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Bad iPhone notches are happening to good Android phones • The Verge
Vlad Savov:
<p>I’ve been coming to Mobile World Congress for close to a decade now, and I’ve never seen the iPhone copied quite so blatantly and cynically as I witnessed during this year’s show. MWC 2018 will go down in history as the launch platform for a mass of iPhone X notch copycats, each of them more hastily and sloppily assembled than the next.

No effort is being made to emulate the complex Face ID system that resides inside Apple’s notch; companies like Noa and Ulefone are in such a hurry to get their iPhone lookalike on the market that they haven’t even customized their software to account for the new shape of the screen. More than one of these notched handsets at MWC had the clock occluded by the curved corner of the display.

<img src="" width="100%" />
<em>Ulefone T2 Pro Photo by Sam Byford / The Verge</em>

Asus is one of the biggest consumer electronics companies in the world, and yet its copycat notch is probably the most galling of them all. The Zenfone 5 looks and feels like a promising phone, featuring loud speakers, the latest Sony imaging sensor with larger-than-average pixels, and a price somewhere south of $499. I should be celebrating it right now, but instead I’m turning away in disgust as Asus leans into its copying by calling Apple a “Fruit Company” repeatedly. If you’re going to copy the iPhone, at least have the decency to avoid trying to mock it.

It would be stating the obvious to say that this trend is not a good one. I’m absolutely of the belief that everyone, Apple included, copies or borrows ideas from everyone else in the mobile industry. This is a great way to see technical improvements disseminated across the market. But the problem with these notched screens on Android phones is that they’re purely cosmetic. Apple’s notch at the top of the iPhone X allows the company to have a nearly borderless screen everywhere else, plus it accommodates the earpiece and TrueDepth camera for Face ID. Asus et al have a sizeable “chin” at the bottom of their phones, so the cutouts at the top are self-evidently motivated by the desire to just look — not function, look — like an iPhone X.</p>

Sure, these are obvious copycats. It's stretching it to call them "good" Android phones though. They're run-of-the-mill, entirely fungible things.
Iphone  notch 
17 days ago by charlesarthur
Spatial constraints govern competition of mutant clones in human epidermis | Nature Communications
Identification of possible selective advantage of clones in cancer prone skin - see notch as overmutated
Notch  preneoplasic  HNSCC  tumorigenesis 
22 days ago by Segalllab
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia | Nature Communications
DLL1 from arterial endothelial cells can induce maturation of macrophages with polarization towards M2.

"Here we show, using conditional genetic deletion strategies together with adoptive cell transfer experiments in a mouse model of hind limb ischemia, that blood vessels control macrophage differentiation and maturation from recruited monocytes via Notch signaling, which in turn promotes arteriogenesis and tissue repair. Macrophage maturation is controlled by Notch ligand Dll1 expressed in vascular endothelial cells of arteries and requires macrophage canonical Notch signaling via Rbpj, which simultaneously suppresses an inflammatory macrophage fate. Conversely, conditional mutant mice lacking Dll1 or Rbpj show proliferation and transient accumulation of inflammatory macrophages, which antagonizes arteriogenesis and tissue repair. Furthermore, the effects of Notch are sufficient to generate mature macrophages from monocytes ex vivo that display a stable anti-inflammatory phenotype when challenged with pro-inflammatory stimuli. Thus, angiocrine Notch signaling fosters macrophage maturation during ischemia."
dll1  Notch  Macrophages  macrophage_differentiation  macrophage_polarization 
25 days ago by Segalllab
Glycogen synthase kinase 3β inhibition enhances Notch1 recycling
So GSK3B affects endosome recycling - coudl be a general mechanism of wnt affecting cell signaling.

"Importantly, our discovery that GSK3β association with Notch1-positive endosomes appears to be dynamic and that GSK3β inhibition enhances Notch1 recycling from endosomal stores supports a model where cells can directly modulate Notch1 signaling capacity and bypass the need for additional transcription of the receptor. For example, GSK3β activity is inhibited when cells are stimulated with Wnt, insulin, or other growth factors (Cross et al., 1995; Metcalfe and Bienz, 2011). Thus, when GSK3β activity is suppressed, Notch1 is mobilized and recycled to the cell surface from endosomal stores. This, in turn, would increase Notch signaling capacity by increasing receptor exposure to ligands on the surfaces of neighboring cells."
wnt  gsk3b  Notch  endosome_recycling 
5 weeks ago by Segalllab
Barclays says second-generation iPhone X could have smaller notch • MacRumors
Joe Rossignol:
<p>Apple will launch a trio of new iPhone models later this year with a second-generation TrueDepth camera system, which will potentially be reduced in size, according to a research note issued today by analysts Andrew Gardiner, Hiral Patel, Joseph Wolf, and Blayne Curtis at investment bank Barclays.

While the analysts believe the new TrueDepth system will only "evolve slightly," they predict it could allow for a "smaller notch" on the 2018 range of iPhones with Face ID, which is rumored to include a second-generation iPhone X, a larger iPhone X Plus, and an all-new mid-range 6.1-inch LCD model.

MacRumors obtained a copy of the research note, which also corroborates rumors about Apple extending Face ID to the iPad Pro this year...</p>

Second generation and smaller and faster makes sense - that was the path with TouchID after all.
Notch  iphonex 
5 weeks ago by charlesarthur
Google's next Android overhaul will embrace iPhone’s ‘notch’ • Bloomberg
Mark Gurman and Mark Bergen:
<p>Google is working on an overhaul of its Android mobile software for a new generation of smartphones mimicking Apple’s controversial new "notch" at the top of the iPhone X, according to people familiar with the situation.

The Android update, due later in the year, will also more tightly integrate Google’s digital assistant, improve battery life on phones and support new designs, like multiple screens and foldable displays, the people added.

A key goal of this year’s update to the Google mobile operating system is to persuade more iPhone users to switch to Android devices by improving the look of the software, the people said. They asked not to be identified discussing the private plans. A Google spokesman declined to comment.

While Android dominates the middle and low-end of the global smartphone market, Apple controls much of the high-end with users who spend more on apps and other services. Embracing the notch may help change that. The design will mean more new Android phones with cutouts at the top of their screens to fit cameras and other sensors. That will likely support new features, helping Android device makers keep up with similar Apple technology.

What’s unlikely to change much is Android’s nagging problem: Most of the billion-plus Android devices globally run outdated versions of the operating system, exposing security holes and holding back Google’s newest mobile innovations.</p>

It sounds as though smartphone OEMs - most likely Samsung - really are anxious about how the notch is such a visual effect that makes the iPhone X stand out if someone is gazing over your shoulder.

Can’t see how adding a notch is going to induce switching, though. Might make them feature-competitive, but do we still think OS switching is done by a significant proportion of the smartphone population?
Apple  android  notch  iphonex 
5 weeks ago by charlesarthur
Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling | Nature Communications
Proteomic analysis of EVs presumably budded off from the plasma membrane. ARRDC1 seems to regulate the formation of this type of vesicle. See C terminus of Notch2 in these vesicles and propse that this gets into recipient cells to perform noncanonical notch signal. Question of how they get into the recipient cells does not seem to be addressed

"ARMMs (arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles) are extracellular vesicles that bud directly at the plasma membrane; however, little is known about the molecular composition and physiological function of these vesicles. Here we report that ARMMs contain active NOTCH receptors and mediate a non-canonical intercellular NOTCH signaling. We identify over 100 proteins that are significantly enriched in ARMMs, including ARRDC1, TSG101 and multiple ESCRT complex proteins. About a third of ARMMs-enriched proteins are plasma membrane proteins, including the NOTCH2 receptor. The incorporation of NOTCH2 into ARMMs is facilitated by the ITCH E3 ligase and the metalloprotease ADAM10, both of which are also secreted into ARMMs. NOTCH2 in ARMMs can be delivered into recipient cells, and upon activation by γ-secretase cleavage, induces NOTCH-specific gene expression. Together, our findings reveal a role for ARMMs in a novel NOTCH signaling pathway that acts in distance and is independent of direct cell–cell contact."
exosomes  extracellular_vesicles  Notch 
8 weeks ago by Segalllab
Apple might have found a way to make the notch smaller on next year’s iPhones • BGR
Zach Epstein:
<p>The TrueDepth Camera is what enables Face ID, an advanced facial recognition system that is far more secure than similar biometric authentication systems on rival phones. It works by using an infrared dot projector to beam 30,000 invisible dots onto the user’s face, and then a special camera reads the dots and matches the resulting data to the phone’s saved face profile.

Apple is expected to unveil three new iPhone models this September, and all three of them will reportedly feature the iPhone X’s “all-screen” design, complete with the infamous notch. According to a new report from ETNews, however, next year’s new iPhones might not be quite as notchy.

“According to industries, it is heard that Apple is planning to strengthen face sensing function starting from 2019 models,” the report reads. “That is why it is planning to increase number of parts that will be used for iPhones and is looking into combination of a face recognition module with a camera module.” It should be noted that this is a translation of a Chinese-language report.

It’s possible that Apple’s upcoming new iPhones will combine elements of the TrueDepth camera with the standard front-facing camera. Apart from allowing Apple to squeeze a more complex solution into the phone, this might also allow the company to reduce the footprint of the sensor array. In other words, next year’s new iPhones might have a smaller notch.</p>

I would expect the notch to stay the same size - devs have built for it already - and Apple to squeeze more dots into its projector thing, which will take up the same space.

More interesting question: will it be the iPhone XI?
apple  notch  iphonex 
9 weeks ago by charlesarthur
Epsin-Dependent Ligand Endocytosis Activates Notch by Force - ScienceDirect
JAGGED/DLL activation of notch relies upon epsin anchoring in the expressing cell so that notch can be pulled on to reveal the cleavage site. Otherwise the ligand is endocytosed by the receiver cell without activating notch
Notch  Jagged1  epsin  signaling 
9 weeks ago by Segalllab
Notch-out for breast cancer therapies - ScienceDirect
review of notch signaling with a focus on breast cancer and small molecule vs antibody inhibitors
Notch  JAG1  dll4  Inhibitors  Review  breast_cancer 
12 weeks ago by Segalllab

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