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This project on NEEDS replies from boys & men. They need to gather data o…
cervicalcancer  cerviccheck  btyste  hpv  from twitter_favs
6 weeks ago by aidan_walsh
A lowered probability of pregnancy in females in the USA aged 25-29 who received a human papillomavirus vaccine injection. - PubMed - NCBI
Results suggest that females who received the HPV shot were less likely to have ever been pregnant than women in the same age group who did not receive the shot. If 100% of females in this study had received the HPV vaccine, data suggest the number of women having ever conceived would have fallen by 2 million. Further study into the influence of HPV vaccine on fertility is thus warranted.
6 weeks ago by literal
Age limit for HPV vaccine just went up, so should you get it? | BottomLine
The age limit for getting the HPV vaccine was increased to 45, but what does that really mean if you’re over the previous ceiling of age 26? Source is Anna Wald, UW Medicine infectious disease specialist.
!UWM  Area:InfectiousDisease  Area:Epidemiology  HPV  vaccination  STDs 
7 weeks ago by UWMedicine
FDA approves HPV vaccine for people up to 45 - The Washington Post
The Food and Drug Administration expanded its approval of the HPV vaccine to include men and women between 27 and 45, an effort to protect more people from several types of cancer caused by the human papillomavirus. via Pocket
via-IFTTT  via-Pocket  health  hpv  medicine  news  vaccines  via-Diigo 
october 2018 by evansthompson
HPV Vaccine Expanded for People Ages 27 to 45 - The New York Times
older people will need three shots, spaced a few months apart

If a person has already been exposed to a particular strain of HPV, the vaccine will not work against that strain. For that reason, vaccination has been strongly recommended for young people before they become sexually active.

But even someone who has already been exposed to a few strains — but not to all nine in the vaccine — can still gain protection against the strains they have not encountered.
HPV  vaccine  health  breakthrough 
october 2018 by dandv
Australia to 'eliminate' cervical cancer by 2028 - CNN
Australia will be free of cervical cancer within 20 years, says a new study, thanks to national vaccination and screening programs.
october 2018 by dougleigh
Attenuated TRAF3 Fosters Activation of Alternative NF-κB and Reduced Expression of Antiviral Interferon, TP53, and RB to Promote HPV-Positive Head and Neck Cancers | Cancer Research
combine tnfa with cisplatin for chemotherapy ?

Human papilloma viruses (HPV) are linked to an epidemic increase in oropharyngeal head and neck squamous cell carcinomas (HNSCC), which display viral inactivation of tumor suppressors TP53 and RB1 and rapid regional spread. However, the role of genomic alterations in enabling the modulation of pathways that promote the aggressive phenotype of these cancers is unclear. Recently, a subset of HPV+ HNSCC has been shown to harbor novel genetic defects or decreased expression of TNF receptor–associated factor 3 (TRAF3). TRAF3 has been implicated as a negative regulator of alternative NF-κB pathway activation and activator of antiviral type I IFN response to other DNA viruses. How TRAF3 alterations affect pathogenesis of HPV+ HNSCC has not been extensively investigated. Here, we report that TRAF3-deficient HPV+ tumors and cell lines exhibit increased expression of alternative NF-κB pathway components and transcription factors NF-κB2/RELB. Overexpression of TRAF3 in HPV+ cell lines with decreased endogenous TRAF3 inhibited NF-κB2/RELB expression, nuclear localization, and NF-κB reporter activity, while increasing the expression of IFNA1 mRNA and protein and sensitizing cells to its growth inhibition. Overexpression of TRAF3 also enhanced TP53 and RB tumor suppressor proteins and decreased HPV E6 oncoprotein in HPV+ cells. Correspondingly, TRAF3 inhibited cell growth, colony formation, migration, and resistance to TNFα and cisplatin-induced cell death. Conversely, TRAF3 knockout enhanced colony formation and proliferation of an HPV+ HNSCC line expressing higher TRAF3 levels. Together, these findings support a functional role of TRAF3 as a tumor suppressor modulating established cancer hallmarks in HPV+ HNSCC.

Significance: These findings report the functional role of TRAF3 as a tumor suppressor that modulates the malignant phenotype of HPV+ head and neck cancers. Cancer Res; 78(16);
HPV  HNSCC  chemotherapy  nfkb 
august 2018 by Segalllab
The molecular landscape of head and neck cancer | Nature Reviews Cancer
good summary of hnscc development and molecular evaluations
HNSCC  tcga  HPV  p53  E6  E7 
august 2018 by Segalllab

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