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Inhibition of Notch signaling pathway enhanced the radiosensitivity of breast cancer cells - Peng - 2018 - Journal of Cellular Biochemistry - Wiley Online Library
4Gy induced NOTCH1 protein and activation in MCF7/T47D as well as invasion. No analysis of ligands. Possibly look at radiation effects on macrophages?

This study aimed to investigate the effect of inhibiting the Notch signaling pathway on the radiosensitivity of breast cancer cells. Human breast cancer cell lines (MCF‐7 and T47D) were selected and treated with radiation of different doses. Cells were treated with Gamma secretase inhibitor (GSI) to analyze the effects of GSI on the Notch signaling, which were detected by Immunofluorescence assay, RT‐qPCR, and Western blot analysis. Besides, Transwell assay, Scratch test, colony formation assay, MTT assay, and flow cytometry were conducted to show the effects of GSI on the invasion and migration, survival fraction, cell viability, and apoptosis of MCF‐7 and T47D cells after radiation therapy. Moreover, cell transfection with a dominant negative mutant of RBPJ, the key transcription factor of Notch signaling pathway, were also applied to show the inhibition of Notch signaling pathway. Initially, we found that the 4 Gy radiation activated Notch signaling pathway, and enhanced the invasion and migration of MCF‐7 and T47D cells. However, GSI inhibited the Notch signaling pathway, and reversed the enhancement of radiation on the migration and invasion, promoted the enhancement of apoptosis and inhibition of proliferation of MCF‐7 and T47D cells induced by radiation. Except that, we also determined that GSI and dnRBPJ suppressed the upregulation of Notch signaling after radiation therapy. Our study demonstrated that inhibition of the Notch signaling pathway enhanced the radiosensitivity of breast cancer cells, which may provide evident for a beneficial adjuvant therapy in the breast cancer treatment.
Notch  radiation  radiosensitivity  MCF-7  T47D  GSI  invasion 
5 weeks ago by Segalllab
Genasys Spain - Home Page
Genasys is a leading provider of technological products and solutions, based on the geo location of mobile people and objects, offering global positioning (outdoor and indoor all over the world), the most appropriate location precision according to any environment, and scalability to manage high-volume data of millions of users.
GSI  location  spain  research  m2m  ML 
february 2014 by shalmaneser
Genasys Spain - Home Page
Genasys is a leading provider of technological products and solutions, based on the geo location of mobile people and objects, offering global positioning (outdoor and indoor all over the world), the most appropriate location precision according to any environment, and scalability to manage high-volume data of millions of users.
GSI  location  spain  research  m2m  ML 
february 2014 by mgrand
Genasys Spain - Home Page
Genasys is a leading provider of technological products and solutions, based on the geo location of mobile people and objects, offering global positioning (outdoor and indoor all over the world), the most appropriate location precision according to any environment, and scalability to manage high-volume data of millions of users.
GSI  location  spain  research  m2m  ML 
february 2014 by BenNorland
Situational intelligence, Geospatial software, smart grid | Space-Time Insight
Next generation geospatial and visual analytics solutions that transform massive volumes of real-time disparate data into intuitive visual displays everyone in your business can use to make fast informed decisions.
software  mapping  analytics  energy  gsi 
october 2013 by mgrand
Situational intelligence, Geospatial software, smart grid | Space-Time Insight
Next generation geospatial and visual analytics solutions that transform massive volumes of real-time disparate data into intuitive visual displays everyone in your business can use to make fast informed decisions.
software  mapping  analytics  energy  gsi 
october 2013 by BenNorland
Fancy - Glacier Stainless Kung Foon spoon by GSI Outdoors
Glacier Stainless Kung Foon spoon by GSI Outdoors, November 23, 2012 at 01:42AM, from Fancy / mrsupercool http://www.thefancy.com/mrsupercool
ifttt  googlereader  Fancy  /  mrsupercool  Glacier  Stainless  Kung  Foon  spoon  by  GSI  Outdoors  November  23  2012  at  01:42AM 
november 2012 by designmakecreate
Some interesting links from a guy that works at Omni
omnigroup p
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september 2012 by hammerheadlemon

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