il1alpha   5

Proinvasive extracellular matrix remodeling in tumor microenvironment in response to radiation | Oncogene
I wonder if macrophages could provide the IL1A to trigger HA to stimulate CD44...

Ionizing radiation is widely used for patient with glioblastoma (GBM). However, the effect of radiation on patient survival is marginal and upon recurrence tumors frequently shift toward mesenchymal subtype adopting invasiveness. Here, we show that ionizing radiation affects biomechanical tension in GBM microenvironment and provides proinvasive extracellular signaling cue, hyaluronic acid (HA)-rich condition. In response to radiation, HA production was increased in GBM cells by HA synthase-2 (HAS2) that was transcriptionally upregulated by NF-ĸB. Notably, NF-ĸB was persistently activated by IL-1α-feedback loop, making HA abundance in tumor microenvironment after radiation. Radiation-induced HA abundance causally has been linked to invasiveness of GBM cells by generating movement track as an extracellular matrix, and by acting as a signaling ligand for CD44 receptor, leading to SRC activation, which is sufficient for mesenchymal shift of GBM cells. Collectively, our findings provide an explanation for the frequent brain tumor relapse after radiotherapy, and potential therapeutic targets to block mesenchymal shift upon relapse.
radiation  il1alpha  nfkb  hyaluronic_acid  U87 
6 weeks ago by Segalllab
Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells: Molecular Membrane Biology: Vol 33, No 1-2
Say that conditioned medium from 231 and zr-75-30 cells affects huvecs. They also look at chemokines in the medium - IL8, VEGF, and IL1A are present in the 231 medium. Blocking IL8 or VEGF did not affect the morphological change
HUVEC  231_cells  IL8  VEGFA  il1alpha  zr-75-30 
january 2017 by Segalllab
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes : Nature Communications : Nature Publishing Group
discussion of mechanisms of IL1A and IL1B release in monocytes - which is different from macrophage mechansims. Also may be specific for human monocytes - they say mouse are much less sensitive .
il1alpha  il1b  human  monocytes  Macrophage  lps  tlr4  src 
february 2016 by Segalllab
Reciprocal Interaction between Carcinoma-Associated Fibroblasts and Squamous Carcinoma Cells through Interleukin-1α Induces Cancer Progression
Interleukin-1α (IL-1α) secreted from OSCC cells had dual effects on CAFs: IL-1α not only promoted the proliferation of CAFs but also upregulated the secretion of cytokines in CAFs such as CCL7, CXCL1, and IL-8. Possiblly IL1A from macrophages could have the same effect on nearby CAFs for a 3 cell interaction?
il1alpha  ccl7  cxcl12  IL8  caf 
february 2015 by Segalllab
Tumour-infiltrating Gr-1 myeloid cells antagonize senescence in cancer : Nature : Nature Publishing Group
they have for prostate cancer that CXCR2 agonists attract Gr1 positive cells that secrete the IL1R antagonist IL1RN to suppress senescence in some way. Gr1+ cells are probably MDSC/immature neutrophils but still. In the Laureen Ojalvo data, the invasive macrophages have significantly reduced IL1RN and IL1alpha. Not sure what to make of this but FYI.
CXCR2  il1alpha  il1rn  senescence 
december 2014 by Segalllab

related tags

231_cells  caf  ccl7  cxcl12  cxcr2  human  huvec  hyaluronic_acid  il1b  il1rn  il8  lps  macrophage  monocytes  nfkb  radiation  senescence  src  tlr4  u87  vegfa  zr-75-30 

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