bottleneck” is helping to explain the puzzling success of today’s artificial-intelligence algorithms — and might also explain how human brains learn.

sounds like he's just talking about autoencoders?
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26 days ago by nhaliday
How & Why Solar Eclipses Happen | Solar Eclipse Across America - August 21, 2017
Cosmic Coincidence
The Sun’s diameter is about 400 times that of the Moon. The Sun is also (on average) about 400 times farther away. As a result, the two bodies appear almost exactly the same angular size in the sky — about ½°, roughly half the width of your pinky finger seen at arm's length. This truly remarkable coincidence is what gives us total solar eclipses. If the Moon were slightly smaller or orbited a little farther away from Earth, it would never completely cover the solar disk. If the Moon were a little larger or orbited a bit closer to Earth, it would block much of the solar corona during totality, and eclipses wouldn’t be nearly as spectacular.
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8 weeks ago by nhaliday
The Flynn effect for verbal and visuospatial short-term and working memory: A cross-temporal meta-analysis
Specifically, the Flynn effect was found for forward digit span (r = 0.12, p < 0.01) and forward Corsi block span (r = 0.10, p < 0.01). Moreover, an anti-Flynn effect was found for backward digit span (r = − 0.06, p < 0.01) and for backward Corsi block span (r = − 0.17, p < 0.01). Overall, the results support co-occurrence theories that predict simultaneous secular gains in specialized abilities and declines in g. The causes of the differential trajectories are further discussed.
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10 weeks ago by nhaliday
Correlated Equilibria in Game Theory | Azimuth
Given this, it’s not surprising that Nash equilibria can be hard to find. Last September a paper came out making this precise, in a strong way:

• Yakov Babichenko and Aviad Rubinstein, Communication complexity of approximate Nash equilibria.

The authors show there’s no guaranteed method for players to find even an approximate Nash equilibrium unless they tell each other almost everything about their preferences. This makes finding the Nash equilibrium prohibitively difficult to find when there are lots of players… in general. There are particular games where it’s not difficult, and that makes these games important: for example, if you’re trying to run a government well. (A laughable notion these days, but still one can hope.)

Klarreich’s article in Quanta gives a nice readable account of this work and also a more practical alternative to the concept of Nash equilibrium. It’s called a ‘correlated equilibrium’, and it was invented by the mathematician Robert Aumann in 1974. You can see an attempt to define it here:
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12 weeks ago by nhaliday
Corrupting cooperation and how anti-corruption strategies may backfire | Nature Human Behaviour
Exposure to Norms:
Here we test how exposure to corruption norms affect behavior in our game. We do so by using our exposure score (a mean of the corruption perceptions of the countries the participant has lived in) and the heritage corruption score (a mean of the corruption perceptions of the countries the participant has an ethnic heritage). Since there is no incentive to offer bribes or contribute, except when compelled to do so by punishment, we predict that exposure to norms should primarily affect Leader decisions. Nonetheless, internalized norms may also affect the behavior of players in contributing and bribing.


The correlation between the direct exposure and heritage measures of corruption is r = 0.67, p < .001.


Then we see that direct exposure to corruption norms results in increased corrupt behavior—i.e. in our Canadian sample, those who have lived in corrupt countries from which they do not derive their heritage behave in more corrupt ways.

hard to interpret

I don't think the solution is to just do nothing. Should look to history for ideas; process of "getting to Denmark" took centuries in NW Euro. Try to replicate and don't expect fast results.

Trust and Bribery: The Role of the Quid Pro Quo and the Link with Crime:
I study data on bribes actually paid by individuals to public officials, viewing the results through a theoretical lens that considers the implications of trust networks. A bond of trust may permit an implicit quid pro quo to substitute for a bribe, which reduces corruption. Appropriate networks are more easily established in small towns, by long-term residents of areas with many other long-term residents, and by individuals in regions with many residents their own age. I confirm that the prevalence of bribery is lower under these circumstances, using the International Crime Victim Surveys. I also find that older people, who have had time to develop a network, bribe less. These results highlight the uphill nature of the battle against corruption faced by policy-makers in rapidly urbanizing countries with high fertility. I show that victims of (other) crimes bribe all types of public officials more than non-victims, and argue that both their victimization and bribery stem from a distrustful environment.

Kinship, Fractionalization and Corruption:
The theory of kin selection provides a straightforward justification for norms of nepotism and favoritism among relatives; more subtly, it also implies that the returns to such norms may be influenced by mating practices. Specifically, in societies with high levels of sub-ethnic fractionalization, where endogamous (and consanguineous) mating within kin-group, clan and tribe increases the local relatedness of individuals, the relative returns to norms of nepotism and favoritism are high. In societies with exogamous marriage practices, the relative returns to norms of impartial cooperation with non-relatives and strangers are increased. Using cross-country and within-country regression analyses and a cross-country lab experiment, we provide evidence for this account.

Ethnic favouritism: Not just an African phenomenon:
Ethnic favouritism is a global phenomenon
We find robust evidence for ethnic favouritism – ethnographic regions that are the current political leader’s ethnic homeland enjoy 7%-10% more intense night-time light, corresponding to 2%-3% higher regional GDP. Furthermore, we show that ethnic favouritism extends to ethnic groups that are linguistically close to the political leader.

Most significantly, these effects are as strong outside of Africa as they are within, challenging the preconception that ethnic favouritism is mainly or even entirely a sub-Saharan African phenomenon. For example, Bolivian presidents tended to favour areas populated by European descendants and Criollos, largely at the expense of the indigenous population. After the election of Evo Morales, a member of the indigenous Ayamara ethnic group, luminosity in indigenous areas grew substantially. Notably, critics suggest Morales gave special attention to the interests and values of the Ayamara at the expense of other indigenous peoples (e.g. Albro 2010, Postero 2010).

Democratisation is not a panacea
Our results further suggest that, while democratic institutions have a weak tendency to reduce ethnic favouritism, their effect is limited. In particular, a change from autocratic regimes to weak democracies does not seem to reduce ethnic favouritism (and may even increase it).

This result could in part be explained by political leaders’ motivations for engaging in ethnic favouritism. We find that the practice intensifies around election years in which the political leader's office is contested, suggesting that leaders may target policies towards their ethnic homelands to improve their re-election prospects, and not solely out of co-ethnic altruism. To the extent that political leaders engage in ethnic favouritism for electoral purposes, democratisation is not likely to be effective in curbing the practice.

Facebook’s war on free will:
Though Facebook will occasionally talk about the transparency of governments and corporations, what it really wants to advance is the transparency of individuals – or what it has called, at various moments, “radical transparency” or “ultimate transparency”. The theory holds that the sunshine of sharing our intimate details will disinfect the moral mess of our lives. With the looming threat that our embarrassing information will be broadcast, we’ll behave better. And perhaps the ubiquity of incriminating photos and damning revelations will prod us to become more tolerant of one another’s sins. “The days of you having a different image for your work friends or co-workers and for the other people you know are probably coming to an end pretty quickly,” Zuckerberg has said. “Having two identities for yourself is an example of a lack of integrity.”

The point is that Facebook has a strong, paternalistic view on what’s best for you, and it’s trying to transport you there. “To get people to this point where there’s more openness – that’s a big challenge. But I think we’ll do it,” Zuckerberg has said. He has reason to believe that he will achieve that goal. With its size, Facebook has amassed outsized powers. “In a lot of ways Facebook is more like a government than a traditional company,” Zuckerberg has said. “We have this large community of people, and more than other technology companies we’re really setting policies.”
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july 2017 by nhaliday
The Greatest Generation | West Hunter
But  when you consider that people must have had 48 chromosomes back then, rather than the current measly 46, much is explained.

Theophilus Painter, a prominent cytologist, had investigated human chromosome number in 1923. He thought that there were 24 in sperm cells, resulting in a count of 48, which is entirely reasonable. That is definitely the case for all our closest relatives (chimpanzees, bonobos, gorillas, and orangutans).

The authorities say that that Painter made a mistake, and that humans always had 46 chromosomes. But then, for 30 years after Painter’s work, the authorities said that people had 48.  Textbooks in genetics continued to say that Man has 48 chromosomes up until the mid 1950s.  Many cytologists and geneticists studied human chromosomes during that period, but they knew that there were 48, and that’s what they saw. Now they know that there are 46, and that’s what every student sees.

Either the authorities are fallible and most people are sheep, or human chromosome number actually changed sometime after World War II.  No one could believe the first alternative: it would hurt our feelings, and therefore cannot be true.  No, we have a fascinating result: people today are fundamentally different from the Greatest Generation, biologically different: we’re two chromosomes shy of a load. .    So it’s not our fault !

funny comment:
“some social environments are better than others at extracting the best from its people”

That’s very true – we certainly don’t seem to be doing a very good job of it. It’s a minor matter, but threatening brilliant engineers with death or professional ruin because of their sexist sartorial choices probably isn’t helping…

I used to do some engineering, and if someone had tried on that on me, I’ve have told him to go fuck itself. Is that a lost art?
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july 2017 by nhaliday
World Without Stars | West Hunter
Seems to me that forming in a galaxy might give a solar system enough heavy elements, while being flung into the intergalactic deeps would protect you from cosmic catastrophes like gamma-ray bursts.   Such stars might be good homes for complex life, especially a few billion years ago.

Interstellar travel is hard enough for us, but for these guys, it would be a bitch. That first step is a doozy.
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june 2017 by nhaliday

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