endocannabinoidsystem   11

WHAT IS CBD? Posted by Brian Bullman on August 04, 2016
Excellent 6-second vid on CBD

What is CBD? CBD is short for Cannabidiol, a molecular compound that is a botanical extract of the industrial Hemp plant. CBD is also found in Marijuana, but with high levels of THC as well. Hemp is legally identified as a strain of cannabis that has 0.3% or less of THC. Hemp products are legal in all 50 states.

CBD Facts
All mammals have an EndoCannabinoid System. Much like the circulatory
or respiratory system, the EndoCannabinoid System makes and regulates the Endo-Cannabinoids made by our bodies. The cannabis plant has the highest concentration of Cannabinoids of any plant on our fine planet. In short, Cannabinoids promote cellular homeostasis, and are ESSENTIAL to the human diet. It has been shown that a host of neurological, inflammatory, and autoimmune conditions are linked to cannabinoid deficiency. See HERE.
EndocannabinoidSystem  CBD  CBDoil  CnnabisMedicineSuppliers 
june 2018 by juandante
How Does CBD Affect the Endocannabinoid System?
How Does CBD Affect the Endocannabinoid System?

The endocannabinoid system exists to respond to endogenous cannabinoids produced by the human body. However, scientists have learned that the system will also recognize and respond to cannabinoids from external sources, including the phytocannabinoid cannabidiol. According to the National Institutes of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in treating a variety of medical ailments.

CBD and Cannabinoid Receptors

The endocannabinoid system includes two primary types of receptors that bind to cannabinoids: CB1 and CB2. Unlike THC, which fits directly into the CB1 receptor, cannabidiol does not fit into either type of receptor perfectly. Instead, it stimulates activity in both receptors without actually binding to them. This results in changes within any cells that contain either receptor. Because CB1 and CB2 receptors are present throughout the body, the effects of CBD are systemic.

According to Project CBD, research has also shown that CBD counteracts the psychoactive effects of THC by inhibiting its effects on CB1 receptors.

CBD's Indirect Effects on the Endocannabinoid System

When introduced into the endocannabinoid system, CBD causes an increased release of 2-AG, one of the endogenous cannabinoids. Like CBD, 2-AG stimulates both CB1 and CB2 receptors, which enhances the overall effect on the body. Studies published by the National Institutes of Health have shown that cannabidiol also inhibits the activity of fatty acid amide hydroxylase, or FAAH. This slows the deterioration of anandamide, another important endogenous cannabinoid found naturally within the body.

Other Effects of CBD

In addition to its impact on the endocannabinoid system, CBD also affects the body in other ways. For example, CBD binds directly to a G-protein coupled receptor known as TRPV-1, which is responsible for mediating body temperature, perceptions of pain and inflammation. CBD also activates serotonin receptors. Furthermore, studies conducted by the California Pacific Medical Center have shown that cannabidiol has the power to inhibit the ID-1 gene, which is known to cause several aggressive cancers, including certain cancers of the breast, brain, lungs, ovaries and pancreas.

Implications in Medicine

Cannabidiol's impact on the endocannabinoid system, as well as its other effects on the human body, indicate that this substance may be useful in treating a variety of medical conditions. For example, the medical community has already identified that THC can be an effective treatment for multiple ailments, including the side effects of chemo. Because CBD inhibits the negative effects of THC, it stands to reason that administering the two substances together could be even more beneficial than treatment with THC alone. Likewise, cannabidiol's stimulation of the endocannabinoid system promotes homeostasis within the body, reduces sensations of pain and inhibits inflammatory processes. Finally, CBD's effects on other genes and systems, such as its inhibition of the ID-1 gene, indicate that it may be an ideal treatment for certain types of effective cancers.

Medical research involving the possible uses of CBD is ongoing, the list of conditions CBD could potentially treat continues to grow. Currently, the list includes the conditions listed above, as well as mood disorders, diabetes, heart disease, glaucoma, asthma, stroke and many more.

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EndocannabinoidSystem  CBD  CannabisHealing  CannabisOilHealing 
june 2018 by juandante
The Science of the Endocannabinoid System: How THC Affects the Brain and the Body First published 2011
After several decades of research, scientists studying the effects of marijuana made several important discoveries. Not only did they identify the active ingredient in marijuana, they also discovered where and how it works in the brain—via a new system they called the endocannabinoid (EC) system. The EC system—named after the marijuana plant Cannabis sativa and its active ingredient delta-9-tetrahydrocannabinol (THC)—is a unique communications system in the brain and body that affects many important functions, including how a person feels, moves, and reacts.

The natural chemicals produced by the body that interact within the EC system are called cannabinoids, and like THC, they interact with receptors to regulate these important body functions. So what makes the EC system unique and how does THC’s impact on this system affect a person’s memory, risk for accidents, and even addiction?

Review Figure 1 and the steps below to take a closer look at the components of the EC system, how it works, and the effects of THC.
EndocannabinoidSystem  THC  CannabisHealing  CannabisOilHealing 
june 2018 by juandante
Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Russo EB. Neuro Endocrinol Lett. 2008.
Abstract
OBJECTIVES: This study examines the concept of clinical endocannabinoid deficiency (CECD), and the prospect that it could underlie the pathophysiology of migraine, fibromyalgia, irritable bowel syndrome, and other functional conditions alleviated by clinical cannabis.

METHODS: Available literature was reviewed, and literature searches pursued via the National Library of Medicine database and other resources.

RESULTS: Migraine has numerous relationships to endocannabinoid function. Anandamide (AEA) potentiates 5-HT1A and inhibits 5-HT2A receptors supporting therapeutic efficacy in acute and preventive migraine treatment. Cannabinoids also demonstrate dopamine-blocking and anti-inflammatory effects. AEA is tonically active in the periaqueductal gray matter, a migraine generator. THC modulates glutamatergic neurotransmission via NMDA receptors. Fibromyalgia is now conceived as a central sensitization state with secondary hyperalgesia. Cannabinoids have similarly demonstrated the ability to block spinal, peripheral and gastrointestinal mechanisms that promote pain in headache, fibromyalgia, IBS and related disorders. The past and potential clinical utility of cannabis-based medicines in their treatment is discussed, as are further suggestions for experimental investigation of CECD via CSF examination and neuro-imaging.

CONCLUSION: Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.

PMID 18404144 []
Republished from
Neuro Endocrinol Lett. 2004 Feb-Apr;25(1-2):31-9.
EndocannabinoidSystem  CBD  CBDoil  CannabisOil 
june 2018 by juandante
OH MY SCIENCE There’s a surprising link between coffee and cannabis by Marla Paul | Northwestern
Scientists were surprised to discover coffee changed many more metabolites in the blood than previously known.

New research shows coffee can affect our metabolism in dozens of ways—including our metabolism of steroids and the neurotransmitters typically linked to cannabis—beyond the caffeine boost we expect in the morning.

“These are entirely new pathways by which coffee might affect health.”

After drinking four to eight cups of coffee in a day, people’s neurotransmitters related to the endocannabinoid system—the same ones that cannabis affects—decreased. That’s the opposite of what occurs after someone uses cannabis.

Neurotransmitters are the chemicals that deliver messages between nerve cells and cannabinoids are the chemicals that give the cannabis plant its medical and recreational properties. Our body also naturally produces endocannabinoids, which mimic cannabinoid activity.

Further, certain metabolites related to the androsteroid system increased after drinking four to eight cups of coffee in a day, which suggests coffee might facilitate the excretion or elimination of steroids. Because the steroid pathway is a focus for certain diseases including cancers, coffee may have an effect on these diseases as well, researchers say.

“These are entirely new pathways by which coffee might affect health,” says lead author Marilyn Cornelis, assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine. “Now we want to delve deeper and study how these changes affect the body.”

Little is known about how coffee directly impacts health. In the new study, which appears in the Journal of Internal Medicine, scientists applied advanced technology that allowed them to measure hundreds of metabolites in human blood samples from a coffee trial for the first time.

For the study, 47 people in Finland didn’t drink coffee for one month, then consumed four cups a day for the second month, and then eight cups a day for the third month. Researchers used advanced profiling techniques to examine more than 800 metabolites in the blood collected after each stage of the study.

Blood metabolites of the endocannabinoid system decreased with coffee consumption, particularly with eight cups per day.

The endocannabinoid metabolic pathway is an important regulator of our stress response, Cornelis says, and some endocannabinoids decrease in the presence of chronic stress.

“The increased coffee consumption over the two-month span of the trial may have created enough stress to trigger a decrease in metabolites in this system,” Cornelis says. “It could be our bodies’ adaptation to try to get stress levels back to equilibrium.”

Sweet, low-calorie foods confuse our metabolism
The endocannabinoid system also regulates a wide range of functions: cognition, blood pressure, immunity, addiction, sleep, appetite, energy, and glucose metabolism.

“The endocannabinoid pathways might impact eating behaviors…the classic case being the link between cannabis use and the munchies.”

The brew also has been linked to aiding weight management and reducing risk of type 2 diabetes.

“This is often thought to be due to caffeine’s ability to boost fat metabolism or the glucose-regulating effects of polyphenols (plant-derived chemicals),” Cornelis says. “Our new findings linking coffee to endocannabinoids offer alternative explanations worthy of further study.”

The American Diabetes Association, the German Federal Ministry of Health, and other sources funded the work.

This article was originally published at northwestern.edu and republished here under the Creative Commons Attribution 4.0 International license.
Cannabis  Coffee  EndocannabinoidSystem  CannabisHealing 
may 2018 by juandante
Rick Simpson - Full Interview (Uncut) - Radio Student Zagreb 2014 - YouTube
Published on Feb 26, 2014 Rick Simpson was guest on Croatian cannabis radio show "Konoplja na Radiju" - Radio Student Zagreb wwww.radiostudent.hr This is full uncut conversation from the studio. The original radio show is here: http://www.youtube.com/watch?v=0DEkZl...
RickSimpson  CannabisOil  HempOil  EndocannabinoidSystem  CannabisOilHealingDocumentation  Delicious 
october 2014 by juandante
700 MEDICINAL USES OF CANNABIS SORTED BY DISEASE - A collection of clinical stud...
A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana. If a link doesnΓÇÖt work , try Weedbay
MedicalMarijuanaResearch  CannabisClinicalStudies  CannabisHealing  EndocannabinoidSystem  MarijuanaClinicalStudies  MarijuanaResearch  Delicious 
september 2014 by juandante
The Endocannabinoid System and How THC Cures Cancer | World Truth.TV
There are close to 20,000 studies on cannabinoids in the pubmed database, and few scientists who concentrate their work around cannabinoids can deny the tremendous therapeutic potential of cannabis. In fact, Dr. Christina Sanchez, a molecular biologist at Compultense University in Madrid Spain, has completed extensive research which led to one of the first discoveries that THC does indeed kill cancer cells. The endocannabinoid system is a group of receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory. It mediates many physiological processes, including motor learning, synaptic plasticity, and appetite. The Endocannabinoid System (ECS) maintains our biological systems by regulating each cell tissue. It uses Arachadonic acid/Omega 6 to make Endo-Cannabinoids: fatty molecules that communicate harm between cells. Dietary cannabis mimics the ECS by providing Cannabinoids when there is an Arachadonic acid defic
CannabinoidMedicine  CannabisOil  EndocannabinoidSystem  MedicalMarijuanaStudies  MedicalMarijuana  Delicious 
september 2014 by juandante
Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] - YouT...
Published on Jan 25, 2014 Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video] Cannabis Science Cannabinoid Compounds Marijuana Documentary [Full Video]
CannabisDocumentaries  EndocannabinoidSystem  CannabisOil  CannabisHealing  CannabinoidMedicine  Cannabinoids  Delicious 
august 2014 by juandante
Endocannabinoids in the immune system and cancer.
[Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar] - PubMed - NCBI.... The present review focuses on the role of the endogenous cannabinoid system in the modulation of immune response and control of cancer cell proliferation. The involvement of cannabinoid receptors, endogenous ligands and enzymes for their biosynthesis and degradation, as well as of cannabinoid receptor-independent events is discussed. The picture arising from the recent literature appears very complex, indicating that the effects elicited by the stimulation of the endocannabinoid system are strictly dependent on the specific compounds and cell types considered. Both the endocannabinoid anandamide and .....
EndocannabinoidSystem  MedicalMarijuana  CannabisHealing  ImmuneSystem  CannabisResearch  PubMed  Delicious 
january 2014 by juandante
Medicinal Cannabis - Educational Documentary - Cannabinoid Compounds - YouTube
THE SEMINAL VIDEO PRODUCTION ABOUT CANNABIS OIL. It runs 1hr22min26sec ~ In my estimation this the best investment for any person who wants to know how and why Cannabis Oil cures any number of "incurable" diseases, as well as how to make "Rick Simpson's Oil." RSO is not the last word on producing the best quality cannabis oil possible, but it is an essential beginning: Numerous cancers treated successful listed at the beginning of documentary ... YouTube link contains a TREASURE TROVE OF CANNABIS RESEARCH LINKS Mobile Version - http://youtu.be/B4xejnsLwKE Legalize - http://petition.liberal.ca/end-prohib... Cannabinoid Research on PubMed ncbi.nlm.nih.gov/pubmed/19638490 ncbi.nlm.nih.gov/pubmed/22776349 ncbi.nlm.nih.gov/pubmed/16682966 ncbi.nlm.nih.gov/pubmed/12648025 ncbi.nlm.nih.gov/pubmed/19914218 ncbi.nlm.nih.gov/pubmed/16893424 ncbi.nlm.nih.gov/pubmed/15361550 ncbi.nlm.nih.gov/pubmed/19889794
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january 2014 by juandante

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