force   1816

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Can we measure force using an accelerometer ?
The main problem that you will face is not getting a pure measurement of acceleration; rather, you will get by an accelerometer what is called "proper acceleration" which is the acceleration vector and projection of gravity on accelerometer axes. There are some methods to separate but it requires accurate knowledge of the orientation of the accelerometer to compensate for gravity components. To get an estimate of the orientation accurately you need to combine the accelerometer with a gyroscope which is needed in dynamic scenarios.
accelerometer  force  fma 
10 hours ago by imaginaryfriend
Transient mechanical strain promotes the maturation of invadopodia and enhances cancer cell invasion in vitro | Journal of Cell Science
Cancer cell invasion is influenced by various biomechanical forces found within the microenvironment. We have previously found that invasion is enhanced in fibrosarcoma cells when transient mechanical stimulation is applied within an in vitro mechano-invasion assay. This enhancement of invasion is dependent on cofilin (CFL1), a known regulator of invadopodia maturation. Invadopodia are actin-rich structures present in invasive cancer cells that are enzymatically active and degrade the surrounding extracellular matrix to facilitate invasion. In this study, we examine changes in gene expression in response to tugging on matrix fibers. Interestingly, we find that integrin β3 expression is downregulated and leads to an increase in cofilin activity, as evidenced by a reduction in its Ser3 phosphorylation levels. As a result, invadopodia lengthen and have increased enzymatic activity, indicating that transient mechanical stimulation promotes the maturation of invadopodia leading to increased levels of cell invasion. Our results are unique in defining an invasive mechanism specific to the invasive process of cancer cells that is triggered by tugging forces in the microenvironment, as opposed to rigidity, compression or stretch forces.
force  invadopodia  invasion  cofilin 
3 days ago by Segalllab
Active Directory: Force replication of all Domain Controllers on all Sites at once – SID-500.COM
Active Directory Domain Services uses pull replication to replicate Active Directory Partitions. This means that the Domain Controller on which replication is started receives the data from the source Domain Controller. It's like a one way ticket. If you want to replicate all Domain Controllers, then you have to start replication on each of them separately. This…
force  replication  powershell  windows  server 
6 days ago by jgear

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