nanotechnology   2609

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Towards experimental P-systems using multivesicular liposomes | SpringerLink
P-systems are abstract computational models inspired by the phospholipid bilayer membranes generated by biological cells. Illustrated here is a mechanism by which recursive liposome structures (multivesicular liposomes) may be experimentally produced through electroformation of dipalmitoylphosphatidylcholine films for use in ‘real’ P-systems. We first present the electroformation protocol and microscopic characterisation of incident liposomes towards estimating the size of computing elements, level of internal compartment recursion, fault tolerance and stability. Following, we demonstrate multiple routes towards embedding symbols, namely modification of swelling solutions, passive diffusion, and microinjection. Finally, we discuss how computing devices based on P-systems can be produced and their current limitations.
unconventional-computing  molecular-machinery  rather-interesting  vesicular-computing  experiment  nanotechnology  to-write-about  to-simulate 
7 days ago by Vaguery
Supermultiplexed optical imaging and barcoding with engineered polyynes | Nature Methods
Optical multiplexing has a large impact in photonics, the life sciences and biomedicine. However, current technology is limited by a 'multiplexing ceiling' from existing optical materials. Here we engineered a class of polyyne-based materials for optical supermultiplexing. We achieved 20 distinct Raman frequencies, as 'Carbon rainbow', through rational engineering of conjugation length, bond-selective isotope doping and end-capping substitution of polyynes. With further probe functionalization, we demonstrated ten-color organelle imaging in individual living cells with high specificity, sensitivity and photostability. Moreover, we realized optical data storage and identification by combinatorial barcoding, yielding to our knowledge the largest number of distinct spectral barcodes to date. Therefore, these polyynes hold great promise in live-cell imaging and sorting as well as in high-throughput diagnostics and screening.
materials-science  nanotechnology  indistinguishable-from-magic  molecular-design  molecular-biology  to-write-about  rather-interesting 
7 weeks ago by Vaguery
Nanoscale tweezers for single-cell biopsies | Nature Nanotechnology
> Here we describe minimally invasive nanotweezers that can be spatially controlled to extract samples from living cells with single-molecule precision. They consist of two closely spaced electrodes with gaps as small as 10–20 nm, which can be used for the dielectrophoretic trapping of DNA and proteins. Aside from trapping single molecules, we also extract nucleic acids for gene expression analysis from living cells without affecting their viability. Finally, we report on the trapping and extraction of a single mitochondrion
nanotechnology  tweezers  single_cell  molecule 
10 weeks ago by porejide
Bacterial Nanobionics via 3D Printing - Nano Letters (ACS Publications)
So 3D printing aligned cynobacteria with graphene boosts spare/extra photocurrent collection 8X. In this case they painted the setup onto a mushroom as a convenient scaffold/host.
biohybrid  bionic  cynobacteria  graphene  photocurrent  collection  power  generator  materials  science  biology  research  technology  nanotechnology  nanoribbon  extracellular  electron  transport  3D  printing  fabbing  symbiosis 
november 2018 by asteroza
Virus-based piezoelectric energy generation
Piezoelectric materials can convert mechanical energy into
electrical energy1,2, and piezoelectric devices made of a
variety of inorganic materials3–5 and organic polymers6 have
been demonstrated. However, synthesizing such materials
often requires toxic starting compounds, harsh conditions
and/or complex procedures7. Previously, it was shown that
hierarchically organized natural materials such as bones8,
collagen fibrils9,10 and peptide nanotubes11,12 can display piezoelectric
properties. Here, we demonstrate that the piezoelectric
and liquid-crystalline properties of M13 bacteriophage (phage)
can be used to generate electrical energy. Using piezoresponse
force microscopy, we characterize the structure-dependent
piezoelectric properties of the phage at the molecular level.
We then show that self-assembled thin films of phage can
exhibit piezoelectric strengths of up to 7.8 pm V21
. We also
demonstrate that it is possible to modulate the dipole strength
of the phage, hence tuning the piezoelectric response, by
genetically engineering the major coat proteins of the phage.
Finally, we develop a phage-based piezoelectric generator
that produces up to 6 nA of current and 400 mV of potential
and use it to operate a liquid-crystal display. Because biotechnology
techniques enable large-scale production of genetically
modified phages, phage-based piezoelectric materials potentially
offer a simple and environmentally friendly approach to
piezoelectric energy generation.
bioengineering  nanotechnology 
october 2018 by whitequark
There are few companies dealing in in Australia and fewer still in the space, which could…
nanotechnology  biotech  from twitter
october 2018 by rhyndes
Strengthening effect of single-atomic-layer graphene in metal–graphene nanolayered composites | Nature Communications
Graphene/metal composites now suck less, as in wow that's a huge improvement for a very small amount of doping the parent metal
graphene  metal  composite  materials  science  research  technology  nanotechnology  copper  nickel  CVD  sandwich  multilayer 
september 2018 by asteroza

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