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Does marijuana use really cause psychotic disorders? | Carl L Hart and Charles Ksir | Opinion | The Guardian
Alex Berenson says the drug causes ‘sharp increases in murders and aggravated assaults’. As scientists, we find his claims misinformed and reckless
3 days ago by asterisk2a
New Yorker article about marijuana strikes nerve with pot researchers | The Seattle Times
The joint you smoked last night isn’t going to give you schizophrenia. It also isn’t going to make you go out and assault your neighbor. You might not know that after reading a recent New Yorker article drawing a connection between marijuana use, schizophrenia and violent crimes in Washington. Beatriz Carlini, a senior research scientist at the UW's Alcohol & Drugs Abuse Institute, and Denise Walker, research associate professor of social work at the UW, are quoted.
Carlini.Beatriz  Alcohol.Drug.Abuse.Institute  !UWitM  2019  regl  Seattle.Times  marijuana  Walker.Denise  School:Social.Work 
5 days ago by uwnews
The Triple Play: Pubescent Boys, Pot, and Paranoia | American Journal of Psychiatry
Results showed that for each year the boys used marijuana 52 times or more (“weekly use”), they had a 21% increase in the number of subsequent psychotic symptoms. Similarly, for each year of weekly use, the odds of experiencing paranoia increased by 133% and hallucinations by 92%. Importantly, the risk of psychosis following marijuana exposure increased even after at least a year of abstinence.
8 days ago by craniac
Is CBD a Miracle Cure or a Marketing Scam? (Both.) -
A recent migraine clinical trial, for instance, used 200 milligrams of CBD daily. A highly rated and reviewed one-ounce bottle of hemp oil I found online delivers 8.33 milligrams of CBD per serving and contains a total of 30 servings. A person would need to consume nearly a bottle per day to achieve the therapeutic effects seen in peer-reviewed CBD studies.

Various CBD products available on Amazon contain roughly the same amount or a few milligrams more per dose—still nowhere close to the therapeutic doses used in research.

Several studies have shown that CBD has a "bell-shaped dose-response curve," as one Brazilian report notes. In that study, which tested CBD as a treatment for anxiety in adults, 57 men were divided into four groups and given three different doses of CBD, plus a placebo. The group that received 300 mg of CBD had the best results, while the placebo group, the 150 mg group, and the 600 mg group fared much worse. There is, in other words, a sweet spot.

There's no question that the explosion of CBD products is creating serious confusion, and consumers are left to try to sort the wheat from the chaff without a lot of help"

While it does contain trace amounts of cannabidiol, all of the clinical research into CBD to date has used derivatives of the marijuana plant, not hemp.

"Many lower-quality producers use hemp oil imported from overseas," West explains in an email. The vast majority of CBD products available on sites like Amazon, for instance, use CBD derived from hemp, and many vendors are not clear about where that hemp was grown.

Consumers know only what they see on the label and in most cases have no third party to help them make decisions. As a result, the paper's authors warned, consumers are ignorant of the "residual presence of toxic solvents used during the extraction procedure" and do not know whether a formulation contains heavy metals absorbed from soil, excessive pesticides sprayed on the plants themselves, or non-CBD drugs designed to give users the sense that the product "works." In 2016, the Food and Drug Administration (FDA) tested 13 different CBD products and found that only two of them contained the amount of CBD listed on the label.

the market has been flooded with crappy products created by companies, both foreign and domestic, hoping to cash in on the hype.

It is against the law for any researcher in the U.S. to test a domestic CBD formulation against Epidiolex in a randomized, controlled trial.
Every year, the FDA sends hundreds of warnings like that one to manufacturers across the United States. What made its letter to the Stanleys so remarkable is that the brothers had created a drug that demonstrably treats the seizures associated with Dravet syndrome but were being told they could not say so. "To be in good standing with the Food and Drug Administration's (FDA) regulations, we simply cannot speak about our product in relation to any disease."

"Researchers in the United States face cumbersome and antiquated barriers to studying CBD, THC, and other compounds contained in marijuana, in part because the Controlled Substances Act has installed cops and prosecutors as the arbiters of what scientists and doctors can investigate and learn."
CBD  marijuana  confusion  research  treat  seizure  epilepsy  against  FDA 
8 days ago by dandv

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