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(4984) Cancer Cure Hits the Market! [Car-T Cells] - YouTube
advances in immunotherapy- first version was dump, 2nd version "targeted", 3rd gen - reprogramming? immunotherapy
Cancer  immunotherapy  immune  system  CAR-T  cells  autoimmune  disease 
5 weeks ago by asterisk2a
What Does a “Normal” Human Genome Look Like? | Science
So, what have our first glimpses of variation in the genomes of generally healthy people taught us? First, balancing selection, the evolutionary process that favors genetic diversification rather than the fixation of a single “best” variant, appears to play a minor role outside the immune system. Local adaptation, which accounts for variation in traits such as pigmentation, dietary specialization, and susceptibility to particular pathogens is also a second-tier player. What is on the top tier? Increasingly, the answer appears to be mutations that are “deleterious” by biochemical or standard evolutionary criteria. These mutations, as has long been appreciated, overwhelmingly make up the most abundant form of nonneutral variation in all genomes. A model for human genetic individuality is emerging in which there actually is a “wild-type” human genome—one in which most genes exist in an evolutionarily optimized form. There just are no “wild-type” humans: We each fall short of this Platonic ideal in our own distinctive ways.
article  essay  org:nat  🌞  bio  biodet  genetics  genomics  mutation  genetic-load  QTL  evolution  sapiens  survey  summary  coding-theory  enhancement  signal-noise  egalitarianism-hierarchy  selection  tradeoffs  immune  recent-selection  perturbation  nibble  ideas 
8 weeks ago by nhaliday
Gut bacteria 'boost' cancer therapy - BBC News
Two studies, in the journal Science, linked specific species and the overall diversity of the microbiome to the effectiveness of immunotherapy drugs. [...] Those that responded to therapy tended to have a richer, more diverse microbiome than those that did not.
Cancer  microbiome  immunotherapy  epigenetics  chronic  sick  inflammation  autoimmune  disease  gut  leaky  diet  lifestyle  S.A.D.  western  public  health  immune  system  immunesystem  antibiotic  antibiotics  post-antibiotic  chemotherapy 
10 weeks ago by asterisk2a
How to Stop Attacking Yourself: 9 Steps to Heal Autoimmune Disease - Dr. Mark Hyman
tion like yoga, deep breathing, biofeedback, or massage, because stress worsens the immune response.
immune  system 
11 weeks ago by nauce
Measles and immunological amnesia | West Hunter
A new paper in Science , by Michael Mina et al,  strongly suggests that measles messes up your immunological defenses for two or three years. This is the likely explanation for the fact that measles inoculation causes much greater decreases in child morbidity and mortality than you’d expect from preventing the deaths directly due to measles infection. The thought is that measles whacks the cells that carry immunological memory, leaving the kid ripe for reinfections.  I think there can be a similar effect with anti-cancer chemotherapy.

If correct, this means that measles is much nastier than previously thought. It must have played a significant role in the demographic collapse of long-isolated peoples (such as the Amerindians). Its advent may have played a role in the population decrease associated with the decline of the Classical world.  Even though it is relatively new (having split off from rinderpest a couple of thousand years ago) strong selection for resistance may have  favored some fairly expensive genetic defenses (something like sickle-cell) in Eurasian populations.

We already know of quite a few complex side effects of infectious disease, such the different kind of immunosuppression we see with AIDs, Burkitt’s lymphoma hitting kids with severe Epstein-Barr infections followed by malaria, acute dengue fever that requires a previous infection by a different strain of dengue, etc: there may well be other important interactions and side effects, news of which has not yet come to Harvard.
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12 weeks ago by nhaliday

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