mammary   11

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RT : Fabulous new pre-print from the lab looking at mechanobiology - I think everyone can appre…
mammary  from twitter_favs
may 2019 by cshier
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours : Nature Cell Biology : Nature Research
whew - very complicated - lgr6 seems to mark unipotent progenitors that can be either basal or luminal(!). However, it seem mainly to mark luminal tumors - is present in PyMT tumors but not some chemically induced basal tumors....Might be interesting to see if lgr6 expression is up or down in the areg KO tumors?
lgr6  mammary_stem_cells  PyMT  luminal_cells  mammary  gland  basal_cells 
march 2017 by Segalllab
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks: Cell Reports
did expression analysis of basal, luminal progenitor, luminal and mesenchymal stem cells as well as methylation analysis. expression analysis uploaded to server as pellacani et al in useful microarray data sets
mammary  gland  luminal_cells  basal_cells  stroma  gene_expression  methylation 
march 2017 by Segalllab
Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids : Nature Communications
Looks like a significant step forward in understanding the interepithelial signaling - I don't think any stromal cell contributions are present here.
"Basal cells secrete Nrg1, resulting in Nrg1/ErbB signalling activation in luminal cells, promoting luminal progenitor cell expansion and differentiation. In contrast, progesterone-stimulated Wnt4 secretion by luminal ER+ cells, alongside R-spondin 1 produced by luminal ER− cells, activate Wnt signalling in the basal stem/progenitor cell population via the Wnt receptors Fz and Lrp5/6 and the R-spondin 1 receptor Lgr5. Wnt signalling activation in this compartment is likely to promote growth and differentiation of the basal cell layer. Fz, frizzled; Lgr5, leucine-rich repeat-containing G-protein-coupled receptor 5; Lrp5/6, low-density lipoprotein receptor-related protein 5/6."
organoid  mammary  gland  NRG1  wnt  ErbB3  ErbB4  luminal_cells  basal_cells 
february 2017 by Segalllab
Internal Mammary Nodes
In this small cohort, 1–3 presumed normal internal mammary lymph nodes measuring 2–9 mm (mean diameter 4.5 mm) were detected in about half of asymptomatic high-risk women presenting for screening MRI of the breasts.

Internal mammary lymph nodes were more frequently visualized on the left (p < 0.001), at the second and third intercostal spaces

>5mm max diameter susp. PET or US bx

Read More: http://www.ajronline.org/doi/full/10.2214/AJR.14.13586
breast  mri  nodes  internal  mammary 
february 2017 by observer1959

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basal_cells  branching_morphogenesis  breast  erbb3  erbb4  expansion  fave  fgf  gene_expression  gland  human  internal  lgr6  luminal_cells  mammary_development  mammary_stem_cells  mesenchyme  methylation  microarray  mri  myoepithelial_cells  nodes  nrg1  organoid  pymt  stroma  suppressor  top  tumor  wnt 

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