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Rheumatoid Arthritis | West Hunter
It causes characteristic changes in the bones.  Key point:  it is vanishingly rare in Old World skeletons before the 17th century.  Those changes, however, been seen in some pre-Columbian Amerindian skeletons [work by Bruce Rothschild].

The obvious explanation is that RA is caused by some pathogen that originated in the Americas and later spread to the rest of the world.  Like the French disease.

https://westhunt.wordpress.com/2012/05/09/montezumas-revenge/
west-hunter  scitariat  discussion  ideas  speculation  critique  disease  parasites-microbiome  usa  age-of-discovery  europe  embodied  history  early-modern  multi  spreading 
16 hours ago by nhaliday
Germline selection | West Hunter
Here’s what seems to be happening: you have cells in the testes that reproduce, producing one daughter cell like the parent and one that develops into a sperm cell. That’s the way it’s supposed to be. But carrying certain very specific mutations of FGFR2 or FGFR3 seem to cause occasional divisions that result in two daughter cells – so the pre-sperm cells that carry such mutations gradually become more and more common in the testes and produce a growing fraction of sperm with those mutations. It’s rather like cancer. You get clumps of cells producing the bad sperm.

Same things is happening with MEN2B (RET gene), which is also more common than it should be, although not as much so as achondroplasia.

Without this unusual mutational mechanism, there would be a shortage of dwarfs.
west-hunter  scitariat  discussion  ideas  trivia  biodet  genetics  genomics  disease  mutation  developmental  embodied  selfish-gene  sex  cooperate-defect  EGT  epidemiology  🌞 
2 days ago by nhaliday
Columbia | West Hunter
If we ever had a real reason for manned space travel – I can imagine some – the first thing you’d need to do is kill everyone in the NASA manned space program. JPL you could keep.

usefulness of LEO:
https://westhunt.wordpress.com/2016/02/01/columbia/#comment-75883
https://westhunt.wordpress.com/2016/02/01/columbia/#comment-75891
west-hunter  scitariat  speculation  rant  stories  error  management  space  the-trenches  usa  government  ideas  discussion  multi  poast 
2 days ago by nhaliday
The struggle for truth | West Hunter
Being the strongest power gives you more latitude to indulge your fantasies. Women aren’t ever going to make useful Army Rangers: if we were fighting a war of survival, one in which that kind of infantry combat was key and against a foe with comparable resources, we would either shed that delusion or lose. War, serious war, keeps your head on straight [or chops it off] . That’s one reason that governments in Europe generally didn’t get as goofy as sometimes happened in China , late in a dynasty. Not for long.

south and WW2: https://westhunt.wordpress.com/2017/05/25/the-struggle-for-truth/#comment-91937
west-hunter  scitariat  discussion  rant  usa  trends  truth  realness  military  war  higher-ed  westminster  rot  zeitgeist  gender  meta:war  meta:rhetoric  history  early-modern  europe  china  asia  revolution  the-south  realpolitik  martial  old-anglo  impact  benchmarks  world-war  mostly-modern  multi  mediterranean  germanic  japan  peace-violence  enlightenment-renaissance-restoration  paying-rent 
3 days ago by nhaliday
/. discusses garbage collection
"you should really treat GC as a way of having infinite memory"
garbageCollection  memoryManagement  C  C++  Java  Slashdot  discussion 
4 days ago by MaxBarraclough
Strange issue with Python program on Windows 7 : learnpython
This resolved a problem running a pyinstaller .exe of a Python script trying to connect to a pymongo database (even on localhost).

"Despite the related Microsoft hotfix saying it could not be applied, the issue was a Windows 7 bug when performing winsock operations from a network share. Moving the files to the local machine drives allowed the program to operate normally again."

(Error was: "pymongo.errors.ServerSelectionTimeoutError: localhost:27017: [Errno 11003] getaddrinfo failed")
python  programming  eca  bug  reddit  discussion  windows 
5 days ago by np

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