modeling   14155

« earlier    

libfive::Studio
Studio is a minimalist GUI for solid modeling with the libfive kernel. It is a design environment based on Guile Scheme, and should be familiar to OpenSCAD users.

The UI combines script-based design with direct modeling: click and drag directly on your models, and the changes will be back-propagated into the script!
3d  modeling  scheme  software  3d-printing 
2 days ago by mayoff
Archi – Open Source ArchiMate Modelling
An open source modelling toolkit to create ArchiMate models and sketches.
archi  archimate  model  modeling  software  architecture  visualization  tool 
4 days ago by vicchow
Archimate as a service modeling framework – Stefan Luyten – Medium
When using the right tool (like Archi), Archimate can (and should!) be used from the early start of a modeling exercise, because it encourages certain aspects from the standard which are essential for good modeling.
data  modeling  architecture  systems  visualization 
5 days ago by wrrn
Rachael Tatman | Kaggle
A great series of tutorials on various aspects of R and doing text analytics with R.
textbook  tutorials  r  nlp  textmining  transformation  modeling 
5 days ago by jerid.francom
The C4 model for software architecture
Formalized modeling approach for software systems to architecture to deployment to code
development  software  design  documentation  modeling  diagrams  architect  tools  free  opensource 
7 days ago by jeffjensen
Predicting Tumor Progression in CRC Patients | Cancer Network
Combining regular liquid plasma biopsies using plasma cell-free DNA (cfDNA) and solid-tissue biopsies with a mathematical modeling of tumor evolution helped anticipate tumor progression in patients with metastatic colorectal cancer, according to the results of a phase II study published in Cancer Discovery.


These methods could inform clinicians about the “timing of clinical decisions and future treatment strategies,” according to researchers led by Nicola Valeri, MD, PhD, team leader in gastrointestinal cancer biology and genomics at the Institute of Cancer Research, London, and consultant medical oncologist at the Royal Marsden NHS Foundation Trust.

According to the study, although clinicians often use tumor biopsies for cancer genotyping, many tumors have intratumor heterogeneity that can drive treatment resistance. Therefore, multiple biopsies in time and space could help provide a better understanding on how tumors evolve to resist therapy.

Valeri and colleagues analyzed the results of the PROSPECT-C trial, a study looking at biomarkers of response and resistance to anti–epidermal growth factor receptor (EGFR) treatments in patients with KRAS/NRAS wild-type chemorefractory metastatic colorectal cancer. The trial included 47 patients enrolled from November 2012 – December 2016. Patients had tumor biopsies at regular time points at baseline, disease progression, and at partial response in some patients. Patients also provided plasma samples every 4 weeks until disease progression.

Analysis of baseline cfDNA showed that 50% of patients with tumors defined as RAS wild-type based on tissue analysis that harbored aberrations in the RAS pathway in pretreatment cfDNA. These aberrations could explain why patients were resistant to the EGFR inhibitor cetuximab. Patients with aberrations in the RAS pathways were associated with worse progression free (hazard ratio [HR] = 3.41) and overall survival (HR = 2.78) compared with wild-type disease.

Valeri and colleagues developed models that used both cfDNA and carcinoembryonic antigen levels from plasma to predict time to progression. They validated their findings using RECIST measurements taken from radiological imaging data. This model was applied to 6 patients to predict time to clinical progression; of the predictions, 3 were within 10% of progression time as measured by RECIST.

“Integration of novel monitoring technologies like cfDNA, in combination with mathematical modeling of tumor forecasting, may offer the opportunity to act early, stop therapy, or change treatment to stay one step ahead of the disease,” Valeri said in a press release. “Our method allows for a more accurate prediction as well as improved monitoring of response to therapy.”

The researchers acknowledged several limitations to the study including its small size and its focus solely on the RAS pathways. The ability of the model to predict time to progression will need to be validated in other prospective clinical trials, the researchers wrote.
cancer  genomics  modeling 
10 days ago by cnk

« earlier    

related tags

2018  21k  3d-printing  3d  aam  adobe  adversary  aec  ai  airbrush  algorithm-modeling  algorithms  alias  aligment  analytics  and  angular  animation  annalowenhaupttsing  annatsing  application  applications  archi  archimate  architect  architecture  architecture_site  artificialintelligence  athiesm  atmosphere  attention  autodesk  b2b  backlash  bayesian  berrisford  blender  bon  book  books:noted  bpmn  buildings  bus  business  cad  calibration  can  cancer  canon  canopen  capitalism  case-fic  cellular_automata  cfd  cg  charts  choices  cinema4d  climate  cloud  code-generation  comments  computergraphics  computing  cost-effectiveness-analysis  coursera  css  ctl  dashboard  data  database  decision.models  decisions  deeplearning  design  dev-ops  development  diagram  diagrams  digitalfabrication  documentation  documenting  domain  drafting  drawing  ecology  econometrics  economic-models  economics  ecosystems  eda  energy  enterprise  enterprisearchitecture  environment  evidence  examples  exploration-and-exploitation  fem  financial  forecasting  fowler  framework  free  freeware  functional-programming  fusion360  futures  gametheory  gan  generator  genomics  geometry  geometryprocessing  girls  global  google-trends  google  grads  graphics  graphql  grasshopper  guide  hdl  heat  heron  hobby  howto  image  immigration  in  java  jenner  js  kendall  labeling  labels  ladybug  language  learning-by-watching  learnprogramming  logo  look-a-like  machinelearning  markovchains  math  mathematics  mcmc  mechatronics  mesh  meshes  metropolis-hastings  might-it-be-distraction?  ml  model  modelling  movies  multi-state-modeling  netlogo  neuralnets  nlp  nosql  nrcs  oligopoly  omg  online  oo  opensource  oriented  over  paint  painting  pattern  pdf  photogrammetry  photos  physics  planetary  pocket-article  polygons  porn  positive  post-apocalypse  postgres  prediction  prioritization  probability  process  productivity  programming  psu  psychology  py  pymc3  python  qr  r-project  r  react  recent  reconstruction  registered  regression  relational  religion  render  rendering  research  responds  review  rhino  roundtrip  rtl  saas  scan  scanning  scheme  scilab/scicos  sculpture  security  service  shape  simulation  snow  soa  social_science  society  software-engineering  software  sparse  sql  stability  stan  startrek  startup  statistics  stats  stochastics  storm  stream-processing  surface  survival-analysis  sysml  systems  systemsthinking  technique  tegabrain  testing  text-processing  textbook  textmining  texture  time-series  time  to  to:nb  to_teach:data_over_space_and_time  togaf  tool  tools  topic  topicmodeling  trade  traffic  transformation  transit  transportation  trivia  tuning  tutorial  tutorials  tya  typescript  uml  urban  usa  verilog  videos  visualization  vlsi  vr  water  weather  web  will/hannibal  wisdom-of-crowds  wmur  wsdl 

Copy this bookmark:



description:


tags: