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Early predictors of metabolic syndrome in healthy 7-9 year-olds identified -- ScienceDaily
Markers that may precede the metabolic syndrome and mechanisms that explain these relationships have yet to be identified. These mechanisms may originate in the intrauterine environment, be exacerbated in susceptible populations, such as African Americans and, be further promoted by a genetic predisposition, particularly among African American children. These abnormalities may work synergistically to create a childhood metabolic syndrome phenotype and may originate earlier in youth than previously proposed.

The purpose of the study was to explore potential correlates of insulin sensitivity, fasting insulin, and insulin resistance, and to determine the best model to predict them in young children. The study of more than 100 healthy children, ages 7-9, found that fat in the liver, abdominal fat, and fat oxidation predicted insulin resistance and appear to be early markers for the metabolic syndrome via a mechanism of impaired lipid metabolism and fat oxidation. Impaired metabolic function may be due, in part, to pre-and post natal factors that are modified by current physical activity. Therefore, race, low or high pregnancy weight and/or birth weight, and low physical activity collectively create a phenotype for poor metabolic function leading to increased risk for insulin resistance in young children.

"Although some of the risk factors cannot be changed, pregnancy weight, birth weight, and physical activity can all be modified and are targets for early intervention to prevent or delay insulin resistance and reduce the risk for metabolic syndrome," noted Dr. Sothern, who is the study's principal investigator.
low  birth  weight  risk  metabolic  syndrome  lipids  fats  blood  cholesterol  skeletal  fat  fatty  liver  epigenetic  insulin  resistance  child  development  children  youth  health  disparities  diabetes  teen  diet  body  disorder  etiology  T2D  research  correlation  type  2  factor  public  genetics  genetic  biomarkers  prognosis  diagnosis  screening  in  vivo  human  clinical  trial  prognostic  leg  prenatal  perinatal  breast  feeding  childhood 
4 weeks ago by Michael.Massing
Comparison of low- and high-carbohydrate diets for type 2 diabetes management: a randomized trial. - PubMed - NCBI
Both diets achieved substantial weight loss and reduced HbA1c and fasting glucose. The LC diet, which was high in unsaturated fat and low in saturated fat, achieved greater improvements in the lipid profile, blood glucose stability, and reductions in diabetes medication requirements, suggesting an effective strategy for the optimization of T2D management. This trial was registered at www.anzctr.org.au as ACTRN12612000369820.
low  carbohydrate  carbohydrates  diet  HbA1c  fasting  glucose  lipid  profile  blood  stability  time  in  range  medication  treatment  cholesterol  fats  lipids  unsaturated  saturated  fat  self  dietary  management 
5 weeks ago by Michael.Massing
flaxseed omega 3 too 6 ratio Flaxseed—a potential functional food source
omega 3/6 post
essential oils preferentially inbuilt to cells
anti-inflammatory
foods  lipids  d?  post? 
9 weeks ago by Brian-Green
fiber Effects of dietary inulin on bacterial growth, short-chain fatty acid production and hepatic lipid metabolism in gnotobiotic mice. - PubMed - NCBI
gnotobiotic relating to or denoting an environment for rearing or culturing organisms in which all the microorganisms are either known or excluded.
microbiome  lipids 
12 weeks ago by Brian-Green
leaky gut lipids The Type of Dietary Fat Modulates Intestinal Tight Junction Integrity, Gut Permeability, and Hepatic Toll-Like Receptor Expression in a Mouse Model of Alcoholic Liver Disease
NIH [mct intestinal permeability ] medium chain fatty acids? triglycerides?
corn oil/linoleic acid
Linoleic acid is a polyunsaturated omega-6 fatty acid and is one of two essential fatty acids for humans, who must obtain it through their diet. Wiki
disease  lipids 
12 weeks ago by Brian-Green
CD317 Activates EGFR by Regulating Its Association with Lipid Rafts | Cancer Research
EGFR regulates various fundamental cellular processes, and its constitutive activation is a common driver for cancer. Anti-EGFR therapies have shown benefit in cancer patients, yet drug resistance almost inevitably develops, emphasizing the need for a better understanding of the mechanisms that govern EGFR activation. Here we report that CD317, a surface molecule with a unique topology, activated EGFR in hepatocellular carcinoma (HCC) cells by regulating its localization on the plasma membrane. CD317 was upregulated in HCC cells, promoting cell-cycle progression and enhancing tumorigenic potential in a manner dependent on EGFR. Mechanistically, CD317 associated with lipid rafts and released EGFR from these ordered membrane domains, facilitating the activation of EGFR and the initiation of downstream signaling pathways, including the Ras–Raf–MEK–ERK and JAK–STAT pathways. Moreover, in HCC mouse models and patient samples, upregulation of CD317 correlated with EGFR activation. These results reveal a previously unrecognized mode of regulation for EGFR and suggest CD317 as an alternative target for treating EGFR-driven malignancies.
EGFR  lipids  rafts 
june 2019 by Segalllab
Effects of detergents on the redistribution of gangliosides and GPI-anchored proteins in brain tissue sections. - PubMed - NCBI
> Gangliosides and glycosylphosphatidylinositol (GPI)-anchored proteins contain lipid tails that tether them to the outer side of the cell membrane. This mode of association with the cell membrane enables them to take part in the organization of lipid rafts, but it also permits gangliosides and GPI-anchored proteins to be actively released from one cell and inserted into the membrane of another cell. Recently, we reported that under conditions of lipid raft isolation, Triton X-100 causes significant redistribution of both gangliosides and GPI-anchored proteins. Aiming to find a less disruptive detergent, we evaluated the effects of CHAPS, Saponin, deoxycholic acid, Trappsol, Tween 20, Triton X-100, Brij 96V, Brij 98, and SDS on brain tissue sections. At room temperature, all detergents (1% concentration) extracted significant amounts of both gangliosides and Thy-1. At 4C, the extraction was weaker, but Triton X-100, CHAPS, and deoxycholic acid caused significant redistribution of GD1a and Thy-1 from gray matter into the white matter. Both redistribution and extraction were significantly augmented when sections were incubated with detergents in the presence of primary antibodies. Of the nine tested detergents, none is the ideal choice. However, Brij 96V appears to be able to suffici
detergent  SDS  lipids 
march 2019 by porejide
perilla oil Effects of perilla oil on plasma concentrations of cardioprotective (n-3) fatty acids and lipid profiles in mice
Dr Gundry
Perilla oil, which contains a very high level of ALA (40-64%) similar to flaxseed oil, has been reported to shows anti-atherosclerosis properties in Japanish quail [13,14]. Dietary flaxseed meal exerts protective effects against hypertriglyceridemia and steatosis of the liver in an animal model of obesity [15].

The purpose of this study was to evaluate the effects of dietary perilla oil as well as several vegetable oils on plasma lipid profiles and cardioprotective (n-3) PUFA levels in mice.
lipids  functional-foods 
december 2018 by Brian-Green

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