meta:research   33

Why read old philosophy? | Meteuphoric
(This story would suggest that in physics students are maybe missing out on learning the styles of thought that produce progress in physics. My guess is that instead they learn them in grad school when they are doing research themselves, by emulating their supervisors, and that the helpfulness of this might partially explain why Nobel prizewinner advisors beget Nobel prizewinner students.)

The story I hear about philosophy—and I actually don’t know how much it is true—is that as bits of philosophy come to have any methodological tools other than ‘think about it’, they break off and become their own sciences. So this would explain philosophy’s lone status in studying old thinkers rather than impersonal methods—philosophy is the lone ur-discipline without impersonal methods but thinking.

This suggests a research project: try summarizing what Aristotle is doing rather than Aristotle’s views. Then write a nice short textbook about it.
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june 2018 by nhaliday
Alzheimers | West Hunter
Some disease syndromes almost have to be caused by pathogens – for example, any with a fitness impact (prevalence x fitness reduction) > 2% or so, too big to be caused by mutational pressure. I don’t think that this is the case for AD: it hits so late in life that the fitness impact is minimal. However, that hardly means that it can’t be caused by a pathogen or pathogens – a big fraction of all disease syndromes are, including many that strike in old age. That possibility is always worth checking out, not least because infectious diseases are generally easier to prevent and/or treat.

There is new work that strongly suggests that pathogens are the root cause. It appears that the amyloid is an antimicrobial peptide. amyloid-beta binds to invading microbes and then surrounds and entraps them. ‘When researchers injected Salmonella into mice’s hippocampi, a brain area damaged in Alzheimer’s, A-beta quickly sprang into action. It swarmed the bugs and formed aggregates called fibrils and plaques. “Overnight you see the plaques throughout the hippocampus where the bugs were, and then in each single plaque is a single bacterium,” Tanzi says. ‘

obesity and pathogens:
not sure about this guy, but interesting:
All too often we see large, long-lasting research efforts that never produce, never achieve their goal.

For example, the amyloid hypothesis [accumulation of amyloid-beta oligomers is the cause of Alzheimers] has been dominant for more than 20 years, and has driven development of something like 15 drugs. None of them have worked. At the same time the well-known increased risk from APOe4 has been almost entirely ignored, even though it ought to be a clue to the cause.

In general, when a research effort has been spinning its wheels for a generation or more, shouldn’t we try something different? We could at least try putting a fraction of those research dollars into alternative approaches that have not yet failed repeatedly.

Mostly this applies to research efforts that at least wish they were science. ‘educational research’ is in a special class, and I hardly know what to recommend. Most of the remedial actions that occur to me violate one or more of the Geneva conventions.

APOe4 related to lymphatic system:
Look,if I could find out the sort of places that I usually misplace my keys – if I did, which I don’t – I could find the keys more easily the next time I lose them. If you find out that practitioners of a given field are not very competent, it marks that field as a likely place to look for relatively easy discovery. Thus medicine is a promising field, because on the whole doctors are not terribly good investigators. For example, none of the drugs developed for Alzheimers have worked at all, which suggests that our ideas on the causation of Alzheimers are likely wrong. Which suggests that it may (repeat may) be possible to make good progress on Alzheimers, either by an entirely empirical approach, which is way underrated nowadays, or by dumping the current explanation, finding a better one, and applying it.

You could start by looking at basic notions of field X and asking yourself: How do we really know that? Is there serious statistical evidence? Does that notion even accord with basic theory? This sort of checking is entirely possible. In most of the social sciences, we don’t, there isn’t, and it doesn’t.

Hygiene and the world distribution of Alzheimer’s disease: Epidemiological evidence for a relationship between microbial environment and age-adjusted disease burden:

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease:

Fungus, the bogeyman:
Fungus and dementia
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july 2017 by nhaliday
Thoughts on graduate school | Secret Blogging Seminar
I’ll organize my thoughts around the following ideas.

- Prioritize reading readable sources
- Build narratives
- Study other mathematician’s taste
- Do one early side project
- Find a clump of other graduate students
- Cast a wide net when looking for an advisor
- Don’t just work on one thing
- Don’t graduate until you have to
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september 2016 by nhaliday

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