human-study   16

Of mice and men: why animal trial results don’t always translate to humans
It showed that of the most-cited animal studies in prestigious scientific journals, such as Nature and Cell, only 37% were replicated in subsequent human randomised trials and 18% were contradicted in human trials. It is safe to assume that less-cited animal studies in lesser journals would have an even lower strike rate.
news  org:mag  org:edu  science  meta:science  medicine  meta:medicine  model-organism  human-study  homo-hetero  data  pro-rata  org:nat  replication  methodology 
september 2017 by nhaliday
Is soy good or bad for me? |
The estimated per capita consumption of soybean oil increased >1000-fold from 1909 to 1999. (increase started during 60s)

Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis:
No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model.
some good ones:
pros and cons:
reproductive consequences:
visuospatial memory:
reject (in humans)t:
A: yes
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may 2017 by nhaliday
Bisphenol A (BPA)
Alternatives to BPA containers not easy for U.S. foodmakers to find:

Food is main source of BPA for consumers, thermal paper also potentially significant:
New data resulting from an EFSA call for data led to a considerable refinement of exposure estimates compared to 2006. For infants and toddlers (aged 6 months-3 years) average exposure from the diet is estimated to amount to 375 nanograms per kilogram of body weight per day (ng/kg bw/day) whereas for the population above 18 years of age (including women of child-bearing age) the figure is up to 132 ng/kg bw/day. By comparison, these estimates are less than 1% of the current Tolerable Daily Intake (TDI) for BPA (0.05 milligrams/kg bw/day) established by EFSA in 2006.

For all population groups above three years of age thermal paper was the second most important source of BPA after the diet (potentially accounting for up to 15% of total exposure in some population groups).

Among other key findings, scientists found dietary exposure to BPA to be the highest among children aged three to ten (explainable by their higher food consumption on a body weight basis). Canned food and non-canned meat and meat products were identified as major contributors to dietary BPA exposure for all age groups.

Tips for Avoiding BPA in Canned Food:

Holding Thermal Receipt Paper and Eating Food after Using Hand Sanitizer Results in High Serum Bioactive and Urine Total Levels of Bisphenol A (BPA):

Bisphenol S Disrupts Estradiol-Induced Nongenomic Signaling in a Rat Pituitary Cell Line: Effects on Cell Functions:
common substitute for BPA

Effect of probiotics, Bifidobacterium breve and Lactobacillus casei, on bisphenol A exposure in rats:

What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?:
Food is a main source of DiBP, DnBP, and DEHP in consumers. In this case, consumers have very few possibilities to effectively reduce their exposure.

Are endocrine disrupting compounds a health risk in drinking water?:

How to Avoid Phthalates (Even Though You Can't Avoid Phthalates):
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january 2017 by nhaliday
Ten Putative Contributors to the Obesity Epidemic
The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects, as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors.
study  meta-analysis  survey  obesity  health  hypochondria  assortative-mating  sleep  model-organism  human-study  🐸  endocrine  metabolic  biodet  epigenetics  epidemiology  sociology  public-health  recent-selection 
january 2017 by nhaliday
Population attributable risks and costs of diabetogenic chemical exposures in the elderly -- Trasande et al. -- Journal of Epidemiology & Community Health
Reduction of chemical exposures was associated with a 13% (95% CI 2% to 22%) reduction in prevalent diabetes, compared with 40% resulting from an identical (25%) reduction in body mass index (BMI) in cross-sectional analyses.
study  embodied  hypochondria  health  fitness  disease  obesity  🐸  medicine  embodied-street-fighting  prediction  human-study  metabolic  biodet  epidemiology  intervention  comparison  effect-size  public-health 
december 2016 by nhaliday
Exposure to exogenous estrogen through intake of commercial milk produced from pregnant cows - Maruyama - 2009 - Pediatrics International - Wiley Online Library
7 men, 6 children, 5 women
After the intake of cow milk, serum estrone (E1) and progesterone concentrations significantly increased, and serum luteinizing hormone, follicle-stimulating hormone and testosterone significantly decreased in men. Urine concentrations of E1, estradiol, estriol and pregnanediol significantly increased in all adults and children. In four out of five women, ovulation occurred during the milk intake, and the timing of ovulation was similar among the three menstrual cycles.

mice study w/ n=60:
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december 2016 by nhaliday
Physical activity in adulthood: genes and mortality : Scientific Reports
Observational studies report a strong inverse relationship between leisure-time physical activity and all-cause mortality. Despite suggestive evidence from population-based associations, scientists have not been able to show a beneficial effect of physical activity on the risk of death in controlled intervention studies among individuals who have been healthy at baseline. On the other hand, high cardiorespiratory fitness is known to be a strong predictor of reduced mortality, even more robust than physical activity level itself. Here, in both animals and/or human twins, we show that the same genetic factors influence physical activity levels, cardiorespiratory fitness, and risk of death. Previous observational follow-up studies in humans suggest that increasing fitness through physical activity levels could prolong life; however, our controlled interventional study with laboratory rats bred for low and high intrinsic fitness contrast with these findings. Also, we find no evidence for the suggested association using pairwise analysis among monozygotic twin pairs who are discordant in their physical activity levels. Based on both our animal and human findings, we propose that genetic pleiotropy might partly explain the frequently observed associations between high baseline physical activity and later reduced mortality in humans.
study  longevity  aging  genetics  fitness  idk  fitsci  variance-components  genetic-correlation  twin-study  evidence-based  🌞  org:nat  environmental-effects  c:**  biodet  intervention  cardio  hmm  null-result  human-study  model-organism  solid-study  multi  reddit  social  commentary  ssc  gwern  ratty 
september 2016 by nhaliday
What is up with carbon dioxide and cognition? An offer - Less Wrong Discussion
n=22, p-values < .001 generally, no multiple comparisons or anything, right?
- note it's CO2 not oxygen that's relevant
- some interesting debate in comments about whether you would find similar effects for similar levels of variation in oxygen, implications for high-altitude living, etc.
- CO2 levels can range quite to quite high levels indoors (~1500, and even ~7000 in some of Gwern's experiments); this seems to be enough to impact cognition to a significant degree
- outdoor air quality often better than indoor even in urban areas (see other studies)

the solution: houseplants,
except that environmental instability tends to be harder on more 'complex' adaptations and co2 ppm directly correlates with decreased effectiveness of cognition-enhancing traits vis chronic low-grade acidosis
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may 2016 by nhaliday

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