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Comparison of Sales Income and Research and Development Costs for FDA-Approved Cancer Drugs Sold by Originator Drug Companies | PracticeUpdate
Comparison of Sales Income and Research and Development Costs for FDA-Approved Cancer Drugs Sold by Originator Drug Companies
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In this observational study of 99 cancer drugs approved by the FDA from 1989 to 2017, the median income return by the end of 2017 was $14.50 (range, $3.30–$55.10) for every $1 of research and development spending. Many drugs, particularly biologics, continued to generate high-sales incomes for the originator companies after expiry of patents and exclusive marketing rights.
Cancer drugs, through high prices, have generated incomes for the companies far in excess of research and development costs; lowering the prices of cancer drugs and facilitating greater competition are essential for improving patient access, financial sustainability of the healthcare system, and future innovation.
cancer  HealthCare  Economics 
yesterday by cnk
Silencing brain cells in mice can make them no longer care about pain | New Scientist
Pain doesn’t have to be painful. That’s the conclusion of a study that identified a set of nerve cells that add emotional content to pain signals in the brains of mice.

The discovery could lead to new treatments for chronic pain that ease patients’ suffering without impairing their ability to sense injuries.

Pain receptors throughout the body detect painful stimuli and send signals via nerves to the brain. But according to Grégory Scherrer at Stanford University, California, these signals don’t have any emotional value until they reach the amygdala, a brain region that deals with emotions. In other words, the unpleasantness of pain is added by the amygdala and is separate to the information that comes from pain receptors.


To see how pain signals are processed in the amygdala, Scherrer and his colleagues added a gene to this region of the brain to make the cells produce a marker that lights up when they are active. The team then identified a group of cells that respond specifically to painful stimuli such as a pin prick or heat.

Read more: How to hack your unconscious… to take control of pain
Next, they silenced these cells by engineering them to express receptors for a drug that turns down their activity. The mice could still detect painful stimuli and withdraw from them, just as you would withdraw your hand if you touched a hot stove.

But they didn’t adopt defensive behaviours, lick their wounds or try to escape as could be normally expected. “It’s as if they don’t care about pain any more, even though they can detect it,” says Scherrer.

The neural circuits for pain have a high degree of similarity across species, so it’s likely that a similar set of cells can be found in humans, says Scherrer. “We’re hoping it’s a new avenue to treat pain,” he says.

New pain drugs are badly needed to replace opioids, which have caused an addiction epidemic in the US that kills 130 people every day. Opioids also don’t normally work for people with damage to their nerve fibres,which can happen as a result of cancer or diabetes.

In mice with nerve injuries, the pain neurons in the amygdala were triggered even by gentle touch. Scherrer plans to look for receptors that are only present on these cells, so that a drug can be developed that targets them specifically.

Journal reference: Science, DOI: 10.1126/science.aap8586
HealthCare  brain 
yesterday by cnk
Increasing the Quality of Patient Care Through Stream Processing
Today’s healthcare technology landscape is disaggregated and siloed. Physicians analyse patient data streams from different systems without much correlation. Even though health-tech domain is mature and rich with data, the value of it is not directed towards increasing the quality of patient care. This article presents a stream processing solution in which streams are co-related.
streamprocessing  healthcare 
yesterday by alpinegizmo
The Fatal Allure of Single Payer | Hoover Institution
The ardent pleas of Bernie Sanders won’t make a socialist system work.
healthcare  policy  america  socialism  rebuttals 
yesterday by Kjaleshire
How Medicare For All Could Become the Leading Cause of Death In America - Foundation for Economic Education
Medicare for All is more a political talking point than a medical solution to improve the overall health outcomes of Americans.
policy  america  studies  healthcare  socialism 
yesterday by Kjaleshire
Anti-vax Movement Listed by World Health Organization as One of the Top 10 Health Threats for 2019
“Vaccine hesitancy” has been identified as one potential factor contributing to the 30 percent increase in measles cases around the world.
healthcare  popularStupidity 
2 days ago by joeybaker

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