epigenetics   1000

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Epigenetic drivers of tumourigenesis and cancer metastasis - ScienceDirect
Since the completion of the first human genome sequence and the advent of next generation sequencing technologies, remarkable progress has been made in understanding the genetic basis of cancer. These studies have mainly defined genetic changes as either causal, providing a selective advantage to the cancer cell (a driver mutation) or consequential with no selective advantage (not directly causal, a passenger mutation). A vast unresolved question is how a primary cancer cell becomes metastatic and what are the molecular events that underpin this process. However, extensive sequencing efforts indicate that mutation may not be a causal factor for primary to metastatic transition. On the other hand, epigenetic changes are dynamic in nature and therefore potentially play an important role in determining metastatic phenotypes and this area of research is just starting to be appreciated. Unlike genetic studies, current limitations in studying epigenetic events in cancer metastasis include a lack of conceptual understanding and an analytical framework for identifying putative driver and passenger epigenetic changes. In this review, we discuss the key concepts involved in understanding the role of epigenetic alterations in the metastatic cascade. We particularly focus on driver epigenetic events, and we describe analytical approaches and biological frameworks for distinguishing between “epi-driver” and “epi-passenger” events in metastasis. Finally, we suggest potential directions for future research in this important area of cancer research.
epigenetics  Review  Cancer 
14 hours ago by Segalllab
Twitter
RT : Great talks in the environmental session at Thanks to all! For further info check out our…
epigenetics  ASLO19  from twitter_favs
17 days ago by sr320
Twitter
Head over to our special session on at today at 9 for this and other exciting research!
epigenetics  ASLO19  from twitter_favs
18 days ago by sr320
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities | JCB
Data are in excel files as supplementary data.

Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes, transcriptomes, and proteomes. We define systems-level relationships between chromatin–DNA–RNA–protein states, identify lineage-specific DNA methylation of transcription factor binding sites, and pinpoint proteins underlying progesterone responsiveness. Comparative proteomics of estrogen and progesterone receptor–positive and –negative cell populations, extensive target validation, and drug testing lead to discovery of stem and progenitor cell vulnerabilities. Top epigenetic drugs exert cytostatic effects; prevent adult mammary cell expansion, clonogenicity, and mammopoiesis; and deplete stem cell frequency. Select drugs also abrogate human breast progenitor cell activity in normal and high-risk patient samples. This integrative computational and functional study provides fundamental insight into mammary lineage and stem cell biology.
mammary_development  gene_expression  proteomics  epigenetics 
4 weeks ago by Segalllab
IMAGE-CpG
Iowa Methylation Array Graphing for Experimental Comparison of Peripheral tissue & Gray matter (Brain)

Compare CpGs between brain, blood, and saliva
genomics  bioinformatics  epigenetics 
6 weeks ago by mark.larios
(752) CSI Genome: From Neanderthals to superhumans? | SRF Sternstunde Philosophie - YouTube
https://www.wired.co.uk/article/future-crispr-babies-gene-editing - Science is racing to stop another CRISPR baby from being born As the world grapples with the first gene-edited babies, questions are being raised about where we go next. &! https://futurism.com/the-byte/gene-editing-mutated-animals-crispr - MUTATED ANIMALS SHOW WHY GENE EDITING ISN’T READY FOR HUMAN TRIALS
CRISPR  genome  China  philosophy  medicine  epigenetics  genetics  ethics  moral  morality  evolution  god  HIV  AIDS  complexity  complex  gene  edit  deletion  interaction  Science  safety 
december 2018 by asterisk2a
Can We Really Inherit Trauma? - The New York Times
“This is a malady in modern science: the more extraordinary and sensational and apparently revolutionary the claim, the lower the bar for the evidence on which it is based, when the opposite should be true.”
science  dna  epigenetics 
december 2018 by craniac
Civil War POWs’ trauma shortened their sons’ lifespans, startling new research says | Fox News
what a surprise
The fact that sons’ lifespans were impacted and daughters were not, indicates an “epigenetic effect transmitted along the Y chromosome,” Costa said. The Y chromosome is only found in males.
genetics  epigenetics  civil  war 
november 2018 by pegasus505
Babies born to older fathers 'tend to have more medical issues' | Science | The Guardian
Men who start families later in life should be aware of the potential health risks to their children, study says
evolution  epigenetics 
november 2018 by asterisk2a

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