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What are the Laws of Biology?
The core finding of systems biology is that only a very small subset of possible network motifs is actually used and that these motifs recur in all kinds of different systems, from transcriptional to biochemical to neural networks. This is because only those arrangements of interactions effectively perform some useful operation, which underlies some necessary function at a cellular or organismal level. There are different arrangements for input summation, input comparison, integration over time, high-pass or low-pass filtering, negative auto-regulation, coincidence detection, periodic oscillation, bistability, rapid onset response, rapid offset response, turning a graded signal into a sharp pulse or boundary, and so on, and so on.

These are all familiar concepts and designs in engineering and computing, with well-known properties. In living organisms there is one other general property that the designs must satisfy: robustness. They have to work with noisy components, at a scale that’s highly susceptible to thermal noise and environmental perturbations. Of the subset of designs that perform some operation, only a much smaller subset will do it robustly enough to be useful in a living organism. That is, they can still perform their particular functions in the face of noisy or fluctuating inputs or variation in the number of components constituting the elements of the network itself.
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november 2017 by nhaliday
What is the connection between special and general relativity? - Physics Stack Exchange
Special relativity is the "special case" of general relativity where spacetime is flat. The speed of light is essential to both.
nibble  q-n-a  overflow  physics  relativity  explanation  synthesis  hi-order-bits  ground-up  gravity  summary  aphorism  differential  geometry 
november 2017 by nhaliday
What is the difference between general and special relativity? - Quora
General Relativity is, quite simply, needed to explain gravity.

Special Relativity is the special case of GR, when the metric is flat — which means no gravity.

You need General Relativity when the metric gets all curvy, and when things start to experience gravitation.
nibble  q-n-a  qra  explanation  physics  relativity  synthesis  hi-order-bits  ground-up  gravity  summary  aphorism  differential  geometry 
november 2017 by nhaliday
If Quantum Computers are not Possible Why are Classical Computers Possible? | Combinatorics and more
As most of my readers know, I regard quantum computing as unrealistic. You can read more about it in my Notices AMS paper and its extended version (see also this post) and in the discussion of Puzzle 4 from my recent puzzles paper (see also this post). The amazing progress and huge investment in quantum computing (that I presented and update  routinely in this post) will put my analysis to test in the next few years.
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november 2017 by nhaliday
“Editor’s Introduction to The New Economic History and the Industrial Revolution,” J. Mokyr (1998) | A Fine Theorem
I taught a fun three hours on the Industrial Revolution in my innovation PhD course this week. The absolutely incredible change in the condition of mankind that began in a tiny corner of Europe in an otherwise unremarkable 70-or-so years is totally fascinating. Indeed, the Industrial Revolution and its aftermath are so important to human history that I find it strange that we give people PhDs in social science without requiring at least some study of what happened.

My post today draws heavily on Joel Mokyr’s lovely, if lengthy, summary of what we know about the period. You really should read the whole thing, but if you know nothing about the IR, there are really five facts of great importance which you should be aware of.

1) The world was absurdly poor from the dawn of mankind until the late 1800s, everywhere.
2) The average person did not become richer, nor was overall economic growth particularly spectacular, during the Industrial Revolution; indeed, wages may have fallen between 1760 and 1830.
3) Major macro inventions, and growth, of the type seen in England in the late 1700s and early 1800s happened many times in human history.
4) It is hard for us today to understand how revolutionary ideas like “experimentation” or “probability” were.
5) The best explanations for “why England? why in the late 1700s? why did growth continue?” do not involve colonialism, slavery, or famous inventions.
econotariat  broad-econ  economics  growth-econ  cjones-like  summary  divergence  industrial-revolution  list  top-n  mokyr-allen-mccloskey  hi-order-bits  aphorism  wealth  wealth-of-nations  malthus  revolution  innovation  the-trenches  science  europe  the-great-west-whale  britain  conceptual-vocab  history  early-modern  technology  long-short-run  econ-metrics  data  time-series  conquest-empire  india  asia  scale  attaq  enlightenment-renaissance-restoration-reformation  roots  cycles  flux-stasis  whiggish-hegelian 
october 2017 by nhaliday
Benedict Evans on Twitter: ""University can save you from the autodidact tendency to overrate himself. Democracy depends on people who know they don’t know everything.""
“The autodidact’s risk is that they think they know all of medieval history but have never heard of Charlemagne” - Umberto Eco

Facts are the least part of education. The structure and priorities they fit into matters far more, and learning how to learn far more again
techtariat  sv  twitter  social  discussion  rhetoric  info-foraging  learning  education  higher-ed  academia  expert  lens  aphorism  quotes  hi-order-bits  big-picture  synthesis  expert-experience 
october 2017 by nhaliday
All models are wrong - Wikipedia
Box repeated the aphorism in a paper that was published in the proceedings of a 1978 statistics workshop.[2] The paper contains a section entitled "All models are wrong but some are useful". The section is copied below.

Now it would be very remarkable if any system existing in the real world could be exactly represented by any simple model. However, cunningly chosen parsimonious models often do provide remarkably useful approximations. For example, the law PV = RT relating pressure P, volume V and temperature T of an "ideal" gas via a constant R is not exactly true for any real gas, but it frequently provides a useful approximation and furthermore its structure is informative since it springs from a physical view of the behavior of gas molecules.

For such a model there is no need to ask the question "Is the model true?". If "truth" is to be the "whole truth" the answer must be "No". The only question of interest is "Is the model illuminating and useful?".
thinking  metabuch  metameta  map-territory  models  accuracy  wire-guided  truth  philosophy  stats  data-science  methodology  lens  wiki  reference  complex-systems  occam  parsimony  science  nibble  hi-order-bits  info-dynamics  the-trenches  meta:science  physics  fluid  thermo  stat-mech  applicability-prereqs  theory-practice 
august 2017 by nhaliday

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